Maria da Conceição Rangel
Associate Professor
Integrated Member
Research Group
Design of Molecules and NanoMaterials for Therapy and Diagnosis
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 PORTO, PORTUGAL and REQUIMTE, Departamento de Química e Bioquímica, Rua do Campo Alegre, 4169-007 PORTO, PORTUGAL
220 402 593
Research Interests
Research interests are centred in Bioinorganic Chemistry and, at present, the focus is on the design of molecules that may be of use in novel therapeutic strategies to fight Infection, Iron Overload and Diabetes. The first two are related with a particular interest in Iron Biology and the third with the potential insulin-like effect of Zinc and Vanadium complexes. The design of metal ion chelators is the common factor, in the first two diseases the drug is the ligand itself and in the third is a metal ion complex. The labelling of chelators with molecules that allow visualization of their pathways within the cell and the study of their interaction with biological membranes by means of spectroscopic methods is a fascinating and relevant area for the development of new drugs.
Main publications
“Design of a water soluble 1,8-naphthalimide/3-hydroxy-4-pyridinone conjugate: investigation of its spectroscopic properties at variable pH and in the presence of Fe3+, Cu2+ and Zn2+”, Tânia Moniz, Carla Queirós, Rita Ferreira, Andreia Leite, Paula Gameiro, Ana M.G. Silva, and Maria Rangel, Dyes and Pigments, 2013, 98, 201-211.

"Rhodamine labelling of 3-hydroxy-4-pyridinone iron chelators is an important contribution to target Mycobacterium avium infection", Tânia Moniz, Ana Nunes, Ana M. G. Silva, Carla Queirós, Galya Ivanova, M. S. Gomes and Maria Rangel, J. Inorg. Biochem., 2013, 121, 156-166.

“Non-transferrin bound iron (NTBI) uptake by T-Lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species”, João Arezes, Mónica Costa, Inês Vieira, Vera Dias, Xiao L. Konk, Rui Fernandes, Graça Porto, Maria Rangel, Robert C. Hider, and Jorge P. Pinto, PloS-One, 2013, 8, (11), e79870.

NMR study of the supramolecular structure of dual drug-loaded poly(butylcyanoacrylate) nanoparticles, Margarita Simeonova, Maria Rangel and Galya Ivanova, Physical Chemistry Chemical Physics, 2013, 15, 16658-16664.

"Discrimination of fluorescence light-up effects induced by pH and metal ion chelation on a spirocyclic derivative of rhodamine B", Andreia Leite, Ana M. G. Silva, Luís Cunha-Silva, Baltazar de Castro, Paula Gameiro and Maria Rangel, Dalton Trans., 2013, 42, 6110-6118.

“Investigation of the insulin-enhancing properties of Zinc(II) 3-hydroxy-4-pyridinone complexes: identification of a new compound with a hypoglycemic effect in type I-like diabetic animals”, Tânia Moniz, M. João Amorim, Rita Ferreira, Ana Nunes, Ana Silva, Carla Queirós, Andreia Leite, Paula Gameiro, Bruno Sarmento, Fernando Remião, Yutaka Yoshikawa, Hiromu Sakurai and Maria Rangel, J. Inorg. Biochem., 2011, 105, 1675–1682

“Fluorescent 3-hydroxy-4-pyridinone hexadentate iron chelators: intracellular distribution and the relevance to anti-mycobacterial properties” Ana Nunes, Maria Podinovskaia, Andreia Leite, Paula Gameiro, Tao Zhou, Yongmin Ma, Xiaole Kong, Ulrich E. Schaible, Robert C. Hider and Maria Rangel, J. Biol. Inorg. Chem., 2010, 15, 861-877.

"Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium", Fernandes, Sofia. S. Fernandes, Ana Nunes, Ana R. Gomes, Baltazar Castro, Robert C. Hider, Maria Rangel, Rui Appelberg, Maria Salomé Gomes, Microbes and Infection, 2010, 12, 287-294.

“Novel 3-hydroxy-4-pyridinonato oxidovanadium(IV) complexes to investigate structure/activity relationships” Maria Rangel, M. João Amorim, Ana Nunes, Andreia Leite, Eulália Pereira, Baltazar de Castro, Carla Sousa, Yutaka Yoshikawa, Hiromu Sakurai, Journal of Inorganic Biochemistry, 2009, 103, 496–502

"Hydroxypyranones, hydroxypyridinones and their complexes", John Burgess and Maria Rangel, Advances in Inorganic Chemistry, 2008, 60, 167-243.

"EPR study of the photolysis of methyl- and adenosyl-cobinamides in the presence of phosphine and pyridine bases. Evidence for the need of a judicious choice of irradiation temperature and solvent to assess ligand binding", João Gomes, Baltazar de Castro and Maria Rangel, Organometallics, 2008, 27, 2536-2543.

”Spectroscopic and potentiometric characterization of oxovanadium(IV) complexes formed by 3-hydroxy-4-pyridinones. Rationalization of the influence of basicity and electronic structure of the ligand on of the ligand on the properties of VIVO species in aqueous solution ”, Maria Rangel, Andreia Leite, M. João Amorim, Eugenio Garriba, Giovanni Micera, Elzbieta Lodyga-Chruscinska, Inorg. Chem., 2006, 45, 8086-8097.