ananeves

Ana Rute de Azevedo Pina Neves
Post-doc Researcher
PhD
Research Group
Biomodels, Bioanalytics and Biophysics
REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
220 428 672
226 093 390
Research Interests
- Biophysical and biochemical approaches to study the interaction of drugs with biomembranes (using liposomes and monolayers as biomimetic systems) in order to explain therapeutic properties.

- Development of nanodelivery systems with specific functionalization for drug delivery and controlled drug release.

PhD in Pharmaceutical Sciences: "A membrane biophysical approach to the therapeutic effects of resveratrol and design of novel nutraceutical nanoformulations."
Main publications
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PEER-REVIEWED PAPERS:

17. Neves A. R., Queiroz J. F., Lima S. A. C., Reis S., ApoE functionalization of solid lipid nanoparticles enhances brain drug delivery: uptake mechanism and transport pathways. Bioconjugate Chem. 2017, 28, 995-1004. [DOI: 10.1021/acs.bioconjchem.6b00705]

16. Loureiro J. A., Andrade S., Duarte A., Neves A. R., Queiroz J. F., Nunes C., Sevin E., Fenart L., Gosselet F., Coelho M. A. N., Pereira M. C., Resveratrol and Grape Extract-Loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s disease. Molecules 2017, 22, 277. [DOI: 10.3390/molecules22020277]

15. Neves A. R., Nunes C., Amenitsch H., Reis S., Resveratrol interaction with lipid bilayers: a synchrotron X-ray scattering study. Langmuir 2016, 32, 12914-12922. [DOI: 10.1021/acs.langmuir.6b03591]

14. Frias I., Neves A. R., Pinheiro M., Reis S., Design, development and characterization of lipid nanocarriers-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation. Drug Des Devel Ther. 2016, 10, 3519-3528. [DOI: 10.2147/DDDT.S109589]

13. Barbosa J. P., Neves A. R., Silva A. M., Barbosa M. A., Reis S., Santos S. G., Nanostructured Lipid Carriers Loaded with Resveratrol Modulate Human Primary Dendritic Cells. Int. J. Nanomedicine 2016, 11, 3501–3516. [DOI: 10.2147/IJN.S108694]

12. Neves A. R., Queiroz J. F., Reis S., Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E. J. Nanobiotechnol. 2016, 14 (27), 1-11. [DOI: 10.1186/s12951-016-0177-x]

11. Neves A. R., Martins S., Segundo M. A., Reis S., Nanoscale delivery of resveratrol towards enhancement of supplements and nutraceuticals. Nutrients 2016, 8, 131. [DOI: 10.3390/nu8030131]

10. Neves A. R., Nunes C., Amenitsch H., Reis S., Effects of resveratrol on the structure and fluidity of lipid bilayers: a membrane biophysical study. Soft Matter 2016, 12, 2118 – 2126. [DOI: 10.1039/C5SM02905H]

9. Neves A. R., Queiroz J. F., Lima S. A. C., Figueiredo F., Fernandes R., Reis S., Cellular uptake and transcytosis of lipid-based nanoparticles across the intestinal barrier: relevance for oral drug delivery. J. Colloid Interface Sci. 2016, 463, 258–265. [DOI: 10.1016/j.jcis.2015.10.057]

8. Neves A. R., Nunes C., Reis S., Resveratrol induces ordered domains formation in biomembranes: Implication for its pleiotropic action. Biochimica et Biophysica Acta 2016, 1858, 12–18. [DOI: 10.1016/j.bbamem.2015.10.005]

7. Lopes–de-Araújo J., Neves A. R., Gouveia V. M., Moura C. C., Nunes C. and Reis S., Oxaprozin-loaded lipid nanoparticles towards overcoming NSAIDs side-effects. Pharm. Res. 2016, 33(2), 301-14. [DOI: 10.1007/s11095-015-1788-x]

6. Neves A. R., Queiroz J. F., Weksler B., Romero I. A., Couraud PO., Reis S., Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E. Nanotechnology 2015, 26, 495103-13. [DOI: 10.1088/0957-4484/26/49/495103]

5. Neves A. R., Nunes C., Reis S., New insights on the biophysical interaction of resveratrol with biomembrane models: relevance for its biological effects. J. Phys. Chem. B. 2015, 119(35), 11664-72. [DOI: 10.1021/acs.jpcb.5b05419]

4. Neves A. R., Reis S., Segundo M. A., Development and validation of a HPLC method using a monolithic column for quantification of trans-resveratrol in lipid nanoparticles for intestinal permeability studies. J. Agric. Food Chem., 2015, 63, 3114−3120. [DOI: 10.1021/acs.jafc.5b00390]

3. Neves A. R., Lúcio M., Martins S., Lima J. L. F. C., Reis S., Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability. Int. J. Nanomedicine, 2013, 8:177-187. [DOI: 10.2147/IJN.S37840] [ Highly Cited Paper according to the Essential Science IndicatorsSM]

2. Neves A. R., Lúcio M., Lima J. L. F. C., Reis S., Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions. Curr. Med. Chem., 2012, 19(11):1663-81. [DOI: 10.2174/092986712799945085] [ Highly Cited Paper according to the Essential Science IndicatorsSM]

1. Neves A. R., Fernandes P. A., Ramos M. J., The accuracy of density functional theory in the description of cation-π and π-hydrogen bond interactions, J. Chem. Theory Comput. 2011, 7 (7), 2059-2067. [DOI: 10.1021/ct2001667]

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SCIENCE DISSEMINATION PAPERS:

1. The power of nanopharmaceutics to cure deadly diseases, International Innovation – Disseminating Science, Research and Technology 2015, 185: 96-98.
http://edition.pagesuite-professional.co.uk/launch.aspx?eid=9d5071ec-31dd-449b-8508-5b3fe627912b&pnum=98

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CONFERENCE PROCEEDINGS:

1. Sousa, S. F.; Cerqueira, N. M. F. S. A.; Perez, M. A. S.; Moreira, I. S.; Ribeiro, A. J. M.; Neves, A. R. A. P.; Ramos, M. J.; Fernandes, P. A.; Recent Advances on Computational Proteomics. Internacional Congress WASET - Conference on Bioinformatics, Computational and Systems Biology, Singapore, August 2009.
http://waset.org/publications/15475/recent-advances-on-computational-proteomics

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BOOK CHAPTERS:

4. Neves A. R. and Reis S., Importance and application of nanotechnology for improving the existing therapy, Book Series: Nanoparticles in the Life Sciences and Biomedicine, 2016, with the ISBN 978-981-4745-98-7 for hardcover and ISBN 978-981-4745-99-4 for eBook.

3. Neves A. R. and Reis S., Nanoparticles and new challenges on site-specific brain drug-delivery, Book Series: Nanoparticles in the Life Sciences and Biomedicine, 2016, with the ISBN 978-981-4745-98-7 for hardcover and ISBN 978-981-4745-99-4 for eBook.

2. Albuquerque J., Neves A. R. and Reis S., Theranostics: simultaneous treatment and diagnosis made possible by nanotechnology, Book Series: Nanoparticles in the Life Sciences and Biomedicine, 2016, with the ISBN 978-981-4745-98-7 for hardcover and ISBN 978-981-4745-99-4 for eBook.

1. Albuquerque J., Neves A. R. and Reis S., Wheat Germ: Protein Contents and Their Dietary Benefits, Book Series: Agricultural Research Updates, 2016, with the ISBN 978-1-63485-648-5.

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BOOK SERIES EDITOR:

1. Neves A. R. and Reis S., editors of the Book Series: Nanoparticles in the Life Sciences and Biomedicine, 2016, with the ISBN 978-981-4745-98-7 for hardcover and ISBN 978-981-4745-99-4 for eBook.