Toxicology

Toxicology

The TOXI Group is developing research in toxicology applied to marine biotechnology, environment and human disease. The group consists of 3 complimentary research laboratories (Toxicology, BioTox, and SeaTox Labs).
 

The Toxicology Lab aims at evaluating the toxicodynamics and toxicokinetics of xenobiotics, namely toxins, drugs of abuse, pesticides, metals, nanomaterials and anti-cancer drugs. These studies have allowed us to develop and patent new antidotes, and ways to modulate pharmacokinetic factors for increasing the xenobiotics safety. The use of metabolomic tools has also allowed us to thrive in the evaluation of specific markers of Toxicology and go deeper into studies of cancer biochemical pathways.
 

The SeaTox Lab aims at firmly establishing itself at the international forefront of novel technologies in Marine Toxicology within its possible range of applications, from the monitoring and testing of emerging environmental toxicants to the discovery of novel bioproducts, with emphasis on animal pigments and proteinaceous toxins.
 

The Biotox Lab aims at developing studies on environmental toxicology (e.g. effects of nanomaterials, heavy metals, quantum dots and endocrine disruptors in organisms). We have also been studying the effects of climate change on the marine biota. A recently implemented research line on food toxicology and food quality is based upon the development of biosensors and analytical methodologies to detect contaminants in seaweeds.
 

In the 2013-2017 period the group has: published 328 papers in international journals with 2701 citations as well as 31 books or book chapters, and 1 patent; supervised 19 PhD theses and 55 MSc theses; participated in 3 international projects and 15 national projects (6 of which as PI), with an approximate total funding of 1.7 M€.

TOXI Research Labs
Recent publications
Silva, JP; Carmo, H; Carvalho, F. 2018. The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis. TOXICOLOGY LETTERS, 287, DOI: 10.1016/j.toxlet.2018.01.023
Proenca, C; Freitas, M; Ribeiro, D; Sousa, JLC; Carvalho, F; Silva, AMS; Fernandes, PA; Fernandes, E. 2018. Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure activity relationship study. FOOD AND CHEMICAL TOXICOLOGY, 111, DOI: 10.1016/j.fct.2017.11.039
Martins, M; Silva, A; Costa, MH; Miguel, C; Costa, PM. 2018. Co-exposure to environmental carcinogens in vivo induces neoplasia-related hallmarks in low-genotoxicity events, even after removal of insult. Scientific Reports, 8, DOI: 10.1038/s41598-018-21975-w
Barboza, LGA; Vieira, LR; Branco, V; Figueiredo, N; Carvalho, F; Carvalho, C; Guilhermino, L. 2018. Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758). AQUATIC TOXICOLOGY, 195, DOI: 10.1016/j.aquatox.2017.12.008
Loureiro-Vieira, S; Costa, VM; Duarte, JA; Duarte-Araujo, M; Goncalves-Monteiro, S; de Lourdes, BM; Carvalho, F; Capela, JP. 2018. Methylphenidate clinically oral doses improved brain and heart glutathione redox status and evoked renal and cardiac tissue injury in rats. BIOMEDICINE & PHARMACOTHERAPY, 100, DOI: 10.1016/j.biopha.2018.02.017