Carlos A. Salgueiro Assistant Professor REQUIMTE/CQFB Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa 2829-516 Caparica, Portugal Phone: + 351 212948310 ; ext-10938/10936 Fax: + 351 212948550 e-mail: csalgueiro@dq.fct.unl.pt
Research Interests
Domain of specialization: Biochemistry, Biophysics, Bioenergetic, and Nuclear Magnetic Resonance (NMR). Present research interests: Application of NMR techniques to the study of Biological Systems, and particularly those that involve electron transfer metalloproteins (multiheme cytochromes, ferredoxins, etc). Structural-functional relationships in electron transfer and elucidation of electron transfer mechanisms involved in metal reduction by biological molecules. The main area of experimental work includes: i) Protein solution structure determination by NMR, ii) folding and unfolding protein studies by NMR, iii) thermodynamic characterization of electron transfer proteins.
Main publications
“Redox Characterization of Geobacter sulfurreducens Cytochrome c7: Physiological Relevance of the Conserved Residue F15 Probed by Site-Specific Mutagenesis”. M. Pessanha, Y.Y. Londer, W.C. Long, J. Erickson, P.R. Pokkuluri, M. Schiffer, C.A. Salgueiro. Biochemistry 43, 9909-9917, 2004. “Redox behaviour of the haem domain of flavocytochrome c3 from Shewanella frigidimarina probed by NMR”. M. Pessanha, E.L. Rothery, R.O. Louro, D.L. Turner, C.S. Miles, G.A. Reid, S.K. Chapman, A.V. Xavier, C.A. Salgueiro.  FEBS Lett. 578, 185-190, 2004. “Binding of ligands originates small perturbations on the microscopic thermodynamic properties of a multicentre redox protein”. C.A. Salgueiro, L.  Morgado, B. Fonseca, P. Lamosa, T. Catarino, D.L. Turner, R.O. Louro.  FEBS J. 272, 2251-2260, 2005. “Solution structures of tetrahaem ferricytochrome c3 from Desulfovibrio vulgaris (Hildenborough) and its K45Q mutant: the molecular basis of cooperativity”. Ana C. Messias, A.P. Aguiar, L. Brennan, C.A. Salgueiro, L.M. Saraiva, A.V. Xavier, D.L. Turner. Biochim. Biophys. Acta 1757, 143-153, 2006. “Thermodynamic characterization of triheme cytochrome PpcA from Geobacter sulfurreducens: evidence for a role played in e-/H+ energy transduction”. M. Pessanha, L. Morgado, R.O. Louro, Y.Y. Londer, P.R. Pokkuluri, M. Schiffer, C.A. Salgueiro. Biochemistry 45, 13910-13917, 2006.