isabelmoura

Isabel Maria Martins Galhardas de Moura
Full Professor
Integrated Member
Research Group
Structural Molecular Biology
FCT/ Chemistry Department Campus da Caparica 2829-516 Caparica Portugal
212 948 381
- ext 10916
212 948 550
Research Interests
IM received her Degree in Chemical Engineering from Technical University of Lisbon (Pt) in 1974.She received her Masters in Physical Inorganic Chemistry in 1977from New University of Lisbon. She was awarded her PHD from New University of Lisbon in 1981 on the thesis entitled “Characterization of two types of iron sulphur centers in two proteins isolated from Desulfovibrio gigas”.Since then she was an Assistant Professor until 1981 in the New University of Lisbon. In 1986 she became an Associate Professor at the same University. She has done the habilitation in 1994 in the same University. She became a Full Professor in 1997 in the same University. During her career she was a Visiting Professor in University of Geogia, Athens,USA. During the period 2000/2011 she was the Head of the Chemistry Department of the Faculty of Sciences and Technology from the New University of Lisbon and the Director of the Associated Laboratory Requimte for Sustainable Chemistry. Her main work is Structure-Function of Metalloproteins. Application of biochemical and spectroscopic tools (NMR, EPR and Mössbauer). Proteins involved in relevant bacterial metabolic pathways – N and S Biocycles. Active sites includes Cu, Co, hemes, iron-sulfur centers (rubredoxin type, [2Fe-4S], [3Fe-4S], [4Fe-4S]) as well as association of Fe-S centers with Mo, W, Ni, siroheme and flavines. New type of clusters and new metal associations is also one of the main topics of research. Publications - circa 370-H=52
Main publications
COMPARATIVE ELECTROCHEMICAL STUDY OF SUPEROXIDE REDUCTASES
C. M. Cordas, P. Raleiras, F. Auchére, I. Moura and J. J. G. Moura
Eur Biophys J. 41, 209-215 (2011) Dec 6. [Epub ahead of print]

BIOCHEMICAL CHARACTERIZATION OF THE PURPLE FORM OF MARINOBACTER HYDROCARBONOCLASTICUS NITROUS OXIDE REDUCTASE
S.Dell’Acqua, S.R. Pauleta, J.J. G. Moura and I.Moura
Proceedings of the Royal society B 367, 1204 1212 (2012)

IRON-SULFUR CENTERS: NEW ROLES FOR ANCIENT METAL SITES
R. Grazina, S. Pauleta, J.J.G. Moura and I. Moura
Bioinorganic Fundamentals and Applications: Metals in Natural Living
Systems, Chapter (2012) in press

PERIPLASM NITRATE REDUCTASES AND FORMATE DEHYDROGENASES:CONTROL OF THE CHEMICAL PROPERTIES OF MO AND W FOR FINE TUNING OF REACTIVITY AND SUBSTRATE SPECIFICITY
Pablo J. Gonzalez, Maria G. Rivas, Cristiano S. Mota, Carlos D. Brondino, Isabel Moura, José J. G. Moura
65th Birthday celebration issue of CCR for Ed Solomon (2013) 2,315-331, DOI:10.1016/j.ccr.2012.05.020

NITROUS OXIDE REDUCTASE
Sofia R. Pauleta, Simone Dell’Acqua, Isabel Moura
65th Birthday celebration issue of CCR for Ed Solomon (2013) 2,332-349DOI: 10.1016/j.ccr.2012.05.026 Online publication complete: 10-JUL-2012

NITROUS OXIDE REDUCTASE
S.Dell’Acqua, S.R.Pauleta, I.Moura and J.J.G.Moura
Encyclopedia of Metalloproteins (2012) in press

ANALYSIS OF RESONANCE RAMAN DATA ON BLUE COPPER SITE IN PSEUDOAZURIN:EXCITED STATE p AND CHARGE TRANSFER DISTORTIONS AND THEIR RELATION TO GROUND STATE REORGANIZATION ENERGY
R.G.Hadt, X.Xie, S.R:Pauleta, I.Moura and E.I.Solomon
J Inorg Biochem. (2012 ) 115,155-62. doi: 10.1016/j.jinorgbio.2012.03.006. Epub 2012 Mar 30.

SUBSTRATE-DEPENDENT MODULATION OF THE ENZYMATIC CATALYTIC ACTIVITY: REDUCTION OF NITRATE, CHLORATE AND PERCHLORATE BY RESPIRATORY NITRATE REDUCTASE FROM MARINOBACTER HYDROCARBONOCLASTICUS 617.
Jacopo Marangon, Patrícia M. Paes de Sousa, Isabel Moura, Carlos D. Brondino, José J.G. Moura and Pablo J. González
Biochim Biophys Acta. 1817,1072-82(2012). Epub 2012 Apr 25.

ELECTROCHEMICAL BEHAVIOUR OF BACTERIAL NOR-EVIDENCES OF LOW REDOX POTENTIAL NON-HEME FeBGIVE NEW PERSPECTIVES ON THE CATALYTIC MECHANISM
C.M.Cordas, A.G.Duarte, J.J.G.Moura and I.Moura
Biochim.Biophys.Acta –Bioenergetics 1827, 233-238 (2013) doi:10.1016/j.bbabio.2012.10.018

SYNTHESIS OF [MOS4](2-)-M (M=CU AND CD) CLUSTERS: POTENTIAL NMR SPECTROSCOPIC STRUCTURAL PROBES FOR THE ORANGE PROTEIN
Biplab K. Maiti, Teresa Avilés, Isabel Moura, Sofia R. Pauleta, and José J. G. Moura
Eur.J.Inorg.Chem. 26, 4159-4166 (2012)

REARRANGEMENT OF MO-CU-S CLUSTER REFLECTS THE STRUCTURAL INSTABILITY OF ORANGE PROTEIN COFACTOR
Biplab K. Maiti, Teresa Avilés, Marta S. P. Carepo, Isabel Moura, Sofia R. Pauleta and José J. G. Moura
ZAAC - Zeitschrift für Anorganische und Allgemeine Chemie 639, 1361-1364 (2013),


COPPER-SUBSTITUTED FORMS OF THE WILD TYPE AND C42A VARIANT OF RUBREDOXIN
A.Thapper, A.C.Rizzi, C.D.Brondino, A.G.Wedd, R.J.Pais, I.Moura, S.R.Pauleta and J.J.G.Moura
J. Inorg. Biol.Chem. 127, 232-237(2013)

MARINOBACTER HYDROCARBONOCLASTICUS IS AN AEROBIC DENITRIFIER
S.R.Pauleta, S.Ramos, M.Pietsch, C.Carreira, S.Dell'Acqua, I.Moura
Proccedings of Eurobic 11 (2013) ,page 49-53 Editors J.M.Gonzalez-Perez, A.Matilla-Hernandez, J.Niclós-Gutiérrez. Medimone, International Proceedings

SUPEROXIDE REDUCTASE: DIFFERENT INTERACTION MODES WITH ITS TWO REDOX PARTNERS
R.Almeida, P.Turano, I.Moura, J.J.G.Moura and S.R.Pauleta
Chem.Biochem. 14, 1858-66 (2013)

IRON-SULFUR CENTERS: NEW ROLES FOR ANCIENT METAL SITES
R. Grazina, S. Pauleta, J.J.G. Moura and I. Moura
Comprehensive Inorganic Chemistry II.Vol.3:Bioinorganic Fundamentals and Applications: Metals in Natural Living Systems and Metals in Toxicology and Medicine, Chapter (2013),vol.3,103-148