Maria Lurdes Pinho Almeida Souteiro Bastos
Full Professor
Research Group
Toxicological Studies
Faculdade de Farmácia da Universidade do Porto Laboratório de Toxicologia Rua de Jorge Viterbo Ferreira n.º 228, 4050-313 PORTO
220 428 599
Research Interests
i) Biokinetics and mechanisms of toxicity of nanoparticles: in vivo and in vitro studies.
ii) Toxicokinetic studies, specially xenobiotic metabolic studies. These studies have been performed with amphetaminic derivatives and the experimental models consist on the mouse and, in vitro, on cultures of hepatocytes from rat, mouse, rabbit, dog, monkey and human. Also neurons and nephrons in culture, and suspensions of cardiomyocytes are currently used for characterization of target organs of toxicity. Similar experiments were already started with the emergent compounds “legal drugs” or “legal highs”.
iii) Mechanistic studies to evaluate the citotoxicity and/or the citoprotection of compounds. The experimental models used are mainly in vitro models consisting on suspensions of isolated rat hepatocytes and cardiomyocytes, and hepatocytes and neurons in culture. Also several human and animal cell lines have been used.
iv) Metal speciation studies in the analytical point of view. Analysis of speciation of metals in food, with special emphasis on the speciation of chromium in several food matrices.
Main publications
Márcia Carvalho, Helena Carmo, Vera Costa, João Capela, Helena Pontes, Fernando Remião, Félix Carvalho, Maria Lourdes Bastos (2012) Toxicity of amphetamines: an update. Archives of Toxicology 86 (8):1167-231

Tiago Morais, Maria Elisa Soares, José Alberto Duarte, Leonor Soares, Sílvia Maia, Paula Gomes, Eulália Pereira, Sónia Fraga, Helena Carmo, Maria de Lourdes Bastos (2012). Effect of surface coating on the biodistribution profile of gold nanoparticles in the rat. European Journal of Pharmaceutics and Biopharmaceutics 80:185–193

M. Elisa Soares, Elsa Vieira, M. Lourdes Bastos (2010) Chromium speciation analysis in bread samples. Journal of Agricultural and Food Chemistry 58(2):1366-70

Helena Pontes, Paula Guedes de Pinho, Eduarda Fernandes, Helena Carmo, Fernando Remião, Félix Carvalho, Maria Lourdes Bastos (2010) Metabolic interactions between ethanol and MDMA in primary cultured rat hepatocytes. Toxicology 270, 150-7

Luís Carvalho, Félix Carvalho, Maria de Lourdes Bastos, Paula Baptista, Nathalie Moreira, Ana Rita Monforte, António Silva Ferreira, Paula Guedes de Pinho (2013) Non-targeted and targeted analysis of wild toxic and edible mushrooms using Gas Chromatography-Ion Trap Mass Spectrometry. Talanta. 10.1016/j.talanta.2013.09.038

Vânia Vilas-Boas; Renata Silva; Andreia Palmeira; Emília Sousa; Luísa Ferreira; Paula Branco; Félix Carvalho; Maria de Lourdes Bastos; Fernando Remião (2013) Development of novel rifampicin-derived P-glycoprotein activators/ inducers. Synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate. PLoS ONE 8(8):e74425

Daniel José Barbosa, João Paulo Capela, Jorge M. A. Oliveira, Renata Silva, Luísa Maria Ferreira, Filipa Siopa, Paula Sério Branco, Eduarda Fernandes, José Alberto Duarte, Maria de Lourdes Bastos and Félix Carvalho (2012) Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes. British Journal of Pharmacology, 165 (4b): 1017–1033