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Pedro Viana Baptista
Associate Professor
Integrated Member
Research Group
Design of Molecules and NanoMaterials for Therapy and Diagnosis
Nanomedicine@FCT Departamento de Ciências da Vida Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa Campus de Caparica 2829-516 Caparica Portugal
212 948 530
- ext 11105
212 948 530
Research Interests
Nanomedicine
Nanotechnology for diagnostics and therapeutics
Human molecular genetics
Cancer diagnostics
Cancer therapy
Cancer genetics
Molecular diagnostics
Biosensors
Nanoparticles
Main publications
Rita Mendes, Alexandra Fernandes, Pedro Baptista*. Gold nanoparticle approach to the selective delivery of gene silencing in cancer – the case for combined delivery? Genes, (2017) 8(3):94; doi:10.3390/genes8030094 (IF=3.242);

Bruno Veigas, Joana Pinto, Raquel Vinhas, Tomás Calmeiro, Rodrigo Martins, Elvira Fortunato and Pedro Viana Baptista*. Quantitative real-time monitoring of RCA amplification of cancer biomarkers mediated by a flexible ion sensitive platform. Biosens. Bioelectron., (2017) 91: 788-795 doi:10.1016/j.bios.2017.01.052 (IF=7.476);

Catarina Roma-Rodrigues, Francisca Pereira, António P. Alves de Matos, Marta Fernandes, Pedro V. Baptista* AND Alexandra R. Fernandes. Smuggling gold nanoparticles across cell types – a new role for exosomes in gene silencing. Nanomedicine, (2017) pii: S1549-9634(17)30015-1 doi: 10.1016/j.nano.2017.01.013 (IF=5.671);

L. Raposo, C. Roma-Rodrigues, J. Jesus, L. Martins, A. Pombeiro, P. Baptista, A. Fernandes. Targeting canine mammary tumors via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds. Vet. Comp. Oncol., (2017) doi:10.1111/vco.12298 (IF=2.452);

Alexandra R. Fernandes, João Jesus, Pedro Martins, Sara Figueiredo, Daniela Rosa, Luísa M.R.D.R.S. Martins, Maria Luísa Corvo, Manuela C. Carvalheiro, Pedro M. Costa, Pedro V. Baptista*. Targeted delivery of chemotherapeutics to lung and colorectal cancer via a gold nanoparticle vectorization system. J. Control. Release (2017) 245: 52–61 doi:10.1016/j.jconrel.2016.11.021 (IF=7.633);

Milton Cordeiro, Lara Carvalho, Joana Silva, Leonor Saúde, Alexandra R. Fernandes and Pedro V. Baptista*. Gold nanobeacons for tracking gene silencing in Zebrafish. Nanomaterials (2017) 7(1), 10 doi:10.3390/nano7010010 (IF=2.690);

Raquel Vinhas, Milton Cordeiro, Pedro Pedrosa, Alexandra R. Fernandes, Pedro V. Baptista*. Current trends in molecular diagnostics of Chronic Myeloid Leukemia. Leuk. Lymphoma., (2016) 1-14 doi:10.1080/10428194.2016.1265116 (IF=2.891);

Milton Cordeiro, Fábio Ferreira Carlos, Pedro Pedrosa, António Lopez, Pedro V. Baptista*. Gold Nanoparticles for diagnostics: Advances towards point-of-care. Diagnostics, (2016) 6(4), pii: E43;

O.A. Lenis-Rojas, A.R Fernandes, C. Roma-Rodrigues, P.V. Baptista, F. Marques, D. Pérez-Fernández, J. Guerra-Varela, L. Sánchez, D. Vázquez-García, M. López Torres, A. Fernández, J.J. Fernández. Heteroleptic mononuclear compounds of ruthenium(II): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos. Dalton Trans., (2016) doi:10.1039/C6DT03591D (IF=4.177);

Raquel Vinhas, Cláudia Correia, Patricia Ribeiro, Alexandra Lourenço, Aida Botelho de Sousa, Alexandra R. Fernandes, Pedro V. Baptista*. Colorimetric Assessment of BCR-ABL1 Transcripts in Clinical Samples via Gold Nanoprobes. Anal Bioanal. Chem., (2016) 408(19), 5277-5284 doi:10.1007/s00216-016-9622-9 (IF=3.44);

Catarina Roma-Rodrigues, Amelie Heuer-Jungemann, Alexandra R. Fernandes, Antonios G. Kanaras and Pedro V. Baptista*. Peptide coated gold nanoparticles for in vivo modulation of angiogenesis. Int. J. Nanomed., (2016) 11:2633–2639 doi: 10.2147/IJN.S108661 (IF=4.383);

Mílton Cordeiro, Letícia Giestas, João C. Lima and Pedro Baptista*. BioCode Gold-Nanobeacon for the detection of fusion transcripts causing chronic myeloid leukemia. J. Nanobiotechnol., (2016) 14:38 doi:10.1186/s12951-016-0192-y (IF=4.12);

LR Raposo, C Roma‐Rodrigues, P Faísca, M Alves, J Henriques, MC Carvalheiro, ML Corvo, PV Baptista, AJ Pombeiro, AR Fernandes. Immortalization and characterization of a new canine mammary tumour cell line FR37‐CMT. Vet. Comp. Oncol., (2016) doi: 10.1111/vco.12235 (IF=2.733);

Pedro V. Baptista*. Editorial: Precision nanomedicine in cancer: how far are we from personalization? Expert Rev. Precision Medicine and Drug Development, (2016) doi:10.1080/23808993.2016.1174063;

Luisa Corvo, Ana Soraia Mendo, Sara Figueiredo, Miguel Larguinho, Rogério Gaspar, Pedro V. Baptista* and Alexandra R. Fernandes. Liposomes as delivery system of a Sn(IV) compound for cancer therapy. Pharm Res., (2016) 33:1351–1358 doi:10.1007/s11095-016-1876-6 (IF=3.42);

Rita Mendes, Bárbara Carreira, Pedro V. Baptista* and Alexandra R. Fernandes. Non-small cell lung cancer biomarkers and targeted therapy - two faces of the same coin fostered by nanotechnology. Expert Rev. Precision Medicine and Drug Development, (2016) 1: 155-168 doi:10.1080/23808993.2016.1159914;

Zhen Ma, Bian Zhang, M. Fátima C. Guedes da Silva, Ana Soraia Mendo, Joana Silva, P. V. Baptista, Alexandra R. Fernandes, Armando J.L. Pombeiro. Synthesis, Characterization, Thermal Properties and Antiproliferative Potential of Copper(II) 4′-phenyl-terpyridine Compounds. Dalton Trans., (2016) 45(12): 5339-5355 (IF= 4.197);

J Conde, F Tian, JM de la Fuente, PV Baptista. Editorial: Cancer Nanotheranostics: What Have We Learned So Far? Frontiers in Chemistry (2016) 3, 71;

Marta Martins, Pedro V. Baptista, Ana Soraia Mendo, Claudia Correia, Paula Videira, António S. Rodrigues, J. Muthukumaran, Teresa Santos-Silva, Ana Silva, M. Fátima C. Guedes da Silva, Joana Gigante, António Duarte, Armando J. L. Pombeiro, Alexandra R. Fernandes. In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex. Mol. Biosyst., (2016) 12(3): 1015-1023 (IF=3.21);

João Conde, Alfredo Ambrosone, Yulán Hernandez, Furong Tian, Mark MacCully, Catherine C. Berry, Pedro V. Baptista, Claudia Tortiglione, Jesus M. de la Fuente. 15 years on siRNA delivery: beyond the State-of-the-Art on inorganic nanoparticles for RNAi therapeutics. NanoToday, (2015) 10(4): 421-450 doi:10.1016/j.nantod.2015.06.008 (IF=15.000);

C Roma-Rodrigues, C Alves-Barroco, LR Raposo, MN Costa, E Fortunato, Pedro Viana Baptista, Alexandra R Fernandes, Ilda Santos-Sanches. Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder. Microbes and Infection (2015) S1286-4579(15)00253-1. doi:10.1016/j.micinf.2015.11.005 (IF=2.861);

Larguinho, M, Canto R, Cordeiro M, Pedrosa P, Fortuna A, Vinhas R, Baptista PV*. Gold nanoprobe-based non-crosslinking hybridization for molecular diagnostics. Expert. Rev. Mol. Diagn., (2015) 15(10): 1355-1368 doi:10.1586/14737159.2015.1077704 (IF=3.516);

Pedro Pedrosa, Raquel Vinhas, Alexandra Fernandes, Pedro V. Baptista*. Nanotheranostics: proof-of-concept or clinical tool? Nanomaterials, (2015) 5: 1853-1879 doi:10.3390/nano5041853 (IF=2.690);

M. McCully, Yulan Hernandez, João Conde, Pedro V. Baptista, Jesus M. de la Fuente, Andrew Hursthouse, David Stirling, C.C. Berry. The significance of the balance between intracellular glutathione and polyethylene glycol (PEG) for successful siRNA release from gold nanoparticles. Nano Research, (2015) 8(10): 3281-3292 doi:10.1007/s12274-015-0828-5 (IF=6.963);

Hannah Child, Yulán Hernandez, João Conde, Margaret Mullin, Pedro Baptista, Jesus Maria de la Fuente, Catherine Cecilia Berry. Gold nanoparticle-siRNA mediated oncogene knockdown: from mRNA through to cell proliferation with off-target effects. Nanomedicine, (2015) 10(16): 2513-2525 doi:10.2217/nnm.15.95 (IF= 5.824);

Pedro Martins, João Jesus, Sofia Santos, Luis R. Raposo, Catarina Roma-Rodrigues, Pedro Viana Baptista* and Alexandra R. Fernandes. Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box. Molecules, (2015) 20(9): 16852-16891 doi:10.3390/molecules200916852 (IF=2.416);

Joana Coimbra, Carolina Mota, Sofia Santos, Pedro Viana Baptista and Alexandra R. Fernandes. Inorganic Compounds Going Nano. Ann. Med. Chem. Res., (2015) 1(2): 1010;

Bruno Veigas, Pedro Pedrosa, Fábio F. Carlos, Liliana Mancio-Silva, Ana Rita Grosso, Elvira Fortunato, Maria M. Mota, Pedro V. Baptista*. One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care. J. Nanobiotech., (2015) 13: 48 doi:10.1186/s12951-015-0109-1 (IF=4.12);

Bruno Veigas, Carla Portugal, Rita Valério, Elvira Fortunato, João G. Crespo, Pedro V. Baptista*. Scalable approach for the production of functional DNA based Gold nanoprobes. J. Membr. Sci., (2015) 492: 528-535 doi:10.1016/j.memsci.2015.06.042 (IF=4.908);

Raquel Vinhas, Anna Tolmatcheva, Rafaela Canto, Patrícia Ribeiro, Alexandra Lourenço, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes. A novel mutation in CEBPA gene in a patient with acute myeloid leukemia. Leuk. Lymphoma., (2015) 16: 1-3 doi:10.3109/10428194.2015.1065979 (IF= 2.605);

João Conde, Furong Tian, Yulan Hernandez, Chenchen Bao, Pedro V. Baptista, Daxiang Cui, Tobias Stoeger and Jesus M de la Fuente. RNAi-based glyconanoparticles trigger apoptotic pathways for in vitro and in vivo enhanced cancer-cell killing. Nanoscale., (2015) 7(19): 9083-91 doi:10.1039/C4NR05742B (IF=6.739);

Bruno Veigas, Elvira Fortunato and Pedro V. Baptista*. Field Effect sensors for nucleic acid detection: Recent advances and future perspectives. Sensors., (2015) 15: 10380-10398 doi:10.3390/s150510380 (IF=2.048);

Ana Mendo, Sara Figueiredo, Catarina Roma-Rodrigues, Paula Videira, Zhen Ma, Mario Diniz, Miguel Larguinho, Pedro Costa, Armando J.L. Pombeiro, Pedro V. Baptista, Alexandra Fernandes. Characterization of antiproliferative potential and biological targets of a copper complex containing 4’-phenyl terpyridine. JBIC., (2015) doi:10.1007/s00775-015-1277-z (IF=3.164);

Rita B. Restani, João Conde, Rita F. Pires, Pedro Martins, Alexandra R. Fernandes, Pedro V. Baptista, Vasco D. B. Bonifácio and Ana Aguiar-Ricardo. POxylated polyurea dendrimers: Smart core-shell vectors with IC50 lowering capacity. Macromol. Biosci., (2015) 1616-5195 doi:10.1002/mabi.201500131 (IF=3.650);

Raquel Vinhas, Milton Cordeiro, Fábio Ferreira Carlos, Soraia Mendo, Alexandra R. Fernandes, Sara Figueiredo, Pedro V. Baptista*. Gold nanoparticle-based theranostics: disease diagnostic and treatment using a single nanomaterial. Nanobiosensors in Disease Diagnosis., (2015) 4:11-23 doi:10.2147/NDD.S60285;

Iwona Bernacka-Wojcik, Hugo Águas, Fabio Ferreira Carlos, Paulo Lopes, Pawel Jerzy Wojcik, Mafalda Nascimento Costa, Bruno Veigas, Rui Igreja, Elvira Fortunato, Pedro Viana Baptista* and Rodrigo Martins. Single nucleotide polymorphism detection using gold nanoprobes and bio-microfluidic platform with embedded microlenses. Biotechnol. Bioeng., (2015) (Online) doi:10.1002/bit.25542 (IF=4.164);

Pedro V. Baptista*. Gold nanobeacons: a potential nanotheranostics platform. Nanomedicine (Lond)., (2014) 9 (15): 2247-2250 doi:10.2217/nnm.14.143 (IF=5.824);