ma.fernandes

Maria Alexandra Carvalho Ramos Fernandes
Assistant Professor
Integrated Member
Research Group
Design of Molecules and NanoMaterials for Therapy and Diagnosis
Research Interests
Cancer Biomarkers for Diagnostics and Therapy. Screening of new anti-tumor agents and their biological targets. Proteomics and Transcriptomics.
Main publications
C. Roma-Rodrigues, A. Heuer-Jungemann, A. R. Fernandes, A. G. Kanarasb and P. V. Baptista*. Peptide coated gold nanoparticles for in vivo targeting of angiogenesis. International J. Nanomedicine (accepted).
Rita Mendes, Bárbara Carreira, Pedro V. Baptista* and Alexandra R. Fernandes*. 2016. Non-small lung cancer biomarkers and targeted therapy - two faces of the same coin fostered by Nanotechnology. Expert Review of Precision Medicine and Drug Development (accepted).
Luisa Corvo, Ana Soraia Mendo, Sara Figueiredo, Miguel Larguinho, Rogério Gaspar, Pedro V. Baptista* and Alexandra R. Fernandes*. 2016. Liposomes as delivery system of a Sn(IV) compound for cancer therapy. Pharmaceutical Research. DOI 10.1007/s11095-016-1876-6.
Luís R. Raposo, Catarina Roma-Rodrigues, Pedro Faísca, Margarida Alves, Joaquim Henriques, Manuela C. Carvalheiro, M. Luisa Corvo, Pedro V. Baptista, Armando JL Pombeiro, Alexandra R. Fernandes*. 2016. Immortalization and characterization of a new canine mammary tumor cell line FR37-CMT. J. Veterinary and Comparative Oncology (accepted). DOI: 10.1111/vco.12235.
Marta Martins, Pedro V. Baptista, Ana Soraia Mendo, Claudia Correia, Paula Videira, António S. Rodrigues, J. Muthukumaran, Teresa Santos-Silva, Ana Silva, M. Fátima C. Guedes da Silva, Joana Gigante, António Duarte, Armando J. L. Pombeiro, Alexandra R. Fernandes*. 2016. In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex. Molecular BioSystems, Mol. BioSyst. 12, 1015. DOI: 10.1039/C5MB00791G
Zhen Ma*, Bian Zhang, M. Fátima C. Guedes da Silva, Ana Soraia Mendo, Joana Silva, Pedro V. Baptista, Alexandra R. Fernandes*, Armando J.L. Pombeiro*. 2016. Synthesis, Characterization, Thermal Properties and Antiproliferative Potential of Copper(II) 4′-phenyl-terpyridine Compounds. Dalton Trans (accepted).
Manas Sutradhar*, Alexandra R Fernandes*, Joana Silva, Kamran T Mahmudov, M. Fátima C. Guedes da Silva, and Armando J. L. Pombeiro*. 2016. Water soluble heterometallic potassium-dioxidovanadium(V) (K+/VO3+) complexes as potential antiproliferative agents. J Inorg Biochem. 155:17-25.
Catarina Roma-Rodrigues, Cynthia Barroco, Luís R Raposo, Mafalda N Costa, Elvira Fortunato, Pedro Viana Baptista, Alexandra R Fernandes*, Ilda Santos-Sanches*. 2015. Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder. Microbes and Infection. (2015)10.1016/j.micinf.2015.11.005 (accepted)
Manas Sutradhar*, Alexandra R Fernandes*, Joana Silva, Kamran T Mahmudov, M. Fátima C. Guedes da Silva, and Armando J. L. Pombeiro*. 2015 Water soluble heterometallic potassium-dioxidovanadium(V) (K+/VO3+) complexes as potential antiproliferative agents. J Inorg Biochem. 155:17-25.
Raquel Vinhas, Anna Tolmatcheva, Rafaela Canto, Patricia Ribeiro, Alexandra Lourenço, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes*. 2015. A novel mutation in the CEBPA gene in a patient with acute myeloid leukemia. Leuk Lymph 2015:1-3.
Pedro Martins, João Jesus, Sofia Santos, Luis R. Raposo, Catarina Roma-Rodrigues, Pedro Viana Baptista, and Alexandra R. Fernandes*. Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box. Molecules 2015, 20: 16852-91.
Susana I. C. J. Palma. Carlos A. V. Rodrigues, Filomena Freitas, Alexandra Carvalho, Alexandra R. Fernandes, Maria del Puerto Morales, Joaquim M.S. Cabral, Ana C. A. Roque. 2015. A value-added exopolysaccharide as a coating agent for MRI nanoprobes. Nanoscale, 7:14272-83.
Ana Soraia Mendo, Sara Figueiredo, Catarina Roma-Rodrigues, Paula A. Videira, Zhen Ma, Mário Diniz, Miguel Larguinho, Pedro M. Costa, Armando J.L. Pombeiro, Pedro V. Baptista, Alexandra R. Fernandes*. 2015. Characterization of antiproliferative potential and biological targets of a copper complex containing 4’-phenyl terpyridine. JBIC (accepted)
R.B. Restani, J. Conde, R.F. Pires, P. Martins, A.R. Fernandes, P.V. Baptista, V.D.B. Bonifácio, A. Aguiar-Ricardo. 2015. POxylated polyurea dendrimers: Smart core-shell vectors with IC50 lowering capacity. Macromol. Biosci. DOI: 10.1002/mabi.201500131 (accepted)
Raquel Vinhas, Milton Cordeiro, Fábio Ferreira Carlos, Soraia Mendo, Alexandra R. Fernandes, Sara Figueiredo, Pedro V. Baptista. 2015. Gold nanoparticle-based theranostics: disease diagnostic and treatment using a single nanomaterial. J. Nanobiosensors in Disease Diagnosis 4:11–23
Susana I.C.J.Palma, Alexandra Carvalho, Joana Silva, Alexandra R Fernandes, Maria del Puerto-Morales, Ana C. A. Roque. 2015. Covalent coupling of gum arabic onto superparamagnetic iron oxide nanoparticles for MRI cell labeling: physiochemical and in vitro characterization. Contrast Media and Molecular Imaging (Accepted)
Pedro Martins, Mara Marques, Lídia Coito, Armando J.L. Pombeiro, Pedro Viana Baptista and Alexandra R Fernandes*. 2014. Organometallic Compounds in Cancer Therapy: Past Lessons and Future Directions. Anti-Cancer Agents in Medicinal Chemistry 14(9):1199-1212. DOI: 10.2174/1871520614666140829124925
Joana Silva, António Sebastião Rodrigues, Paula A. Videira, Jamal Lasri, Adília Januário Charmier, Armando J.L. Pombeiro, and Alexandra R. Fernandes*. 2014. Characterization of the antiproliferative potential and biological targets of a trans ketoimine platinum complex. Inorganica Chimica Acta 423:156-167. DOI: 10.1016/j.ica.2014.07.067
Catarina Roma-Rodrigues, Alexandra R. Fernandes*. 2014. The Genetics of Hypertrophic Cardiomyopathy: advances and pitfalls in molecular diagnosis and therapy. The Application of Clinical Genetics 7: 195–208.
Catarina Roma-Rodrigues, Alexandra R. Fernandes* and Pedro V. Baptista*. 2014. Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells. BioMed Research International 2014, 10 pages (http://dx.doi.org/10.1155/2014/179486)
Pedro Martins, Daniela Rosa, Alexandra R. Fernandes and Pedro V. Baptista. 2014. Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine. Recent Patents on Nanomedicine 3: 105-118 (DOI: 10.2174/1877912304666140304000133).
João Conde, Miguel Larguinho, Ana Cordeiro, Luís R. Raposo, Pedro M. Costa, Susana Santos, Mário S. Diniz, Alexandra R. Fernandes, Pedro V. Baptista. 2014. Gold-nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis. Nanotoxicology 8: 521-532. (DOI:10.3109/17435390.2013.802821).
Kamran T. Mahmudov, M. Fátima C. Guedes da Silva, Archana Mizar, Maximilian N. Kopylovich, Alexandra R. Fernandes, Ana Silva, Armando J. L. Pombeiro. 2014. Di- and triorganotin(IV) complexes of arylhydrazones of methylene active compounds and their antiproliferative activity. J. Organometellic Chemistry 760: 67–73. (DOI: 10.1016/j.jorganchem.2013.12.019)
Daniel V. Luís, Joana Silva, Ana Isabel Tomaz, Rodrigo F.M. de Almeida, M. Larguinho, PV Baptista, Luísa M.D.R.S. Martins, Telma F.S. Silva, Pedro M. Borralho, Cecília M.P. Rodrigues, António S. Rodrigues, Armando J.L. Pombeiro, Alexandra R. Fernandes*. 2014. Insights into the mechanisms underlying the anti-proliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies. J Biol Inorg Chem. 19: 787-803 (DOI 10.1007/s00775-014-1110-0)
Telma F.S. Silva, Luísa M.D.R.S. Martins, M. Fátima Guedes da Silva, Maxim L. Kuznetsov, Alexandra R. Fernandes, Ana Silva, Chun-Jern Pan, Jyh-Fu Lee, Bing-Joe Hwang, and Armando J.L. Pombeiro. 2014. Cobalt complexes bearing scorpionate or pyrazole ligands as catalysts for the peroxidative oxidation of cyclohexane. XAS studies and biological applications. Chemistry – an Asian Journal 9, 1132-1143 http://dx.doi.org/10.1002/asia.201301331
Alexandra R. Fernandes & Pedro Viana Baptista. 2013. Nanotechnology for Cancer Diagnostics and Therapy – An Update on Novel Molecular Players. Current Cancer Therapy Reviews 9: 164-172.
Ana Silva, Daniel Luís, Susana Santos, Joana Silva, Ana Soraia Mendo, Lidia Coito, Telma FS Silva, Maria Fátima C Guedes da Silva, Luísa MDRS Martins, Armando JL Pombeiro, Pedro M Borralho, Cecília MP Rodrigues, Maria Guadalupe Cabral, Paula A Videira, Carolino Monteiro, Alexandra R Fernandes*. 2013. Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: a comparative proteomic approach. Drug Metabolism and Drug Interactions 28, 167-176. (http://www.degruyter.com/view/j/dmdi.2013.28.issue-3/dmdi-2013-0015/dmdi-2013-0015.xml) (DOI: 10.1515/dmdi-2013-0015)
Telma F.S. Silva, Piotr Smoleński, Luísa M.D.R.S. Martins, M. Fátima Guedes da Silva, Alexandra R. Fernandes, Daniel Luis, Ana Silva, Susana Santos, Pedro M. Borralho, Cecília M.P. Rodrigues and Armando J.L. Pombeiro. 2013. Cobalt and zinc compounds bearing 1,10-phenantroline-5,6-dione or 1,3,5-triaza-7-phosphaadamantane derivatives: synthesis, characterization, cytotoxicity and selectivity studies. EurJIC 21, 3651-3658. (http://onlinelibrary.wiley.com/doi/10.1002/ejic.201300197/abstract)(DOI: 10.1002/ejic.201300197).
Marta Gromicho, Marta Magalhães, Fátima Torres, Joana Dinis, Alexandra R Fernandes, Paula Rendeiro, Purificação Tavares, António Laires, José Rueff, António Sebastião Rodrigues. 2013. Instability of mRNA expression signatures of drug transporters in chronic myeloid leukemia patients resistant to imatinib. Oncology Reports 29(2):741-50. (http://www.ncbi.nlm.nih.gov/pubmed/23229016) (DOI: 10.3892/or.2012.2153).
Telma F.S. Silva, Luísa M.D.R.S. Martins, M. Fátima Guedes da Silva, Alexandra R. Fernandes, Ana Silva, Pedro M. Borralho, Susana Santos, Cecília M.P. Rodrigues and Armando J.L. Pombeiro. 2012. Cobalt complexes bearing scorpionate or pyrazole ligands: synthesis, characterization and applications as in vitro tumour-inhibitors. Dalton Trans 41, 12888- 12897 (http://pubs.rsc.org/en/Content/ArticleLanding/2012/DT/c2dt11577h) (DOI: 10.1039/C2DT11577H)
Santos, S., Marques, V., Pires, M., Silveira, L., Oliveira, H., Lança, V., Brito, D., Madeira, H., Carreira, I.M., Gaspar, I.M., Monteiro, C., Fernandes, A.R*. 2012. “High resolution melting: improvements in the genetic diagnosis of Hypertrophic Cardiomyopathy in a Portuguese cohort”. BMC Medical Genetics 13:17 (http://www.ncbi.nlm.nih.gov/pubmed/22429680) (doi: 10.1186/1471-2350-13-17).