Toxicology

GROUP MEMBERS

Félix Dias Carvalho (Full Professor)  (Group Leader)
Maria Lurdes Pinho Almeida Souteiro Bastos (Full Professor)
Fernando Manuel Gomes Remião (Associate Professor)
Helena Maria Ferreira da Costa Ferreira Carmo (Auxiliary Professor)
Maria Paula do Amaral Alegria Guedes de Pinho (Auxiliary Researcher)
Ricardo Jorge Dinis Oliveira  (Auxiliary Researcher)
Sónia Alexandra Teixeira Fraga  (Auxiliary Researcher)
Vera Marisa Freitas Costa  (Auxiliary Researcher)

 

LABs WEBSITEs
Laboratory of Toxicology of Faculty of Pharmacy of University of Porto: www.ff.up.pt/toxicologia/

 

RESEARCH INTERESTS AND OBJECTIVES 

The TOXI group has a long established expertise in in vitro and in vivo toxicology, and in chemical analysis in the ambit of toxicity mechanisms, toxicokinetics, forensic and clinical toxicology. We have been successfully developing studies for toxicokinetic and mechanistic clarification of several types of compounds contributing not only to the safety profiling of these substances, but also to the efficacy assessment of potentially pharmacologically active drugs. The TOXI achievements can be divided into 4 main topics: i) new treatment approaches for intoxications, ii) clarification of mechanisms of drug toxicity, iii) toxicity of drugs of abuse and iv) safety assessment of nanoparticles (NP).

The TOXI group intends to continue and improve the main areas of research for which a capital of experience and international recognition has already been acquired:

  • Develop toxicokinetic and mechanistic studies for an insight into the so-called legal drugs toxicity
  • Study interindividual factors governing the susceptibility towards the toxicity of drugs of abuse by using mixture toxicology models
  • Search for new antidotes, integrating the in silico data obtained by other group for candidate compounds with our in vitro and in vivo studies
  • Toxicological evaluation of nanomaterials for biomedical applications after their synthesis by other group 
  • Use metabolomic tools to dissect mechanisms of action and to find new and sensitive biomarkers of toxicity in the modern context of Systems Toxicology
  • Continue to devot a great effort to the refinement and replacement of in vivo by in vitro assays, especially in metabolic, bioavailability and mechanistic studies

Overall, it is our main objective to strengthen our most successfully implemented lines of research for which solid expertise exists and also to pursue the most innovative lines for which new collaborations will be established to acquire new expertise. It is also our goal to apply not only for nationally funded projects but also for transnational projects and integrate international networks especially in those areas that are considered a priority, such as is the case of nanotoxicology.

 

REPRESENTATIVE PUBLICATIONS

Jorge P Pinto, Sara Ribeiro, Helena Pontes, Shifaan Thowfeequ, David Tosh, Félix Carvalho, Graça Porto (2008) Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα. Blood 111(12):5727-5733. IF 9.06, C 93

Ricardo Dinis-Oliveira, Fernando Remião, José Alberto Duarte, Amparo Sánchez Navarro, Maria de Lourdes Bastos, Félix Carvalho (2008) Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment. Critical Reviews in Toxicology 38:13–71. IF 6.253, C 86

João Capela, Helena Carmo, Fernando Remião, Maria Lourdes Bastos, Andreas Meisel, Félix Carvalho (2009) Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: An overview. Molecular Neurobiology 39(3):210-71. IF 5.471, C 84

Helena Pontes, José Alberto Duarte, Paula Guedes de Pinho, Maria Elisa Soares, Eduarda Fernandes, Ricardo Dinis-Oliveira, Carla Sousa, Renata Silva, Helena Carmo, Susana Casal, Fernando Remião, Félix Carvalho, Maria de Lourdes Bastos (2008) Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice. Toxicology 252(1-3):64-71. IF 4.017, C 22

Vilas-Boas V, Silva R, Palmeira A, Sousa E, Ferreira LM, Branco PS, Carvalho F, Bastos Mde L, Remião F. Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate. PLoS One. 2013 Aug 26;8(8):e74425. IF 3.730

Ricardo Jorge Dinis-Oliveira, Helena Pontes, Maria de Lourdes Bastos, Fernando Remiao, José Alberto Duarte, Félix Carvalho (2009) An effective antidote for paraquat poisonings: The treatment with lysine acetylsalicylate. Toxicology, 255(3):187-193. IF 4.017, C 18

Márcia Carvalho, Helena Pontes, Fernando Remião, Maria de Lourdes Bastos, Félix Carvalho (2010) Mechanisms underlying the hepatotoxic effects of ecstasy. Current Pharmaceutical Biotechnology 11:476-495. IF 3.455, C 15

Ema Alves, Teresa Summavielle, Cecília Juliana Alves, José Barata Custódio, Eduarda Fernandes, Maria de Lourdes Bastos, Maria Amélia Tavares, Félix Carvalho (2009) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: Influence of monoamine oxidase type A. Addiction Biology 14:185–193. IF 5.914, C 14

Márcia Carvalho, Helena Carmo, Vera Marisa Costa, João Paulo Capela, Helena Pontes, Fernando Remião, Félix Carvalho, Maria de Lourdes Bastos, (2012) Toxicity of amphetamines: an update. Archives of Toxicology, 86(8):1167-1231, IF 5.215, C 13

Vera Marisa Costa, Félix Carvalho, Maria de Lourdes Bastos, Rui Carvalho, Márcia Carvalho, Fernando Remião (2011) Contribution of Catecholamine Reactive Intermediates and Oxidative Stress to the Pathologic Features of Heart Diseases. Current Medicinal Chemistry, 18(15):2272-2314. IF 4.070, C 11