Ana Cecília Roque Assistant Professor REQUIMTE/CQFB Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa 2829-516 Caparica, Portugal Phone: + 351 212948300; ext-10985 Fax: +351 212948385 e-mail: cecilia.roque@dq.fct.unl.pt http://www.dq.fct.unl.pt/docentes/index-docentes.html
Research Interests
The domain of specialization is Biotechnology and the fields of Bioprocessing (emphasis on Affinity Interactions), de novo Design of artificial receptors, Combinatorial Chemistry and Nanobiotechnology. Current research projects focus on: - Affinity interactions between natural partners and between biomolecules and artificial receptors. Study of molecular interactions for the development of biomimetic ligands to purify and detect biomolecules with potential biotechnological interest. - Synthesis of solid-phase combinatorial libraries in miniaturised formats. - Biosensors; Detection of molecular interactions and selection of binding partners.
Main publications
“Antibodies and Genetically Engineered Related Molecules: Production and Purification”, Roque, A.C.A., Lowe, C.R., Taipa, M.A. (2004), Biotechnology Progress, 20, 639-654. “A new method for the screening of solid-phase combinatorial libraries for affinity chromatography”, Roque, A.C.A., Taipa, M.A., Lowe, C.R. (2004), Journal of Molecular Recognition, 17, 262-267. “An artificial Protein L for the purification of immunoglobulins and Fab fragments by affinity chromatography”, Roque, A.C.A., Taipa, M.A., Lowe, C.R. (2005), Journal of Chromatography A, 1064, 157-167. “Advances and applications of de novo designed affinity ligands in proteomics”, Roque, A.C.A. and Lowe, C.R., (2006) Biotechnology Advances, 24, 17-26. “Magnetic Acoustic Resonance Immunoassay (MARIA): a Multifrequency Acoustic Approach for the Non-labelled detection of Biomolecular Interactions”, Araya-Kleinsteuber, B., Roque, A.C.A, Kioupritzi, E., Stevenson, A.C., and Lowe, C.R. (2006) Journal of Molecular Recognition, 19, 379-385.