miguel.larguinho

Miguel Larguinho
PhD Student
Research Group
Design of Molecules and NanoMaterials for Therapy and Diagnosis
Nanomedicine@FCT/UNL, Department of Life Sciences, FCT/UNL; REQUIMTE, Department of Chemistry, FCT/UNL
Research Interests
Bionanotechnology, detection of biological molecules, nanodiagnostics, biosensors, therapy, nanotoxicology, genetic and aquatic toxicology, cell biology and genetics, mass spectrometry.
Main publications
M. Larguinho, D. Correia, M.S. Diniz, P.V. Baptista (2014) Evidence of one-way flow bioaccumulation of gold nanoparticles across two trophic levels. Journal of Nanoparticle Research. Submitted for revision.

D.V. Luis, J. Silva, A.I. Tomaz, R.F.M. de Almeida, M. Larguinho, P.V. Baptista, L.M.D.R.S. Martins, T.F.S. Silva, P.M. Borralho, C.M.P. Rodrigues, A.S. Rodrigues, A.J.L. Pombeiro, A.R. Fernandes (2014) Insights into the mechanisms underlying the anti-proliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies. Journal of Biological Inorganic Chemistry. Just Accepted.

M. Larguinho, P.M. Costa, G. Sousa, M.H. Costa, M.S. Diniz, P.V. Baptista (2014) Histopathological findings on Carassius auratus hepatopancreas upon exposure to acrylamide: correlation with genotoxicity and metabolic alterations. Journal of Applied Toxicology (doi:10.1002/jat.2936).

J. Conde, M. Larguinho, A. Cordeiro, L.R. Raposo, P.M. Costa, S. Santos, M.S. Diniz, A.R. Fernandes, P.V. Baptista (2014) Gold-nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis. Nanotoxicology 8:521-532 (doi:10.3109/17435390.2013.802821).

M. Larguinho, J.L. Capelo, P.V. Baptista (2013) Fast nucleotide identification through fingerprinting using gold nanoparticle-based surface-assisted laser desorption/ionisation. Talanta 105:417-421 (doi:10.1016/j.talanta.2012.10.072).

M. Larguinho and P.V. Baptista (2012) Gold and silver nanoparticles for clinical diagnostics - From genomics to proteomics. Journal of Proteomics 75:2811-2823 (doi:10.1016/j.jprot.2011.11.007).

C. Nuñez, J. Fernandez-Lodeiro, M.S. Diniz, M. Larguinho, J.L. Capelo, C. Lodeiro (2011) Synthesis and photophysical studies of two luminescent chemosensors based on cathecol and 8-Hydroxyquinolone chromophores, and their complexes with group 13 metal ions. Inorganic Chemistry Communications 14:831-835 (doi:10.1016/j.inoche.2011.02.023).

G. Doria, M. Larguinho, J.T. Dias, E. Pereira, R. Franco, P.V. Baptista (2010) Gold-silver alloy nanoprobes for one-pot multiplex DNA detection. Nanotechnology 21:255101 (doi:10.1088/0957-4484/21/25/255101).

M. Larguinho, H.M. Santos, G. Doria, H. Scholz, P.V. Baptista, J.L. Capelo (2010) Development of a fast and efficient ultrasonic-based strategy for DNA fragmentation. Talanta 81:881-886 (doi:10.1016/j.talanta.2010.01.032).