Margarida Borges
Assistant Professor
Integrated Member
Research Group
Drugs Targets & Biomarkers
Faculdade de Farmácia da Universidade do Porto Departamento de Ciências Biológicas Rua de Jorge Viterbo Ferreira nº228 4050-313 Porto
220 428 565
- ext 8762
226 093 390
Research Interests
My research focus on the study of cell players and the mechanisms implicated in the immunopathology of chronic infections, using the mice model, as a mean to intervene and avoid pathology. A murine model of congenital toxoplasmosis has been established and the effect of the immune response to Toxoplasma gondii infection on pregnancy and vice versa is being study. The metabolomic profile at the feto-maternal interface and systemic levels are being determined during pregnancy and T. gondii infection.
Main publications
-Cardoso MS, Silva TM, Resende M, Appelberg R, Borges M. Lack of the Transcription Factor Hypoxia-Inducible Factor 1α (HIF-1α) in Macrophages Accelerates the Necrosis of Mycobacterium avium-Induced Granulomas. Infect Immun. 83(9):3534-44, 2015.
-Borges M, Barreira-Silva P, Flórido M, Jordan MB, Correia-Neves M, Appelberg R. “Molecular and Cellular Mechanisms of Mycobacterium avium-Induced Thymic Atrophy”. Journal of Immunology 189, 3600–3608, 2012.