Thematic Line Coordinator: Maria João Romão

Brief Description:
Understanding the relationship between biomolecular interactions, cellular functions and disease needs an integrated vision and the combined effort of the different groups at UCIBIO. A vast work is being developed in the structure determination of large macromolecular complexes, proteins and cell communication systems. One of our goals is to understand the molecular mechanisms, from primary processes of molecular recognition to interaction networks in and between living cells, their populations and hosts. This encompasses a vast array of phenomena that include protein-carbohydrate interactions and their role in disease; protein-protein and protein-ligand interactions; the assembling and functioning of macromolecular machines; the regulation of gene expression and elucidation at the molecular level of cellular signal transduction pathways. 

The research conducted under this Thematic Line relates to the study of Cellular Function and associated Molecular Mechanisms in order to answer fundamental questions regarding Inflammation and Oxidative Stress, Infection & Pathogenesis, Drug Resistance Mechanisms (antibiotic, anti-cancer) and Adaption in Microbial Populations. Such studies integrate fundamental and applied research lines and anticipate, as major tangible outcomes, contributions in the areas of (a) Drug-Discovery; (b) identification of Novel Molecular Targets; (c) Therapeutics and (d) Diagnosis. 

Research Groups:
Chem4Omics (C4O)
Functional Molecules & Nanomaterials (FMN)
Structural Molecular Biology (SMB) 
Molecular Microbiology (MM)
Theoretical & Computational Biochemistry (TCB)
Biomodels, Bioanalytics & Biophysics (BBB)