Bruno M Fonseca
Assistant Researcher
Integrated Member
Research Group
Drugs Targets & Biomarkers
UCIBIO, REQUIMTE Laboratory of Biochemistry, Biological Sciences Department Faculty of Pharmacy, University of Porto Rua de Jorge Viterbo Ferreira n.º 228 Ed.2 Piso 5 - 4050-313 Porto - Portugal
220 428 559
226 093 390
Research Interests
I’m interested in the potential impact of endocannabinoid system modulation in endocrine function with particular emphasis in fertility and cancer progression. I would like to advance the understanding of how endocannabinoid system is regulated and their contribution to human physiology. Some of my additional research interests include the study of Cannabinoid derivatives on cellular differentiation, vascular permeability and angiogenesis.
Main publications
Sá S, Fonseca BM. Dynamics of progesterone and estrogen receptor alpha in the ventromedial hypothalamus. Journal of Endocrinology; 2017 doi: 10.1530/JOE-16-0663

Almada M, Amaral C, Diniz-da-Costa M, Correia-da-Silva G, Teixeira NA, Fonseca BM. The endocannabinoid anandamide impairs in vitro decidualization of human cells. Reproduction; 2016 152(4):351-61. doi: 10.1530/REP-16-0364

Fonseca B.M., Correia-da-Silva G., Teixeira N.A. “Anandamide restricts uterine stromal differentiation and is critical for complete decidualization.” Mol Cell Endocrinol. 2015 15;411:167-76

Sá SI, Fonseca B.M., Teixeira N, Madeira MD. “Estrogen receptor α and β have different roles in the induction and trafficking of progesterone receptors in hypothalamic ventromedial neurons.” FEBS Journal. 2015 282(6):1126-36

Costa MA, Fonseca B.M., Keating E, Teixeira NA, Correia-da-Silva G 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. Reproduction, 2014 3;147(3):301-11

Fonseca BM, Costa MA, Almada M, Correia-da-Silva G, Teixeira NA. “The endocannabinoid system revisited: a biochemistry perspective.” Prostaglandins Other Lipid Mediat 2013 102-103: 13.30

Fonseca B.M., Correia-da-Silva G., Taylor A.H., Lam P.M.W., Marczylo T.H.,Konje J.C., Bell S.C., Teixeira N.A. “N-acylethanolamine levels and expression of their metabolizing enzymes during pregnancy.” Endocrinology, 2010, 151:3965-3974.