Chem4Omics

GROUP MEMBERS

Carlos Lodeiro-Espiño (Assistant Professor) (Group Leader)
José Luis Capelo-Martínez (Assistant Professor)
Mario Emanuel de Sousa Diniz (Assistant Researcher)
Hugo Miguel Baptista Carreira dos Santos (Postdoctoral Researcher)
Elisabete de Jesus Oliveira Marques (Postdoctoral Researcher)
Javier Fernandez Lodeiro (Postdoctoral Researcher)
Gilberto Paulo Peixoto Igrejas (Associate Professor)
Patricia Alexandra Curado Quintas Dinis Poeta (Full Professor)

 

Group Researcher ID 
http://www.researcherid.com/rid/M-5599-2013

 

LABs WEBSITEs

 

RESEARCH INTERESTS AND OBJECTIVES

The Chem-4-Omics group is a multidisciplinary international research group, integrated by chemists, biologist and biotechnology researchers. The group encompasses three main research lines in an integrative and cooperative approach, in cooperation with international universities, hospital settings and industry. 
The group integrating three research lines:  i) starting with the chemical synthesis of new emissive organic and inorganic chemosensors (NECs), nano-synthesis of functionalized materials and new MALDI matrices for biological, environmental and medical applications, ii) application of the NECs to the medical and proteomics area has been developed to help in the diagnosis of diseases by finding new biomarkers of diagnosis and prognosis, or by classifying patients by the type of disease they suffer. Further to aforementioned works, the implementation of ultrasonic energy as a tool in the approaches using NECs has been also extensively addressed, and iii) application of the NECs to environmental studies has been done in zebra and gold fish, with the main aim to verify if current compounds being developed worldwide are dangerous for the living organisms or not. In addition to such studies, a number of studies addressing the influence of the climate change in living organism have been also developed.

There is extensive experience in Synthesis of Organic and Inorganic dyes, synthesis of nanoparticles and functionalized quantum dots, absorption and emission spectroscopy studies, MALDI-Mass Spectrometry, Ultrasonic devices, Electrophoresis 1D and 2D, Elisa and Western Blot studies, among other biophysical techniques. The group has access to all necessary infrastructures for, Synthesis, Omics and Nanomics, Nanotoxicological issues, either in-house or within the scope of National or International Networks Collaborations.

 

REPRESENTATIVE PUBLICATIONS

Galesio, M.; Vieira, D.V.; Rial-Otero, R.; Lodeiro, C.; Moura, I.; Capelo. J.L. Influence of the protein staining in the fast ultrasonic sample treatment for protein identification through peptide mass fingerprint and matrix-assisted laser desorption ionization time of flight mass spectrometry. JOURNAL OF PRETEOME RESEARCH, Vol. 7(5), Pages 2097-2106; (2008); DOI: 10.1021/pr700850w. 

Santos, H.M.; Mota, Lodeiro, C.; Moura, I.; Isaac, I.; Capelo, J. L.; An improved clean sonoreactor-based method for protein identification by mass spectrometry-based techniques.
TALANTA, Vol. 77(2), Pages 870-875 (2008); DOI: 10.1016/j.talanta.2008.07.048.

Lodeiro, C.; Capelo, J.L.; Mejuto, J.C.; Oliveira, E.; Santos, H.M.; Pedras, B.; Nunez, C.; Light and colour as analytical detection tools: A Journey into the periodic table using polyamines to bio-inspired systems as chemosensors.
CHEMICAL SOCIETY REVIEWS, Vol 39(8), Pages 2948-2976, (2010); DOI: 10.1039/b819787n. 

Mayoral, M.J.; Ovejero, P.; Campo, J.A.; Heras, J.V.; Oliveira, E.; Pedras, B.; Lodeiro, C.; Cano, M. Exploring photophysical properties of new boron and palladium(II) complexes with beta-diketone pyridine type ligands: from liquid crystals to metal fluorescence probes. JOURNAL OF MATERIALS CHEMISTRY, Vol. 21(4), Pages 1255-1263 (2011),. DOI: 10.1039/c0jm02698k.

Oliveira, E.; Nunez C.; Rodriguez-Gonzalez, B.; Capelo, J.L.; Lodeiro, C. Novel Small Stable Gold Nanoparticles Bearing Fluorescent Cysteine-Coumarin Probes as New Metal-Modulated Chemosensors.
INORGANIC CHEMISTRY, Vol 50(18), Pages 8797-8807 (2011,); DOI: 10.1021/ic200664z; 

Oliveira, E.; Genovese, D.; Juris, R.; Zaccheroni, N.; Capelo, J.L.; Raposo, M.M.M.; Costa, S.P.G.; Prodi, L.; Lodeiro, C. Bioinspired Systems for Metal-Ion Sensing: New Emissive Peptide Probes Based on Benzo[d]oxazole Derivatives and Their Gold and Silica Nanoparticles.
INORGANIC CHEMISTRY, 50 (18), 8834-88492011,; DOI: 10.1021/ic200792t.

Santos C. I. M.; Oliveira, E.; Barata, J.F.B.; Faustino, M.A.F.; Cavaleiro, J.A.S.; Neves, M.G.P.M.S.; Lodeiro, C. Corroles as anion chemosensors: exploiting their fluorescence behaviour from solution to solid-supported devices.
JOURNAL OF MATERIALS CHEMISTRY, Vol 22 (27), Pages 13811-13819 (2012); DOI: 10.1039/c2jm31281f.

Lopez Cortes, R.; Oliveira, E. ; Nuñez, C.; Lodeiro, C.; de la Cadena, MP.; Fdez Riverola, F.; Lopez Fernandez, H.; Reboiro Jato, M.; Glez Peña, D.; Capelo, J. L.; Santos, HM. Fast Human serum profiling through chemical depletion coupled to gold-nanoparticles assisted protein separation.
TALANTA, Vol. 100, Pages 239-245 (2012,); DOI: 10.1016/j.talanta.2012.08.02; 

Rosa, R.; Pimentel, M.S.; Boavida-Portugal, J.; Teixeira, T.; Trübenbach, K.; Diniz, M.S. Ocean warming enhances malformations, premature hatching, metabolic suppression and oxidative stress in the early stages of a keystone squid.
PLoS ONE, Vol. 7(6) 1-11 e38282 (2012); DOI: 10.1371/journal.pone.0038282

Fernandez-Lodeiro, J.; Nuñez, C.; Oliveira, E.; Capelo J.L.; Lodeiro, C. 1D Chain Fluorescein-functionalized gold and silver nanoparticles as new optical mercury chemosensor in aqueos media. JOURNAL OF NANOPARTICLE RESEARCH, Vol. 15(8), Pages UNSO1828 (2013)  DOI: 10.1007/s11051-013-1828-6

Santos, H.M.; Kouvonen, P.; Capelo, J.L.; Corthals, G.; On-Target ultrasonic digestion of proteins. PROTEOMICS, Vol 13(9), Pages 1423-1427, (2013), DOI: 10.1002/pmic.201200241