shreis

Maria de la Salette Fernandes Hipolito Reis
Associate Professor
Research Group
Biomodels, Bioanalytics and Biophysics
REQUIMTE, Faculdade de Farmácia da Universidade do Porto, Química Aplicada, Rua Jorge Viterbo Ferreira,228, 4050-313, Porto, Portugal.
22 048 672
226 093 390
Research Interests
Investigation has been focused in biophysics and pharmaceutical chemistry, namely:
- Use of biomimetic membrane models to study the effect of drugs on biological membranes trying to establish a relationship between this effect and their activity/mechanism of action;
- Use of proteoliposomes to evaluate the membrane lipid composition on modulation of drugs interaction with membrane proteins;
- Nanopharmaceutics (liposomes, lipid nanoparticles and nanotubes) as drug delivery systems.
Main publications
Pinheiro, M., et al., Evaluation of the Structure-Activity Relationship of Rifabutin and Analogs: A Drug-Membrane Study. Chemphyschem, 2013. 14(12): p. 2808-2816.
Pinheiro, M., et al., The Influence of Rifabutin on Human and Bacterial Membrane Models: Implications for Its Mechanism of Action. Journal of Physical Chemistry B, 2013. 117(20): p. 6187-6193.
Pinheiro, M., et al., Interactions of N '-acetyl-rifabutin and N '-butanoyl-rifabutin with lipid bilayers: A synchrotron X-ray study. International Journal of Pharmaceutics, 2013. 453(2): p. 560-568.
Pinheiro, M., et al., Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: A biophysical approach to disease. Biochimica Et Biophysica Acta-Biomembranes, 2013. 1828(2): p. 896-905.
Pinheiro, M., et al., Differential Interactions of Rifabutin with Human and Bacterial Membranes: Implication for Its Therapeutic and Toxic Effects. Journal of Medicinal Chemistry, 2013. 56(2): p. 417-426.
Pinheiro, M., et al., Effects of a novel antimycobacterial compound on the biophysical properties of a pulmonary surfactant model membrane. International Journal of Pharmaceutics, 2013. 450(1-2): p. 268-277.
Pinheiro, M., et al., Drug-membrane interaction studies applied to N'-acetyl-rifabutin. European Journal of Pharmaceutics and Biopharmaceutics, 2013. 85(3): p. 597-603.
Pereira-Leite, C., C. Nunes, and S. Reis, Interaction of nonsteroidal anti-inflammatory drugs with membranes: In vitro assessment and relevance for their biological actions. Prog Lipid Res, 2013. 52(4): p. 571-84.
Pereira-Leite, C., et al., Biophysical characterization of the drug-membrane interactions: The case of propranolol and acebutolol. European Journal of Pharmaceutics and Biopharmaceutics, 2013. 84(1): p. 183-191.
Nunes, C., et al., Synchrotron small angle X-ray scattering for the evaluation of the interaction of silica nanotubes with lipid membranes. Rsc Advances, 2013. 3(26): p. 10323-10328.
Nunes, C., et al., In Vitro Assessment of NSAIDs-Membrane Interactions: Significance for Pharmacological Actions. Pharmaceutical Research, 2013. 30(8): p. 2097-2107.
Neves, A.R., et al., Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability. International Journal of Nanomedicine, 2013. 8: p. 177-187.
Sousa, C.T., et al., pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery. Colloids and Surfaces B-Biointerfaces, 2012. 94: p. 288-295.
Pinheiro, M., et al., Molecular Interaction of Rifabutin on Model Lung Surfactant Monolayers. Journal of Physical Chemistry B, 2012. 116(38): p. 11635-11645.
Pereira-Leite, C., et al., Interaction of Celecoxib with Membranes: The Role of Membrane Biophysics on its Therapeutic and Toxic Effects. Journal of Physical Chemistry B, 2012. 116(46): p. 13608-13617.
Neves, A.R., et al., Resveratrol in Medicinal Chemistry: A Critical Review of its Pharmacokinetics, Drug-Delivery, and Membrane Interactions. Current Medicinal Chemistry, 2012. 19(11): p. 1663-1681.
Pinheiro, M., et al., Liposomes as drug delivery systems for the treatment of TB. Nanomedicine, 2011. 6(8): p. 1413-1428.
Nunes, C., et al., NSAIDs Interactions with Membranes: A Biophysical Approach. Langmuir, 2011. 27(17): p. 10847-10858.
Nunes, C., et al., Lipid-Drug Interaction: Biophysical Effects of Tolmetin on Membrane Mimetic Systems of Different Dimensionality. Journal of Physical Chemistry B, 2011. 115(43): p. 12615-12623.
Nunes, C., et al., Effects of non-steroidal anti-inflammatory drugs on the structure of lipid bilayers: therapeutical aspects. Soft Matter, 2011. 7(6): p. 3002-3010.
Nunes, C., et al., Synchrotron SAXS and WAXS Study of the Interactions of NSAIDs with Lipid Membranes. Journal of Physical Chemistry B, 2011. 115(24): p. 8024-8032.
Reis, S., et al., Use of liposomes to evaluate the role of membrane interactions on antioxidant activity. Methods Mol Biol, 2010. 606: p. 167-88.
Magalhaes, L.M., et al., High-throughput microplate assay for the determination of drug partition coefficients. Nature Protocols, 2010. 5(11): p. 1823-1830.
Lucio, M., J.L.F.C. Lima, and S. Reis, Drug-Membrane Interactions: Significance for Medicinal Chemistry. Current Medicinal Chemistry, 2010. 17(17): p. 1795-1809.
Gaspar, D., et al., A biophysical approach to phospholipase A(2) activity and inhibition by anti-inflammatory drugs. Biophysical Chemistry, 2010. 152(1-3): p. 109-117.