Luisa Maia
Post-doc Researcher
Integrated Member
Research Group
Structural Molecular Biology
Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa 2829-516 Caparica, Portugal
212 948 300
- ext 10927
Research Interests
• Metalloenzymes, structure-activity relationships
• Reactive oxygen and nitrogen species (ROS/RNS) biochemistry
- formation/elimination and enzymes structure-activity relationships
• Mechanisms of ROS/RNS-mediated diseases
• New catalytic activities of molybdoenzymes
- NADH oxidation, nitrite reduction, nitric oxide formation, carbon dioxide reduction (carbon dioxide scavenging)
- structural and mechanistic studies | reactions mechanism with atomic detail
- in situ studies (mammalian enzymes)
• Xanthine oxidase, xanthine dehydrogenase, aldehyde oxidase, aldehyde oxidoreductase,
superoxide dismutase, catalase
mammalian (rat, bovine and human liver, blood and milk) and bacterial sources (Desulfovibrio and Marinobacter bacteria)
Main publications
All publications can be found at
or at

• Lessons from denitrification for the human metabolism of signalling nitric oxide
Maia LB, Moura JJG
in Metalloenzymes in Denitrification: Applications and Environmental Impacts (2017),
Eds Moura, I, Moura JJG, Pauleta SR, Maia L,
RSC Metallobiology Series No. 9 (ISBN: 978-1-78262-376-2)
The Royal Society of Chemistry (DOI: 10.1039/9781782623762-00419)

• Molybdenum and tungsten-containing formate dehydrogenases: aiming to inspire a catalyst for carbon dioxide utilization
Maia LB, Moura I, Moura JJG
Inorg Chim Acta (2017) 455: 350-363 (DOI: 10.1016/j.ica.2016.07.010)

• Reduction of carbon dioxide by a molybdenum-containing formate dehydrogenase: a kinetic and mechanistic study
Maia LB, Fonseca L. Moura I, Moura JJG
JACS (2016) 138: 8834-8846 (DOI: 10.1021/jacs.6b03941)

• Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo
Maia LB, Pereira V, Mira L, Moura JJG
Biochemistry (2015) 54: 685-710 (DOI: 10.1021/bi500987w)

• Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases
Maia LB, Moura JJG
J Biol Inorg Chem (2015) 20: 403-433 (DOI: 10.1007/s00775-014-1234-2)

• How Biology handles nitrite
Maia LB, Moura JJG
Chem Rev (2014) 114: 5273-5357 (DOI: 10.1021/cr400518y)