Daniel Silva
Post-doc Researcher
Research Group
Design of Molecules and NanoMaterials for Therapy and Diagnosis
Research Interests
Organic synthesis, bioinorganic chemistry, medicinal chemistry.
Main publications
Daniela Arduíno, Daniel Silva, Sandra M. Cardoso, Sílvia Chaves, Catarina R. Oliveira, M. Amélia Santos. “Synthesis and investigation of new hydroxypyridinone based iron-chelators as potential anti-neurodegenerative drug candidates”, Frontiers in Bioscience, (2008), 13, 6763-74.

D. Silva, F. Norberto, S. Santos, P. Hervés, “Chemistry of novel aryl N-(2- pyridyl)thionocarbamates in basic media”, J. Phys. Org. Chem. (2009), 22:3, 221-8.

Daniel da Silva, Abdelouahid Samadi, Mourad Chioua, Maria do Carmo Carreiras, José Marco-Contelles, "The Sandmeyer Reaction on Some Selected Heterocyclic Ring Systems: Synthesis of Useful 2-Chloroheterocyclic-3-Carbonitrile Intermediates", Synthesis, (2010), 16, 2725-30.

Daniel Botelho da Silva, Abdelouahid Samadi, Lourdes Infantes, Maria do Carmo Carreiras, José Marco-Contelles, "Synthesis of (E)-Diethyl 6,6'-(Diazene-1,2-diyl)bis(5-cyano-2-methyl-4-phenylnicotinates, a New Type of 2,2’-Azopyridine Dyes", Tetrahedron Letters, (2010), 51, 6278-81.

David Sucunza, Abdelouahid Samadi, Mourad Chioua, Daniel Botelho da Silva, Lourdes Infantes, Maria C. Carreiras, José Marco-Contelles, “A Practical Two-Step Synthesis of Imidazo[1,2-a]pyridines by Sandmeyer Reaction of 2-Amino-6-(prop-2-yn-1-ylamino)pyridines”, Chem. Comm., (2011), 47, 5043-5.

Abdelouahid Samadi, Daniel Silva, Mourad Chioua, Elena Soriano, Maria do Carmo Carreiras José Marco-Contelles, “Microwave Irradiation-Assisted Amination of 2-Chloropyridine Derivatives with Amide Solvents”, Synthetic Communications (2011), 41, 2859–69.

Daniel Silva, Mourad Chioua, M. Carmo Carreiras, María-Luisa Jimeno, Cristóbal de los Ríos, Alejandro Romero, Mercedes Villarroya, Manuela G. López, José Marco- Contelles, “Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives”, European Journal of Medicinal Chemistry, (2011), 46:9, 4676-81.

Daniel Silva, Fatima Norberto, Susana Santos, Jim Iley, “Kinetics and Mechanism of Basic Hydrolysis of Quinoliyl N,N-dimethylcarbamates”, J. Phys. Org. Chem. (2011), 24:11, 1081-7.

Daniel Silva, Mourad Chioua, Abdelouahid Samadi, Paula Agostinho, Pedro Garção, Rocío Lajarín-Cuesta, Cristobal de los Ríos, Isabel Iriepa, Ignacio Moraleda, Laura Gonzalez-Lafuente, Eduarda Mendes, Concepción Pérez, María Isabel Rodríguez-Franco, José Marco-Contelles, and M. Carmo Carreira, "Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity", ACS Chemical Neuroscience (2013), 4:4, 547-65.

Jordi Juárez-Jiménez, Eduarda Mendes, Carles Galdeano, Carla Martins, Daniel B. Silva, José Marco-Contelles, Maria do Carmo Carreiras, F. Javier Luque, and Rona R. Ramsay “Exploring the structural basis of the selective inhibition of monoamino oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies”, BBA - Proteins and Proteomics (in press; DOI:10.1016/j.bbapap.2013.11.003).