Maria de la Salette Fernandes Hipolito Reis
Associate Professor
Research Group
Biomodels, Bioanalytics and Biophysics
REQUIMTE, Faculdade de Farmácia da Universidade do Porto, Química Aplicada, Rua Jorge Viterbo Ferreira,228, 4050-313, Porto, Portugal.
22 048 672
226 093 390
Research Interests
Investigation has been focused in biophysics and pharmaceutical chemistry, namely:
- Use of biomimetic membrane models to study the effect of drugs on biological membranes trying to establish a relationship between this effect and their activity/mechanism of action;
- Use of proteoliposomes to evaluate the membrane lipid composition on modulation of drugs interaction with membrane proteins;
- Nanopharmaceutics (liposomes, lipid nanoparticles and nanotubes) as drug delivery systems.
Main publications
Pinheiro, M., et al., Evaluation of the Structure-Activity Relationship of Rifabutin and Analogs: A Drug-Membrane Study. Chemphyschem, 2013. 14(12): p. 2808-2816.
Pinheiro, M., et al., The Influence of Rifabutin on Human and Bacterial Membrane Models: Implications for Its Mechanism of Action. Journal of Physical Chemistry B, 2013. 117(20): p. 6187-6193.
Pinheiro, M., et al., Interactions of N '-acetyl-rifabutin and N '-butanoyl-rifabutin with lipid bilayers: A synchrotron X-ray study. International Journal of Pharmaceutics, 2013. 453(2): p. 560-568.
Pinheiro, M., et al., Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: A biophysical approach to disease. Biochimica Et Biophysica Acta-Biomembranes, 2013. 1828(2): p. 896-905.
Pinheiro, M., et al., Differential Interactions of Rifabutin with Human and Bacterial Membranes: Implication for Its Therapeutic and Toxic Effects. Journal of Medicinal Chemistry, 2013. 56(2): p. 417-426.
Pinheiro, M., et al., Effects of a novel antimycobacterial compound on the biophysical properties of a pulmonary surfactant model membrane. International Journal of Pharmaceutics, 2013. 450(1-2): p. 268-277.
Pinheiro, M., et al., Drug-membrane interaction studies applied to N'-acetyl-rifabutin. European Journal of Pharmaceutics and Biopharmaceutics, 2013. 85(3): p. 597-603.
Pereira-Leite, C., C. Nunes, and S. Reis, Interaction of nonsteroidal anti-inflammatory drugs with membranes: In vitro assessment and relevance for their biological actions. Prog Lipid Res, 2013. 52(4): p. 571-84.
Pereira-Leite, C., et al., Biophysical characterization of the drug-membrane interactions: The case of propranolol and acebutolol. European Journal of Pharmaceutics and Biopharmaceutics, 2013. 84(1): p. 183-191.
Nunes, C., et al., Synchrotron small angle X-ray scattering for the evaluation of the interaction of silica nanotubes with lipid membranes. Rsc Advances, 2013. 3(26): p. 10323-10328.
Nunes, C., et al., In Vitro Assessment of NSAIDs-Membrane Interactions: Significance for Pharmacological Actions. Pharmaceutical Research, 2013. 30(8): p. 2097-2107.
Neves, A.R., et al., Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability. International Journal of Nanomedicine, 2013. 8: p. 177-187.
Sousa, C.T., et al., pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery. Colloids and Surfaces B-Biointerfaces, 2012. 94: p. 288-295.
Pinheiro, M., et al., Molecular Interaction of Rifabutin on Model Lung Surfactant Monolayers. Journal of Physical Chemistry B, 2012. 116(38): p. 11635-11645.
Pereira-Leite, C., et al., Interaction of Celecoxib with Membranes: The Role of Membrane Biophysics on its Therapeutic and Toxic Effects. Journal of Physical Chemistry B, 2012. 116(46): p. 13608-13617.
Neves, A.R., et al., Resveratrol in Medicinal Chemistry: A Critical Review of its Pharmacokinetics, Drug-Delivery, and Membrane Interactions. Current Medicinal Chemistry, 2012. 19(11): p. 1663-1681.
Pinheiro, M., et al., Liposomes as drug delivery systems for the treatment of TB. Nanomedicine, 2011. 6(8): p. 1413-1428.
Nunes, C., et al., NSAIDs Interactions with Membranes: A Biophysical Approach. Langmuir, 2011. 27(17): p. 10847-10858.
Nunes, C., et al., Lipid-Drug Interaction: Biophysical Effects of Tolmetin on Membrane Mimetic Systems of Different Dimensionality. Journal of Physical Chemistry B, 2011. 115(43): p. 12615-12623.
Nunes, C., et al., Effects of non-steroidal anti-inflammatory drugs on the structure of lipid bilayers: therapeutical aspects. Soft Matter, 2011. 7(6): p. 3002-3010.
Nunes, C., et al., Synchrotron SAXS and WAXS Study of the Interactions of NSAIDs with Lipid Membranes. Journal of Physical Chemistry B, 2011. 115(24): p. 8024-8032.
Reis, S., et al., Use of liposomes to evaluate the role of membrane interactions on antioxidant activity. Methods Mol Biol, 2010. 606: p. 167-88.
Magalhaes, L.M., et al., High-throughput microplate assay for the determination of drug partition coefficients. Nature Protocols, 2010. 5(11): p. 1823-1830.
Lucio, M., J.L.F.C. Lima, and S. Reis, Drug-Membrane Interactions: Significance for Medicinal Chemistry. Current Medicinal Chemistry, 2010. 17(17): p. 1795-1809.
Gaspar, D., et al., A biophysical approach to phospholipase A(2) activity and inhibition by anti-inflammatory drugs. Biophysical Chemistry, 2010. 152(1-3): p. 109-117.