carlos.novo

Carlos Novo
Assistant Researcher
Integrated Member
Research Group
Molecular Microbiology
Carlos Novo, PhD; Glycoimmunology Group, UCIBIO; Departamento Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
Research Interests
He has a Chemistry degree from the Science Faculty of the Classic University of Lisbon and a PhD in Biochemistry, King’s College London.

Researcher in Biotechnology and more recently in cancer research. He was the director of the Research Unit UTPAM from The Biothecnology Departmnet of INETI. He is the coordinator of the optional Curricular Unit of “Monoclonal antibodies; production and application” of the Medical Parasitology MSc of the IHMT/UNL.

His main areas of interest are the role of Protein disulphide isomerase and chaperones in diverse human cancer as well the production of monoclonal antibodies for diagnosis and therapy of several cancers. He has participated in several research projects and supervised several BsC, MsC and PhD thesis.

Main publications
Silva Z, Veríssimo T, Videira PA, Novo C (2015) Protein Disulfide Isomerases: Impact of Thapsigargin treatment on their expression in melanoma cell lines. IJBIOMAC 79, 44-48.

Novo C., Martins TM., Prata S., Lopes A, Armada A. (2009) Gene sequencing, modelling and immunolocalization of the protein disulfide isomerase from Plasmodium chabaudi. IJBIOMAC 45, 399-406.

Novo C, Farnaud S, Clemente A, Brown PR (2002) Support for a 3D structure predicting a Cys-Glu-Lys catalytic triad for Pseudomonas aeruginosa amidase comes from site-directed mutagenesis and mutations altering substrate specificity. Biochem. J. 365, 731-738.

Novo C, Tata R, Clemente A, Brown PR (1995) Pseudomonas aeruginosa aliphatic amidase is related to the nitrilase/cyanide hydratase enzyme family and Cys 166 is predicted to be the active site nucleophile of the catalytic mechanism. FEBS Lett, 367, 275-279.

Novo C, Fonseca E, Freitas A. (1987) Altered fatty acids membrane composition modifies lymphocyte localization in vivo, Cell Immunol, 106, 387-396.