Natércia Teixeira
Full Professor
Integrated Member
Research Group
Drugs Targets & Biomarkers
Faculdade de Farmácia, Dept Ciências Biológicas, Universidade do Porto
220 428 560
22 609 339
Research Interests
My main interests are: i) the understanding of the mechanisms that underpin the dynamic uterine-embryo interactions during successful and complicated pregnancy, as well as the role of the lipid modulators (endo)cannabinoids and their metabolites in fetoplacental development; ii) the search for a potent aromatase inhibitor for the treatment of hormone-dependent breast cancer as well as the elucidation of the underlying mechanisms associated to endocrine resistance
Main publications
Silva F, Nogueira LC, Gonçalves C, Ferreira AA,Ferreira IMPLVO,Teixeira N (2008)"Electrophoretic and HPLC Methods for Comparative Study of the Protein Fractions of Malts, Worts and Beers Produced From Scarlett and Prestige Barley (Hordeum vulgare L.) Varieties" Food Chemistry, 106, 820-829
Cepa M, Correia-da-Silva G, Tavares da Silva EJ, Roleira FMF, Hong Y, Chen S, Teixeira NA (2008) Molecular Mechanisms Of Aromatase Inhibition By New A, D-Ring Modified Steroids Biol Chem, 389: 1183-1191.
Cepa M, Correia-da-Silva G, Tavares da Silva EJ, Roleira FMF, Borges M, Teixeira NA (2008) New steroidal aromatase inhibitors: suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death BMC Cell Biology 9:41, 1-14
Cepa M, Tavares da Silva EJ, Correia-da-Silva G, Roleira FMF, Teixeira NA (2008) Synthesis and biochemical studies of 17-substituted androst-3-enes 3,4-epoxyandrostanes as aromatase inhibitors, Steroids 73, 1409–1415
E Teixeira de Lemos, F Reis, S Baptista, R Pinto, B Sepodes, H Vala, P Rocha-Pereira, G. Correia da Silva, N. Teixeira, A Santos Silva, L. Carvalho, F Teixeira, Das Un, (2009) Exercise training decreases proinflammatory profile in Zucker Diabetic (Type 2) Fatty rats Nutrition 25, 330-339
Fonseca BM, Correia-da-Silva G, Teixeira NA. (2009) Anandamide-induced cell death: dual effects in primary rat decidual cell cultures Placenta, 30(8):686-92.
Fonseca BM, Correia-da-Silva G, Taylor AH, Konje JC, Bell SCTeixeira NA (2009) Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development.Reprod Biol Endocrinol., 7 :121-134
Fonseca B.M., Correia-da-Silva G., Taylor A.H., Lam P.M.W., Marczylo T.H., Konje J.C., Bell S.C., Teixeira N.A. (2010) N-acylethanolamine levels and expression of their metabolizing enzymes during pregnancy“ Endocrinology, 151(8), 3965-3974
B.M. Fonseca, G. Correia-da-Silva, A.H. Taylor, P.M.W. Lam, T.H. Marczylo, S.C. Bell, J.C. Konje and N.A. Teixeira (2010) The endocannabinoid 2-arachidonoylglycerol (2-AG) and metabolizing enzymes during rat fetoplacental development: A role in uterine remodelling. Int J Biochem Cell Biol, 42(11):1884-92.
Fonseca, B. M., N. A. Teixeira, M. Almada, A. H. Taylor, J. C. Konje and G. Correia-da-Silva (2011). "Modulation of the novel cannabinoid receptor - GPR55 - during rat fetoplacental development." Placenta 32(6): 462-469.
Pereira D.M.,Vinholes J., Correia-da-Silva G., Valentão P.,Teixeira N., Andrade P.B. (2011). Fatty acids in marine organisms: in the pursuit of bioactive agents. Current Pharmaceutical Analysis, 7, 108-119.
Pereira DM, Valentão P, Correia-da-Silva G, Teixeira N, Andrade PB. (2012) Plant secondary metabolites in cancer chemotherapy: where are we? Current Pharmaceutical Biotechnology, 13, 632-650.
Bronze-da-Rocha E, Nóvoa A, Teixeira N, Vasconcelos CS, Cerveira C, Castro E Melo J, Carvalho MC.(2012) Evaluation of the Reactivity of Sera from Patients with Systemic Lupus Erythematosus Against the Human MCP1.J Clin Immunol. 32, 721-728
David M. Pereira, Georgina Correia da Silva, Patrícia Valentão, Natércia Teixeira, Paula B. Andrade. Marine Metabolomics in Cancer Chemotherapy. In OMICS: Biomedical Prospective and applications", CRC Press. Edited by Debmalya Barh.
Pereira DM, Valentão P, Correia-da-Silva G, Teixeira N, Andrade PB. Plant secondary metabolites in cancer chemotherapy: where are we? Current Pharmaceutical Biotechnology, 2012, 13, 632-650.
David M. Pereira, Juliana Vinholes, Paula Guedes de Pinho, Patrícia Valentão, Teresa Mouga, Natércia Teixeira, Paula B. Andrade. A gas chromatography-mass spectrometry multi-target method for the analysis of three classes of metabolites in marine organisms. Talanta, 100, 391-400.
Lilian R. B. Mariutti, David M. Pereira, Adriana Zerlotti Mercadante, Patrícia Valentão, Natércia Teixeira, Paula B. Andrade. Further insights on the carotenoid profile of the echinoderm Marthasterias glacialis. Marine Drugs, 2012, 10, 1498-1510.
Cristina Amaral, Margarida Borges, Soraia Melo, Elisiário Tavares da Silva, Georgina Correia-da-Silva, Natércia Teixeira. “Apoptosis and autophagy in breast cancer cells following exemestane treatment”, PLoS One, 2012; 7 (8): e42398.
Carla Varela, Elisia´rio J. Tavares da Silva, Cristina Amaral, Georgina Correia da Silva, Teresa Baptista, Stefano Alcaro, Giosue` Costa, Rui A. Carvalho, Nate´rcia A. A. Teixeira, Fernanda M. F. Roleira. “New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation”, Journal of Medicinal Chemistry, 2012; 55 (8): 3992-4002.
Fonseca BM, Correia-da-Silva G, Teixeira NA. “The rat as an animal model for fetoplacental development: a reappraisal of the post-implantation period.” Reproductive Biology 2012 12 2: 97–118.
Fonseca BM, Correia-da-Silva G, Taylor AH, Lam PM, Marczylo TH, Konje JC, Teixeira NA. “Characterisation of the endocannabinoid system in rat haemochorial placenta.” Reproductive Toxicology 2012 Nov;34(3):347-56.
David M. Pereira, Patrícia Valentão, Natércia Teixeira, Paula B. Andrade. Amino acids, fatty acids and sterols profile of some marine organisms from Portuguese waters. Food Chemistry, 2013, 141, 2412-2417.
Fonseca B, Correia-da-Silva G, Teixeira N (2013) "The endocannabinoid anandamide induces apoptosis of rat decidual cells through a mechanism involving ceramide synthesis and p38 MAPK activation" Apoptosis 18, 1526-1535
Cristina Amaral, Carla Varela, Georgina Correia-da-Silva, Elisiário Tavares da Silva, Rui A. Carvalho, Saul C. P. Costa, Sara C. Cunha, José O. Fernandes, Natércia Teixeira, Fernanda M. F. Roleira (2013). “New Steroidal 17ß-Carboxy Derivatives Present Anti-5a-Reductase Activity and Anti-proliferative Effects in a Human Androgen-Responsive Prostate Cancer Cell Line.” Biochimie 95, 2097-2106
Amaral C, Varela C, Borges M, Tavares da Silva E, Roleira FM, Correia-da-Silva G, Teixeira N. (2013) Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis. Apoptosis, 18, 1426-1436
Cristina Amaral,Sara C Cunha,José O Fernandes,Elisiário T Silva,Fernanda Roleira, Natércia Teixeira and Georgina Correia-da-Silva (2013) Development of a new Gas Chromatography - Mass Spectrometry (GC-MS) methodology for the evaluation of 5alpha-reductase activity" .Talanta, Mar 30;107:154-61.
Cristina Amaral, Carla Varela, Margarida Azevedo, Elisiário Tavares da Silva, Fernanda Roleira, Shiuan Chen, Georgina Correia-da-Silva, Natércia Teixeira. (2013). Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: aromatase inhibition and autophagy”, J Steroid Biochem Mol Biol. May, 135: 51-9.
Fonseca BM, Costa MA, Almada M, Correia-da-Silva G, Teixeira NA. (2013) Endogenous cannabinoids revisited: a biochemistry perspective. Prostaglandins Other Lipid Mediat. Apr-May;102-103:13-30.
Varela CL, Amaral C, Correia-da-Silva G, Carvalho RA, Teixeira NA, Costa SC, Roleira FM, Tavares-da-Silva EJ (2013) Design, synthesis and biochemical studies of new 7a-allylandrostanes as aromatase inhibitors. Steroids. 78(7):662-9.
BM Fonseca, G Correia-da-Silva, M Almada, M Costa, N. A. Teixeira (2013) The Endocannabinoid System in the Postimplantation Period: A Role during Decidualization and Placentation Int J Endocrinol, 2013 Article ID 510540, 11 pages