aj.barbosa

Arménio Jorge Barbosa
Post-doc Researcher
Collaborator
Research Group
Design of Molecules and NanoMaterials for Therapy and Diagnosis
Chemistry Department, FCT - Universidade Nova de Lisboa Campus de Caparica, Quinta da Torre 2829-516 Caparica Portugal
212 949 624
- ext 10984
212 948 550
Research Interests
Drug Design and Discovery with several protein targets, such as:
- Nuclear Receptors;
- GPCRs;
- Ligand-Gated Ion Channels;
- RNA binding proteins;
- Epigenetic targets, with focus on methyltransferases.

Homology protein models, ligand- and structure base drug design, highthroughput
virtual screening, molecular docking, molecular dynamics simulations.
Main publications
Moura Barbosa, A.J., Rocchi, L., Montanaro, L., Del Rio, A. “Inhibition of human dyskerin as a new approach to target ribosome biogenesis”, Plos One, 9(7): e101971, 2014.

Moura Barbosa, A.J., Andreoli, F., Moura Barbos, A.J., Parenti, M. D., Del Rio, A.. “Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives”, Curr pharm design, 19(4):578-613, September 2013.

Sanders, M., Moura Barbosa, A.J., Zarzycka, B., Nicolaes, G., Klomp, J., de Vlieg, J., Del Rio, A.; “A comparative analysis of pharmacophore screening tools”, J of Cheml Inf Mod, 2012, 52 (6): 1607-1620.

Moura Barbosa, A.J., Del Rio, A.; “Freely accessible databases of commercial compounds for high-throughput virtual screenings”, CTMC , 2012, 12, 866-877.

Del Rio, A., Moura Barbosa, A.J., Caporuscio, F., Mangiatordi, G.F.; “CoCoCo: a free suite of multiconformational chemical databases for high-throughput virtual screening purposes” Mol. Biosys, 2010, 6, 2122-2128

Moura Barbosa, A.J.; De Rienzo, F.; Ramos, M. J. Menziani, M. C.; “Computational analysis of ligand recognition sites of homo- and heteropentameric 5-HT3 Receptors.” Eur. J. Med. Chem., 2010, 45, 4746-4760.