egracas

Eduarda das Graças Rodrigues Fernandes
Associate Professor
Integrated Member
Research Group
Biomodels, Bioanalytics and Biophysics
REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
220 428 675
- ext 220428675
226 093 483
Research Interests
Development and application of methodologies for the in vitro study of pro-oxidant and pro-inflammatory processes.

Topics:

Flavonoids and xanthone derivatives with potential anti-inflammatory activity: in vitro structure/activity studies of their effects in pro-inflammatory signaling systems.

Carotenoids with potential antioxidant activity: in vitro structure/activity studies in human erythrocytes.

Antioxidant and anti-inflammatory activity of plant extracts in in vitro chemical and biological systems.

Development of new selective COX-2 inhibitors as potential anti-inflammatory candidates.

Effects of paramagnetic and superparamagnetic iron oxide nanoparticles on human neutrophils.
Main publications
Book Chapters

Eduarda Fernandes, José L.F.C. Lima and Salette Reis, Involvement of reactive oxygen and nitrogen species in inflammatory processes. Implications for the potential therapeutic use of NSAIDs with antioxidant activity, In: Current Topics in Medicinal Chemistry, (Eds. D.T.W. Chu, W.B. Gratzer, F. Halberg, P. Herdewijn, V.J. Hruby, J.A. Katzenellenbogen, A.J. Lin, V. Nacci, M.E. Nasr, C.H. Robinson, D.F. Veber, D.A. Winkler), Research Trends, 2003, 3, 221-236.

Rosa M. Seabra, Paula B. Andrade, Patrícia Valentão, Eduarda Fernandes, Félix Carvalho and Maria de Lourdes Bastos, Antioxidant compounds extracted from several plant materials, In: Biomaterials from Aquatic and terrestrial Organisms, (Eds. Miltion Fingerman and Rachakonda Nagabhushanam), Science Publishers Inc., 2006, 115-174.

Most Relevant Publications (last 5 years)

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2013

Daniela Ribeiro, Marisa Freitas, Sara Tomé, Artur Silva, Graça Porto, Eduarda Fernandes, Modulation of human neutrophils oxidative burst by flavonoids, Eur. J. Med. Chem. 2013, 67, 280-292.

Noelia González, Daniela Ribeiro, Eduarda Fernandes, Daniele R. Nogueira, Enma Conde, Andrés Moure, María Pilar Vinardell, Montserrat Mitjans, Herminia Domínguez, Potential use of Cytisus scoparius extracts in topical applications for skin protection against oxidative damage, J. Photochem. Photobiol. B: Biology 2013,125, 83-89.

Marisa Freitas, Vera M. Costa, Daniela Ribeiro, Diana Couto, Graça Porto, Félix Carvalho, Eduarda Fernandes, Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils, Toxicol. Lett. 2013, 219, 170-177.

Clementina M.M. Santosa, M. Beatriz Q. Garcia, Artur M.S. Silva, René Santus, Patrice Morlière, Eduarda Fernandes, Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry, Tetrahedron Lett. 2013, 5, 85-90.

Marisa Freitas, Pedro Barcellos-de-Souza, Christina Barja-Fidalgo, Eduarda Fernandes, Nickel induces apoptosis in human neutrophils, Biometals 2013, 26(1), 13-21.

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2012

Beatriz Días Reinoso, Diana Couto, Andrés Moure, Eduarda Fernandes, Herminia Domíguez, Juan Carlos Parajó, Optimization of antioxidants-Extraction from Castanea sativa leaves, Chem. Eng. J. 2012, 203, 101-109.

Mónica S. Estevão, Luísa C. Carvalho, Marisa Freitas, Ana Gomes, Aldino Viegas, João Manso, Stefan Erhardt, Eduarda Fernandes, Eurico J. Cabrita, M. Manuel B. Marques, Indole based cyclooxygenase inhibitors: synthesis, biological evaluation, docking and NMR screening, Eur. J. Med. Chem. 2012, 54, 823-833.

Renan Campos Chisté, Marisa Freitas, Adriana Zerlotti Mercadante, Eduarda Fernandes, The potential of extracts of Caryocar villosum pulp to scavenge reactive oxygen and nitrogen species, Food Chem. 2012, 135, 1740-1749.

Ana Gomes, Diana Couto, Andreia Alves, Irene Dias, Marisa Freitas, Graça Porto, José Alberto Duarte, Eduarda Fernandes, Trihydroxyflavones with antioxidant and anti-inflammatory efficacy, BioFactors 2012, 38(5), 378-386.

Beatriz Díaz Reinoso, Ana Gomes, Marisa Freitas, Eduarda Fernandes, Daniele Rubert, José González, Andrés Moure, Argimiro Levoso, María Pilar Vinardell, Montserrat Mitjans, Herminia Domínguez, Juan Carlos Parajó, Valuable polyphenolic antioxidants from Wine vinasses, Food Bioprocess Technol. 2012, 5, 2708-2716.

Mónica S. Estevão, Filipe J. S. Duarte, Eduarda Fernandes, A. Gil Santos, M. Manuel B. Marques, Unexpected reactivity of trifluoromethylated olefins with indole: a mechanistic investigation, Tetrahedron Lett. 2012, 53, 2132-2136.

Patrice Morlière, Larry K. Patterson, Clementina M.M. Santos, Artur M.S. Silva, Jean-Claude Mazière, Paulo Filipe, Ana Gomes, Eduarda Fernandes, M. Beatriz Q. Garcia, René Santus, The dependence of α-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment, Org. Biomol. Chem. 2012, 10, 2068-2076.

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2011

Marisa Freitas, Eduarda Fernandes, Zinc, cadmium and nickel increased the activation of NF-κB and the release of cytokines from THP-1 monocytic cell, Metallomics, 2011, 3, 1238-1243.

Luísa R. Carvalho, Eduarda Fernandes, M. Manuel B. Marques, Developments towards regioselective synthesis of 1,2-disubstituted benzimidazoles, Chem. Eur. J. 2011, 17, 12544-12555.

Renan Campos Chisté, Adriana Zerlotti Mercadante, Ana Gomes, Eduarda Fernandes, José Luís Fontes Costa Lima, Neura Bragagnolo, In vitro scavenging capacity of annatto seed extracts against reactive oxygen and nitrogen species, Food Chem. 2011, 127(2), 419-426.

Mónica S. Estevão, Luísa C. Carvalho, Luísa M. Ferreira, Eduarda Fernandes and M. Manuel B. Marques, Analysis of the antioxidant activity of an indole library: cyclic voltammetry vs ROS scavenging activity, Tetrahedron Lett. 2011, 52, 101-106.

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2010

Diana Couto, Daniela Ribeiro, Marisa Freitas, Ana Gomes, José L.F.C. Lima, Eduarda Fernandes, Scavenging of reactive oxygen and nitrogen species by the pro-drug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine, Redox Rep. 2010, 15(6), 259-267.

Marisa Freitas, Ana Gomes, Graça Porto, Eduarda Fernandes, Nickel induces oxidative burst, NF-kB activation and interleukin-8 production in human neutrophils, J. Biol. Inorg. Chem. 2010, 15, 1275-1283.

Mónica S. Estevão, Luísa C. Carvalho, Luísa M. Ferreira, Eduarda Fernandes, M. Manuel B. Marques, A new insight on the hypochlorous acid scavenging mechanism of tryptamine and triptophan derivatives, Bioorg. Med. Chem. Lett. 2010, 20(22), 6475-6478.

Mónica S. Estevão, Luísa C. Carvalho, Daniela Ribeiro, Diana Couto, Marisa Freitas, Ana Gomes, L.P. Ferreira, Eduarda Fernandes, M. Manuel B. Marques, Antioxidant activity of unexplored indole derivatives: synthesis and screening, Eur. J. Med. Chem. 2010, 45(11), 4869-4878.

Clementina M.M. Santos, Marisa Freitas, Daniela Ribeiro, Ana Gomes, Artur M.S. Silva, José A.S. Cavaleiro, Eduarda Fernandes, 2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: a structure/activity study, Bioorg. Med. Chem. 2010, 18, 6776-6784.

Marisa Freitas, José L.F.C. Lima, Graça Porto, Eduarda Fernandes, Metal-induced oxidative burst in isolated human neutrophils, Microchem. J. 2010, 96, 167-171.

Pedro M.P. Santos, Alexandra M.M. Antunes, João Noronha, Eduarda Fernandes, Abel J.S.C. Vieira, Scavenging activity of aminoantipyrines against hydroxyl radical, Eur. J. Med. Chem. 2010, 45, 2258-2264.

A. Gomes, M. Freitas, E. Fernandes, J.L.F.C. Lima, Biological activities of 2-styrylchromones, Mini Rev. Med. Chem. 2010, 10, 1-7.

Marisa Freitas, Graça Porto, José L.F.C. Lima, Eduarda Fernandes, Zinc activates neutrophils’ oxidative burst, Biometals 2010, 23(1), 31-41.

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2009

Ana Gomes, Ondrej Neuwirth, Marisa Freitas, Diana Couto, Daniela Ribeiro, Eduarda Fernandes, Andrea G.P.R. Figueiredo, Artur M.S. Silva, Raquel S.G.R. Seixas, Diana C.G.A. Pinto, Augusto C. Tomé, José A.S. Cavaleiro, José L.F.C. Lima, Synthesis and antioxidant activity of new chromone derivatives, Bioorg. Med. Chem. 2009, 17(20), 7218-7226.

Isabel F. Almeida, Eduarda Fernandes, José L.F.C. Lima, P.C. Costa, M.F. Bahia, In vitro protective effect of Hypericum androsaemum extract against oxygen and nitrogen reactive species, Basic Clin. Pharmacol. Toxicol. 2009, 105, 222-227.

Marisa Freitas, José L.F.C. Lima, Eduarda Fernandes, Optical probes for detection and quantification of neutrophils’oxidative burst. A review, Anal. Chim. Acta 2009, 649, 8-23.

Ana Gomes, Eduarda Fernandes, Artur M.S. Silva, Clementina M.M. Santos, Diana C.G.A. Pinto, José A.S. Cavaleiro, José L.F.C. Lima, Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways, Biochem. Pharmacol. 2009, 78, 171-177.

Marisa Freitas, Graça Porto, José L.F.C. Lima, Eduarda Fernandes, Optimization of experimental settings for the analysis of human neutrophils oxidative burst in vitro, Talanta 2009, 78, 1476-1483.

Isabel F. Almeida, Eduarda Fernandes, José L.F.C. Lima, Patrícia Valentão, Paula B. Andrade, Rosa M. Seabra, P.C. Costa, M.F. Bahia, Oxygen and nitrogen reactive species are effectively scavenged by Eucalyptus globulus leaf water extract, J. Med. Food 2009, 12 (1), 175-183.