luisbelo

Luís Belo
Assistant Professor
Integrated Member
Research Group
Drugs Targets & Biomarkers
Departamento de Ciências Biológicas, Faculdade de Farmácia da Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
220 428 500
- ext 8562
226 093 390
Research Interests
The work I have been developing since the cradle of my research has spanned several areas mainly related to clinical medicine that have in common the existence of inflammatory and / or oxidative stress in their pathophysiological mechanisms .
In my research work I would like to highlight some work done in the areas of pregnancy and pre -eclampsia, chronic renal insufficiency, obesity and psoriasis. Are actually different clinical areas, but have in common the change in cardiovascular risk factors, including inflammatory parameters (mainly acute phase proteins, adipokines, cell adhesion molecules and endothelial dysfunction), dyslipidemia (pro – inflammatory states) and insulin resistance. It should be noted that all these areas were already covered with the allocation of funding for research projects by institutions of recognized merit (FCT, among others).
Main publications
Seabra A, Katzmarzyk P, Carvalho M, Seabra A, Coelho-e-Silva M, Abreu S, Vale S, Nascimento H, Belo L, Torres S, Oliveira J, Mota J, Santos-Silva A, Rêgo C, Malina RM. "Effects of 6-month soccer and traditional physical activity programs on body composition, cardiometabolic risk factors, inflammatory, oxidative stress markers and cardiorespiratory fitness in obese boys”. Journal of Sports Sciences 2016. In press.

Ribeiro S, Garrido P, Fernandes J, Rocha-Pereira P, Costa E, Belo L, Reis F, Santos-Silva A. “Liver iron is a major regulator of hepcidin gene expression via BMP/SMAD pathway in a rat model of chronic renal failure under treatment with high rHuEPO doses”. BioFactors 2016. In press.

Ribeiro S, Belo L, Reis F, Santos-Silva A. "Iron therapy in chronic kidney disease: recent changes, benefits and risks". Blood Reviews 2016; 30: 65–72.

Nascimento H, Alves AI, Coimbra S, Catarino C, Gomes D, Bronze-da-Rocha E, Costa E, Rocha-Pereira P, Aires L, Mota J, Mansilha HF, Rêgo C, Santos-Silva A, Belo L. “Bilirubin is independently associated with oxidized LDL levels in young obese patients”. Diabetology & Metabolic Syndrome 2015; 7:4. eCollection 2015.

Nascimento H, Costa E, Rocha S, Lucena C, Rocha-Pereira P, Rêgo C, Mansilha HF, Quintanilha A, Aires L, Mota J, Santos-Silva A, Belo L. “Adiponectin and markers of metabolic syndrome in obese children and adolescents: Impact of 8 month regular physical exercise program”. Pediatric Research 2014; 76:159–165.

Do Sameiro-Faria M, Ribeiro S, Costa E, Mendonça D, Teixeira L, Rocha-Pereira P, Fernandes J, Nascimento H, Kohlova M, Reis F, Amado L, Bronze-da-Rocha E, Miranda V, Quintanilha A, Belo L, Santos-Silva A. "Risk factors for mortality in hemodialysis patients: two year follow-up study". Disease Markers 2013; 35: 791–798.

Nascimento H, Costa E, Rocha-Pereira P, Rego C, Ferreira Mansilha H, Quintanilha A, Santos-Silva A, Belo L. “Cardiovascular risk factors in Portuguese obese children and adolescents: Impact of small reductions in body mass index imposed by lifestyle modifications”. The Open Biochemistry Journal 2012; 6:23–30.

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy”. British Journal of Dermatology 2010; 163:1282-1290.

Nascimento H, Silva L, Lourenço P, Vieira E, dos Santos R, Rego C, Ferreira Mansilha H, Santos-Silva A, Belo L. “Lipoprotein (a) levels in Portuguese obese children and adolescents: contribution of a pentanucleotide repeat (TTTTA)n polymorphism in apolipoprotein (a) gene”. Archives of Pediatrics & Adolescent Medicine 2009; 163:393-394.

Nascimento H, Silva L, Lourenço P, Castro E, Weinfurterová R, Guerra A, Rego C, Ferreira Mansilha H, Quintanilha A, Santos-Silva A, Belo L. “Lipid profile in portuguese obese children and adolescents. Interaction of apolipoprotein E polymorphism with adiponectin levels”. Archives of Pediatrics & Adolescent Medicine 2009; 163:1030-1036.

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. “Circulating levels of adiponectin, oxidized LDL and C-reactive protein in Portuguese patients with psoriasis vulgaris, according to body mass index, severity and duration of the disease”. Journal of Dermatological Science 2009; 55:202-204.

Costa E, Lima M, Alves JM, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Faria MD, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. “Inflammation, T-cell phenotype, and inflammatory cytokines in chronic kidney disease patients under hemodialysis and its relationship to resistance to recombinant human erythropoietin therapy”. Journal of Clinical Immunology 2008; 28: 268–275.

Belo L, Rebelo I, Belmiro P. “Aspectos analíticos na gravidez normal e na patológica. Modificações metabólicas e fisiológicas desencadeadas pela gravidez e suas implicações”. Editora: LIDEL. Ano: 2009.

Belo L, Santos-Silva A, Quintanilha A, Rebelo I. “Similarities between pre-eclampsia and atherosclerosis. A protective effect of physical exercise?”. Current Medicinal Chemistry 2008; 22: 2223–2229.

Belo L, Caslake M, Santos-Silva A, Castro EMB, Pereira-Leite L, Quintanilha A, Rebelo I. “LDL size, total antioxidant status and oxidised LDL in normal human pregnancy: a longitudinal study”. Atherosclerosis 2004; 177: 391–399.

Belo L, Caslake M, Gaffney D, Santos-Silva A, Pereira-Leite L, Quintanilha A, Rebelo I. “Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies”. Atherosclerosis 2002; 162: 425–432.

Belo L, Santos-Silva A, Rumley A, Lowe G, Pereira-Leite L, Quintanilha A, Rebelo I. “Elevated tissue plasminogen activator as a potential marker of endothelial dysfunction in pre-eclampsia: correlation with proteinuria”. British Journal of Obstetrics & Gynaecology 2002; 109: 1250–1255.