emcosta

Elisio Costa
Assistant Professor
Integrated Member
Research Group
Drugs Targets & Biomarkers
Laboratory of Biochemistry Department of Biological Sciences Faculty of Pharmacy Rua de Jorge Viterbo Ferreira n.º 228, 4050-313 PORTO Portugal
220 428 500
- ext 8566
226 093 390
Research Interests
Biological aging and cardiovascular disease; Chronic inflammation and systemic effects; Hemodialysis and animal models of chronic kidney disease; anti-oxidant and anti-inflammatory properties of natural compounds.
Main publications
- Moura, A; Madureira J; Alija P; Fernandes JC, Oliveira JG, Lopez M, Filgueiras M, Amado L, Sameiro-Faria M, Miranda V, Vieira M, Santos-Silva A, Costa E. type of vascular access and location in onlinr hemodiafiltration and its association with patients perception of health-related quality of life. The Journal of Vascular Access, in press.

- Sameiro-Faria, M; Ribeiro, S; Rocha-Pereira, P; Fernandes, J; Reis, F; Bronze-da-Rocha, E; Miranda, V; Quintanilha, A; Costa, E; Belo, E; Santos-Silva, A. Body mass index and resistance to recombinant human erythropoietin therapy in maintenance hemodialysis patients. Renal Failure, in press.

- Kohlova, M; Ribeiro, S; Sameiro-Faria, M; Rocha-Pereira, P; Fernandes, J; Reis, F; Miranda, V; Quintanilha, A; Belo, E; Bronze-da-Rocha, E; Costa, E; Santos-Silva, A. Circulating cell-free DNA levels in hemodialysis patients and its association with inflammation, iron metabolism, and rhEPO doses. Hemodialysis International, in press.

- Sameiro-Faria, M; Ribeiro, S; Rocha-Pereira, P; Miranda, V; Quintanilha, A; Reis, F; Costa, E; Belo, L; Santos-Silva, A. Vascular access versus the effect of statins on inflammation and fibrinolysis in renal dialysis patients. The Journal of Vascular Access, in press.

- Rodrigues, C; Rocha, S; Nascimento, H; Vieira, E; Dos Santos, R; Santos-Silva, A; Costa, E; Bronze-da-Rocha, E. Bilirubin Levels and Redox Status in a Young Healthy Population. Acta Haematologica 2013;130: 57 - 60.


2012

- Rodrigues, C; Costa, E; Vieira, E; Carvalho, JR; Dos Santos, R; Rocha-Pereira, P; Santos-Silva, A; Bronze-da-Rocha, E. Bilirubin Is Mainly Dependent on UGT1A1 Polymorphisms, Hemoglobin, Fasting Time and Body Mass Index. The American Journal of the Medical Sciences 2012; 2: 114 - 118.

- Nascimento, H; Costa, E; Rocha-Pereira, P; Rego, C; Mansilha, HF; Quintanilha, A; Santos-Silva, A; Belo, L. Cardiovascular Risk Factors in Portuguese Obese Children and Adolescents: Impact of Small Reductions in Body Mass Index Imposed by Lifestyle Modifications. The Open Biochemistry Journal2012; 6: 43 - 50.

- Reis, F; Teixeira, M; Garrido, P; Parada, B; Alves, R; Teixeira, F; Rodrigues-Santos, P; Costa, E; Sereno, J; Belo, L; Santos-Silva, A. Cardiac antiapoptotic and proproliferative effect of recombinant human erythropoietin in a moderate stage of chronic renal failure in the rat. Journal of Pharmacy and Bioallied Sciences 2012;4: 76 - 83.

- Rodrigues, C; Vieira, E; Dos Santos, R; Carvalho, JR; Santos-Silva, A; Costa, E; Bronze-da-Rocha, E. Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects. Blood Cells, Molecules, and Diseases 2012; 48: 166 - 172.

- Ribeiro, S; Sameiro-Faria, M; Silva, G; Nascimento, H; Rocha-Pereira, P; Miranda, V; Vieira, E; Dos Santos, R; Mendonça, D; Quintanilha, A; Costa, E; Belo, E; Santos-Silva, A. Oxidized low-density lipoprotein and lipoprotein(a) levels in chronic kidney disease patients under hemodialysis: Influence of adiponectin and of a polymorphism in the apolipoprotein(a) gene. Hemodialysis International 2012;16: 481 - 490.

- Sameiro-Faria, M; Ribeiro, S; Nascimento, H; Rocha-Pereira, P; Miranda, V; Mendonça, D; Quintanilha, A; Costa, E; Belo, E; Santos-Silva, A. Adiponectin is an independent predictor of tissue plasminogen activator levels in patients under haemodialysis. Scandinavian Journal of Urology and Nephrology 2012;46: 461 - 465.

- Ribeiro, S; Sameiro-Faria, M; Mascarenhas-Melo, F; Freitas, I; Mendonça, MI; Nascimento, H; Rocha-Pereira, P; Miranda, V; Mendonça, D; Quintanilha, A; Belo, E; Costa, E; Reis, F; Santos-Silva, A. Main Determinants of PON1 Activity in Hemodialysis Patients. American Journal of Nephrology 2012;36: 317 - 323.

- Costa, E; Coimbra, J; Catarino, C; Ribeiro, S; Reis, F; Nascimento, H; Fernandes, J; Miranda, V; Sameiro-Faria, M; Belo, E; Santos-Silva, A.. Major Determinants of BMP-2 Serum Levels in Hemodialysis Patients, Renal Failure 2012;34, 10: 1355 - 1358.

2011

- Rocha, S; Costa, E; Rocha-Pereira, P; Ferreira, F; Cleto, E; Barbot, J; Quintanilha, A; Belo, L;Santos-Silva, A. Erythropoiesis versus inflammation in Hereditary Spherocytosis clinical outcome. Clinical Biochemistry 2011;44:1137-1143.

- Ribeiro, S; Nascimento, H; Borges, A; Sameiro-Faria, M; Rocha-Pereira, P; Costa, E; Belo, L;Santos-Silva, A. Comparison of Bio-Plex measurements with standard techniques. Clinical Chemistry and Laboratory Medicine 2011 Nov 14;50(2):399-402

- adeira, I; Frada, R; Marvão, J; Cruz, F; Casal, M; Costa, E. Morphine Patient Controlled Analgesia for Postoperative Analgesia in Patients Who Have Transplanted Cadaver Donor Kidneys. Transplantation Proceedings 2011; 1:125-130.

- Rocha, S; Costa, E; Rocha-Pereira, P; Ferreira, F; Cleto, E; Barbot, J; Quintanilha, A; Belo, L; Santos-Silva, A. Complementary markers for the clinical severy classification of Hereditary Spherocytosis. Blood Cells Mol Dis 2011; 46: 166-170.

2010

- Pereira, R; Costa, E; Gonçalves, M; Miranda, V; Sameiro-Faria, M; Quintanilha, A; Luis Belo; Lima, M; Santos-Silva, A. Neutrophil and monocyte activation in chronic kidney disease patients under hemodialysis and its relationship with resistance to rhEPO and to hemodialysis procedure. Hemodial Int 2010; 14: 295-301.

- Rocha, S; Costa, E; Rocha-Pereira, P; Ferreira, F; Cleto, E; Barbot, J; Quintanilha, A; Belo, L; Santos-Silva, A. Erythrocyte membrane protein destabilization versus clinical outcome in 160 Portuguese Hereditary Spherocytosis patients. British Journal of Haematology 2010;149:785-794.

- Teixeira M; Garrido, P; Santos P; Costa, E; Parada, B; Alves, R; Almeida, A; Teixeira de Lemos, E; Sereno, J; Pinto, R; Belo, L; Santos-Silva, A; Teixeira, F; Reis, F. Recombinant human erythropoietin treatment protects the cardio-renal áxis in a model of moderate chronic renal failure. Renal Failure 2010; 25: 9-22.

- Garrido, P; Reis, F; Costa, E; Almeida, A; Parada, B; Teixeira de Lemos, E; Santos, P; Alves, R; Sereno, J; Pinto, R; Tavares, CA; Figueiredo, A; Rocha-Pereira, P; Belo, L; Santos-Silva, A; Teixeira, F. Effect of Recombinant Human Erythropoietin in a Rat Model of Moderate Chronic Renal Failure – Focus on Inflammation, Oxidative Stress and Function/Renoprotection. The Open Drug Discovery Journal 2010; 2:25-32.

- Costa, E. Non-Haematological effects of erythropoietin. The Open Drug Discovery Journal 2010;2:1-2. (Editorial)

- Rocha, S; Costa, E; Ferreira, F; Cleto, E; Barbot, J; Rocha-Pereira, P; Quintanilha, A; Belo, L; Santos-Silva, A. Hereditary sphrocytosis and the (TA)(n)TAA polymorphism of UGT1A1 gene promoter region - a comparison of the bilirubin plasmatic levels in the different clinical forms. Blood Cells Mol Dis 2010;44:117-119.

2009

- Rocha, S; Costa, E; Coimbra, S; Nascimento, H; Catarino, C; Rocha-Pereira, P; Belo, L; Santos-Silva, A. Linkage of cytosolic peroxiredoxin 2 to erythrocyte membrane imposed by hydrogen peroxide-induced oxidative stress. Blood Cells Mol Dis 2009;43:68-73.

- Garrido, P; Reis, F; Costa, E; Teixeira de Lemos, E; Parada, B; Alves, R; Piloto, N; Sereno, J; Figueiredo, A; Pinto, R; Carvalho, L; Rocha-Pereira, P; Belo, L; Santos-Silva, A; Teixeira, F. Characterization of a rat model of moderate chronic renal failure — focus on hematological, biochemical and cardiovascular-renal profiles. Renal Failure 2009; 31: 833-842.

- Piloto, N; Teixeira, HE; Teixeira de Lemos, E; Parada, B; Garrido, P; Sereno, J; Pinto, R; Carvalho, L; Costa, E; Belo, L; Santos-Silva, A; Teixeira, F; Reis, F. Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping. Cardiovasc Toxicol 2009; 9:201-210.

- Reis, F; Parada, B; Teixeira de Lemos, E; Garrido, P; Dias, A; Piloto, N; Batista, S; Sereno, J; Eufrásio, P; Costa, E; Rocha-Pereira, P; Santos-Silva, A; Figueiredo, A; Mota, A; Teixeira, F. Hypertension induced by immunosupressive drugs - comparative analysis between sirolimus and cyclosporine. Transplantation Proceedings 2009; 41:868-873.

- Costa, E; Belo, L; Quintanilha, A; Santos-Silva, A. Resistence to recombinant human erytropoietin therapy in haemodialysis patients – focus on inflammation, iron status and erythrocyte damage. Journal de Nephrology and Renal Transplantation 2009;2:66-83.

- Costa, E; Swinkels, DW; Laarakkers, CM; Rocha-Pereira, P; Rocha, S; Reis, F; Teixeira, F; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients. Acta Haematol 2009;122(4):226-229.

- costa, E; Rocha, S; Rocha-Pereira, P; Reis, F; Castro, EM; Teixeira, F; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. Effect of hemodialysis procedure in prohepcidin serum levels in chronic kidney disease patients. Clin Nephrol 2009; 72: 233-234.

- Gama, S; Costa, E; Rego, M. Alterations in the spermiogram in Portuguese infertile couples. Alterações no espermograma em casais inférteis Portugueses. Revista Iberoamericana de Fertilidad y Reproduccion Humana 2009;26:119-126.

- Costa, E; Vieira, E; Lopes, A; Saldanha, MJ; Brites, D; Dos Santos, R. Identification of a novel deletion in UDP-glucuronosyltransferase gene in a patient with Crigler-Najjar syndrome type I. Blood Cells Mol Dis 2009;42:265-266.

2008

- Ferreira, H; Costa, E; Vieira, E; Barbot, J; Dos Santos, R. Single nucleotide polymorphism in tha APO(a) kringle IV type 8 domain are not associated with atherothrombotic serum lipoprotein (a) concentration, in a Portuguese pediatric population. Int J Lab Hematol 2008; 30:240-243.

- João, JR; Pinto, S; Costa, E. Subpopulações dos reticulócitos e fracção de reticulócitos imaturos como indicador de aumento da eritropoieses em doentes com anemia por défice de ferro. Revista Brasileira de Hematologia e Hemoterapia 2008;30:188-192.

- Costa, E; Rocha, S; Rocha-Pereira, P; Reis, F; Castro, E; Teixeira, F; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. Cross-talk between inflammation, coagulation/Fibrinolysis and vascular access in chronic kidney disease patients under haemodialysis and recombinant human erythropoietin therapy. J Vasc Access 2008; 9: 248-253.

- Costa, E; Rocha, S; Rocha-Pereira, P; Castro, E; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. Changes in red blood cells membrane protein composition during haemodialysis procedure. Renal Failure 2008; 30:971-975.

- Costa, E; Rocha, S; Rocha-Pereira, P; Castro, E; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. Band 3 profile as a marker of erythrocyte changes in chronic kidney disease. The Open Clinical Chemistry Journal 2008; 1: 57-63.

- Costa, E; Vieira, E; Rodrigues, L; Lopes, AI; Dos Santos, R. GENE SYMBOL: UGT1A1. DISEASE: CRIGLER-NAJJAR SYNDROME 1. Hum Genet 2008;124:301.

- Costa, E; Rocha, S; Rocha-Pereira, P; Reis, F; Castro, E; Teixeira, F; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. DMT1 (NRAMP2/DCT1) genetic variability and resistance to rhEPO therapy in chronic kidney disease patients under haemodialysis. Acta Haematol 2008; 120:11-13.

- Costa, E; Rocha, S; Rocha-Pereira, P; Nascimento, H; Castro, EM; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. Neutrophil activation and resistance to recombinant human erythropoietin therapy in hemodialysis patients. Am J Nephrol 2008; 25:935-940.

- Costa, E; Lima, M; Rocha, S; Rocha-Pereira, P; Castro, E; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. IL-7 serum levels and lymphopenia in hemodialyis patients, non responders to recombinant human erythropoietin therapy. Blood Cells Mol Dis 2008; 41: 134-135.

- Costa, E; Pereira, BJG; Rocha-Pereira, P; Rocha, S; Reis, F; Teixeira, F; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. Role of prohepcidin, inflammatory markers and iron status in resistance to rhEPO therapy in hemodialysis patients. Am J Nephrol 2008; 28: 677-683.

- Costa, E; Lima, M; Alves, JM; Rocha, S; Rocha-Pereira, P; Castro, E; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. Inflammation, T-cell phenotype, and inflammatory cytokines in chronic kidney Disease patients under hemodialysis and its relationship to resistance to recombinant human erythropoietin therapy. J Clin Immunol 2008; 28: 268-275.

- Costa, E; Dos Santos, R. Hematologically important mutations: Shwachman-Diamond Syndrome. Blood Cells Mol Dis 2008; 40:183-184.

- Costa, E; Rocha, S; Rocha-Pereira, P; Castro, EM; Miranda, V; Sameiro-Faria, M; Loureiro, A; Quintanilha, A; Belo, L; Santos-Silva, A. Altered erythrocyte membrane protein composition in chronic kidney disease stage 5 patients under haemodialysis and recombinant human erythropoietin therapy. Blood Purification 2008;26:267-273.

2007

- Costa, AC; Ribeiro, B; Costa, E. Índices plaquetários em indivíduos com doença hepática crónica. Arq Gastroenterol 2007;44:201-204.

- Costa, E; Duque, F; Oliveira, J; Garcia, P; Gonçalves, I; Diogo, L; Dos Santos, R. Identification of a novel ALUSX-mediated deletion of exon 3 in the SBDS gene in a patients with Shwachman-Diamond Syndrom. Blood Cells Mol Dis 2007; 39: 96-101.

2006

- Costa, E; Vieira, E; Martins, M; Saraiva, J; Cancela, E; Costa, M; Bauerle, R; Freitas, T; Carvalho, JR; Santos-Silva, E; Barbot, J; Dos Santos, R. Analysis of the UDP-glucuronosyl transferase gene in Portuguese patients with a clinical diagnosis of Gilbert and Crigller-Najjar syndromes. Blood Cells Mol Dis 2006; 36: 91-97.

- Costa, E. Hematologically important mutations: bilirubin UDP-Glucuronosyltransferase gene mutations in Gilbert and Crigler-Najjar syndromes. Blood Cells Mol Dis 2006; 36: 77-80.

2005

- Rocha, S; Costa, E; Catarino, C; Belo, L; Castro, E; Barbot, J; Quintanilha, A; Santos-Silva, A. Erythropoietin levels in the different clinical forms of hereditary spherocytosis. Br J Haematol 2005; 131: 534-542.

- Lima, RM; Costa, E; Rocha, C; Vieira, E; Dos Santos, R; Barbot, J; Rocha, H. Molecular characterization of a portuguese patient with Shwachman-Diamond Syndrome. J Pediatr Gastroenterol Nutr 2005; 41: 114-116.

- Neves, J; Costa, E; Branca, R; Carrilho, I; Barbot, J; Barbot, C. Múltiples factores de riesgo trombofílicos identificados en un lactante com accidente vascular cerebral. Revista Neurología 2005;40:479-481.

- Costa, E; Vieira, E; Dos Santos, R. The polymorphism c.-3279T>G in the Phenobarbital-responsive enhancer module of the bilirubin UDP-glucuronosyltransferase gene is associated with Gilbert Syndrome. Clin Chem 2005;51:2204-6.

- Rocha, S; Rebelo, I; Costa, E; Catarino, C; Belo, L; Castro, EM; Cabeda, JM; Barbot, J; Quintanilha, A; Santos-Silva, A. Protein deficiency balance as a predictor of clinical outcome in hereditary spherocytosis. Eur J Haematol 2005;74:374-80.

2004

- Coelho, H; Costa, E; Vieira, E; Branca, R; Dos Santos, R; Barbot, J. A new case of (TA)8 allele in the UGT1A1 gene promoter in a caucasian girl with gilbert´s syndrome. Pediatr Hematol Oncol 2004;21:371-4.

- Costa, E; Bini Antunes, M; Faria, S; Vieira, E; Barbot, J; Dos Santos, R. Determination of neutrophil Fc- receptor IIIB (HNA-1A, HNA–1B and HNA–1C) by fluorescence-primed allele-specific polymerase chain reaction. Clinical and Laboratory Haematology 2004;26:319-321. (Nome actual da revista: International Journal of Laboratory Hematology)

- Branca, R; Costa, E; Rocha, S; Coelho, H; Quintanilha, A; Cabeda, JM; Santos-Silva, A; Barbot. Coexistence of congenital red cell pyruvate kinase and band 3 deficiencies. Clinical and Laboratory Haematology 2004, 26:297-300. (Nome actual da revista: International Journal of Laboratory Hematology)

2003

- Ferreira, H; Costa, E; Vieira, E; Leão, A; Magalhães, R; Lourenço-Gomes, J; Barbot, J; Dos Santos, R. Pentanucleotide repeat (TTTTA)n polymorphism in the 5´control region of the apolipoprotein (a) gene and atherothrombotic serum lipoprotein (a) concentration, in a pediatric population. Haematologica 2003;88(3):ELT07.

- Barreirinho, MS; Ferro, A; Santos, M; Costa, E; Pinto-Bastos, J; Sousa, A; Sequeiros, J; Maciel, P; Barbot, C; Barbot, J. Multiple inherited and acquired risk factors have combined effects in pediatric stroke. Paediatric Neurology 2003;28: 134-138.

2002

- Barbot, J., Costa, E., Guerra, M., Barreirinho, M.S., Isvarlal, P., Robles, R., Gerritsen, H.E., Furlan, M. Ten years of prophylactic treatment with fresh-frozen plasma in a child with chronic relapsing thrombotic thrombocytopenic purpura as a result of a congenital deficiency of von Willebrand factor-cleaving protease. Br J Haematol 2002; 113: 649-651.

- Barreirinho, MS; Guerra, M; Costa, E; Couceiro, A; Rodrigues, E; Barbot, J. Transient erythroblastopenia in the contexto f Epstein-Barr vírus infection. Anales Espanholes Pediatria 2002;56:459-461. (Nome actual da revista: Anales de Pediatría)

- Costa, E; Pinto, R; Vieira, E; Polo, S; Sarmento, AM; Oliveira, I; Pimenta, R; Dos Santos, R; Barbot, J. Influencia del síndrome de Gilbert en los niveles de bilirrubina sérica y presencia de litiasis vesicular en pacientes com hemólisis crónica congénita. Anales Espanholes de Pediatria 2002;57:529-533. (Nome actual da revista: Anales de Pediatría)

- Costa, E; Vieira, E; Santos-Silva, E; Barbot, J; Dos Santos, R. TATA-box polymorphism in the uridine diphosphate glucuronosyl transferase gene in Portuguese patients with clinical diagnosis of Gilbert Syndrome. Haematologica 2002 Apr;87(4):ELT21.

- Costa, E; Vasconcelos, J; Santos, E; Larangeira, A; Castro e Melo, J; Barbot, J. Neutrophil dysfunction in a case of glucose-6-phosphate dehydrogenase deficiency. Journal of Pediatric Hematology/Oncology 2002;24:164-165

2001

- Carrilho, I; Costa, E; Barreirinho, MS; Santos, M; Barbot, C; Barbot, J. Protrombotic study in full term neonates with arterial stroke. Haematologica 2001; 86(8):E16

- Brandão, C; Abreu, ME; Carvalho, C; Iglésias, I; Costa, E; Duarte, C; Barbot, J. A case of transplacental transmission of EDTA- dependent pseudotrombocitopenia. Prenatal and Neonatal Medecine 2001;6:242-243. (Nome actual da revista: Journal of Maternal-Fetal & Neonatal Medicine)

- Alexandrino, AM; Carvalho, C; Costa, E; Vieira, E; Oliveira, P; Duarte, C; Barbot, J; Dos Santos, R; Areias, A. TATA-box polymorphism in the UDP-glucuronosyltransferase-1 gene promoter and neonatal hyperbilirubinemia. Prenatal and Neonatal Medecine 2001;6:133-136. (Nome actual da revista: Journal of Maternal-Fetal & Neonatal Medicine)

- Costa, E; Portal, C; Rodrigues, M; Barbot, J. Revisão da avaliação pré-operatória da hemostase em 2839 crianças. Revista Iberoamericana de Trombosis y Hemostasia 2001;14:85-88.

2000

- Ferreira, P; Morais, L; Costa, R; Resende, C; Dias, CP; Araújo, F; Costa, E; Barbot, J; Vilarinho, A. Hydrops fetalis associated with erythrocyte pyruvate kinase deficiency. European Journal of Pediatrics 2000;159:481-482.

- Costa, E; Cabeda, JM; Vieira, E; Pinto, R; Pereira, S; Ferraz, L; Dos Santos, R; Barbot, J. Glucose-6-phosphate dehydrogenase Aveiro: a de novo mutation associated with chronic nonspherocytic hemolytic anemia. Blood 2000;95:1499-1501.

1999

- Sameiro-Faria, M; Costa, E; Moreira, A; Barbot, J; Barbot, C; Santos, M. Isquemia del tronco cerebral en nino com resistência a ala proteína C activada y a la lipoproteina (a)elevada. Rev Neurol 1999; 28:1061-1064.