assilva

Alice Santos Silva
Associate Professor
Integrated Member
Research Group
Drugs Targets & Biomarkers
Faculdade de Farmácia da Universidade do Porto Rua de Jorge Viterbo Ferreira, nº 228 4050-213 Porto
220 428 563
- ext 8563
226 093 390
Research Interests
I have colaborated with other researchers in different projects, with specific aims, though having in common the search for the identification and characterisation of blood cells and molecules as markers of risk in humans. These studies were performed in different physiological models, such as pregnancy and physical exercise, and in pathological models, including inflammatory conditions, such as cardiovascular diseases,obesity, psoriasis, pre-eclamptic pregnancy, chronic renal failure, and hereditary hemolytic anemias, in which the clinical features grow worse when an acute or chronic infectious or inflammatory process devellops.
In these research areas, as Prof. of Haematology, I am especially interested in the ethiopathogeny of the associated anemia. Indeed, my more recent research activity is mainly focused on the mechanism underlying anemia due to erythropoietic disorders and to abnormal erythrocytes. Therefore I am focusing on the physiophatology of erythropoiesis and of the erythrocyte.

actual research interests
The aim of our group is to study the biology of erythropoiesis and erythropoietic disturbances, as well as the role of erythropoietin beyond the erythroid lineage, by using different human models associated with erythropoietic disturbances. One of such models, for its characteristics, that has been used by our group, is the anemia of chronic disease.
We are studying the clinical and analytical presentation of Hereditary Spherocytosis (HS), studying its biology and moving into flow cytometry studies to aplly to erythrocyte membrane pathologies. Some chronic renal failure patients under recombinant human eryhropoietin therapy, present resistance to this stimulation. We are studying the mechanism of this resistance and the associated cardiovascular risk in patients, and in animal models with induced renal failure. We are studying risk markers in obese children and adolecents as well as in adults. We are also studying the erythropoietic disturbances underlying anemia in elderly.
Main publications
2008

Rocha S, Vitorino RMP, Lemos-Amado FM, Castro E, Rocha-Pereira P, Barbot J, Cleto E, Ferreira F, Quintanilha A, Belo L, Santos-Silva A. “Presence of cytosolic peroxiredoxin 2 in the erythrocyte membrane of patients with Hereditary Spherocytosis”. Blood Cells Molecules and Diseases, 2008, 41 : 5-9. FI: 2,901. Citações: 21

Costa E, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Altered erythrocyte membrane protein composition in chronic kidney disease stage 5 patients under haemodialysis and recombinant human erythropoietin therapy”. Blood Purification, 2008, 26 (3) : 267-273. FI: 1,893. Citações: 5

Costa E, Rocha-Pereira P, Rocha S, Reis F, Castro E, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Role of prohepcidin, inflammatory markers and iron status in resistance to rhEPO therapy in hemodialysis patients”. American Journal of Nephrology, 2008, 28 (4) : 677-683. FI: 3,481. Citações: 15

Costa E, Lima M, Alves JM, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Inflammation, T-cell phenotype, and inflammatory cytokines in chronic kidney disease patients under hemodialysis and its relationship to resistance to recombinant human erythropoietin therapy”. Journal of Clinical Immunology, 2008, 28 (3) : 268-275. FI: 3,932. Citações: 29

Costa E, Lima M, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Faria MD, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “IL-7 serum levels and lymphopenia in hemodialysis patients, non-responders to recombinant human erythropoietin therapy. Blood Cells and Molecular Diseases, 2008, 41 (1) : 134-135.FI: 2,901.Citações: 2

Garrido EMPJ, Garrido JMPJ, Esteves M, Santos-Silva A, Marques MPM, Borges F. “Voltametric and DFT studies on viloxazine: analytical application to pharmaceuticals and biological fluids:” Electroanalysis, 2008, 20 (13) : 1454-1462. FI: 2,630. Citações: 5

Catarino C, Rebelo I, Belo L, Rocha-Pereira P, Rocha S, Castro E, Patrício B, Quintanilha A, Santos-Silva A. “Fetal lipoprotein changes in preeclampsia”. Acta Obstetricia et Gynecologica Scandinavica, 2008, 87 (6) : 628-634. FI: 1,618. Citações: 10

Costa E, Rocha S, Rocha-Pereira P, Reis F, Castro E, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “DMT1 (NRAMP2/DCT1) genetic variability and resistance to rhEPO therapy in chronic kidney disease patients under haemodialysis”. Acta Haematologica, 2008, 120 (1) : 11-13. FI: 1,069. Citações: 3

Costa E, Rocha S, Rocha-Pereira P, Nascimento H, Castro E, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Neutrophil activation and resistance to recombinant human erythropoietin therapy in hemodialysis patients” American Journal of Nephrology, 2008, 28 (6) : 935-940. FI: 3,481. Citações: 8

Belo L, Santos-Silva A, Quintanilha A, Rebelo I. “Similarities between pre-eclampsia and atherosclerosis: a protective effect of physical exercise?”. Current Medicinal Chemistry, 2008, 15 (22) : 2223-2229. FI: 4,708. Citações: 4

Catarino C, Rebelo I, Belo L, Rocha-Pereira P, Rocha S, Castro E, Patrício B, Quintanilha A, Santos-Silva A. “Relationship between maternal and fetal hemostatic disturbances in preeclamptic pregnancies”. Thrombosis Research, 2008, 123 (2) : 219-224. FI: 2,406. Citações: 8

Costa E, Rocha S, Rocha-Pereira, Reis F, Castro E, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Band 3 profile as a marker of erythrocyte changes in chronic kidney disease patients”. The Open Clinical Chemistry Journal, 2008, 1 : 57-63.

Costa E, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Changes in red blood cells membrane protein composition during haemodialysis procedure”. Renal Failure, 2008, 30 (10) : 971-975. FI: 0,840. Citações: 4

Costa E, Rocha S, Rocha-Pereira, Flávio Reis P, Castro E, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in Chronic Kidney Disease Patients under haemodialysis and recombinant human erythropoietin therapy”. Journal of Vascular Access, 2008, 9 (4) : 248-253. FI: 1,065. Citações: 9

Fernandes JC, Eaton P, Nascimento H, Belo L, Rocha S, Vitorino R, Amado F, Gomes J, Santos-Silva A, Pintado ME, Malcata FX. “Effects of chitooligosacharides on human red blood cell morphology and membrane protein structure”. Biomacromolecules, 2008, 9 (12) : 3346-3352. FI: 4,502. Citações: 14

2009
Catarino C, Rebelo I, Belo L, Rocha-Pereira P, Rocha S, Castro E, Patrício B, Quintanilha A, Santos-Silva A. “Erythrocyte changes in Preeclampsia: relationship between maternal and fetal erythrocyte damage”. Journal of Perinatal Medicine, 2009, 37 : 19-27. FI: 1.871. Citações: 3

Teixeira de Lemos E, Reis F, Baptista S, Pinto R, Sepodes B, Vala H, Rocha-Pereira P, Correia da Silva G, Teixeira N, Santos-Silva A, Carvalho L, Teixeira F, Das UN. “Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats”. Nutrition, 2009, 25 : 330-339. FI: 4,502. Citações: 3

Costa E, Rocha S, Rocha-Pereira P, Reis F, Castro E, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Effect of hemodialysis procedure in prohepcidin serum levels in regular hemodialysis patients” Clinical Nephrology, 2009, 71 (2) : 233-235. FI: 1,373.

Nascimento H, Silva L, Lourenço P, Vieira E, dos Santos R, Rego C, Ferreira Mansilha H, Santos-Silva A, Belo L. “Lipoprotein (a) levels in obese Portuguese children and adolescents: contribution of the pentanucleotide repeat (TTTTA)n polymorphism in the apolipoprotein(a) gene”. Archives of Pediatrics & Adolescent Medicine, 2009, 163 (4) : 393-394. FI: 4,726. Citações: 1

Paiva-Martins F, Fernandes J, Rocha S, Nascimento H, Vitorino R, Amado F, Borges F, Belo L, Santos-Silva A. “Effects of olive oil polyphenols on erythrocyte oxidative damage” Molecular Nutrition & Food Research, 2009, 53 (5) : 609-616. FI: 4,356. Citações: 32

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “Circulating levels of adiponectin, oxidized LDL and C-reactive protein in Portuguese patients with psoriasis vulgaris, according to body mass index, severity and duration of the disease”. Journal of Dermatological Science, 2009, 55 (3) : 202-204. FI: 3,713. Citações: 19

Rocha S, Costa E, Coimbra S, Nascimento H, Catarino C, Rocha-Pereira P, Quintanilha A, Belo L, Santos-Silva A. “Linkage of cytosolic peroxiredoxin 2 to erythrocyte membrane imposed by hydrogen peroxide induced oxidative stress”. Blood Cells and Molecular Diseases, 2009, 43 (1) : 68-73. FI: 2,901.Citações: 9

Reis F, Parada B, Teixeira de Lemos E, Garrido P, Dias A, Piloto N, Baptista S, Sereno J, Eufrásio P, Costa E, Rocha-Pereira P, Santos-Silva A, Figueiredo A, Mota A, Teixeira F. “Hypertension induced by immunossupressive drugs: a comparative analysis between sirolimus and cyclosporine”. Transplantation Proceedings, 2009, 41 (3) : 868-873. FI: 1,197. Citações: 9

Garrido P, Reis F, Costa E, Teixeira-Lemos E, Parada B, Alves R, Piloto N, Sereno J, Figueiredo A, Pinto R, Carvalho L, Rocha-Pereira P, Belo L, Santos-Silva A, Teixeira F. “Characterization of a rat model of moderate chronic renal failure - focus on hematological, biochemical, and cardio-renal profiles”. Renal Failure, 2009, 31(9) : 833-842. FI: 0,840. Citações: 2

Costa E, Swinkles DW, Laarakkers CM, Rocha-Pereira P, Rocha S, Reis F, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in hemodialysis patients” Acta Haematologica, 2009, 122 (4) : 226-229. FI: 1,069. Citações: 13

Catarino C, Rebelo I, Belo L, Rocha S, Castro E, Patrício B, Quintanilha A, Santos-Silva A. “Fetal and maternal angiogenic/anti-angiogenic factors in normal and preeclamptic pregnancy”. Growth Factors, 2009, 27 (6) : 345-351. FI: 2,468. Citações: 14

Nascimento H, Silva L, Lourenço P, Weinfurterová R, Castro E, Rego C, Ferreira H, Guerra A, Quintanilha A, Belo L, Santos-Silva A. “Lipid profile in portuguese obese children and adolescents: interaction of apolipoprotein E polymorphism with adiponectin levels”. Archives of Pediatrics & Adolescent Medicine, 2009, 163 (11) : 1030-1036. FI: 4,726. Citações: 6
Fernandes JC, Borges M, Nascimento H, Bronze E, Ramos OS, Belo L, Pintado ME, Malcata FX, Santos-Silva A. “Evaluation of the cytotoxicity and genotoxicity of chitooligosaccharides upon human lymphocytes”. Advances in Chitin Science, 11 : 412-416, 2009.

Costa E, Belo L, Quintanilha A, Santos-Silva A. “Resistance to recombinant human erythropoietin therapy in haemodialysis patients - focus on inflammatory cytokines, leukocyte activation, iron status and erythrocyte damage” Journal of Nephrology and Renal Transplantation, 2009, 2(3) : 66-83.

Gião MS, Leitão I, Pereira A, Borges AB, Guedes CJ, Fernandes JC, Belo L, Santos-Silva A, Hogg TA, Pintado ME, Malcata FXL. “Plant aqueous extracts: Antioxidant capacity via haemolysis and bacteriophage P22 protection”. Food Control, 2009, 21 : 633-638. FI: 2,463.

Piloto N, Teixeira HM, Teixeira-Lemos E, Parada B, Pinto R, Garrido P, Sereno J, Carvalho L, Costa E, Belo L, Santos-Silva A, Teixeira F, Reis F. “Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping”. Cardiovascular Toxicology, 2009, 9 (4) : 201-210. FI: 2,222. Citações: 8

2010

Nascimento H, Belo L, Fernandes J, Rocha S, Quintanilha A, Santos-Silva A. “In vitro studies with “acatalasemic-like” erythrocytes and hydrogen peroxide: attention to the formation of lysis resistant erythrocytes”. International Journal of Laboratory Hematology, 2010, 32 : 127-131. FI: 1,304.

Paiva-Martins F, Fernandes J, Santos V, Rocha S, Silva L, Borges F, Belo L, Santos-Silva A. “Powerful protective role of 3,4-dihydroxyphenylethanol elenolic acid dialdehyde against erythrocyte oxidative induced hemolysis” Journal of Agricultural and Food Chemistry, 2010, 58 (1) : 135-140. FI: 2.469. Citações: 16

Rocha S, Costa E, Ferreira F, Cleto E, Barbot J, Rocha-Pereira P, Quintanilha A, Belo L, Santos-Silva A. “Hereditary Spherocytosis and the (TA)nTAA polymorphism of UGT1A1 gene promoter region – a comparison of the bilirubin plasmatic levels in the different clinical forms. Blood Cells and Molecular Diseases, 2010, 44 : 117-119. FI: 2,901. Citações: 3

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “C –reactive protein and leukocyte activation in psoriasis vulgaris according to severity and therapy”. Journal of the European Academy of Dermatology and Venereology, 2010, 24 (7) : 789-796. FI: 2,787.Citações: 28

Rocha S, Costa E, Rocha-Pereira P, Ferreira F, Cleto E, Barbot J, Quintanilha A, Belo L, Santos-Silva A. “Erythrocyte membrane protein destabilization versus clinical outcome in 160 Portuguese Hereditary Spherocytosis patients”. British Journal of Hematology, 2010, 149 (5) : 785-794. FI: 4,597. Citações: 11

Da Silva Neves MM, González-Garcia MB, Nouws HP, Delerue-matos C, Santos-Silva A, Costa-García A. “Celiac disease diagnosis and glúten-free food analytical control”. Analytical and Bioanalytical Chemistry, 2010, 397 (5) : 1743-1753. FI: 3,480. Citações: 11

Garrido P, Reis F, Costa E, Almeida A, Parada B, Teixeira de Lemos E, Santos P, Alves R, Sereno J, Pinto R, Tavares CA, Figueiredo A, Rocha-Pereira P, Belo L, Santos-Silva A, Teixeira F. “Effect of recombinant human erythropoietin in a rat model of moderate chronic renal failure – focus on inflammation, oxidative stress and function/renoprotection”. The Open Drug Discovery Journal, 2010, 2 : 25-32. Citações: 1

Fernandes JC, Nascimento H, Gião MS, Ramos OS, Belo L, Santos-Silva A, Pintado ME, Malcata FX. “Antioxidant activity of chitooligosacharides upon two biological systems: erythrocytes and bacteriophages”. Carbohydrate Polymers, 2010, 1101-1106. FI: 3,167. Citações: 11

Fernandes JC, Spindola H, de Sousa V, Santos-Silva A, Pintado ME, Malcata FX, Carvalho JE. “Anti-inflammatory activity of chitooligosacharides in vivo”. Marine Drugs, 2010, 8 (6) : 1763-1768. FI: 3.471.Citações: 6

Pereira R, Costa E, Gonçalves M, Miranda V, Sameiro MS, Quintanilha A, Belo L, Lima M, Santos-Silva A. “Neutrophil and monocyte activation in chronic kidney disease patients under haemodialysis and its relationship with resistance to recombinant human erythropoietin and to the hemodialysis procedure” Hemodialysis International, 2010, 14(3) : 295-301. Citações: 2

Nascimento H, Rocha S, Rego C, Mansilha HF, Quintanilha A, Santos-Silva A, Belo L. “Leukocyte count versus C-reactive protein levels in obese Portuguese patients aged 6-12 years old”. The Open Biochemistry Journal, 2010, 10 (4) : 72-76.

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “Circulating adipokine levels in Portuguese patients with psoriasis vulgaris according to BMI, severity and therapy”. Journal of the European Academy of Dermatology and Venereology, 2010; 24 (12): 1386-1394. FI: 2,787. Citações: 32

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “Psoriasis therapy and cardiovascular risk factors: a 12-week follow-up study”. American Journal of Clinical Dermatology, 2010; 11 (6): 423-432. FI: 1,820. Citações: 12

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy”. The British Journal of Dermatology, 2010; 163 (6):1282-1290. FI: 4,260. Citações: 27

Teixeira AM, Garrido P, Santos P, Alves R, Parada B, Costa E, Almeida A, Teixeira-Lemos E, Sereno J, Pinto R, Belo L, Santos-Silva A, Teixeira F, Reis F. “Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure”. Renal Failure, 2010,32 (9) : 1073-1080. FI: 0,840. Citações: 2

Piloto N, Teixeira HM, Reis F, Teixeira-Lemos E, Parada B, Garrido P, Sereno J, Costa E, Alves R, Lourenço M, Tavares CA, Ferrer-Antunes CA, Santos-Silva A, Teixeira F. “Toxicological effects of recombinant human erythropoietin doping - chronic versus acute aerobic exercise”. Acta Medicine Legalis et Socialis, 2010, 275-282.
Piloto N, Teixeira HM, Teixeira LE, Parada B, Garrido P, Sereno J, Pinto AF, Costa E, Belo L, Santos-Silva A, Pinto R, Couceiro P, Neto P, Xavier F, Carvalho L, Teixeira F, Reis F. "Erythropoietin doping as cause of sudden death in athetes - an experimental study", Acta Medicine Legalis et Socialis, 2010, 267-274.

2011

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “Health-related quality of life in Portuguese psoriatic patients: relation with PASI and different types of classical psoriatic treatment”. The Journal of Dermatology, 2011, 38 (8) : 816-819. FI: 1,008. Citações: 3

Rocha S, Costa E, Rocha-Pereira P, Ferreira F, Cleto E, Barbot J, Quintanilha A, Belo L, Santos-Silva A. “Complementary markers for the clinical severity classification of hereditary spherocytosis in unsplenectomized patients”. Blood Cells Molecules and Disease, 2011, 46 (2) : 166-170. FI: 2,901.Citações: 4

Borges A, Borges M, Costa E, Nascimento H, Sameiro-Faria M, Miranda V, Reis F, Belo L, Costa E, Santos-Silva A. Apoptosis of peripheral CD4+ T-lymphocytes in End Stage Renal Disease patients under Hemodialysis and rhEPO therapies. Renal Failure, 2011, 33 (2) : 138-143.
Factor de impacto da revista: 0,840. Citações: 4

Fernandes JC, Borges M, Nascimento H, Bronze-da-Rocha E, Ramos OS, Pintado ME, Malcata FX, Santos-Silva A. Cytotoxicity and genotoxicity of chitooligosaccharides upon lymphocytes. International Journal of Biological Macromolecules, 2011, 49 : 433-438.
Factor de im pacto da revista: FI: 2.502. Citações: 1

Rocha S, Rocha-Pereira P, Ferreira F, Cleto E, Barbot J, Quintanilha A, Belo L, Santos-Silva A. Erythropoiesis versus inflammation in Hereditary Spherocytosis clinical outcome. Clinical Biochemistry, 2011, 44 (13) : 1137-1143. FI: 2.238. Citações: 1

Pereira R, Rocha S, Borges A, Nascimento H, Reis F, Miranda V, Sameiro Faria MD, Quintanilha A, Belo L, Costa E, Santos-Silva A. Elastase release during the hemodialysis procedure seems to induce changes in red blood cell membrane proteins. Hemodialysis International, 2011, 15(3) : 429-431. FI: 1.093

Ribeiro S, Nascimento H, Borges, Faria MS, Rocha-Pereira P, Costa E, Belo L, Santos-Silva A. Comparison of Bio-Plex measurements with standard techniques. Clinical Chemistry and Laboratory Medicine, 2011, 50 (2) : 399-402. FI: 2.069

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. A potential mechanism for the pathogenesis of psoriasis vulgaris. International Journal of Dermatology. 2011, 51: 4, 1-4. FI 1.485

2012

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “Erythroid disturbances before and after treatment of Portuguese psoriasis vulgaris patients: A cross-sectional and longitudinal study.”. American Journal of Clinical Dermatology. 2012, 13 (1), 37-47. FI: 2.238: 1,820. Citações: 1

Coimbra S, Figueiredo A, Castro E, Rocha-Pereira P, Santos-Silva A. “The roles of cells and cytokines in the pathogenesis of psoriasis”. International Journal of Dermatology, 2012, 51(4) : 389-395. FI 1.485

Fernandes JC, Eaton P, Franco I, Ramos OS, Sousa S, Nascimento H, Gomes A, Santos-Silva A, Xavier Malcata F, Pintado ME. Evaluation of chitoligosaccharides effect upon probiotic bacteria. International Journal of Biololgy and Macromolecules, 2012, 50 (1) : 148-152.
Citações: 1

Rodrigues C, Costa E, Vieira E, De Carvalho J, Santos R, Rocha-Pereira P, Santos-Silva A, Bronze-da-Rocha E. Bilirubin dependence on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index. American Journal of Medical Sciences. 2012, 343(2) : 114-118. FI: 1.257

Teixeira M, Rodrigues-Santos P, Garrido P, Costa E, Parada B, Sereno J, Alves R, Belo L, Teixeira F, Santos-Silva A, Reis F. Cardiac antiapoptotic and proproliferative effect of recombinant human erythropoietin in a moderate renal failure stage. Journal of Pharmacy and Bioallied Sciences, 2012, 4 (1), 76-83. Citações: 1

Nascimento H, Costa E, Rocha-Pereira P, Rego C, Ferreira Mansilha H, Quintanilha A, Santos-Silva A, Belo L. Cardiovascular risk factors in Portuguese obese children and adolescents: impact of small reductions in body mass index imposed by lifestyle modification”. The Open Biochemistry Journal, 2012, 6 : 23-30.

Rodrigues C, Vieira E, Santos R, Carvalho J, Santos-Silva A, Costa E, Bronze-da-Rocha E. “Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert Syndrome patients and in healthy subjects”. Blood Cells Molecules and Diseases, 2012, 48(3) : 166-172. FI: 2.716.

Neves M, González-García MB, Santos-Silva A, Costa-Garcia A. “Voltammetric immunosensor for the diagnosis of celiac disease based on the quantification of anti-gliadin antibodies" Sensors and Actuators B-Chemical, 2012, 163(1) : 253-259. FI: 3.370.

Ribeiro S, Faria MS, Silva G, Nascimento H, Rocha-Pereira P, Miranda V, Vieira E, Santos R, Mendonça D, Quintanilha A, Costa E, Belo L, Santos-Silva A. Oxidized-LDL and lipoprotein (a) levels in chronic kidney disease patients under hemodialysis: influence of adiponectin and of a polymorphism in the apolipoprotein (a) gene. Hemodialysis International, 2012, 16(4) : 481-490.

Catarino C, Santos-Silva A, Belo L, Rocha-Pereira P, Rocha S, Patricio B, Quintanilha A Rebelo I. Inflammatory disturbances in preeclampsia: relationship between maternal and umbilical cord blood. Journal of Pregnancy, 2012, Article ID 684384, 10 pages.

Faria MS, Ribeiro S, Nascimento H, Rocha-Pereira P, Miranda V, Mendonça D, Quintanilha A, Costa E, Belo L, Santos-Silva A. Adiponectin is na independente predictor of tissue plasminogen activator levels in patients under haemodialysis. Scandinavian Journal of Urology and Nephrology, 2012, 46(6) : 461-465. FI: 1.007

Rodrigues C, Vieira E, Santos R, Carvalho J, Santos-Silva A, Costa E, Bronze-da-Rocha E. “Variantes no gene UGT1A1 que condicionam os níveis de bilirrubina”. Este artigo foi escrito a convite de Salud Ciencia, órgão oficial da Sociedad Iberamericana de Información Científica (SIIC), a fim de dar destaque ao artigo Rodrigues C et al., “Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert Syndrome patients and in healthy subjects”, publicado na revista Blood Cells Molecules and Diseases, 2012, 48(3) : 166-172. Foi publicado na Internet, no “site” da SIIC (http://www.siicsalud.com), em Agosto de 2012.

Ribeiro S, do Sameiro Faria M, Mascarenhas-Melo F, Freitas I, Mendonça MI, Nascimento H, Rocha-Pereira P, Miranda V, Mendonça D, Quintanilha A, Belo L, Costa E, Reis F, Santos-Silva A. Main Determinants of PON1 Activity in Hemodialysis Patients. American Journal of Nephrology. 2012, 36(4) : 317-323. FI: 2.539

Costa E, Coimbra J, Catarino C, Ribeiro S, Reis F, Nascimento H, Fernandes J, Miranda V, do Sameiro Faria M, Belo L, Santos-Silva A. “Major determinants of BMP-2 serum levels in hemodialysis patients”. Renal Failure 2012; 34 : 1355-1358.

Fernandes J, Sereno J, Garrido P, Parada B, Cunha M, Reis F, Pintado M, Santos-Silva A.
Inhibition of bladder tumour growth by chitooligosaccharides in an experimental carcinogenesis model. Marine Drugs, 2012, 10 (12) : 2661-2675. FI: 3.854

2013

Coimbra S, Oliveira H, Belo L, Figueiredo A, Rocha-Pereira P, Santos-Silva A. “Principal determinants of the length of remission of psoriasis vulgaris after topical, NB-UVB, and PUVA therapy: a follow-up study”. American Journal of Clinical Dermatology, 2013, 14(1) : 49-53.
Factor de impacto da revista: 1,820.

Coimbra S, Oliveira H, Neuparth MJ, Figueiredo A, Rocha-Pereira P, Santos-Silva A. Inflammatory markers of cardiovascular disease risk in Portuguese psoriatic patients: relation with narrow-band ultravioleta B and psoralen plus ultravilet A. International Journal of Dermatology, 2012, In Press. FI 1.485


Silva FSG, Oliveira H, Moreiras A, Fernandes JC, Bronze-da-Rocha E, Figueiredo A, Custódio JBA, Rocha-Pereira P, Santos-Silva A. The in vitro and in vivo genotoxicity of isotretinoin assessed with cytokinesis blocked micronucleus assay and comet assay. Toxicology in Vitro, 2013, 27 : 900-907. FI: 2.755

Silva FSG, Oliveira H, Moreiras A, Fernandes JC, Bronze-da-Rocha E, Figueiredo A, Custódio JBA, Rocha-Pereira P, Santos-Silva A. Cyto- and genotoxic effects of acitretin alone or combined with psoralen–ultraviolet A and narrowband ultraviolet B therapy in psoriatic patients. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2013, 753 : 42-47, FI: 3.175.

Silva FSG, Ribeiro M, Santos M, Rocha-Pereira P, Santos-Silva A, Custódio JBA, Acitretin affects bioenergetics of liver mitochondria and promotes mitochondrial permeability transition: Potential mechanisms of hepatotoxicity. Toxicology, 2013, 306 : 93-100. FI: 3.763

Faria MS, Ribeiro S, Rocha-Pereira P, Miranda V, Mendonça D, Quintanilha A, Costa E, Belo L, Santos-Silva A. “Vascular access versus the effect of statins on inflammation and fibrinolysis in renal dialysis patients”. The Journal of Vascular Access, In Press.

Neuparth MJ, Proença JB, Santos-Silva A, Coimbra S. Adipokines, oxidized LDL and C-reactive protein levels in lean, overweight and obese Portuguese patients with type 2 diabetes. ISRN Obesity. In press.

Rodrigues C, Rocha E, Nascimento H, Vieira E, Santos R, Santos-Silva A, Costa E, Bronze-da-Rocha E. ”Bilirubin levels and redox status in a young healthy population” Acta Haematologica, 2013, 130(1) : 57-60.

Faria MS, Ribeiro S, Costa E, Mendonça D, Teixeira L, Rocha-Pereira P, Fernandes J, Nascimento H, Kohlova M, Reis F, Amado L, Bronze-da-Rocha E, Miranda V, Quintanilha A, Belo L, Santos-Silva A. “Risk factors for mortality in hemodialysis patients: two years follow-up study”. Disease Markers, 2013, 35 (6) : 791-798.

Coimbra S, Catarino C, Santos-Silva A. “The role of adipocytes in the modulation of iron metabolism in obesity”. Obesity Reviews, 2013, 14 (10) : 771-7799
FI: 7.038

Paiva-Martins F, Silva A, Almeida V, Carvalheira M, Serra C, Rodríguez-Borges J, Fernandes J Santos-Silva A. "Protective activity of hydroxytyrosol metabolites on erythrocyte oxidative-induced hemolysis". Journal of Agricultural and Food Chemistry, 2013, 61(27) : 6636-6642.

Silva FSG, Ribeiro MPC, Santos MS, Rocha-Pereira P, Santos-Silva A, Custódio JBA. “The antiestrogen 4-hydroxytamoxifen protects against isotretinoin-induced permeability transition and bioenergetic dysfunction of liver mitochondria: comparison with tamoxifen”. Journal of Bioenergetics and Biomembranes. 2013, 45 (4) : 383-396.

Kohlova M, Ribeiro S, do Sameiro-Faria M, Rocha-Pereira P, Fernandes J, Reis F, Miranda V, Quintanilha A, Belo L, Bronze-Rocha E, Costa E, Santos-Silva A. “Circulating cell-free DNA levels in hemodialysis patients and its association with inflammation, iron metabolism, and rhEPO doses”. Hemodialysis International, 2013, 17 (4) : 664-667.

Coimbra S, Oliveira H, Figueiredo A, Rocha-Pereira P, Santos-Silva A. “Factors associated with the length of remission of psoriasis vulgaris”, Clinical Drug Investigation, 2013, 33 : 855-860.

Sameiro-Faria M, Ribeiro S, Rocha-Pereira P, Fernandes J, Reis F, Bronze-da-Rocha E, Miranda V, Quintanilha A, Costa E, Belo L, Santos-Silva A. “Body mass index and resistence to recombinant human erythropoietin therapy in maintenance hemodialysis patients”, Renal Failure, 2013, 35 (10) : 1392-1398.

Moura A, Madureira J, Alija P, Fernandes J, Oliveira JG, Lopez M, Filgueiras M, Amado L, Sameiro-Faria M, Miranda V, Vieira M, Santos-Silva A, Costa E. “Type of vascular access and location in online-hemodiafiltration and its association with patient’s perception of health-related quality of life”. Journal of Vascular Access, In Press. FI: 0.97

Rossato LG, Costa VM, Dallegrave E, Arbo M, Dinis-Oliveira RJ, Santos-Silva A, Duarte JA, de Lourdes Bastos M, Palmeira C, Remião F. Cumulative mitoxantrone-induced haematological and hepatic adverse effects in a sub-chronic in vivo study. Basic and Clinical Pharmacology Toxicology. 2013, In press. FI: 2.124

Neuparth MJ, Proença JB, Santos-Silva A, Coimbra S. “The positive effect of moderate walking exercise on chemerin levels in Portuguese patients with type 2 diabetes mellitus”. Journal of Investigative Medicine, In press. FI: 1.746

Coimbra S, Catarino C, Costa E, Oliveira H, Figueiredo A, Rocha-Pereira P, Santos-Silva A. “Circulating cell-free DNA levels in Portuguese patients with psoriasis vulgaris according to severity and therapy”. British Journal of Dermatology In Press. FI: 4,260




Book chapters

Piloto N, Reis F, Teixeira HM, Parada B, Garrido P, Sereno J, Costa E, Pinto R, Pinto AF, Ferreira L, Rocha-Pereira P, Santos-Silva A, Teixeira F. “Recombinant human erythropoietin doping in sports - cardiovascular effects in chronic and acute aerobic exercise in an animal model”. Publicado no livro “Proceedings of the European Association for Clinical Pharmacology and Therapeutics”, Medimond Ed. 2009, 181-185.

Garrido P, Reis F, Teixeira de Lemos E, Costa E, Parada B, Piloto N, Sereno J, Figueiredo A, Alves R, Rocha-Pereira P, Belo L, Santos-Silva A, Teixeira F. “Recombinant human erythropoietin therapy has benefficial cardio-renal effects on moderate stages of chronic renal failure in the rat”. Publicado no livro “Proceedings of the European Association for Clinical Pharmacology and Therapeutics”, Medimod Ed. 2009, 177-180.

Tavaria FK, Fernandes JC, Santos-Silva A, Baptista da Silba S, Sarmento B, Pintado MM. “Biological activities of chitin, chitosan and respective oligomers”. Publicado no livro “Chitosan: Manufacture, Properties and Usage”, Davis S.P. (Ed.) Illinois, US, Nova Publishers, 2010, 170-191.

Coimbra S, Oliveira H, Reis F, Belo L, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. Psoriasis comorbidities and the incidence of risk factors for cardiovascular disease events in psoriasis. Publicado no livro “Psoriasis: Causes, Diagnosis and Treatment”. Editor: Julian A. Carrasco; Nova Science Publishers. NY 2011. ISBN: 978-1-61324-595-8.

Coimbra S, Oliveira H, Reis F, Belo L, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “Psoriasis comorbidities and the incidence of risk factors for cardiovascular disease events in psoriasis”. Publicado no livro “Psoriasis: causes, diagnosis and treatment”. Editor: Julian A. Carrasco; Nova Science Publishers. NY 2011. ISBN 978-1-61209-314-7. Livro também publicado como e-Book, ISBN 978-1-62081-072-9.

Costa E, Belo L, Santos-Silva A. Resistance to recombinant human erythropoietin therapy in haemodialysis patients. Cap. Do livro "Hemodialysis / Book 3", ISBN 979-953-307-261-5, 2011, cap. 3, pag. 35-54.

Coimbra S, Oliveira H, Figueiredo A, Rocha-Pereira P, Santos-Silva A. Psoriasis: epidemiology, clinical and histological features, triggering factors, assessment of severity and psychosocial aspects. In the book Psoriasis - A Systemic Disease , ISBN 978-953-51-0281-6, edited by Jose O'Daly; InTech, Open Access Publisher, 2012, chap. 3, pp 69-88.

Costa E, Belo L, Santos-Silva A. Neutrophil activation and erythrocyte membrane protein composition in stage 5 chronic kidney disease patients. Cap. Livro “Chronic Kidney Disease”, InTech, Edited by Monika G, ISBN 978-953-51-0171-0, 2012, Chap 13, pp. 209-224.

Catarino C, Rebelo I, Belo L, Quintanilha A, Santos-Silva A. Umbilical cord blood changes in neonates from a preeclamptic pregnancy. No livro “From Preconception to Postpartum”, ISBN 978-953-51-0353-0, edited by Stavros Sifakis and Nikolaos Vrachnis, 2012, Cap. 17, pag. 269-296.

Teixeira-Lemos E, Teixeira HM, Piloto N, Teixeira M, Parada B, Rodrigues-Santos P, Carvalho L, Alves R, Costa E, Belo L, Santos-Silva A, Teixeira F, Reis F. Cardiometabolic injure due to recombinant human erythropoietin dopping for improvement of sports performance – chronic (training) versus acute (extenuating) aerobic exercise. Publicado no livro "Sport performance and Injuries", Editores: João H. Bastos e Andreia C. Silva. Nova Science Publishers. NY 2012. ISBN: 978-1-61942-659-7.

Coimbra S and Santos-Silva A. Body mass index (BMI) importance in Psoriasis. Publicado no livro “New Trends in Body Mass Index Research”. Editors: Alard Vermeulen and Edme De Smet; Nova Science Publishers. NY 2012 ISBN: 978-1-61942-430-2. Livro também publicado com e-Book, ISBN 978-1-62081-072-9.

Coimbra S, Santos-Silva A. Erythropoiesis: Cellular and Molecular Implications. In: Frontiers in Drug Discovery - Erythropoietic Stimulating Agents; editores: Costa E, Reis F, Santos-Silva A. Benthan edicões, 2013: 3-26.

Fernandes JC, Reis F, Costa E, Santos-Silva A. Modulation of Erythropoietin Gene Expression. In: Frontiers in Drug Discovery - Erythropoietic Stimulating Agents; editores: Costa E, Reis F, Santos-Silva A. Benthan edicões, 2013: 27-42.

Garrido P, Costa E, Santos-Silva A, Reis F. Animal Models of Kidney Disease-associated Anemia. Frontiers in Drug Discovery - Erythropoietic Stimulating Agents; editores: Costa E, Reis F, Santos-Silva A. Benthan edicões, 2013: 61-80.

Ribeiro S, Costa E, Reis F, Santos-Silva A. Risks and Benefits Associated with High Therapeutic Doses of Erythropoiesis Stimulating Agents. Frontiers in Drug Discovery - Erythropoietic Stimulating Agents; editores: Costa E, Reis F, Santos-Silva A. Benthan edicões, 2013: 81-97.

Ribeiro S, Costa E, Belo L, Reis F, Santos-Silva A. “RhEPO for the treatment of erythropoietin resistant anemia in hemodialysis patients – risks and benefits”. In "Hemodialysis". Editor: Hiromichi Suzuki. InTech. (2013) ISBN 978-953-51-0988-4. Chap. 6, pg 291-314.

Costa E, Reis F, Santos-Silva A. Editores do Livro “Frontiers in Drug Discovery - Erythropoietic Stimulating Agents” Benthan edicões, 2013.