Marino F. A. Santos
Post-doc Researcher
Research Group
Structural Molecular Biology
Laboratórios 6.05 e 6.07 - Cristalografia de Proteínas, Departamento de Química da Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
212 948 300
- ext 10962
212 948 550
Research Interests
Protein X-ray Crystallography applied to Drug Design

Biological and therapeutic effects of carbon monoxide and vanadium

Crystallization, structure determination and functional studies of:
Serum proteins/oxygen carriers and interactions with CORMs (CO-Releasing Molecules) as putative drugs with anti-inflammatory, anti-apoptotic and anti-proliferative effects
Serum proteins and interactions with vanadium compounds (insulin-enhancing action) as possible oral substitutes for the treatment of diabetes
Main publications
8 - Isabel Correia, Ielyzaveta Chorna, Isabel Cavaco, Somnath Roy, Maxim L. Kuznetsov, Nádia Ribeiro, Gonçalo Justino, Fernanda Marques, Teresa Santos-Silva, Marino F. A. Santos, Hugo M. Santos, José L. Capelo, James Doutch, João Costa Pessoa, Interaction of VIVO(acac)2 with human serum transferrin and albumin, Chemistry - An Asian Journal 2017, DOI: 10.1002/asia.201700469

7 - João Costa Pessoa, Eugenio Garribba, Marino F.A. Santos, Teresa Santos-Silva, Vanadium and proteins: uptake, transport, structure, activity and function, Coordination Chemistry Reviews 2015, 301-302, 49-86.

6 - Maria João Romão, Teresa Santos-Silva, Isabel Bento, Filipe Freire, Marino F. A. Santos, Ana Luísa Carvalho, Marcos Históricos em Cristalografia, Química - Boletim da Sociedade Portuguesa de Química 2015, 136, 21-30.

5 - João D. Seixas, Marino F. A. Santos, Abhik Mukhopadhyay, Ana C. Coelho, Patrícia M. Reis, Luís F. Veiros, Ana R. Marques, Nuno Penacho, Ana M. L. Gonçalves, Maria J. Romão, Gonçalo J. L. Bernardes, Teresa Santos-Silva, Carlos C. Romão, A contribution to the rational design of Ru(CO)3Cl2L complexes for in vivo delivery of CO, Dalton Transactions 2015, 44, 5058-5075.

4 - Marino F. A. Santos, Isabel Correia, Ana R. Oliveira, Eugenio Garribba, João Costa Pessoa, Teresa Santos-Silva, Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a VIV Lysozyme Adduct, European Journal of Inorganic Chemistry 2014, 2014(21), 3293-3297.

3 - João Costa Pessoa, Gisela Gonçalves, Somnath Roy, Isabel Correia, Sameena Mehtab, Marino F.A. Santos, Teresa Santos-Silva, New insights on vanadium binding to human serum transferrin, Inorganica Chimica Acta 2014, 420, 60-68.

2 - Sameena Mehtab, Gisela Gonçalves, Somnath Roy, Ana Isabel Tomaz, Teresa Santos-Silva, Marino F.A. Santos, Maria J. Romão, Tamás Jakusch, Tamás Kiss, João Costa Pessoa, Interaction of vanadium (IV) with human serum apo-transferrin, Journal of Inorganic Biochemistry 2013, 121, 187-195.

1 - Marino F. A. Santos, João D. Seixas, Abhik Mukhopadhyay, Patrícia M. Reis, Maria J. Romão, Carlos C. Romão, Teresa Santos-Silva, New insights into the chemistry of fac-[Ru(CO)3]2+ fragments in biologically relevant conditions: The CO releasing activity of [Ru(CO)3Cl2(1,3-thiazole)], and the X-ray crystal structure of its adduct with lysozyme, Journal of Inorganic Biochemistry 2012, 117, 285-291.