felixdc@ff.up.pt

Félix Dias Carvalho
Full Professor
Integrated Member
Research Group
Toxicological Studies
Laboratory of Toxicology Department of Biological Sciences Faculty of Pharmacy, University of Porto (FFUP) Rua de Jorge Viterbo Ferreira nº 228 4050-313 Porto Portugal
220 428 597
- ext 8597
226 093 390
Research Interests
Toxicology, with particular emphasis on the evaluation of mechanisms of citoxicity and/or citoprotection mediated by xenobiotics, using different experimental models in vivo (rats and mice), and vitro (isolated perfused lung, cultures of Rat neurons, cultures of Human and Rat proximal tubular cells, as well as freshly isolated rat hepatocytes and cardiomyocytes). A special attention has been given to the involvement of pharmacokinetics and cellular signaling systems in those mechanisms. The final goal of my studies is the development of effective antidotes, through the interference on the toxic pathways found. This approach has been applied successfully in drugs of abuse, toxins, and pesticides.
Main publications
Book Chapters:


1. Félix Carvalho, Maria de Lurdes Bastos, John Timbrell, Catherine Waterfield, Margarida Ferreira (1994) Alteration of some biochemical parameters in mice and rats by exposure to salbutamol. In: In Vitro Toxicological Studies and Real Time Analysis of Residues in Food (ISBN 90-5601-006-9); pp: 68-78.

2. Rosa M. Seabra, Paula B. Andrade, Patrícia Valentão, Eduarda Fernandes, Félix Carvalho, Maria de Lourdes Bastos (2006) Antioxidant compounds extracted from several plant materials. In: Biomaterials from Aquatic and terrestrial Organisms (Eds. Miltion Fingerman and Rachakonda Nagabhushanam), Science Publishers Inc, (ISBN-13: 978-1-57808-429-6); pp: 115-174.


3. Vera Marisa Costa, Félix Carvalho, Maria de Lourdes Bastos, Rui Carvalho, Márcia Carvalho, Fernando Remiao (2012) Adrenaline and Noradrenaline: Partners and Actors in the Same Play. In: Neurochemistry, (Ed: Carlos M. Contreras), Intech Open Access Publisher (ISBN 978-953-51-0207-6), pp: 1-44.

4. Maria João Valente, Félix Carvalho, Maria De Lourdes Bastos, Márcia Carvalho and Paula Guedes De Pinho (2012) Chromatographic methodologies for analysis of cocaine and its metabolites in biological matrices. In: Gas Chromatography - Biochemicals, Narcotics and Essential Oils. (Eds: Bekir Salih and Ömür ÇelikbÄçak) Intech Open Access Publisher (ISBN 979-953-307-302-5), pp: 163-194.

5. Teresa Sousa, Joana Afonso, Félix Carvalho and António Albino-Teixeira (2012) Lipid Peroxidation and Antioxidants in Arterial Hypertension. In: Lipid Peroxidation, Intech Open Access Publisher, ISBN 980-953-307-143-0 pp: 345-392.

6. Teresa Cunha-Oliveira, Ana Cristina Rego, Félix Carvalho, Catarina Oliveira (2013) Medical Toxicology of Drugs of Abuse. In: Principles of Addiction. Comprehensive Addictive Behaviors and Disorders (Ed. Peter M. Miller), Academic Press, ISBN: 978-0123785985, Volume 1, Chapter 17, pp: 159-175.

7. Ricardo Jorge Dinis-Oliveira, Teresa Magalhães, Félix Carvalho (2013) A perícia em Toxicologia Forense: da suspeita à interpretação de resultados. In: Ciências Forenses ao Serviço da Justiça, PACTOR – Edições de Ciências Sociais, Forenses e da Educação (Eds: Maria Fátima Pinheiro), Capítulo 4, pp: 159-188.

8. Félix Carvalho, Helena Carmo, Paula Guedes de Pinho, Fernando Remião, Maria de Lourdes Bastos, Márcia Carvalho (2014) Mephedrone. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 194–196.

9. João Paulo Capela, Maria de Lourdes Bastos, Félix Carvalho (2014) Ecstasy. In: Aminoff M.J. and Daroff R.B. (eds.) Encyclopedia of the Neurological Sciences, 2nd edition, vol. 1, pp. 1064-1067. Oxford: Academic Press.

10. Félix Carvalho e Daniel Moura (2014) Tóxicos e intoxicações. In: “Terapêutica Medicamentosa e suas Bases Farmacológicas, 6ª edição” (Eds: Serafim Correia Pinto Guimarães, Daniel Filipe Lima Moura e Patrício Manuel Vieira Araújo Soares da Silva), Porto Editora, pp: 812-821.
11. Barbosa J, Faria J, Carvalho F, Queirós O, Moreira R, Dinis-Oliveira R J (2015). Meconium as an alternative matrix in bioanalysis. In: New sampling strategies in toxicology and therapeutic drug monitoring" (ED: Christophe Stove), Future Science, pp 139-150.

12. Maria Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, Maria de Lourdes Bastos and Félix Carvalho (2015) Paraquat: molecular mechanisms of neurotoxicity and its relation with autophagy. In: Toxicity and Autophagy in Neurodegenerative Disorders (Ed. José M. Fuentes), Springer, pp. 159-170.

13. Ricardo Jorge Dinis-Oliveira, Teresa Magalhães, Félix Carvalho (2015) Introdução à Toxicologia Forense. In: Toxicologia Forense (Eds. Ricardo Dinis-Oliveira, Félix Carvalho, Maria de Lourdes Bastos), Pactor, Edições de Ciências Sociais, Forenses e da Educação (ISBN: 9789896930455), Capítulo 1, pp. 1–8.

14. Ricardo Jorge Dinis-Oliveira, Félix Carvalho, José Alberto Duarte e Teresa Magalhães (2015) Recomendações Gerais para Colheita de Amostras Biológicas em Toxicologia Forense. In: Toxicologia Forense (Eds. Ricardo Dinis-Oliveira, Félix Carvalho, Maria de Lourdes Bastos), Pactor, Edições de Ciências Sociais, Forenses e da Educação (ISBN: 9789896930455), Capítulo 5, pp. 103–108.

15. Ricardo Jorge Dinis-Oliveira, Maria Augusta Vieira-Coelho e Félix Carvalho (2015) Introdução às Toxicodependências. In: Toxicologia Forense (Eds. Ricardo Dinis-Oliveira, Félix Carvalho, Maria de Lourdes Bastos), Pactor, Edições de Ciências Sociais, Forenses e da Educação (ISBN: 9789896930455), Capítulo 1, pp. 1–8.

16. Ana Oliveira, Ricardo Jorge Dinis-Oliveira e Félix Carvalho (2015) Opióides. In: Toxicologia Forense (Eds. Ricardo Dinis-Oliveira, Félix Carvalho, Maria de Lourdes Bastos), Pactor, Edições de Ciências Sociais, Forenses e da Educação (ISBN: 9789896930455), Capítulo 7, pp. 131–139.

17. João Paulo Capela e Félix Carvalho (2015) Anfetaminas e Derivados. In: Toxicologia Forense (Eds. Ricardo Dinis-Oliveira, Félix Carvalho, Maria de Lourdes Bastos), Pactor, Edições de Ciências Sociais, Forenses e da Educação (ISBN: 9789896930455), Capítulo 11, pp. 203–215.

18. Ricardo Jorge Dinis-Oliveira, Renata Silva e Félix Carvalho (2015) Pesticidas. In: Toxicologia Forense (Eds. Ricardo Dinis-Oliveira, Félix Carvalho, Maria de Lourdes Bastos), Lidel, Pactor, Edições de Ciências Sociais, Forenses e da Educação (ISBN: 9789896930455), Capítulo 23, pp. 415–440.

19. Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos and Félix Carvalho (2016) Mitochondrial trails in the neurotoxic mechanisms of MDMA. In: The Neuropathology Of Drug Addictions And Substance Misuse (Ed: Victor R. Preedy), Elsevier (in press).

20. João Paulo Capela e Félix Carvalho (2016) Serotonina. In: Neurociências (Eds. Catarina Oliveira, Ana Cristina Rego, Carlos Duarte), Lidel, (in press).


Publications of full papers in International journals with pair-review

1. Jorge Gonçalves, Félix Carvalho, Serafim Guimarães (1989) Uptake inhibitors do not change the effect of imidazoline alpha-adrenoceptor agonists on transmiter release evoked by single pulse stimulation in mouse vas deferens. Naunyn-Schmiedeberg´s Archives of Pharmacology 339:288-292.
2. Félix Carvalho, Maria de Lurdes Bastos, John A. Timbrell (1993) Depletion of total non protein sulphydryl groups in mouse tissues after administration of d-amphetamine. Toxicology 83:31-40.
3. José Alberto Duarte, Hans Joachim Appell, Félix Carvalho, Maria de Lourdes Bastos, José Soares (1993) Endothelium-derived oxidative stress may contribute to exercise-induced muscle damage. International Journal of Sports Medicine 14(8):440-443.
4. José Alberto Duarte, Félix Carvalho, Maria de Lourdes Bastos, José Soares, Hans Joachim Appell (1994) Do invading leucocytes contribute to the decrease in glutathione concentrations indicating oxidative stress in exercised muscle, or are they important for its recovery? European Journal of Applied Physiology and Occupational Physiology 68:48-53.
5. Félix Carvalho, Fernando Remião, Pedro Vale, John Timbrell, Maria de Lourdes Bastos, Margarida Ferreira (1994) Glutathione and cysteine measurement in biological samples by HPLC with a glassy carbon working detector. Biomedical Chromatography 8(3):134-136.
6. Maria de Lourdes Bastos, Félix Carvalho, Maria Elisa Soares, José Fernandes, Margarida Ferreira (1994) Bioavailability of residues of diazepam and its metabolites. Bollettino Chimico Farmaceutico 133(1):27-31.
7. Glória Queiroz, Félix Carvalho, Pedro Vale, Jorge Gonçalves (1995) Electrically-evoked release of taurine in the rat vas deferens: Evidence for a purinoceptor-mediated effect. Naunyn-Schmiedeberg´s Archives of Pharmacology 351:60-66.
8. Maria Elisa Soares, Maria de Lourdes Bastos, Félix Carvalho, Margarida Ferreira (1995) Determination of As, Cd, and Pb in feedstuff by graphite furnace AAS. Atomic Spectroscopy 16(4):149-153.
9. Félix Carvalho, Maria de Lourdes Bastos, Fernando Remião, Margarida Ferreira (1995) HPLC-ECD determination of oxalates in cork stopper for wine botling. American Journal of Enology and Viticulture 46(1):63-66.
10. Félix Carvalho, Catherine Waterfield, Margarida Ferreira, Maria de Lourdes Bastos, John Timbrell (1995) The effect of repeated administration of salbutamol on urinary and liver taurine levels in rats. Pharmacology Communications 5(3): 171-180.
11. Eduarda Fernandes, Félix Carvalho, Fernando Remião, Maria de Lourdes Bastos, Madalena Pinto, Otto Gottlieb (1995) Hepatoprotective activity of xanthones and xanthonolignoids against tert-butylhydro-peroxide-induced toxicity in isolated rat hepatocytes - Comparison with silybin. Pharmaceutical Research 12(11):1756-1760.
12. Catherine Waterfield, Félix Carvalho, John Timbrell (1996) Effect of treatment with β-agonists on tissue and urinary taurine levels in rats: Mechanism and implications for protection. Advances in Experimental Medicine and Biology 403:233-245.
13. Félix Carvalho, Fernando Remião, Francisco Amado, Pedro Domingues, António Ferrer-Correia, Maria de Lourdes Bastos (1996) d-Amphetamine interaction with glutathione in freshly isolated rat hepatocytes. Chemical Research in Toxicology 9(6):1031-1036.
14. Maria de Lourdes Bastos, Félix Carvalho, Fernando Remião, Maria Eulália Mendes, Margarida Ferreira, Maria Elisa Soares, John Timbrell (1997) Changes in taurine levels in response to repeated administration of the β2-agonist salbutamol in lambs. Journal of Veterinary Pharmacology and Therapeutics 20:33-37.
15. Félix Carvalho, Fernando Remião, M. Elisa Soares, Rita Catarino, Glória Queiroz, Maria de Lourdes Bastos (1997) d-Amphetamine-induced hepatotoxicity: Possible contribution of catecholamines and hyperthermia to the effect studied in isolated rat hepatocytes. Archives of Toxicology 71:429-436.
16. José Alberto Duarte, S. Glöser, Fernando Remião, Félix Carvalho, Maria de Lourdes Bastos, José Soares, Hans Joachim Appell (1997) Administration of tourniquet: I. Are edema and oxidative stress related to each other and to the duration of ischemia in reperfused skeletal muscle? Archives of Ortophopedics and Trauma Surgery 116:97-100.
17. Hans Joachim Appell, José Alberto Duarte, S. Glöser, Fernando Remião, Félix Carvalho, Maria de Lourdes Bastos, José Soares (1997) Administration of tourniquet: II. Prevention of postischemic oxidative stress can reduce muscle edema. Archives of Ortophopedics and Trauma Surgery 116:101-105.
18. Félix Carvalho, Eduarda Fernandes, Fernando Remião, Maria de Lourdes Bastos (1999) Effect of d-amphetamine repeated administration on rat antioxidant defences. Archives of Toxicology 73:83-89.
19. Fernando Remião, Helena Carmo, Félix Carvalho, Maria de Lourdes Bastos (1999) Inhibition of glutathione reductase by isoproterenol oxidation products. Journal of Enzyme Inhibition 15:47-61.
20. José Alberto Duarte, Félix Carvalho, K. Natsis, Fernando Remião, Maria de Lourdes Bastos, Hans Joachim Appell, José Soares (1999) Structural alterations in skeletal muscle induced by chronic administration of d-amphetamine and food restriction. Basic and Applied Myology 9(2):65-69.
21. Fernando Remião, Helena Carmo, Félix Carvalho, Maria de Lourdes Bastos (2000) Simultaneous determination of reduced and oxidized glutathione in freshly isolated rat hepatocytes and cardiomyocytes by HPLC with electrochemical detection. Biomedical Chromatography 14:1-6.
22. Fernando Remião, Helena Carmo, Félix Carvalho, Maria de Lourdes Bastos (2001) Cardiotoxicity studies using freshly isolated calcium-tolerant cardiomyocytes from adult rat. In Vitro Cellular & Developmental Biology-Animal 37:1-4.
23. Márcia Carvalho, Félix Carvalho, Maria de Lourdes Bastos (2001) Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? An in vitro study using freshly isolated Mouse hepatocytes. Archives of Toxicology 74:789-793.
24. Maria Elisa Soares, Félix Carvalho, Maria de Lourdes Bastos (2001) Determination of amphetamine and its metabolite p-hydroxyamphetamine in rat urine by reversed-phase high-performance liquid chromatography after dabsyl derivatization. Biomedical Chromatography 15:452-456.
25. Félix Carvalho, Eduarda Fernandes, Fernando Remião, Joana Gomes-da-Silva, Amélia Tavares, Maria de Lourdes Bastos (2001) Adaptative response of antioxidant enzymes in different areas of rat brain after repeated d-amphetamine administration. Addiction Biology 6:213-221.
26. Patrícia Valentão, Eduarda Fernandes, Félix Carvalho, Paula Andrade, Rosa Seabra, Maria de Lourdes Bastos (2001) Antioxidant activity of Centaurium erythraea infusion evidenced by its superoxide radical scavenging and xanthine oxidase inhibitory activity. Journal of Agricultural and Food Chemistry 49:3476-3479.
27. Fernando Remião, Helena Carmo, Félix Carvalho, Maria de Lourdes Bastos (2001) The study of oxidative stress in freshly isolated Ca2+-tolerant cardiomyocytes from the adult rat. Toxicology In Vitro 15(4-5):283-287.
28. Félix Carvalho, José Alberto Duarte, Helena Carmo, Maria João Neuparth, Eduarda Fernandes, Fernando Remião, Maria de Lourdes Bastos (2001) Hydrogen peroxide production in mouse tissues after acute d-amphetamine administration. Influence of monoamine oxidase inhibition. Archives of Toxicology 75:465-469.
29. Fernando Remião, Helena Carmo, Félix Carvalho, Maria de Lourdes Bastos (2001) Copper enhances isoproterenol toxicity in isolated rat cardiomyocytes: Effects on oxidative stress. Cardiovascular Toxicolog. 1(3):195-204.
30. Francisco Lemos-Amado, Pedro Domingues, A. Ferrer-Correia, Fernando Remião, Nuno Milhazes, Félix Carvalho, Fernanda Borges, Maria de Lourdes Bastos (2001) Electrospray tandem mass spectrometry of aminochromes. Rapid Communications in Mass Spectrometry 15 (24):2466-2471.
31. Helena Carmo, Douwe de Boer, Fernando Remião, Félix Carvalho, Lesseps A. dos Reys, Maria de Lourdes Bastos (2002) Identification of 4-methylthioamphetamine and some of its metabolites in mouse urine by GC-MS after acute administration. Journal of Analitical Toxicology 26(4):228-232.
32. Márcia Carvalho, Félix Carvalho, Maria de Lourdes Pereira, Ricardo Pires-das-Neves, Maria de Lourdes Bastos (2002) Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: Influence of ambient temperature. Archives of Toxicology 76:166-172.
33. Eduarda Fernandes, Félix Carvalho, Artur Silva, Clementina Santos, Diana Pinto, José A. S. Cavaleiro, Maria de Lourdes Bastos (2002) 2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study. Journal of Enzyme Inhibition and Medicinal Chemistry 17(1):45-48.
34. Fernando Remião, Márcia Carvalho, Helena Carmo, Félix Carvalho, Maria de Lourdes Bastos (2002) Cu2+-induced isoproterenol oxidation into isoprenochrome in adult rat calcium-tolerant cardiomyocytes. Chemical Research in Toxicology 15(6):861-869.
35. Patrícia Valentão, Eduarda Fernandes, Félix Carvalho, Paula Andrade, Rosa Seabra, Maria de Lourdes Bastos (2002) Antioxidative properties of cardoon (Cynara cardunculus L.) infusion against superoxide radical, hydroxyl radical, and hypochlorous acid. Journal of Agricultural and Food Chemistry 50:4989-4993.
36. Patrícia Valentão, Eduarda Fernandes, Félix Carvalho, Paula Andrade, Rosa Seabra, Maria de Lourdes Bastos (2002) Studies on the antioxidant activity of Lippia citriodora infusion: scavenging effect on superoxide radical, hydroxyl radical and hypochlorous acid. Biological and Pharmaceutical Bulletin 25(10):1320-1323.
37. Patrícia Valentão, Eduarda Fernandes, Félix Carvalho, Paula Andrade, Rosa Seabra, Maria de Lourdes Bastos (2002) Antioxidant Activity of Hypericum androsaemum Infusion: Scavenging Activity Against Superoxide Radical, Hydroxyl Radical and Hypochlorous Acid. Biological and Pharmaceutical Bulletin 25(10):1324-1327.
38. Márcia Carvalho, Gabrielle Hawksworth, Nuno Milhazes, Fernanda Borges, Terrence Monks, Eduarda Fernandes, Félix Carvalho, Maria de Lourdes Bastos (2002) Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using Rat and Human renal proximal tubular cells. Archives of Toxicology 76:581–588.
39. Félix Carvalho, Inês Machado, M. Sánchez Martínez, Amadeu Soares, Lúcia Guilhermino (2003) Use of atropine-treated Daphnia magna survival for detection of environmental contamination by acetylcholinesterase inhibitors. Ecotoxicology and Environmental Safety 53:43-46.
40. Fernando Remião, Nuno Milhazes, Fernanda Borges, Félix Carvalho, Maria de Lourdes Bastos, Francisco Lemos-Amado, Pedro Domingues, A. Ferrer-Correia (2003) Synthesis and analysis of aminochromes by HPLC-photodiode array. Adrenochrome evaluation in rat blood. Biomedical Chromatography 17:6-13.
41. Patrícia Valentão, Eduarda Fernandes, Félix Carvalho, Paula B. Andrade, Rosa M. Seabra, Maria de Lourdes Bastos (2003) Hydroxyl radical and hypochlorous acid scavenging activity of small Centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis). Phytomedicine 10:517-522.
42. Helena Carmo, Fernando Remião, Félix Carvalho, Eduarda Fernandes, Douwe de Boer, Lesseps A. dos Reys, Maria de Lourdes Bastos (2003) 4-Methylthioamphetamine-induced hyperthermia in mice: Influence of serotonergic and catecholaminergic pathways. Toxicology and Applied Pharmacology 190:262-271.
43. Eduarda Fernandes, Márcia Carvalho, Félix Carvalho, Artur M. S. Silva, Clementina M. M. Santos, Diana C. G. A. Pinto, José A. S. Cavaleiro, Maria de Lourdes Bastos (2003) Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly isolated rat hepatocytes. Archives of Toxicology 77:500-505.
44. Félix Carvalho (2003) The toxicological potential of khat. Journal of Ethnopharmacology 87: 1-2.
45. Maria Elisa Soares, Márcia Carvalho, Helena Carmo, Fernando Remião, Félix Carvalho, Maria de Lourdes Bastos (2004) Simultaneous determination of amphetamine derivatives in human urine after SPE extraction and HPLC-UV analysis. Biomedical Chromatography 18:125-131.
46. Márcia Carvalho, Nuno Milhazes, Fernando Remião, Fernanda Borges, Eduarda Fernandes, Francisco Amado, Terrence Monks, Félix Carvalho, Maria de Lourdes Bastos (2004) Hepatotoxicity of 3,4-methylenedioxy-amphetamine and α-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates. Archives of Toxicology 78:16–24.
47. José Alberto Duarte, Félix Carvalho, Eduarda Fernandes, Fernando Remiao, Maria de Lourdes Bastos, José Magalhães, Hans Joachim Appell (2004) d-Amphetamine-induced hydrogen peroxide production in skeletal muscle is modulated by monoamine oxidase inhibition. International Journal of Sports Medicine 25(6):446-449.
48. Teresa Sousa, Manuela Morato, Eduarda Fernandes, Félix Carvalho, António Albino-Teixeira (2004) Xanthine oxidase inhibition by 1,3-dipropyl-8-sulfophenyl-xanthine (DPSPX), an antagonist of adenosine receptors. Journal of Enzyme Inhibition and Medicinal Chemistry 19(1):11-15.
49. Helena Carmo, Jan G. Hegstler, Douwe de Boer, Michael Ringel, Félix Carvalho, Eduarda Fernandes, Fernando Remião, Lesseps dos Reys, Franz Oesch, Maria de Lourdes Bastos (2004) Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse. Naunyn-Schmiedeberg's Archives of Pharmacology 369:198-205.
50. Cristóvão Lima, Félix Carvalho, Eduarda Fernandes, Maria de Lourdes Bastos, PC Santos-Gomes, Manuel Fernandes-Ferreira, Cristina Pereira-Wilson (2004) Evaluation of toxic/protective effects of the essential oil of Salvia officinalis on freshly isolated rat hepatocytes. Toxicology In Vitro 18:457-465.
Frequently downloaded paper, according to the TOP25 Hottest Articles by ScienceDirect:
• 9th during the third quarter of 2004 (July-September)
• 14th during the fourth quarter of 2004 (October-December)
• 16th during the first quarter of 2005 (January-March)
51. Patrícia Valentão, Márcia Carvalho, Eduarda Fernandes, Félix Carvalho, Paula Branquinho Andrade, Rosa Maria Seabra, Maria de Lourdes Bastos (2004) Protective activity of Hypericum androsaemum infusion against tert-butylhydroperoxide-induced oxidative damage in isolated rat hepatocytes. Journal of Ethnopharmacology 92:79-84.
52. Márcia Carvalho, Fernando Remião, Nuno Milhazes, Fernanda Borges, Eduarda Fernandes, Maria do Céu Monteiro, Maria José Gonçalves, Vítor Seabra, Francisco Amado, Félix Carvalho and Maria Lourdes Bastos (2004) Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro. Chemical Research in Toxicology 17:623-632.
53. Márcia Carvalho, Fernando Remião, Nuno Milhazes, Fernanda Borges, Eduarda Fernandes, Félix Carvalho and Maria Lourdes Bastos (2004) The toxicity of N-methyl-α-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine. Toxicology 200(2-3):193-203.
54. Maria Elisa Soares, Márcia Carvalho, Fernando Remião, Félix Carvalho and Maria de Lourdes Bastos (2004) Implementation of HPLC methodology for the quantification of malondialdehyde in cell suspensions and liver. Journal of Liquid Chromatography and Related Technologies.27 (15):2357-2369.
55. Patrícia Valentão, Márcia Carvalho, Félix Carvalho, Eduarda Fernandes, Ricardo Pires das Neves, M. Lourdes Pereira, Paula B. Andrade, Rosa M. Seabra, M. Lourdes Bastos (2004) Hypericum androsaemum infusion increases tert-butylhydroperoxide-induced mice hepatotoxicity in vivo. Journal of Ethnopharmacology 94:345-351.
56. Ricardo Pires das Neves, Félix Carvalho, Márcia Carvalho, Eduarda Fernandes, Maria Elisa Soares, Maria de Lourdes Bastos, Maria de Lourdes Pereira (2004) Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice. Toxicologic Pathology 32:527–535.
57. Fernando Remião, Daniel Rettori, Derick Han, Félix Carvalho, Maria de Lourdes Bastos, Enrique Cadenas (2004) Leucoisoprenochrome-o-semiquinone formation in freshly isolated adult rat cardiomyocytes. Chemical Research in Toxicology 17:1584-1590.
58. Helena Carmo, Douwe de Boer, Fernando Remião, Félix Carvalho, Lesseps A. dos Reys, Maria de Lourdes Bastos (2004) Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration. Journal of Chromatography B 811:143–152.
59. Bruno Nunes, Félix Carvalho, Lúcia Guilhermino (2004) Acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish, Gambusia holbrooki. Chemosphere 57:1581–1589.
60. Bruno Nunes, Félix Carvalho, Lúcia Guilhermino (2004) Marine and estuarine algal species as tes ganisms in Ecotoxicology. Current Topics in Toxicology 1:33-51.
61. José Alberto Duarte, Anabela Leão, José Magalhães, A. Ascensão, Maria de Lourdes Bastos, Francisco Lemos Amado, L. Vilarinho, D. Quelhas, Hans Joaquim Appell, Félix Carvalho (2005) Strenuous exercise aggravates MDMA-induced skeletal muscle damage in mice. Toxicology 206(3):349-358.
62. Helena Carmo, Jan G. Hengstler, Douwe de Boer, Michael Ringel, Fernando Remião, Félix Carvalho, Eduarda Fernandes, Lesseps A. dos Reys, Franz Oesch and Maria de Lourdes Bastos (2005) Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): Analysis of phase I metabolism with hepatocytes of six species including human. Toxicology 206(1):75-89.
63. Bruno Nunes, Félix Carvalho, Lúcia Guilhermino (2005) Acute toxicity of widely used pharmaceuticals in aquatic species: Gambusia holbrooki, Artemia parthenogenetica and Tetraselmis chuii. Ecotoxicology and Environmental Safety 61(3):413-419.
Frequently downloaded paper, according to the TOP25 Hottest Articles by ScienceDirect:
• 9th during the second quarter of 2005 (April, May and June)
• 16th during the third quarter of 2005 (July, August and September)
64. Teresa Sousa, Eduarda Fernandes, Carla Nunes, João Laranjinha, Félix Carvalho, Dora Pinho, Manuela Morato, António Albino-Teixeira (2005) Scavenging of nitric oxide by an antagonist of adenosine receptors. Journal of Pharmacy and Pharmacology 57:399–404.
65. Bruno Nunes, Félix Carvalho, Lúcia Guilhermino (2005) Characterization and use of the total head soluble cholinesterases from mosquitofish (Gambusia holbrooki) for screening of anticholinesterase activity. Journal of Enzyme Inhibition and Medicinal Chemistry 20(4):369–376.
66. Manuela F. Frasco, Didier Fournier, Félix Carvalho, Lúcia Guilhermino (2005) Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity. Biomarkers 10(5):360-375.
67. Bruno Nunes, Félix Carvalho, Lúcia Guilhermino, Gilbert van Stappen (2006) Use of the genus Artemia in ecotoxicity testing. Environmental Pollution 144(2):453-462.
68. João Paulo Capela, Andreas Meisel, Artur Abreu, Paula Branco, Luísa Ferreira, Ana Lobo, Fernando Remião, Maria de Lourdes Bastos, Félix Carvalho (2006) Neurotoxicity of ecstasy metabolites in rat cortical neurons, and influence of hyperthermia. Journal of Pharmacology and Experimental Therapeutics 316(1):53-61.
69. Beatriz Porto, Carla Sousa, Ricardo Dinis, Jorge Gaspar, José Rueff, Félix Carvalho, Isabel Malheiro (2006) The role of foetal red blood cells in protecting cultured lymphocytes against diepoxybutane-induced chromosome breaks. Mutation Research, Genetic Toxicology and Environmental Mutagenesis 603(1):41-47.
70. Manuela F. Frasco, Didier Fournier, Félix Carvalho, Lúcia Guilhermino (2006) Cholinesterase from the common prawn (Palaemon serratus) eyes: Catalytic properties and sensitivity to organophosphate and carbamate compounds. Aquatic Toxicology 77(4):412-421.
71. Bruno Nunes, Félix Carvalho, Lúcia Guilhermino (2006) Effects of widely used pharmaceuticals and a detergent on oxidative stress biomarkers of the crustacean Artemia parthenogenetica. Chemosphere 62(4):581-594.
72. Ricardo Dinis Oliveira, António Sarmento, Paulo Reis, Augusta Amaro, Fernando Remião, Maria de Lourdes Bastos, Félix Carvalho (2006) Acute paraquat poisoning: report of a survival case following intake of a potential lethal dose. Pediatric Emergency Care 22(7):537-540.
73. João Paulo Capela, Karsten Ruscher, Marion Lautenschlager, Dorette Freyer, Ulrich Dirnagl, Maria de Lourdes Bastos, Andreas Meisel, Félix Carvalho (2006) Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia. Neuroscience 139(3):1069–1081.
74. Maria João S. Marques, Rui Vitorino, Rita Ferreira, Carla Sousa, Fernando Remião, Francisco Amado, José Alberto Duarte, Félix Carvalho, Maria de Lourdes Bastos (2006) Cytotoxicity and cell signalling induced by continuous mild hyperthermia in freshly isolated mouse hepatocytes. Toxicology 224(3):210-218.
75. Ricardo Dinis Oliveira, Maria de Jesús Valle, Maria de Lourdes Bastos, Félix Carvalho, Amparo Sánchez Navarro (2006) Kinetics of paraquat in the isolated rat lung: Influence of sodium depletion. Xenobiotica 36(8):724-737.
76. Ricardo Dinis Oliveira, José Alberto Duarte, Fernando Remião, Helena Carmo, Amparo Sánchez Navarro, Maria de Lourdes Bastos, Félix Carvalho (2006) Paraquat exposure as an etiological factor of Parkinson’s disease. Neurotoxicology 27:1110–1122.
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77. Ricardo Jorge Dinis-Oliveira, Fernando Remião, José Alberto Duarte, Rita Ferreira, Amparo Sánchez Navarro, Maria de Lourdes Bastos, Félix Carvalho (2006) P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity. Free Radical Biology and Medicine 41:1213–1224.
78. Helena Carmo, Marc Brulport, Matthias Hermes, Franz Oesch, Renata Silva, Luísa M. Ferreira, Paula S. Branco, Douwe de Boer, Fernando Remião, Félix Carvalho, Michael R Schön, Niels Krebsfaenger, Johannes Doehmer, Maria de Lourdes Bastos, Jan G. Hengstler (2006) Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine (“Ecstasy”) cytotoxicity. Pharmacogenetics and Genomics 16(11):789-799.
79. Ricardo Jorge Dinis-Oliveira, José Alberto Duarte, Fernando Remião, Amparo Sánchez Navarro, Maria de Lourdes Bastos, Félix Carvalho (2006) Single high dose dexamethasone treatment decreases the pathological score and increases the survival rate of paraquat-intoxicated rats. Toxicology 227(1-2):73-85.
80. Helena Carmo, Marc Brulport, Matthias Hermes, Franz Oesch, Douwe de Boer, Fernando Remião, Félix Carvalho, Michael R Schön, Niels Krebsfaenger, Johannes Doehmer, Maria de Lourdes Bastos, Jan G. Hengstler (2007) CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA). Toxicology 229(3):236-244.
81. Carla Macedo, Paula Branco, Luísa Ferreira, Ana Lobo, João Paulo Capela, Eduarda Fernandes, Maria de Lourdes Bastos, Félix Carvalho (2007) Synthesis and cyclic voltammetry studies of 3,4- methylenedioxymethamphetamine (MDMA) human metabolites. Journal of Health Science 53(1):31-42.
82. Renata Silva, Sílvia Boldt, Vera Marisa Costa, Helena Carmo, Márcia Carvalho, Félix Carvalho, Maria de Lourdes Bastos, Francisco Lemos-Amado, Fernando Remião (2007) Evaluation of GSH adducts of adrenaline in biological samples. Biomedical Chromatography 21(7):670-679.
83. Ricardo Jorge Dinis-Oliveira, Carla Sousa, Fernando Remião, José Alberto Duarte, Amparo Sánchez Navarro, Maria de Lourdes Bastos, Félix Carvalho (2007) Full survival of paraquat-exposed rats after treatment with sodium salicylate. Free Radical Biology and Medicine 42:1017–1028.
84. Manuela Faria Frasco, Jacqes-Philippe Colletier, Martin Weik, Félix Carvalho, Lúcia Guilhermino, Jure Stojan, and Didier Fournier (2007) Mechanisms of cholinesterase inhibition by inorganic mercury. FEBS Journal 274:1849-1861.
85. Ricardo Jorge Dinis-Oliveira, Carla Sousa, Fernando Remião, José Alberto Duarte, Amparo Sánchez Navarro, Maria de Lourdes Bastos, Félix Carvalho (2007) Sodium salicylate prevents paraquat-induced apoptosis in the rat lung. Free Radical Biology and Medicine 43(1):48-61.
86. João Paulo Capela, Carla Macedo, Paula Sério Branco, Luísa Maria Ferreira, Ana Maria Lobo, Eduarda Fernandes, Fernando Remião, Maria Lourdes Bastos, Andreas Meisel, Félix Carvalho (2007) Neurotoxicity mechanisms of thioether ecstasy metabolites. Neuroscience 146(4):1743-1757.
87. Marco Assunção, Maria João Santos-Marques, Victor de Freitas, Félix Carvalho, Nikolai V. Lukoyanov, Manuel Paula-Barbosa (2007) Red wine antioxidants protect hippocampal neurons against ethanol-induced damage: A biochemical, morphological and behavioral study. Neuroscience 146(4):1581-1592.
88. João Paulo Capela, Eduarda Fernandes, Fernando Remião, Maria de Lourdes Bastos, Ulrich Dirnagl, Andreas Meisel, Félix Carvalho (2007) Ecstasy induces apoptosis via 5-HT2A-receptor stimulation in cortical neurons. Neurotoxicology 28: 868–875.
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89. Félix Carvalho, Maria Elisa Soares, Eduarda Fernandes, Fernando Remião, Márcia Carvalho, José Alberto Duarte, Ricardo Pires-das-Neves, Maria de Lourdes Pereira, Maria de Lourdes Bastos (2007) Repeated administration of d-amphetamine results in a time-dependent and dose-independent sustained increase in urinary excretion of p-hydroxy-amphetamine in mice. Journal of Health Science 53(4):371-377.
90. Vera Costa, Renata Silva, Luísa Ferreira, Paula Branco, Félix Carvalho, Maria de Lourdes Bastos, Rui Carvalho, Márcia Carvalho, Fernando Remião (2007) Oxidation process of adrenaline in freshly isolated rat cardiomyocytes: Formation of adrenochrome, quinoproteins, and GSH adduct. Chemical Research in Toxicology 20(8):1183-1191.
91. Ema Alves, Teresa Summavielle, Cecília Juliana Alves, Joana Gomes-da-Silva, José Custódio Barata, Eduarda Fernandes, Maria de Lourdes Bastos, Maria Amélia Tavares, Félix Carvalho (2007) Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. Journal of Neuroscience 27(38):10203–10210.
92. Maria José de Jesús Valle, Ricardo Dinis-Oliveira, Félix Carvalho, Maria de Lourdes Bastos, Amparo Sánchez Navarro (2008) Toxicological evaluation of lactose and chitosan delivered by inhalation. Journal of Biomaterials Science. Polymers Edition 19(3):387–397.
93. Ricardo Dinis-Oliveira, Fernando Remião, José Alberto Duarte, Amparo Sánchez Navarro, Maria de Lourdes Bastos, Félix Carvalho (2008) Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment. Critical Reviews in Toxicology 38:13–71.
94. Bruno Nunes, Margarida Cardoso, Félix Carvalho, Lúcia Guilhermino (2008) The microalga Tetraselmis chuii (Chlorophyceae) in ecotoxicology: Culture conditions and growth model. Fresenius Environmental Bulletin 17(4):408-414.
95. Ana Rita Álvaro, João Martins, Ana Carina Costa, Eduarda Fernandes, Félix Carvalho, António Francisco Ambrósio, Cláudia Cavadas (2008) Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy. Neuroscience 152: 97-105.
96. Miguel Ângelo Lopes, Andreas Meisel, Félix Carvalho, Maria de Lourdes Bastos, Ulrich Dirnagl (2008) Doxorubicin induces biphasic neurotoxicity to rat cortical neurons. Neurotoxicology 29(2):286-293.
97. Bruno Nunes, Ana Rita Gaio, Félix Carvalho, Lúcia Guilhermino (2008) Behaviour and biomarkers of oxidative stress in Gambusia holbrooki after acute exposure to widely used pharmaceuticals and a detergent. Ecotoxicology and Environmental Safety 71(2):341-354.
98. Helena Pontes, Maria João Santos-Marques, Eduarda Fernandes, José Alberto Duarte, Fernando Remião, Félix Carvalho, Maria Lourdes Bastos (2008) Effect of chronic ethanol exposure on the hepatotoxicity of ecstasy in mice: an ex vivo study. Toxicology In Vitro 22(4):910-920.
99. Helena Pontes, Márcia Carvalho, Paula Guedes de Pinho, Helena Carmo, Fernando Remião, Félix Carvalho, Maria Lourdes Bastos (2008) Ethanol, the forgotten artifact in cell culture. Archives of Toxicology 82(3):197-198.
100. Marco Assunção, Maria J. Santos-Marques, Félix Carvalho, José Paulo Andrade, Manuel Paula-Barbosa (2008) Modulation of rat cerebellum oxidative status by prolonged red wine consumption. Addiction Biology 13(3-4):337-44.
101. Teresa Sousa, Dora Pinho, Manuela Morato, Eduarda Fernandes, Félix Carvalho, António Albino-Teixeira (2008) Role of superoxide and hydrogen peroxide in hypertension induced by an antagonist of adenosine receptors. European Journal of Pharmacology 588(2-3):267-276.
102. Jorge P Pinto, Sara Ribeiro, Helena Pontes, Shifaan Thowfeequ, David Tosh, Félix Carvalho, Graça Porto (2008) Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα. Blood 111(12):5727-5733.
103. Ricardo Dinis-Oliveira, Paula Pinho, António Ferreira, Artur Silva, Carlos Afonso, Maria Lourdes Bastos, Fernando Remião, José Duarte, Félix Carvalho (2008) Reactivity of paraquat with sodium salicylate: formation of stable complexes. Toxicology 249(2-3):130-139.
104. João Paulo Capela, Marion Lautenschlager, Ulrich Dirnagl, Maria de Lourdes Bastos, Félix Carvalho, Andreas Meisel (2008) 5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures. European Journal of Pharmacology 588(2-3):232-238.
105. Manuela Faria Frasco, J Didier Fournier, Félix Carvalho, Lúcia Guilhermino (2008) Does mercury interact with the inhibitory effect of dichlorvos on Palaemon serratus (Crustacea: Decapoda) cholinesterase? Science of the Total Environment 404(1):88-93.
106. Helena Pontes, José Alberto Duarte, Paula Guedes de Pinho, Maria Elisa Soares, Eduarda Fernandes, Ricardo Dinis-Oliveira, Carla Sousa, Renata Silva, Helena Carmo, Susana Casal, Fernando Remião, Félix Carvalho, Maria de Lourdes Bastos (2008) Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice. Toxicology 252(1-3):64-71.
107. Helena Pontes, Carla Sousa, Renata Silva, Eduarda Fernandes, Helena Carmo, Fernando Remião, Félix Carvalho, Maria Lourdes Bastos (2008) Synergistic toxicity of ethanol and MDMA towards primary cultured rat hepatocytes. Toxicology 254(1-2):42-50.
108. Ricardo Jorge Dinis-Oliveira, Helena Pontes, Maria de Lourdes Bastos, Fernando Remião, José Alberto Duarte, Félix Carvalho (2009) An effective antidote for paraquat poisonings: the treament with lysine acetylsalicylate. Toxicology 255(3):187-193.
109. Vera Marisa Costa, Luísa Ferreira, Paula Branco, Félix Carvalho, Maria de Lourdes Bastos, Rui Albuquerque Carvalho, Márcia Carvalho, Fernando Remião (2009) Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes. Chemical Research in Toxicology 22(1):129–135.
110. Ema Alves, Zbigniew Binienda, Félix Carvalho, Cecilia Juliana Alves, Eduarda Fernandes, Maria de Lourdes Bastos, Maria Amélia Tavares, Teresa Summavielle (2009) Acetyl-L-carnitine provides effective in vivo neuroprotection over MDMA-induced mitochondrial neurotoxicity in the adolescent rat brain. Neuroscience 158(2):514-523.
111. Ema Alves, Teresa Summavielle, Cecília Juliana Alves, José Barata Custódio, Eduarda Fernandes, Maria de Lourdes Bastos, Maria Amélia Tavares, Félix Carvalho (2009) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: Influence of monoamine oxidase type A. Addiction Biology 14:185–193.
112. Helena Pontes, Paula Guedes de Pinho, Susana Casal, Agostinho Santos, Teresa Magalhães, Fernando Remião, Félix Carvalho, Maria Lourdes Bastos (2009) GC determination of acetone, acetaldehyde, ethanol, and methanol in biological matrices and cell culture. Journal of Chromatographic Science 47(4):272-278.
113. João Capela, Helena Carmo, Fernando Remião, Maria Lourdes Bastos, Andreas Meisel, Félix Carvalho (2009) Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: An overview. Molecular Neurobiology 39(3):210-71.
114. Sylvia K. Shenouda, Pamela A. Lucchesi, Félix Carvalho, Kurt J. Varner (2009) Metabolites of MDMA induce oxidative stress and contractile dysfunction in adult rat left ventricular myocytes. Cardiovascular Toxicology 9:30–38.
115. Vera Marisa Costa, Renata Silva, Rita Ferreira, Francisco Amado, Félix Carvalho, Maria de Lourdes Bastos, Rui Albuquerque Carvalho, Márcia Carvalho, Fernando Remião (2009) Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes. Toxicology 257:70–79.
116. Vera Costa, Renata Silva, Ludgero C Tavares, Rui Vitorino, Francisco Amado, Félix Carvalho, Maria Lourdes Bastos, Márcia Carvalho, Rui A Carvalho, Fernando Remião (2009) Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes. Toxicology 260:84–96.
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117. Ricardo Jorge Dinis-Oliveira, Teresa Magalhães, Félix Carvalho, Agostinho Santos (2009) A cocaine body packer case report: Clinical and forensic aspects. Clinical Toxicology 47:590–591.
118. Marco Assunção, Maria J. Santos-Marques, Rosário Monteiro, Isabel Azevedo, José Paulo Andrade, Félix Carvalho, Maria João Martins (2009) Red wine protects against ethanol-induced oxidative stress in rat liver. Journal of Agricultural and Food Chemistry 57:6066–6073.
119. Carla Sousa, Helena Pontes, Helena Carmo, Ricardo Dinis-Oliveira, Patrícia Valentão, Paula B. Andrade, Fernando Remião, Maria Lourdes Bastos, Félix Carvalho (2009) Water extracts of Brassica oleracea var. costata potentiate paraquat hepatotoxicity in vitro. Toxicology in vitro 23(6):1131-1138.
120. Félix Carvalho (2009) How bad is accelerated senescence in consumers of drugs of abuse? Adicciones 21(2):99-104.
121. Susana J. Oliveira, Jorge P. Pinto, Gonçalo Picarote, Vera M. Costa, Félix Carvalho, Jorge E. Azevedo, Maria de Sousa and Sérgio F. de Almeida (2009) ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity. PLoS ONE 4(8):e6618.
122. Ricardo Dinis-Oliveira, Paula Guedes de Pinho, Liliana Santos, Helena Teixeira, Teresa Magalhães, Agostinho Santos, Maria Bastos, Fernando Remião, José Duarte, Felix Carvalho (2009) Postmortem analyses unveil the poor efficacy of decontamination, anti-inflammatory and immunosuppressive therapies in paraquat human intoxications. PLoS ONE 4(9):e7149.
123. Jorge Pereira Pinto, Vera Dias, Heinz Zoller, Graça Porto, Helena Carmo, Félix Carvalho, Maria de Sousa (2010) Hepcidin messenger RNA expression in human lymphocytes. Immunology 130(2):217-230.
124. Marco Assunção, Maria João Santos-Marques, Félix Carvalho, José P. Andrade (2010) Green tea averts age-dependent decline of hippocampal signaling systems related to antioxidant defenses and survival. Free Radical Biology and Medicine 48(6):831-838.
125. Helena Pontes, Paula Guedes de Pinho, Eduarda Fernandes, Helena Carmo, Fernando Remião, Félix Carvalho, Maria Lourdes Bastos (2010) Metabolic interactions between ethanol and MDMA in primary cultured rat hepatocytes. Toxicology 270:150–157.
126. Daniel Gomes da Silva, Paula Guedes de Pinho, Helena Pontes, Luísa Ferreira, Paula Branco, Fernando Remião, Félix Carvalho, Maria de Lourdes Bastos, Helena Carmo (2010) Gas chromatography-ion trap mass spectrometry method for the simultaneous measurement of MDMA (ecstasy) and its metabolites, MDA, HMA, and HMMA in plasma and urine. Journal of Chromatography B 878:815–822.
127. José B. A. Custódio, Maria S. Santos, Dália I.R. Gonçalves, António J.M. Moreno, Eduarda Fernandes, Maria de Lourdes Bastos, Félix Carvalho, Joaquim A. F. Vicente, Maria A. S. Fernandes (2010) Comparative effects of 3,4-methylenedioxymethamphetamine and 4-methylthioamphetamine on rat liver mitochondrial function. Toxicology 270:99–105.
128. Márcia Carvalho, Helena Pontes, Maria de Lourdes Bastos, Félix Carvalho (2010) Mechanisms underlying the hepatotoxic effects of ecstasy. Current Pharmaceutical Biotechnology 11:476-495.
129. Sylvia K. Shenouda, Félix Carvalho and Kurt J. Varner (2010) The cardiovascular and cardiac actions of ecstasy and its metabolites. Current Pharmaceutical Biotechnology 11:470-475.
130. Luciana Grazziotin Rossato, Paula Guedes de Pinho, Renata Silva, Helena Carmo, Félix Carvalho, Maria de Lourdes Bastos, Vera Marisa Costa, Fernando Remião (2010) Development and validation of a GC/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples. Journal of Pharmaceutical and Biomedical Analysis 52:721–726.
131. Ricardo Jorge Dinis-Oliveira, Félix Carvalho, Teresa Magalhães, Agostinho Santos (2010) Postmortem changes in carbon monoxide poisoning. Clinical Toxicology 48(7):762-763.
132. Ricardo Jorge Dinis-Oliveira, Félix Carvalho, Ricardo Dias, Teresa Magalhães, Agostinho Santos (2010) Suicide by hanging under the influence of ketamine and ethanol. Forensic Science International 202(1-3):e23-e27.
133. Ricardo Jorge Dinis-Oliveira, Inês Caldas, Félix Carvalho, Teresa Magalhães (2010) Bruxism after 3,4-methylenedioxymethamphetamine (ecstasy) abuse. Clinical Toxicology 48(8):863-864.
134. Ricardo J. Dinis-Oliveira, Félix Carvalho, José Alberto Duarte, Fernando Remião, Agostinho Santos, Teresa Magalhães (2010) Collection of biological samples in forensic toxicology. Toxicology Mechanisms and Methods 20(7):363-414.
135. Maria João Valente, Paula Guedes de Pinho, Félix Carvalho, Maria de Lourdes Bastos, Márcia Carvalho (2010) Development and validation of a gas chromatography/ion trap-mass spectrometry method for simultaneous quantification of cocaine and its metabolites benzoylecgonine and norcocaine: Application to the study of cocaine metabolism in human primary cultured renal cells. Journal of Chromatography B 878:3083–3088.
136. Karsten Ruscher, Eduarda Fernandes, João Capela, Maria de Lourdes Bastos, Tadeusz W. Wieloch, Ulrich Dirnagl, Andreas Meisel, Felix Carvalho (2011) Effect of 3,4-methylenedioxyamphetamine on dendritic spine dynamics in rat neocortical neurons - Involvement of heat shock protein 27. Brain Research 1370:43-52.
137. Marta Correia-da-Silva, Emília Sousa, Bárbara Duarte, Franklim Marques, Félix Carvalho, Luís M. Cunha-Ribeiro, Madalena M. M. Pinto (2011) Flavonoids with an oligopolysulfated moiety: A new class of anticoagulant agents. Journal of Medicinal Chemistry 54:95–106.
138. Miguel Ângelo Lopes. Andreas Meisel, Félix Dias Carvalho, Maria de Lourdes Bastos (2011) Neuronal nitric oxide synthase is a key factor in doxorubicin-induced toxicity to rat-isolated cortical neurons. Neurotoxicity Research 19(1):14-22.
139. Luciana Grazziotin Rossato, Vera Marisa Costa, Paula Guedes Pinho, Félix Carvalho, Maria de Lourdes Bastos, Fernando Remião (2011) Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes. Archives of Toxicology 85(8):929-39.
140. Renata Silva, Helena Carmo, Ricardo Dinis-Oliveira, Anabela Cordeiro-da-Silva, Sofia Costa Lima, Félix Carvalho, Maria de Lourdes Bastos, Fernando Remião (2011) In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells. Archives of Toxicology. 85(4): 315-326.
141. Marco Assunção, Maria João Santos-Marques, Félix Carvalho, Nikolai V. Lukoyanov, José P. Andrade (2011) Chronic green tea consumption prevents age-related changes in rat hippocampal formation. Neurobiology of Aging. 32(4): 707-717.
142. Patty Nooijen, Félix Carvalho, Robert Flanagan (2011) Haematological Toxicity of Clozapine and Other Drugs Used in Psychiatry: An Update. Human Psychopharmacology: Clinical and Experimental 26(2): 112-119.
143. Vera Marisa Costa, Félix Carvalho, Maria Lourdes Bastos, Rui Albuquerque Carvalho, Márcia Carvalho, Fernando Remião (2011) Contribution of catecholamine reactive intermediates and oxidative stress to the pathologic features of heart diseases. Current Medicinal Chemistry 18(15): 2272-314.
144. Maria João Valente, Rui Henrique, Vera Costa, Carmen Jerónimo, Félix Carvalho, Maria de Lourdes Bastos, Paula Guedes de Pinho, Márcia Carvalho (2011) A rapid and simple procedure for the establishment of human normal and cancer renal primary cell cultures from surgical specimens. PLoS ONE, 6(5): e19337.
145. Maria Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, José Alberto Duarte, Maria de Lourdes Bastos, Félix Carvalho (2011) Antioxidant properties and associated mechanisms of salicylates. Current Medicinal Chemistry 18 (21): 3252-3264.
146. Marta Correia-da-Silva, Emília Sousa, Bárbara Duarte, Franklim Marques, Félix Carvalho, Luís M. Cunha-Ribeiro, Madalena M. M. Pinto (2011) Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents. Journal of Medicinal Chemistry 54 (15) :5373-5384.
147. Filipa Ponte, Félix Carvalho, Beatriz Porto (2011) Protective effect of acetyl-L-carnitine and α-lipoic acid against the acute toxicity of diepoxybutane to human lymphocytes. Archives of Toxicology 289 (1):52-58
148. João Martins, Miguel Castelo-Branco, Ana Batista, Bárbara Oliveiros, Ana Raquel Santiago, Joana Galvão, Eduarda Fernandes, Félix Carvalho, Cláudia Cavadas and António F. Ambrósio (2011) Effects of 3,4-Methylenedioxymethamphetamine Administration on Retinal Physiology in the Rat. PLoS ONE 6(12): e29583.
149. Ricardo Jorge Dinis-Oliveira, Félix Carvalho, José Alberto Duarte, Jorge Brandão Proença, Agostinho Santos, Teresa Magalhães (2012) Clinical and forensic signs related to cocaine abuse. Current Drug Abuse Reviews. 5(1):64-83.
150. Daniel José Barbosa, João Paulo Capela, Jorge M. A. Oliveira, Renata Silva, Luísa Maria Ferreira, Filipa Siopa, Paula Sério Branco, Eduarda
Fernandes, José Alberto Duarte, Maria de Lourdes Bastos and Félix Carvalho (2012) Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes. British Journal of Pharmacology, 165 (4b): 1017–1033.
151. Pedro Nuno Moreira, Paula Guedes de Pinho, Maria Teresa Baltazar, Maria Lourdes Bastos, Agostinho Santos, Teresa Magalhães, Félix Carvalho, Ricardo Jorge Dinis-Oliveira (2012) Quantification of paraquat in postmortem samples by gas chromatography-ion trap mass spectrometry and review of literature. Biomedical Chromatography 26: 338–349.
152. Maria João Valente, Rui Henrique, Vânia Vilas Boas, Renata Silva, Maria de Lourdes Bastos, Félix Carvalho, Paula Guedes de Pinho, Márcia Carvalho (2012) Cocaine-induced kidney toxicity: an in vitro study using primary cultured human proximal tubular epithelial cells. Archives of Toxicology 86(2):249-861.
153. Márcia Carvalho, Helena Carmo, Vera Costa, João Capela, Helena Pontes, Fernando Remião, Félix Carvalho, Maria Lourdes Bastos (2012) Toxicity of amphetamines: an update. Archives of Toxicology. 86(8):1167-231.
154. Teresa Sousa, Sofia Oliveira, Joana Afonso, Manuela Morato, Daniela Patinha, Sónia Fraga, Félix Carvalho, António Albino-Teixeira (2012) Role of H2O2 in hypertension, renin-angiotensin system activation and renal medullary disfunction caused by angiotensin II. British Journal of Pharmacology. 166(8):2386-2401.
155. Filipa Ponte, Rosa Sousa, Ana Paula Fernandes, Cristina Gonçalves, José Barbot, Félix Carvalho and Beatriz Porto (2012) Improvement of genetic stability in lymphocytes from Fanconi Anemia patients through the combined effect of α-lipoic acid and N-acetylcysteine. Orphanet Journal of Rare Diseases. 7:28. – Considered and 'Highly accessed' article by BIOMED Central (articles that has been especially highly accessed, relative to their age, and the journal in which it was published).
156. Carla Alexandra Gouveia, Ana Oliveira, Sandra Pinho, Carlos Vasconcelos, Félix Carvalho, Roxana Falcão Moreira, Ricardo Jorge Dinis-Oliveira (2012) Simultaneous quantification of morphine and cocaine in hair samples from drug addicts by GC-EI/MS. Biomedical Chromatography 26(8):1041-1047.
157. Maria João Valente, Paula Guedes, Felix Carvaho, Maria de Lourdes Bastos, Márcia Carvalho (2012) Contribution of oxidative metabolism to cocaine-induced liver and kidney damage. Current Medicinal Chemistry. 19 (33): 5601-5606.
158. Ricardo Jorge Dinis-Oliveira, Félix Carvalho, Roxana Moreira, José Alberto Duarte, Jorge Brandão Proença, Agostinho Santos, Teresa Magalhães (2012) Clinical and forensic signs related to opioids abuse Current Drug Abuse Reviews 5(4): 273-290.
159. Maria Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, José Alberto Duarte, Maria de Lourdes Bastos, Félix Carvalho (2013) Paraquat research. Do recent advances in limiting its toxicity make its use safer? British Journal of Pharmacology 168: 44-45.
160. João Paulo Capela, Silvana Costa Araújo, Vera Marisa Costa, Karsten Ruscher, Eduarda Fernandes, Maria Lourdes Bastos, Ulrich Dirnagl, Andreas Meisel, Félix Carvalho (2013) Hallucinogenic amphetamines neurotoxicity in primary cultures of hippocampal neurons. Neurotoxicology 34: 254-263.
161. Maria Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, Lúcia Guilhermino, Maria de Lourdes Bastos, José Alberto Duarte, Félix Carvalho (2013) New formulation of paraquat with lysine acetylsalicylate with low mammalian toxicity and effective herbicidal activity. Pest Management Science 69 (4):553-558.
162. Patrícia Silva Ferreira, Tiago Bernardes Nogueira, Vera Marisa Costa, Paula Sério Branco, Luísa Maria Ferreira, Eduarda Fernandes, Maria Lourdes Bastos, Andreas Meisel, Félix Carvalho and João Paulo Capela (2013) Neurotoxicity of “ecstasy” and its metabolites in human dopaminergic differentiated SH-SY5Y cells. Toxicology Letters 216 (2-3): 159-170.
163. Renata Silva, Helena Carmo, Vânia Vilas-Boas, Paula Guedes de Pinho, Ricardo Dinis-Oliveira, Félix Carvalho, Isabel Silva, Paulo Correia-de-Sá, Maria de Lourdes Bastos and Fernando Remião (2013) Doxorubicin decreases Paraquat accumulation and toxicity in Caco-2 cells. Toxicology Letters 217 (1): 34-41.
164. Fernanda Sampaio-Silva; Teresa Magalhães; Félix Carvalho; Ricardo Dinis-Oliveira; Ricardo Silvestre (2013) Profiling of RNA degradation for accurate determination of Post Mortem interval. PLoS ONE. 8(2):e56507.
165. João Barbosa Martins, Maria de Lourdes Bastos, Félix Carvalho, and João Paulo Capela (2013) Differential Effects of Methyl-4-Phenylpyridinium Ion, Rotenone and Paraquat to Differentiated SH-SY5Y Cells. Journal of Toxicology, Article ID 347312, 10 pages.
166. Sandra Pinho, Isabel Costa, Ana Oliveira, Carla Alexandra Gouveia, Félix Carvalho, Roxana Falcão Moreira, Ricardo Jorge Dinis-Oliveira (2013) Simultaneous quantification of tramadol and O-desmethyltramadol in hair samples by gas chromatography-electron impact/mass spectrometry. Biomedical Chromatography 27(8):1003-1011.
167. Jorge Rodrigues, Marco Assunção, Nikolay Lukoyanov, Armando Cardoso, Félix Carvalho, José Paulo Andrade (2013) Multiple protective effects of a catechin-rich extract on the hippocampal formation of aging rats. Behavioural Brain Research 246 (2013) 94-102.
168. Joana Barbosa, Juliana Faria, Félix Carvalho, Madalena Pedro, Odília Queirós, Roxana Moreira, Ricardo Jorge Dinis-Oliveira (2013) Hair as an alternative matrix in bioanalysis. Bioanalysis 5 (8) 895-914.
169. Marisa Freitas, Vera Costa, Graça Porto, Félix Carvalho, Eduarda Fernandes (2013) Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils. Toxicology Letters 219: 170-177.
170. Rosa Sousa, Filipa Ponte, Sara Teixeira, Lara Andrade, Cristina Gonçalves, José Barbot, Jorge Coutinho, Félix Carvalho and Beatriz Porto (2013) Fosfomycin increases chromosome instability in lymphocytes from Fanconi Anemia patients. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 754(1-2):58-62.
171. Vânia Vilas-Boas, Renata Silva, Cláudia Nunes, Marlene Lúcio, Salette Reis, Luísa Ferreira, Paula Branco, Félix Carvalho, Maria de Lourdes Bastos and Fernando Remião (2013) Mechanisms of P-gp inhibition and effects on membrane fluidity of a new rifampicin derivative, 1,8-dibenzoyl-rifampicin. Toxicology Letters, 220 (3) 259-266.
172. Vânia Vilas-Boas; Renata Silva; Andreia Palmeira; Emília Sousa; Luísa Ferreira; Paula Branco; Félix Carvalho; Maria de Lourdes Bastos; Fernando Remião (2013) Development of novel rifampicin-derived P-glycoprotein activators/ inducers. Synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate. PLoS ONE, 8(8):e74425.
173. Isabel Costa, Ana Oliveira, Paula Guedes de Pinho, Roxana Moreira, Félix Carvalho, Ricardo Jorge Dinis-Oliveira (2013) Postmortem redistribution of tramadol and o-desmethyltramadol. Journal of Analytical Toxicology, 37(9): 670-675.
174. Vera Marisa Costa, Félix Carvalho, José Alberto Duarte, Maria de Lourdes Bastos, and Fernando Remião (2013) The heart as a target for xenobiotic toxicity: the cardiac susceptibility to oxidative stress. Chemical Research in Toxicology, 26(9):1285-311. Este artigo foi seleccionado para destaque na capa da revista da edição de Setembro de 2013.
175. Maria Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, Alexandra Martins, Maria de Lourdes Bastos, José Alberto Duarte, Lúcia Guilhermino and Félix Carvalho (2013) The presence of lysine acetylsalicylate increases the safety of a paraquat formulation to freshwater primary producers: a case study with the microalga Chlorella vulgaris. Aquatic Toxicology, 146C:137-143.
176. Diana Dias da Silva, Elisabete Silva, Félix Carvalho, Helena Carmo (2014) Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations. Journal of Applied Toxicology, 34(6):618-27.
177. Vânia Vilas-Boas, Renata Silva, Paula Guedes-de-Pinho, Félix Carvalho, Maria de Lourdes Bastos and Fernando Remião (2014) RBE4 cells are highly resistant to paraquat-induced cytotoxicity - studies on uptake and efflux mechanisms. Journal of Applied Toxicology, 34(9):1023-1030.
178. Daniel José Barbosa, João Paulo Capela, Renata Silva, Vânia Vilas-Boas, Luísa Ferreira, Paula Sério Branco, Eduarda Fernandes, Maria de Lourdes Bastos, and Félix Carvalho (2014) The mixture of ecstasy and its metabolites is toxic to human SH-SY5Y differentiated cells, at in vivo relevant concentrations. Archives of Toxicology, 88: 455 - 473.
179. Luís Miguel Carvalho, Félix Carvalho, Maria de Lourdes Bastos, Paula Baptista, Nathalie Moreira, Ana Rita Monforte, António César da Silva Ferreira, Paula Guedes de Pinho (2014) Application of Gas Chromatography-Mass Spectrometry for targeted and non-targeted analysis in wild toxic and edible mushrooms. Talanta, 118: 292-303.
180. Daniel José Barbosa, João Paulo Capela, Renata Silva, Luísa Ferreira, Paula Sério Branco, Eduarda Fernandes, Maria de Lourdes Bastos, and Félix Carvalho (2014) Ecstasy-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites and their stability under normothermic and hyperthermic conditions. Archives of Toxicology, 88:515 -531.
181. Ana Oliveira, Ricardo Jorge Dinis-Oliveira, Augusto Nogueira, Andreia Azevedo, Ferraz Gonçalves, Paula Silva, Félix Carvalho, Rui Medeiros (2014) Genetic profile and cancer-related pain: a tale from two outlier cases with bone metastatic disease. Pain Medicine, 15(4):710-712.
182. Maria João Valente, Paula Guedes de Pinho, Maria de Lourdes Bastos, Félix Carvalho, Márcia Carvalho (2014) Khat and synthetic cathinones: a review. Archives of Toxicology, 88:15 - 45.
183. Ricardo Jorge Dinis-Oliveira, Teresa Magalhães, Roxana Moreira, Jorge Brandão Proença, Helena Pontes, Agostinho Santos, José Alberto Duarte, Félix Carvalho (2014) Clinical and forensic signs related to ethanol abuse: a mechanistic aproach. Toxicology Mechanisms and Methods, 24 (2) 81-110.
184. Diana Couto, Marisa Freitas, Vânia Vilas-Boas, Irene Dias, Graça Porto, M. Arturo Lopez-Quintela, José Rivas, Paulo Freitas, Félix Carvalho, Eduarda Fernandes (2014) Interaction of polyacrylic acid coated and non-coated iron oxide nanoparticles with human neutrophils. Toxicology Letters, 225: 57- 65.
185. Maria Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, Maria de Lourdes Bastos, Aristidis M. Tsatsakis, José Alberto Duarte, Félix Carvalho (2014) Pesticides exposure as etiological factors of Parkinson´s Disease and other neurodegenerative diseases - a mechanistic approach. Toxicology Letters, 230(2):85-103.
186. Ana Oliveira, Félix Carvalho, Paula Guedes Pinho, Fernando Remião, Rui Medeiros, Ricardo Jorge Dinis-Oliveira (2014) Quantification of morphine and its major metabolites M3G and M6G in antemortem and postmortem samples. Biomedical Chromatography, 28 (9): 1263–1270.
187. Daniel José Barbosa, Romàn Serrat, Serena Mirra, Martí Quevedo, Elena Gómez de Barreda, Jesús Àvila, Eduarda Fernandes, Maria de Lourdes Bastos, João Paulo Capela, Félix Carvalho, and Eduardo Soriano (2014) MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner. Archives of Toxicology, 88(8):1561-1572.
188. Maria Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, Maria de Lourdes Bastos, José Alberto Duarte, Félix Carvalho (2014) Lysine acetylsalicylate improves the safety of paraquat formulation in rats, by increasing its elimination, and preventing lung and kidney injury. Toxicology Research, 3: 266-277.
189. Daniel José Barbosa, Romàn Serrat, Serena Mirra, Martí Quevedo, Elena Goméz de Barreda, Jesús Àvila, Luísa Maria Ferreira, Paula Sério Branco, Eduarda Fernandes, Maria de Lourdes Bastos, João Paulo Capela, Eduardo Soriano, and Félix Carvalho (2014) The mixture of “ecstasy” and its metabolites impairs mitochondrial fusion/fission equilibrium and trafficking in hippocampal neurons, at in vivo relevant concentrations. Toxicological Sciences, 139 (2):407-420.
190. Marta Reina-Couto, Jorge Carvalho, Maria João Valente, Luís Vale, Joana Afonso, Félix Carvalho, Paulo Bettencourt, Teresa Sousa, and António Albino-Teixeira (2014) Impaired resolution of inflammation in human chronic heart failure. European Journal of Clinical Investigation, 44 (6): 527-38.
191. Helena Campanhã, Félix Carvalho, Paul Schlosser (2014) Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the ng108-15 cell line. Toxicology Letters, 230(2):122-131.
192. Ana Oliveira, Ricardo Jorge Dinis-Oliveira, Augusto Nogueira, Ferraz Gonçalves, Paula Silva, Cláudia Vieira, Ricardo Silvestre, Félix Carvalho, Rui Medeiros (2014) Interleukin-1β Genotype and Circulating Levels in Cancer Patients: Metastatic Status and Pain Perception. Clinical Biochemistry, 47 (13-14):1209-1213.
193. Renata Silva, Helena Carmo, Vânia Vilas-Boas, Daniel Barbosa, Palmeira A, Emilia Sousa, Félix Carvalho, Maria de Lourdes Bastos, Fernando Remião (2014) Colchicine effect on P-glycoprotein expression and activity: in silico and in vitro studies. Chemico-Biological Interactions, 218: 50-62.
194. Juliana Garcia, Alexandra T.P. Carvalho, Daniel F.A.R. Dourado, Paula Baptista, Maria de Lourdes Bastos, Félix Carvalho (2014) New in silico insights into the inhibition of RNA polymerase II by α-amanitin and the protective effect mediated by effective antidotes. Journal of Molecular Graphics and Modelling, 51C:120-127.
195. Ana Oliveira, Dora Pinho, António Albino-Teixeira, Rui Medeiros, Ricardo Jorge Dinis-Oliveira, Félix Carvalho (2014) Morphine glucuronidation increases its analgesic effect in guinea-pigs. Life Sciences, 109(2):104-110.
196. Daniel José Barbosa, Romàn Serrat, Luísa Maria Ferreira, Paula Sério Branco, Maria de Lourdes Bastos, João Paulo Capela, Eduardo Soriano, and Félix Carvalho (2014) Neuronal mitochondrial trafficking impairment: the cause or a consequence of neuronal dysfunction caused by amphetamine-like drugs. Journal of Drug and Alcohol Research, 3 art235868.
197. Tiago Bernardes Nogueira, Silvana da Costa Araújo, Félix Carvalho, Frederico C. Pereira, Eduarda Fernandes, Maria Lourdes Bastos, Vera Marisa Costa and João Paulo Capela (2014) Modelling chronic brain exposure to amphetamines using primary rat neuronal cortical cultures. Neuroscience, 277C: 417-434.
198. Fernando Xavier Moreira, Félix Carvalho, Maria de Lourdes Bastos, Paula Guedes de Pinho (2014) Analytical investigation of legal high products containing Salvia divinorum traded in smartshops and internet. Forensic Science International, 242C:255-260.
199. Ana Margarida Araújo, Maria João Valente, Márcia Carvalho, Diana Dias da Silva, Helena Gaspar, Félix Carvalho, Maria de Lourdes Bastos, Paula Guedes de Pinho (2015) Raising awareness of new psychoactive substances: chemical analysis and in vitro toxicity screening of ‘legal high’ packages containing synthetic cathinones. Archives of Toxicology, 89(5):757-71.
200. Diana Couto, Marisa Freitas, Graça Porto, M. Arturo Lopez-Quintela, José Rivas, Paulo Freitas, Félix Carvalho, Eduarda Fernandes (2015) Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways. Archives of Toxicology. 89(10):1759-69.
201. Renata Silva, Vânia Vilas-Boas, Helena Carmo, Ricardo Jorge Dinis-Oliveira, Félix Carvalho, Maria de Lourdes Bastos and Fernando Remião (2015) Induction and activation of P-glycoprotein efflux pump as a therapeutic strategy. Pharmacology and Therapeutics 149:1-123.
202. Ricardo Jorge Dinis-Oliveira, Félix Carvalho, Roxana Moreira, Jorge Brandão Proença, Agostinho Santos, José Alberto Duarte, Maria de Lourdes Bastos, Teresa Magalhães (2015) Clinical and forensic signs related to chemical burns: a mechanistic approach. Burns, 41(4):658-679.
203. Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos, Félix Carvalho (2015) In vitro models for neurotoxicology research. Toxicology Research, 4: 801-842.
204. Juliana Garcia, Ana Oliveira, Paula Guedes de Pinho, Victor Freitas, Alexandra Carvalho, Paula Baptista, Eric Pereira, Maria de Lourdes Bastos, Félix Carvalho (2015) Determination of Amatoxins and Phallotoxins in Amanita phalloides mushrooms from Northeast Portugal by HPLC-DAD-MS. Mycologia 107(4):679-87.
205. Armanda Teixeira-Gomes, Vera Marisa Costa, Rita Feio-Azevedo, Maria de Lourdes Bastos, Félix Carvalho and João Paulo Soares Capela (2015) The neurotoxicity of amphetamines during the adolescent period. International Journal of Developmental Neuroscience 41C:44-62.
206. José Luís Dores-Sousa, José A Duarte, Vitor Seabra, Maria de Lourdes Bastos, Félix Carvalho, Vera Costa (2015) The age factor for mitoxantrone's cardiotoxicity: multiple hits render the heart in adult mice more susceptible to injury. Toxicology 329:106-119.
207. Félix Carvalho, Eugene A Kiyatkin, Daniel E Rusyniak, Andrej A. Romanovsky (2015) Temperature in the spotlight of drug abuse research. Temperature 2:1, 27- 28.
208. Diana Couto; Rosa Sousa; Lara Andrade; Magdalena Leander; Arturo Lopez-Quintela; José Rivas; Paulo Freitas; Margarida Lima; Graça Porto; Beatriz Porto; Felix Dias Carvalho, Eduarda Fernandes (2015) Polyacrylic acid coated and non-coated iron oxide nanoparticles are not genotoxic to human T
lymphocytes. Toxicology Letters, 234(2):67-73.
209. Emanuele Alves, Jean-Paul C. Grund, Carlos Manuel Afonso, Annibal
Duarte Pereira Netto, Félix Carvalho, Ricardo Jorge Dinis-Oliveira (2015) The harmful chemistry behind krokodil (desomorphine). Synthesis and mechanisms of toxicity. Forensic Science International, 249: 207–213.
210. Daniel José Barbosa, João Paulo Capela, Rita Feio-Azevedo, Armanda Teixeira-Gomes, Maria de Lourdes Bastos, and Félix Carvalho (2015)
Mitochondria: key players in the neurotoxic effects of amphetamines.
Archives of Toxicology. 89(10):1695-725.
211. Emanuele Amorim Alves, José Xavier Soares, Carlos Manuel Afonso, Jean-Paul C. Grund, Ana Sofia Agonia, Sara Manuela Cravo, Annibal Duarte Pereira Netto, Félix Carvalho, Ricardo Jorge Dinis-Oliveira (2015) The chemistry behind "krokodil": street-like synthesis and product analysis forensic science international. Forensic Science International 257:76-82.
212. Diana Couto, Marisa Freitas, Félix Carvalho, Eduarda Fernandes (2015) Iron oxide nanoparticles: an insight into their biomedical applications. Current Medicinal Chemistry. 22 (15): 1808-1828.
213. Paula Silva, Eduarda Fernandes, Félix Carvalho (2015) Dual effect of red wine on liver redox status: a concise and mechanistic Review. Archives of Toxicology. 89(10):1681-93.
214. Ana Margarida Araújo, Félix Carvalho, Maria de Lourdes Bastos, Paula Guedes de Pinho, Márcia Carvalho (2015) The hallucinogenic world of tryptamines: an updated review. Archives of Toxicology. 89(8):1151-1173.
215. Juliana Garcia, Vera Costa, Ana Elisa Costa, Sérgio Andrade, Ana Cristina Carneiro, Filipe Conceição, José Artur Paiva, Paula Guedes Pinho, Paula Baptista, Maria de Lourdes Bastos, Félix Carvalho (2015) Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report. Toxicon, 103: 55-59.
216. Juliana Garcia, Vera M. Costa, Paula Baptista, Maria de Lourdes Bastos, Félix Carvalho (2015) Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV-diode array and electrochemical detection. Journal of Chromatography B, 997: 85-95.
217. Luís Gales, Ricardo Amorim, Carlos Manuel M. Afonso, Félix Carvalho, Ricardo Jorge Dinis-Oliveira (2015) Decreasing the toxicity of paraquat through the complexation with sodium salicylate: Stoichiometric analysis. Toxicology 336 (2015) 96 - 98.
218. Garcia J, Costa VM, Carvalho ATP, Baptista P, Guedes P, Bastos LM, Carvalho F. Amanita phalloides poisoning: mechanisms of toxicity and treatment. Food and Chemical Toxicology 86: 41-55.
219. Isabel Costa, Félix Carvalho, Teresa Magalhães, Paula Guedes de Pinho, Ricardo Silvestre and Ricardo Jorge Dinis-Oliveira (2015) Promising blood-derived biomarkers for estimation of the postmortem interval. Toxicology Research 4: 1443-1452.
Hot article in Toxicology Research 2015, as recommended by referees.
220. Juliana Garcia, Vera Costa, Alexandra Carvalho, Ricardo Silvestre, José Alberto Duarte, Daniel Dourado, Marcelo Arbo, Teresa Baltazar, Ricardo Dinis-Oliveira, Paula Baptista, Maria de Lourdes Bastos, Felix Carvalho (2015) A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B. Archives of Toxicology. 89(12): 2305-2323.
222. Ricardo Jorge Dinis-Oliveira, Teresa Magalhaes, Odilia Queiros, Jorge Brandao Proenca, Roxana Moreira, Maria de Lourdes Bastos and Felix Carvalho. (2015) Signs and related mechanisms of ethanol hepatotoxicity. Current Drug Abuse Reviews. 8(2): 86-103.
221. Ricardo Jorge Dinis-Oliveira, Mariana Soares, Carolina Rocha-Pereira, Félix Carvalho (2016) Human and experimental toxicology of orellanine. Human and Experimental Toxicology (in press).
223. Maria João Valente, Ana Margarida Araújo, Renata Silva, Maria de Lourdes Bastos, Félix Carvalho, Paula Guedes de Pinho, Márcia Carvalho (2016) 3,4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions. Archives of Toxicology (in press).
224. João Neves, Emanuele Amorim Alves, José Xavier Soares, Sara Manuela Cravo, Annibal Duarte Pereira Netto, Félix Carvalho, Ricardo Jorge Dinis-Oliveira, Carlos Manuel Afonso (2016) Data analysis of “Krokodil” samples obtained by street-like synthesis. Data in Brief. 6: 83-88.
225. Joana Alves, Pedro Madureira, Maria Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, Adília Ribeiro, Luís Mira Vieira, Patrick Trieu-Cuot, José Alberto Duarte, Félix Carvalho, Paula Ferreira (2016) A Safe and Stable Neonatal Vaccine Targeting GAPDH Confers Protection Against GBS Infections in Adult Susceptible Mice. PLOS ONE. 10 (12): e0144196.
226. Alexander I. Vardavas, Persefoni Fragkiadaki, Athanasios K. Alegakis, Kouretas Dimitrios, Nikolaos Goutzourelas, John Tsiaoussis, Christina Tsitsimpikou, Polychronis D. Stivaktakis, Félix Carvalho, Aristidis M. Tsatsakis (2016) Downgrading the systemic condition of rabbits after long term exposure to cypermethrin and piperonyl butoxide. Life Sciences (in press).
227. Pedro Ferreira, Elsa Fonte, M. Elisa Soares, Felix Carvalho, Lúcia Guilhermino (2016) Effects of multi-stressors on juveniles of the marine fish Pomatoschistus microps: gold nanoparticles, microplastics and temperature. Aquatic Toxicology. 170: 89-103.
228. Sofia D. Viana, Rosa C. Fernandes, Paula Canas, Andréa M. Silva, Félix Carvalho, Syed F. Ali, Carlos A. Fontes Ribeiro and Frederico C. Pereira (2016) Striatal neurotrophic S100B/mRAGE levels are synchronous with motor recovery of MPTP-chronically injected mice. CNS Neuroscience & Therapeutics (in press).
229. Ana Sofia Oliveira, Sónia Fraga, Félix Carvalho, Ana Margarida Araújo, Cristiana Costa Pereira, João Paulo Teixeira, Maria de Lourdes Bastos, Paula Guedes de Pinho (2016) Chemical characterization and in vitro cyto- and genotoxicity of ‘legal high’ products containing Kratom (Mitragyna speciosa). Forensic Toxicology (in press).
230. Ricardo Jorge Dinis-Oliveira, Félix Carvalho, Isabel Costa, Ricardo Silvestre and Teresa Magalhães (2016) Response to the comment on “Promising blood-derived biomarkers for estimation of the postmortem interval”†. Toxicology Research (in press).


Publications of full papers in national journals with pair-review

1. Anabela Silva, Félix Carvalho, Isabel Silveira (1987) Algumas notas sobre antidepressivos. Revista Portuguesa de Farmácia 37(4):137-142.
2. Félix Carvalho, Maria de Lourdes Bastos, Margarida Ferreira (1993) Hepatotoxicidade do paracetamol. Arquivos do Instituto Nacional de Saúde 19:15-25.
3. Maria de Lurdes Bastos, Felix Carvalho, Fernando Remião, Maria Elisa Soares, Margarida Ferreira (1995) Marcadores bioquímicos indiciadores da toxicidade dos fármacos. Revista Portuguesa de Farmácia 45(1):11-15.
4. Félix Carvalho, Maria de Lourdes Bastos (1997) Estudo da hepatotoxicidade da anfetamina. Ensaios in vitro. Revista Portuguesa de Farmácia 47:111-120.
5. Márcia Carvalho, Félix Carvalho, Maria de Lourdes Bastos (1998) Avaliação dos efeitos tóxicos das anfetaminas no Homem – O que tem sido feito em Portugal? Boletim de Medicina Legal e Toxicologia Forense 12(1):143-147.
6. Rui Castro, Catarina Prata, Luis Oliveira, Maria João Carvalho, Josefina Santos, Félix Carvalho, Teresa Morgado (2005) Intoxicação por Paraquato e terapêutica com hemocarboperfusão. Acta Médica Portuguesa 18:423-432.
7. Maria Teresa Ferreira, Rita Ferreira, Félix Carvalho, José Alberto Duarte (2006) Influência do exercício físico em marcadores de cardiotoxicidade aguda, induzida pela administração de d-anfetamina, no modelo animal. Revista Portuguesa de Cardiologia 25 (11):983-996.
8. Jorge P. Pinto, Sara Ribeiro, Helena Pontes, Shifaan Thowfeequ, David Tosh, Félix Carvalho, Graça Porto (2009) A eritropoetina medeia a expressão de hepcidina em hepatócitos através da via de sinalização do EPOR e da regulação de C/EBPα. ABO – Revista de Medicina Transfusicional 39:23-30.
9. Ricardo Jorge Dinis-Oliveira, Rui Nunes, Félix Carvalho, Agostinho Santos, Helena Teixeira, Duarte Nuno Vieira, Teresa Magalhães (2010) Procedimentos técnicos, éticos e legais da competência do médico no cumprimento da lei da fiscalização da condução rodoviária sob influência do álcool e substâncias psicotrópicas. Acta Médica Portuguesa 23:1059-1082.
10. Vera Marisa Costa, Maria de Lourdes Bastos, Félix Carvalho (2011) Género masculino vs feminino: factor relevante para as respostas farmacológicas e efeitos adversos de fármacos? Acta Farmacêutica Portuguesa vol 1, nº 1, 55-64.

Publicação na base de dados “PROTEIN DATA BANK (PDB):

Jacques Philippe Colletier, Manuela Frasco, Félix Carvalho, Lúcia Guilhermino, Jure Stojan, Didier Fournier, Martin Weik (2006) Structure of human butyrylcholinesterase in complex with 10 mM HgCl2. PDB accession code 2J4C (DOI:10.2210/pdb2j4c/pdb)