Ana Raquel Freitas
Post-doc Researcher
Research Group
Molecular Microbiology
REQUIMTE - Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto Rua Jorge Viterbo Ferreira nº 228 4050-313 Porto, Portugal
914 324 211
Research Interests
The present research is focused on the ecology and evolution of antimicrobial-resistant Enterococcus from different origins, and the characterization of particular ecotypes with special emphasis on the factors involved in the selection, dissemination and evolution of antibiotic resistance genes, plasmids and clonal complexes. Current research interests include the identification of risk factors involved in the emergence and amplification of high-risk enterococcal clones from different origins (humans, food products, animals and environment).
Main publications
Freitas AR, Novais C, Tedim AP, Francia MV, Baquero F, Peixe L, Coque TM. 2013. Microevolutionary Events Involving Narrow Host Plasmids Influences Local Fixation of Vancomycin-Resistance in Enterococcus. PLoS One. 8(3):e60589.

Freitas AR, Coque TM, Novais C, Hammerum AM, Lester CH, Jensen LB, Zervos MJ, Donadedian S, Francia MV, Baquero F, Peixe L. 2011. Human and swine hosts share vancomycin-resistant Enterococcus faecium CC17, CC5, and Enterococcus faecalis CC2 clonal clusters harboring Tn1546 on indistinguishable plasmids. Journal of Clinical Microbiology. 49(3):925-931.

Freitas AR, Novais C, Correia R, Monteiro M, Coque TM, Peixe L. 2011. Non-susceptibility to tigecycline in enterococci from hospitalized patients, food products and community sources. International Journal of Antimicrobial Agents. 38:174-176.

Werner G, Freitas AR, Coque TM, Sollid JE, Lester C, Hammerum AM, Garcia-Migura L, Jensen LB, Francia MV, Witte W, Willems RJ, Sundsfjord A. 2011. Host range of enterococcal vanA plasmids among Gram-positive intestinal bacteria. Journal of Antimicrobial Chemotherapy. 66(2):273-282.

Freitas AR, Tedim AP, Novais C, Ruiz-Garbajosa P, Werner G, Laverde-Gomez JA, Cantón R, Peixe L, Baquero F, Coque TM. 2010. Global spread of the colonization-virulence hylEfm gene in megaplasmids of CC17 Enterococcus faecium polyclonal sub-cluster. Antimicrobial Agents and Chemotherapy. 54(6):2660-2665.

Freitas AR, Novais C, Ruiz-Garbajosa P, Coque TM, Peixe L. 2009. Dispersion of multidrug resistant Enterococcus faecium belonging to major clonal complexes in different Portuguese settings. Applied and Environmental Microbiology. 75(14):4904-4908.

Freitas AR, Novais C, Ruiz-Garbajosa P, Coque TM, Peixe L. 2009. Clonal expansion within CC2 and dissemination of vancomycin-resistant plasmids in different Enterococcus faecalis clonal lineages of Portugal. Journal of Antimicrobial Chemotherapy. 63(6):1104-1111.