remiao

Fernando Manuel Gomes Remião
Associate Professor
Integrated Member
Research Group
Toxicological Studies
Faculdade de Farmácia da Universidade do Porto Laboratório de Toxicologia Rua de Jorge Viterbo Ferreira n.º 228, 4050-313 PORTO
220 428 598
226 093 390
Research Interests
Estudos de avaliação dos mecanismos de cardiotoxicidade de xenobióticos, nomeadamente drogas de abuso, catecolaminas e fármacos quimioterápicos
Estudos de toxicocinética, nomeadamente transporte ativo membranar. Indução dos transportadores ABC como mecanismo de proteção celular.
Main publications
Silva R, Vilas-Boas V, Carmo H, Dinis-Oliveira RJ, Carvalho F, de Lourdes Bastos M, Remiao F. Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy. Pharmacology & therapeutics. 2015;149:1-123.

Silva R, Palmeira A, Carmo H, Barbosa DJ, Gameiro M, Gomes A, Paiva AM, Sousa E, Pinto M, Bastos MDL, Remião F. P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity. Archives of Toxicology. 2014; DOI 10.1007/s00204-014-1333-4.

Rossato LG, Costa VM, De Pinho PG, Arbo MD, De Freitas V, Vilain L, De Lourdes Bastos M, Palmeira C, Remião F. The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity. Archives of Toxicology. 2013;87(10):1809-1820.

Vilas-Boas V, Silva R, Palmeira A, Sousa E, Ferreira LM, Branco PS, Carvalho F, de Bastos ML, Remião F. Development of Novel Rifampicin-Derived P-Glycoprotein Activators/Inducers. Synthesis, In Silico Analysis and Application in the RBE4 Cell Model, Using Paraquat as Substrate. PLoS ONE. 2013;8(8).

Silva T, Teixeira J, Remião F, Borges F. Alzheimer's disease, cholesterol, and statins: The junctions of important metabolic pathways. Angewandte Chemie - International Edition. 2013;52(4):1110-1121.