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The Molecular Synthesis group integrates organic, inorganic, physical and biological chemists whose common interest is to create molecules. Molecules are synthesized because they are needed. Either as simple molecules, as units to produce complex structures or even to prove a scientific hypothesis – molecules are key players in everyday life.

Research is focused on the design of Molecules and Materials for biomedical, agricultural, environmental, energy and food applications, and improvement of Synthetic Methods granting the sustainable chemistry concept.

Several classes of molecular frameworks such as hydroxypyridinones, porphyrins, carbohydrates, amino acids, benzimidazoles and peptides are functionalized with several chemical groups to produce molecules whose physicochemical properties are fine-tuned according to the application in view. Examples are fluorescent chelators to monitor and sensing metal ions in body fluids and natural waters, anticancer, antimalarial, antimicrobial and novel anti-inflammatory drug candidates.

Peptides, carbohydrates, porphyrin, and dyes like coumarin and xanthene derivatives are preferential frameworks to produce innovative [Bio]materials with potential applications in Biomedical Engineering, [Bio]sensing, Catalysis, Separation and Cleaner Energies.

Research Interests

MOLECULES

 

Chemical synthesis of a wide diversity of molecules for:

 

Biomedical applications

  • Chelates and chelators to address iron imbalance-related diseases
  • Membrane-active peptides as novel antimicrobial agents
  • Modification of classical anti-malarials to bypass parasite resistance
  • Bioactive ionic liquids derived from anti-infective drugs
  • Synthetic analogues of vitamin D3 precursors
  • Peptidomimetics to address neurodegenerative disorders
  • Benzimidazole-based compounds as cyclooxygenase-inhibitors
  • Nature-inspired molecules, from marine compounds, and xenobiotic metabolites, to bacterial cell wall disaccharide components, and sugar-based compounds with bactericidal and cytotoxic activities
  • Oxygen heterocycles as potential antioxidant, anticancer and anti-diabetic agents
  • Porphyrin derivatives as potential anticancer and antimicrobial agents

Agricultural, environmental and food applications

  • Chelators for regulation of iron uptake and storage in plants
  • Pyridinone chelators for iron speciation in waters
  • Peptides and proteins of relevance in wine properties
  • Ferrocene-based imine ligands as selective sensors for mercury(II)
  • Organometallic molecules as catalysts for CO2 functionalization, and other chemical reactions
  • Porphyrin derivatives as potential antimicrobial agents
  • Porphyrin derivatives and analogues as chemosensors for anions

Catalysis

  • Homogeneous and heterogeneous oxidation of alkenes, alkanes, catechol, organosulfur compounds
  • Homogeneous oxidation of indole to afford indigo dye

 

METHODS

 

Development of innovative methods for the chemical synthesis or computational design and study of relevant target molecules

 

Synthetic approaches

  • Innovative approaches for one-pot synthesis of oligopeptides, and heterocycles of interest in medicinal and process chemistry
  • Solid-phase synthesis and grafting of peptides onto biomaterials
  • New routes for enantioselective synthesis of chiral compounds with potential pharmaceutical interest
  • Ohmic heating as an emerging concept in organic synthesis and their application in the synthesis of bioactive compounds
  • Design and synthesis of efficient solid fluorophores with potential application in luminescent materials
  • Cycloaddition reactions for creating improved porphyrin-based photosensitizers
  • Aza-Michael addition reactions – unprecedented sapphyrin derivatives
  • Design and synthesis

 

MATERIALS

 

Use of molecular synthesis tools towards development of innovative [bio]materials with potential applications in Biomedical Engineering, Drug Delivery, Separation Techniques and Cleaner Energies.

 

Biomedical engineering

  • Peptide-tethered antimicrobial coatings for bone implants
  • “click”-chemistry-coated microspheres for bacterial removal
  • Sugar-based polymeric nano/microparticles and amino
  • Acid-based surfactants for drug delivery and gene therapy

 

Separation and cleaner energies

  • Drug-imprinted xerogels for chromatographic applications
  • Coumarin-based chromophores for dye-sensitized solar cells

 

Highlights

  • Better Fe-shuttles to address crop Fe deficiency
    Effect of tris(3-hydroxy-4-pyridinonate) iron(III) complexes on iron uptake and storage in soybean (Glycine max L.) Plant Physiology and Biochemistry, 2016, 106, 91-100.
    Effect of tris(3-hydroxy-4-pyridinonate) iron(III) complexes on iron uptake and storage in soybean (Glycine max L.) Plant Physiology and Biochemistry, 2016, 106, 91-100.

    Iron Deficiency Chlorosis (IDC) is a disorder that has consequence not only in plant growth but also in the Fe content of seeds and fruits. To solve the problem, Fe-chelates with properties that allow more efficient pathways for root uptake, root to shoot translocation and maintenance of metal homeostasis are needed. In a pilot study performed in soybean (Glycine max L.) we tested a family of Fe-chelates that permits to design compounds with a variety of chemical properties that can be fine-tuned according to the results obtained on plants. We found that the Fe-chelates have potential as new IDC correctors since plants were significantly greener and had increased biomass when compared to plants supplied with the commercial fertilizers. In particular, plants supplied with one of the compounds, were able to translocate more iron from the roots to the shoots.

  • Ionic liquids derived from active pharmaceutical ingredients
    Primaquine-based ionic liquids as a novel class of antimalarial hits RSC Advances, 2016, 6, 56134-56138.
    Primaquine-based ionic liquids as a novel class of antimalarial hits RSC Advances, 2016, 6, 56134-56138.

    Ionic liquids derived from active pharmaceutical ingredients (API-ILs) may open new perspectives towards greener methods for the rescuing of classical drugs. Following our long track record in the recycling of classical antimalarial drugs currently in decline due to resistance and/or toxicity issues, we have recently unveiled novel ionic liquids derived from the antimalarial drug primaquine as triple-stage antimalarial leads. This unprecedented approach opens a new chapter concerning sustainable development of low-cost drugs, not exclusive to the arena of antiparasitic drug discovery.

  • Sugar-based polymeric nanoparticles
    Formation of spherical and core-shell polymeric microparticles from glycopolimers Carbohydrate Research, 2015, .125, 281-287.
    Formation of spherical and core-shell polymeric microparticles from glycopolimers Carbohydrate Research, 2015, .125, 281-287.

    Carbohydrates are very important in biology, and excellent targets for the development of therapeutics. Following recent progress in nanoscience, which disclosed the relevance of nanomaterials in healthcare, glycopolymers are gaining prominence for drug delivery, given their high affinity and binding specificity towards targeted receptors.
    Our Research Unit has combined nanotechnology and polymer science to develop polymeric nanoparticles (PNPs), based on glycosylation of biocompatible biopolymers. Novel polymer-based materials prepared from monosaccharides obtained by enzyme-catalyzed synthesis, that were homo-polymerized and copolymerized with styrene by a free radical process. Thus, polymer materials with sugar moieties, attached to the polymer backbone via ester linkages were attained where the structural features of the monomers greatly affected the thermal and rheological properties of the polymers. We have further produced novel amphiphilic polymers composed of poly(ethylene glycol) (PEG), cholic acid and sucrose. Owing to their amphiphilic characteristics in aqueous media, these PNPs could be prepared via a greener surfactant-free nanoprecipitation method. The spherical shape and size of the PNPs thus produced were suitable for drug delivery applications.

  • Coumarin-based chromophores for dye sensitized solar cells
    Styryl and phenylethynyl based coumarin chromophores for dye sensitized solar cells Journal of Photochemistry and Photobiology A, 2018, 353, 564-569.
    Styryl and phenylethynyl based coumarin chromophores for dye sensitized solar cells Journal of Photochemistry and Photobiology A, 2018, 353, 564-569.

    Dye-sensitized solar cells (DSSCs) are low-cost thin film solar cells with many attractive features, such as their ease of preparation and multiple applications, owing to their flexibility and transparency features. Although still less efficient than the best thin-film cells, their price/performance ratio is expected to become good enough to make them competitive with fossil fuels for generation of electricity. Bearing this in mind, and in line with the European Union Photovoltaic Roadmap that targets a significant contribution of DSSCs to renewable electricity generation by 2020, we have produced highly fluorescent coumarin dyes with styryl and phenylethynyl π-bridge moieties, via Sonogashira and regioselective Heck arylation reactions, for application in DSSCs.

  • Highly efficient one-pot synthetic routes towards bioactive compounds
    Highly efficient one-pot assembly of peptides by double chemoselective coupling Organic & Biomolecular Chemistry, 2017, 15, 7533-7542.
    Highly efficient one-pot assembly of peptides by double chemoselective coupling Organic & Biomolecular Chemistry, 2017, 15, 7533-7542.

    The development of new chemical methodologies and greener approaches for the assembly of important scaffolds is one of the main goals of modern organic chemistry. Our Research Unit has been devoted to synthesis of challenging scaffolds, such as azaindoles - a very popular class of compounds for both medicinal and process chemists, and developed a practical and straightforward syntheses of substituted and 1,2-disubstituted  azaindoles. Thus, one-pot approaches were developed, involving several Pd-catalyzed cross-coupling reactions, such as Heck, Sonogashira, Buchwald-Hartwig reactions, opening a fast and elegant access to this not always easy to make class of compounds.
    Equally noteworthy, a methodological advancement in solution-phase peptide synthesis was achieved, through development of a protocol to synthesize oligopeptides in a one-pot three-step cascade method, in which two peptide bonds are introduced chemoselectively. Oligopeptides were obtained in high global yields with no observable epimerization, through a faster, easier and milder approach that operates at equimolar amounts, and is compatible with virtually all protection schemes relevant in the context of peptide synthesis.

  • Ohmic heating: a new method in chemical synthesis
    Reactor para síntese química com aquecimento óhmico, método e suas aplicações PT 105908
    Reactor para síntese química com aquecimento óhmico, método e suas aplicações PT 105908

    Ohmic heating (ΩH) is an advanced thermal processing method. In ΩH, the reaction mixture, which behaves as an electrical ohmic heater, is heated by passing an AC electrical current of high frequency through it. The heat is generated in situ and dissipated directly in the reaction, with high-energy efficiency, by Joule effect.
    The first ΩH reactor for chemical synthesis was constructed in our group in 2013. This reactor has been used to perform several reactions, including Diels–Alder reactions, nucleophilic substitutions, N-alkylations, C-C cross coupling reactions, sequential Knoevenagel condensations followed by a hetero-Diels–Alder reaction, indium (In)-promoted reductive dehalogenations and reductive eliminations. ΩH allows a rapid and uniform heating of the reaction medium and increases the dynamics/mobility of the charged particles in solution, leading in most cases to better yields, better selectivity and shorter reaction times than classical and microwave heating methods. 

  • Tuning antibacterial activity of 3,4-HPO chelators through fluorophores
    The influence of functional groups on the permeation and distribution of antimycobacterial rhodamine chelators Journal of Inorganic Biochemistry, 2017, 175, 138-147.
    The influence of functional groups on the permeation and distribution of antimycobacterial rhodamine chelators Journal of Inorganic Biochemistry, 2017, 175, 138-147.

    Controlling the sources of Fe available to pathogens is one of the possible strategies that can be successfully targeted by novel antibacterial drugs. By analysing the effect of a variety of 3-Hydroxy-4-Pyridinone Fe chelators in the inhibition of the intramacrophagic growth of Mycobacterium avium, we have gathered information regarding the chemical properties necessary for an efficient antimycobacterial chelator. 
    The results showed that the chelation of Fe is a determinant but not sufficient property for antimicrobial activity. The activity is strongly dependent on the presence of the xanthene fluorophore, its type and on the linker binding the fluorophore and the chelating unit. The more active compound is a rhodamine hexadentate chelator bearing N-ethyl substituents on the rhodamine framework and the thiourea linkage. Such a combination is also responsible for an enhanced uptake by macrophages, thus implying that the efficiency of rhodamine-labelled 3,4-HPO chelators as antimycobacterial agents is strongly determined by the structural features that provide a better permeation through membranes and consequently a superior ability to reach the infection target.

  • Highly selective optical chemosensor for cyanide in aqueous medium
    Highly selective optical chemosensor for cyanide in aqueous medium Sensors Actuators: B. Chemical. 2016, 224, 81-87.
    Highly selective optical chemosensor for cyanide in aqueous medium Sensors Actuators: B. Chemical. 2016, 224, 81-87.

    Starting from commercially available precursors, we developed cyanide selective chromogenic chemosensors based on metallophthalocyanines. The new compounds revealed high sensitivity for several anions (AcO−, F−,CN−, NO2−, H2PO4− and OH−) over other anions, such as Br−, Cl−, NO3− and HSO4−, both in DMSO and THF solutions. Surprisingly, in 1:2 DMSO:water mixtures an extremely high selectivity was observed for CN− anion. Interestingly, the host:guest complexes formed during the sensing event can be undo by acid treatment without loss of the sensing ability of the chemosensors allowing their reuse. The selectivity of the new phthalocyanines for CN− anion is preserved when they are adsorbed in filter paper. That allowed the preparation of a simple detection kit for monitoring cyanide anion in contaminated environments.

  • Antimicrobial peptide-based coatings for biomedical application
    Dhvar5 antimicrobial peptide (AMP) chemoselective covalent immobilization results on higher antiadherence effect than simple physical adsorption. Biomaterials 2015, 52, 531-538.
    Dhvar5 antimicrobial peptide (AMP) chemoselective covalent immobilization results on higher antiadherence effect than simple physical adsorption. Biomaterials 2015, 52, 531-538.

    Implant-associated infection (IAI) and chronic wound infections (CWI) are a considerable burden in medical care. IAI are amongst the most common problems of in vivo implantation of any material and involve bacterial colonization and biofilm formation on the implant surface. CWI occur in individuals with alterations in the complex process of wound healing such as patients with diabetes or poor vascular supply, whose incapacity to fight infection on its onset leads to bacterial growth and subsequent establishment of mixed-species biofilms, resistant to host defenses and existing antibiotics. Also, the growing prevalence of antibiotic-resistant bacteria compromises current antibiotherapy. Antimicrobial peptides (AMP) are well-known components of the innate immune system that can be used to overcome IAI and CWI, as their relevance as alternatives to conventional antibiotics is increasing. Chemical synthesis of AMP and their covalent immobilization onto chitosan-based materials is being addressed by us, with overall results showing that the AMP-tethered surfaces reduce bacterial adhesion, which holds promise towards development of novel antimicrobial coatings for biomedical applications.

  • All-organic fluorophores with potential application in luminescent materials
    Synthesis, post-modification and fluorescence properties of boron-diketonate complexes. European Journal of Organic Chemistry, 2015, 16, 3423-3426.
    Synthesis, post-modification and fluorescence properties of boron-diketonate complexes. European Journal of Organic Chemistry, 2015, 16, 3423-3426.

    The fluorophores were based on a difluoroboron diketonate core, decorated with peripheral substituents to fine tune the photo-physical properties. The synthesis of the dyes involved the selective complexation of boron in a diketonate pocket and not in another, and were obtained in good yields. The dyes present good photo-physical properties in dilute solutions, and more interestingly they are highly emissive in the solid state, due to their organization into J-dimers, which prevents their self-quenching. With this design, the best dye emits in the solid state at 700 nm with a quantum yield of 12%, this performance being rare for solid state all-organic dyes. These exceptional photo-physical properties make this family of dyes promising building blocks for the preparation of luminescent materials.

Representative Publications

Sequeira, A; Lourenco, A; Ferreira, LM; Branco, PS; Mendes, Z; Lourenco, NMT; Figueiredo, M; Carvalho, LCR. 2018. A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis. SYNLETT, 29, 1346-1350. DOI: 10.1055/s-0037-1610127
Pereira, F; Aires-de-Sousa, J. 2018. Computational Methodologies in the Exploration of Marine Natural Product Leads. Marine Drugs, 16. DOI: 10.3390/md16070236
Pereira, F; Aires-de-Sousa, J. 2018. Machine learning for the prediction of molecular dipole moments obtained by density functional theory. Journal of Cheminformatics, 10. DOI: 10.1186/s13321-018-0296-5
Queiros, C; Leite, A; Cunha-Silva, L; de Castro, B; Rangel, M; Sousaraei, A; Cabanillas-Gonzalez, J; Gamez, F; Jamardo, E; Vargas, AP; Moscoso, FG; Lopes-Costa, T; Pedrosa, JM; Silva, AMG. 2018. Synthesis and characterization of two fluorescent isophthalate rosamines: From solution to immobilization in solid substrates. DYES AND PIGMENTS, 157, 405-414. DOI: 10.1016/j.dyepig.2018.05.005
Batalha, PN; Gomes, ATPC; Forezi, LSM; Costa, L; De Souza, MCBV; Boechat, FDCS; Ferreira, VF; Almeida, A; Faustino, MAF; Neves, MGPMS; Cavaleiro, JAS. 2015. Synthesis of new porphyrin/4-quinolone conjugates and evaluation of their efficiency in the photoinactivation of Staphylococcus aureus. RSC Advances, 5(87), 71228-71239. DOI: 10.1039/c5ra11070j
Barata, JFB; Zamarrón, A; Neves, MGPMS; Faustino, MAF; Tomé, AC; Cavaleiro, JAS; Röder, B; Juarranz, A; Sanz-Rodríguez, F. 2015. Photodynamic effects induced by meso-tris(pentafluorophenyl)corrole and its cyclodextrin conjugates on cytoskeletal components of HeLa cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 92, 135-144. DOI: 10.1016/j.ejmech.2014.12.025
Vânia Jesus; Diana Martins; Tatiana Branco; Nádia Valério; Maria GPMSNeves; Maria AFFaustino; Luís Reis; Esther Barreal; Pedro PGallego; Adelaide Almeida. 2018. An insight into the photodynamic approach versus copper formulations in the control of Pseudomonas syringae pv. actinidiae in kiwi plants. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. DOI: 10.1039/C7PP00300E
da Silva, RN; Tomé, AC; Tomé, JPC; Neves, MGPMS; Faustino, MAF; Cavaleiro, JAS; Oliveira, A; Almeida, A; Cunha, A. 2012. Photo-inactivation of bacillus endospores: Inter-specific variability of inactivation efficiency. MICROBIOLOGY AND IMMUNOLOGY, 56(10), 692-699. DOI: 10.1111/j.1348-0421.2012.00493.x
De Paula, R; Faustino, MAF; Pinto, DCGA; Neves, MGPMS; Cavaleiro, JAS. 2008. Kinetic study of meso-tetraphenylporphyrin synthesis under microwave irradiation. JOURNAL OF HETEROCYCLIC CHEMISTRY, 45(2), 453-459. DOI:
Lopes, SP; Menezes, JCJMDS; Hackbarth, S; Pinto, DCGA; Faustino, MAF; Silva, AMS; Neves, MGPMS; Röder, B; Cavaleiro, JAS. 2013. New flavonoid-porphyrin conjugates via Buchwald-Hartwig amination: Synthesis and photophysical studies. TETRAHEDRON LETTERS, 54(38), 5253-5256. DOI: 10.1016/j.tetlet.2013.07.089
Cardote, TAF; Barata, JFB; Amador, C; Alves, E; Neves, MGPMS; Cavaleiro, JAS; Cunha, Â; Almeida, A; Faustino, MAF. 2018. Evaluation of meso-substituted cationic corroles as potential antibacterial agents. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 90(1), 1175-1185. DOI: 10.1590/0001-3765201820170824
Alves, E; Moreirinha, C; Faustino, MAF; Cunha, Â; Delgadillo, I; Neves, MGPMS; Almeida, A. 2016. Overall biochemical changes in bacteria photosensitized with cationic porphyrins monitored by infrared spectroscopy. Future Medicinal Chemistry, 8(6), 613-628. DOI: 10.4155/fmc-2015-0008
Alves, E; Esteves, AC; Correia, A; Cunha, A; Faustino, MAF; Neves, MGPMS; Almeida, A. 2015. Protein profiles of Escherichia coli and Staphylococcus warneri are altered by photosensitization with cationic porphyrins. Photochemical and Photobiological Sciences, 14(6), 1169-1178. DOI: 10.1039/c4pp00194j
Alves, E; Rodrigues, JMM; Faustino, MAF; Neves, MGPMS; Cavaleiro, JAS; Lin, Z; Cunha, Â; Nadais, MH; Tomé, JPC; Almeida, A. 2014. A new insight on nanomagnet-porphyrin hybrids for photodynamic inactivation of microorganisms. DYES AND PIGMENTS, 110, 80-88. DOI: 10.1016/j.dyepig.2014.05.016
Alves, E; Faustino, MAF; Neves, MGPMS; Cunha, A; Tome, J; Almeida, A. 2014. An insight on bacterial cellular targets of photodynamic inactivation. Future Medicinal Chemistry, 6(2), 141-164. DOI: 10.4155/fmc.13.211
Alves, E; Faustino, MAF; Neves, MGPMS; Cunha, T; Nadais, H; Almeida, A. 2014. Potential applications of porphyrins in photodynamic inactivation beyond the medical scope. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS, 22, 34-57. DOI: 10.1016/j.jphotochemrev.2014.09.003
Alves, E; Faustino, MAF; Tomé, JPC; Neves, MGPMS; Tomé, AC; Cavaleiro, JAS; Cunha, A; Gomes, NCM; Almeida, A. 2013. Erratum: Nucleic acid changes during photodynamic inactivation of bacteria by cationic porphyrins (Bioorganic and Medicinal Chemistry (2013) 21 (4311-4318)). Bioorganic and Medicinal Chemistry, 21(17), 5648-. DOI: 10.1016/j.bmc.2013.06.051
Alves, E; Faustino, MAF; Tomé, JPC; Neves, MGPMS; Tomé, AC; Cavaleiro, JAS; Cunha, A; Gomes, NCM; Almeida, A. 2013. Nucleic acid changes during photodynamic inactivation of bacteria by cationic porphyrins. Bioorganic and Medicinal Chemistry, 21(14), 4311-4318. DOI: 10.1016/j.bmc.2013.04.065
Alves E; Costa L; Cunha A; Faustino MA; Neves MG; Almeida A. 2011. Bioluminescence and its application in the monitoring of antimicrobial photodynamic therapy.. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 92(6), 1115-1128. DOI: 10.1007/s00253-011-3639-y
Tavares A; Dias SR; Carvalho CM; Faustino MA; Tomé JP; Neves MG; Tomé AC; Cavaleiro JA; Cunha Â; Gomes NC; Alves E; Almeida A. 2011. Mechanisms of photodynamic inactivation of a gram-negative recombinant bioluminescent bacterium by cationic porphyrins.. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 10(10), 1659-1669. DOI: 10.1039/c1pp05097d
Alves, E; Faustino, MAF; Tomé, JPC; Neves, MGPMS; Tomé, AC; Cavaleiro, JAS; Cunha, A; Gomes, NCM; Almeida, A. 2011. Photodynamic antimicrobial chemotherapy in aquaculture: Photoinactivation studies of Vibrio fischeri. PLoS One, 6(6), e20970-. DOI: 10.1371/journal.pone.0020970
Carvalho CM; Alves E; Costa L; Tomé JP; Faustino MA; Neves MG; Tomé AC; Cavaleiro JA; Almeida A; Cunha A; Lin Z; Rocha J. 2010. Functional cationic nanomagnet-porphyrin hybrids for the photoinactivation of microorganisms.. ACS Nano, 4(12), 7133-7140. DOI: 10.1021/nn1026092
Tavares, A; Carvalho, CMB; Faustino, MA; Neves, MGPMS; Tomé, JPC; Tomé, AC; Cavaleiro, JAS; Cunha, Â; Gomes, NCM; Alves, E; Almeida, A. 2010. Antimicrobial photodynamic therapy: Study of bacterial recovery viability and potential development of resistance after treatment. Marine Drugs, 8(1), 91-105. DOI: 10.3390/md8010091
Carvalho, CMB; Tomé, JPC; Faustino, MAF; Neves, MGPMS; Tomé, AC; Cavaleiro, JAS; Costa, L; Alves, E; Oliveira, A; Cunha, Â; Almeida, A. 2009. Antimicrobial photodynamic activity of porphyrin derivatives: Potential application on medical and water disinfection. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 13(4-5), 574-577. DOI:
Alves, E; Costa, L; Carvalho, CM; Tomé, JP; Faustino, MA; Neves, MG; Tomé, AC; Cavaleiro, JA; Cunh, A; Almeida, A. 2009. Charge effect on the photoinactivation of gram-negative and gram-positive bacteria by cationic meso-substituted porphyrins. BMC MICROBIOLOGY, 9(70). DOI: 10.1186/1471-2180-9-70
Costa, L; Alves, E; Carvalho, CMB; Tomé, JPC; Faustino, MAF; Neves, MGPMS; Tomé, AC; Cavaleiro, JAS; Cunha, Â; Almeida, A. 2008. Sewage bacteriophage photoinactivation by cationic porphyrins: A study of charge effect. Photochemical and Photobiological Sciences, 7(4), 415-422. DOI: 10.1039/b712749a
Almeida, A; Cunha, Â; Gomes, NCM; Alves, E; Costa, L; Faustino, MAF. 2009. Phage therapy and photodynamic therapy: Low environmental impact approaches to inactivate microorganisms in fish farming plants. Marine Drugs, 7(3), 268-313. DOI: 10.3390/md7030268
Alves, E; Carvalho, CMB; Tomé, JPC; Faustino, MAF; Neves, MGPMS; Tomé, AC; Cavaleiro, JAS; Cunha, Â; Mendo, S; Almeida, A. 2008. Photodynamic inactivation of recombinant bioluminescent Escherichia coli by cationic porphyrins under artificial and solar irradiation. Journal of Industrial Microbiology and Biotechnology, 35(11), 1447-1454. DOI: 10.1007/s10295-008-0446-2
Cardote, TAF; Barata, JFB; Faustino, MAF; Preuß, A; Neves, MGPMS; Cavaleiro, JAS; Ramos, CIV; Santana-Marques, MGO; Röder, B. 2012. Pentafluorophenylcorrole-d-galactose conjugates. TETRAHEDRON LETTERS, 53(47), 6388-6393. DOI: 10.1016/j.tetlet.2012.09.038
R. Ferraz, M. Pinheiro, C. Teixeira, A. Gomes, C. Prudencio, S. Reis, P. Gomes. 2017. Effects of novel triple-stage antimalarial ionic liquids on lipid membrane modelsEffects of novel triple-stage antimalarial ionic liquids on lipid membrane models. Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2017.07.006
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CARDOSO, AM; CLARK, RJH; MOORHOUSE, S. 1980. SYNTHESIS OF EARLY TRANSITION-METAL COMPLEXES CONTAINING METAL-SILICON BONDS. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 186(2), 241-245. DOI:
CARDOSO, AM; FERRERCORREIA, AJ; FOKKENS, RH; NIBBERING, NMM. 1990. THE ROLE OF DISTONIC IONS IN THE FORMATION OF CH3NH3+ AND (CH3)2NH2+ FROM THE MOLECULAR-IONS OF OCTOPAMINE AND SYNEPHRINE. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1(1), 104-106. DOI: 10.1016/1044-0305(90)80012-C
CARDOSO, AM; CORREIA, AJF. 1995. 2-DIMENSIONAL MASS-SPECTRA OF 2-PHENYLETHYLAMINES. JOURNAL OF MASS SPECTROMETRY, 30(9), 1255-1259. DOI: 10.1002/jms.1190300907
Cardoso, AM; Barros, CMF; Correia, AJF; Cardoso, JM; Cortez, A; Carvalho, F; Baldaia, L. 1997. Identification of vertebrate type steroid hormones in the shrimp Penaeus japonicus by tandem mass spectrometry and sequential product ion scanning. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 8(4), 365-370. DOI: 10.1016/S1044-0305(96)00282-6
CARDOSO, AM; CLARK, RJH; MOORHOUSE, S. 1980. REACTIONS OF TRIMETHYLSILYLCYCLOPENTADIENE DERIVATIVES WITH TITANIUM, NIOBIUM, AND TANTALUM HALIDES. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1156-1160. DOI: 10.1039/dt9800001156
Cardoso, AM; Silva, AMS; Barros, CMF; Almeida, LMPM; FerrerCorreia, AJ; Cavaleiro, JAS. 1997. 3-aroyl-5-hydroxyflavones: Synthesis and mechanistic studies by mass spectrometry. JOURNAL OF MASS SPECTROMETRY, 32(9), 930-939. DOI: 10.1002/(SICI)1096-9888(199709)32:9<930::AID-JMS549>3.0.CO;2-E
Cardoso, AM; Alexandre, SMG; Barros, CMF; Ferrer-Correia, AJ; Nibbering, NMM. 1998. Proton affinities of phenylalkylamines by the kinetic method. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 172(1-2), 123-127. DOI: 10.1016/S0168-1176(97)00252-8
Cardoso, AM; Alexandre, SMG; Barros, CMF; Ferrer-Correia, AJ; Nibbering, NMM. 1998. Gas-phase protonation of arylalkylamines. A metastable ion study. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 12(13), 825-832. DOI: 10.1002/(SICI)1097-0231(19980715)12:13<825::AID-RCM243>3.3.CO;2-B
Cardoso, AM; Alexandre, SMG; Barros, CMF; Correia, AJF; Nibbering, NMM. 1999. Gas-phase deprotonation of arylalkylamines. A collision-induced dissociation study. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 13(19), 1885-1888. DOI: 10.1002/(SICI)1097-0231(19991015)13:19<1885::AID-RCM716>3.0.CO;2-K
Cardoso, AM; Correla, AJF. 1999. Fragmentation reactions of molecular ions and dications of indoleamines. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 5(1), 11-18. DOI: 10.1255/ejms.244
Ramos, LE; Cardoso, AM; Correia, AJF; Nibbering, NMM. 2000. Dimethyl ether chemical ionization of arylalkylamines. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 14(6), 408-416. DOI: 10.1002/(SICI)1097-0231(20000331)14:6<408::AID-RCM884>3.3.CO;2-B
Ramos, LE; Cardoso, AM; Correia, AJF; Nibbering, NNM. 2000. Behaviour of arylalkylamines toward trimethyl borate as a gas-phase reagent. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 203(1-3), 101-110. DOI: 10.1016/S1387-3806(00)00292-X
Cardoso, AM; Ramos, LE; Ferrer-Correia, AJ. 2001. Gas-phase reactions of the oxygen radical anion with arylalkylamines. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 210(1-3), 563-568. DOI: 10.1016/S1387-3806(01)00425-0
Fernandes, AM; Correia, AJF; Fokkens, RH; Nibbering, NMM. 2002. Evidence for the formation of acyclic ions from the radical cations and cyclic ions from the protonated molecules of alpha,omega-diamines upon loss of ammonia. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 217(1-3), 55-63. DOI: 10.1016/S1387-3806(02)00535-3
Ramos, LE; Fernandes, AM; Correia, AJF; Nibbering, NMM. 2003. Chemical ionization of amino and hydroxy group containing arylalkyl compounds with ions in a nitromethane plasma. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 222(1-3), 101-116. DOI: 10.1016/S1387-3806(02)00985-5
Ramos, CIV; Barros, CM; Fernandes, AM; Santana-Marques, MG; Correia, AJF; Tome, JPC; Carrilho, MDT; Faustino, MAF; Tome, AC; Neves, MGPMS; Cavaleiro, JAS. 2005. Interactions of cationic porphyrins with double-stranded oligodeoxynucleotides: a study by electrospray ionisation mass spectrometry. JOURNAL OF MASS SPECTROMETRY, 40(11), 1439-1447. DOI: 10.1002/jms.936
Freire, Mara G; Carvalho, Pedro J; Fernandes, Ana M; Marrucho, Isabel M; Queimada, Antonio J; Coutinho, Joao AP. 2007. Surface tensions of imidazolium based ionic liquids: Anion, cation, temperature and water effect. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 314(2), 621-630. DOI: 10.1016/j.jcis.2007.06.003
Freire, Mara G; Neves, Catarina MSS; Carvalho, Pedro J; Gardas, Ramesh L; Fernandes, Ana M; Marrucho, Isabel M; Santos, Luis MNBF; Coutinho, Jooa AP. 2007. Mutual Solubilities of water and hydrophobic ionic liquids. JOURNAL OF PHYSICAL CHEMISTRY B, 111(45), 13082-13089. DOI: 10.1021/jp076271e
Freire, MG; Santos, LMNBF; Fernandes, AM; Coutinho, JAP; Marrucho, IM. 2007. An overview of the mutual solubilities of water-imidazolium-based ionic liquids systems. FLUID PHASE EQUILIBRIA, 261(1-2), 449-454. DOI: 10.1016/j.fluid.2007.07.033
Fernandes, Ana M; Coutinho, Joao AP; Marrucho, Isabel M. 2009. Gas-phase dissociation of ionic liquid aggregates studied by electrospray ionisation mass spectrometry and energy-variable collision induced dissociation. JOURNAL OF MASS SPECTROMETRY, 44(1), 144-150. DOI: 10.1002/jms.1484
Freire, Mara G; Neves, Catarina MSS; Ventura, Sonia PM; Pratas, Maria J; Marrucho, Isabel M; Oliveira, Joao; Coutinho, Joao AP; Fernandes, Ana M. 2010. Solubility of non-aromatic ionic liquids in water and correlation using a QSPR approach. FLUID PHASE EQUILIBRIA, 294(1-2), 234-240. DOI: 10.1016/j.fluid.2009.12.035
Freire, Mara G; Neves, Catarina MSS; Marrucho, Isabel M; Coutinho, Joao AP; Fernandes, Ana M. 2010. Hydrolysis of Tetrafluoroborate and Hexafluorophosphate Counter Ions in Imidazolium-Based Ionic Liquids. JOURNAL OF PHYSICAL CHEMISTRY A, 114(11), 3744-3749. DOI: 10.1021/jp903292n
Fernandes, Ana M; Rocha, Marisa AA; Freire, Mara G; Marrucho, Isabel M; Coutinho, Joao AP; Santos, Luis MNBF. 2011. Evaluation of Cation-Anion Interaction Strength in Ionic Liquids. JOURNAL OF PHYSICAL CHEMISTRY B, 115(14), 4033-4041. DOI: 10.1021/jp201084x
Almeida, Hugo FD; Passos, Helena; Lopes-da-Silva, Jose A; Fernandes, Ana M; Freire, Mara G; Coutinho, Joao AP. 2012. Thermophysical Properties of Five Acetate-Based Ionic Liquids. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 57(11), 3005-3013. DOI: 10.1021/je300487n
Fernandes, Ana M; Schroeder, Bernd; Barata, Tania; Freire, Mara G; Coutinho, Joao AP. 2014. Inclusion Complexes of Ionic Liquids and Cyclodextrins: Are They Formed in the Gas Phase?. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25(5), 852-860. DOI: 10.1007/s13361-013-0820-9
Ferreira, AM; Coutinho, JAP; Fernandes, AM; Freire, MG. 2014. Complete removal of textile dyes from aqueous media using ionic-liquid-based aqueous two-phase systems. SEPARATION AND PURIFICATION TECHNOLOGY, 128, 58-66. DOI: 10.1016/j.seppur.2014.02.036
Almeida, Hugo FD; Freire, Mara G; Fernandes, Ana M; Lopes-da-Silva, Jose A; Morgado, Pedro; Shimizu, Karina; Filipe, Eduardo JM; Canongia Lopes, Jose N; Santos, Luis MNBF; Coutinho, Joao AP. 2014. Cation Alkyl Side Chain Length and Symmetry Effects on the Surface Tension of Ionic Liquids. LANGMUIR, 30(22), 6408-6418. DOI: 10.1021/la501308q
Vilas, Miguel; Rocha, Marisa AA; Fernandes, Ana M; Tojo, Emilia; Santos, Luis MNBF. 2015. Novel 2-alkyl-1-ethylpyridinium ionic liquids: synthesis, dissociation energies and volatility. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 17(4), 2560-2572. DOI: 10.1039/c4cp05191b
Neves, Catarina MSS; Silva, Artur MS; Fernandes, Ana M; Coutinho, Joao AP; Freire, Mara G. 2017. Toward an Understanding of the Mechanisms behind the Formation of Liquid-liquid Systems formed by Two Ionic Liquids. Journal of Physical Chemistry Letters, 8(13), 3015-3019. DOI: 10.1021/acs.jpclett.7b01234
Neves, Catarina Seica; Silva, Artur; Fernandes, Ana; Coutinho, Joao; Freire, Mara. 2017. Liquid-liquid equilibrium between two hydrophobic ionic liquids. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 254. DOI:
Passos, Helena; Costa, Sara H; Fernandes, Ana M; Freire, Mara G; Rogers, Robin D; Coutinho, Joao AP. 2017. A Triple Salting-Out Effect is Required for the Formation of Ionic-Liquid-Based Aqueous Multiphase Systems. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(47), 15058-15062. DOI: 10.1002/anie.201705704
Simoes, Carlos; Gomes, Maria C; Neves, Maria GPMS; Cunha, Angela; Tome, Joao PC; Tome, Augusto C; Cavaleiro, Jose AS; Almeida, Adelaide; Faustino, Maria AF. 2016. Photodynamic inactivation of Escherichia coli with cationic meso-tetraarylporphyrins - The charge number and charge distribution effects. CATALYSIS TODAY, 266, 197-204. DOI: 10.1016/j.cattod.2015.07.031
Figueira, Flavio; Marques, Igor; Farinha, Andreia SF; Tome, Augusto C; Cavaleiro, Jose AS; Silva, Artur MS; Sessler, Jonathan; Felix, Vitor; Tome, Joao PC. 2016. Unprecedented Double aza-Michael Addition within a Sapphyrin Core. CHEMISTRY-A EUROPEAN JOURNAL, 22(40), 14349-14355. DOI: 10.1002/chem.201602313
Rodrigues, Joao MM; Farinha, Andreia AS; Tome, Augusto C; Cavaleiro, Jose AS; Tome, Joao PC. 2016. Highly selective optical chemosensor for cyanide in aqueous medium. SENSORS AND ACTUATORS B-CHEMICAL, 224, 81-87. DOI: 10.1016/j.snb.2015.10.026
Figueira, F; Farinha, ASF; Muteto, PV; Polêto, MD; Verli, H; Gomes, MTSR; Tomé, AC; Cavaleiro, JAS; Tomé, JPC. 2016. Hexaphyrin derivatives for anion recognition in organic and aqueous media. CHEMICAL COMMUNICATIONS, 52(10), 2181-2184. DOI: 10.1039/c5cc08128a
Joana ITCosta; Andreia SFFarinha; Maria GPMSNeves; Augusto CTomé. 2016. An easy access to porphyrin triads and their supramolecular interaction with a pyridyl [60]fulleropyrrolidine. DYES AND PIGMENTS, 135, 163-. DOI: 10.1016/j.dyepig.2016.02.035
Raquel Nunes da Silva; Ângela Cunha; Augusto CTomé. 2018. Phthalocyanine–sulfonamide conjugates: Synthesis and photodynamic inactivation of Gram-negative and Gram-positive bacteria. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 154, 60-. DOI: 10.1016/j.ejmech.2018.05.009
Santos, ICMS; Gamelas, JAF; Balula, MSS; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS; Cavaleiro, AMV. 2007. Sandwich-type tungstophosphates in the catalytic oxidation of cycloalkanes with hydrogen peroxide. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 262(1-2), 41-47. DOI: 10.1016/j.molcata.2006.08.051
Balula, MSS; Santos, ICMS; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS; Cavaleiro, AMV. 2004. A comparative study between Keggin-type tungstophosphates and tungstosilicates in the oxidation of cyclooctane with hydrogen peroxide. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 222(1-2), 159-165. DOI: 10.1016/j.molcata.2004.07.025
Simões, MMQ; Santos, ICMS; Balula, MSS; Gamelas, JAF; Cavaleiro, AMV; Neves, MGPMS; Cavaleiro, JAS. 2004. Oxidation of cycloalkanes with hydrogen peroxide in the presence of Keggin-type polyoxotungstates. CATALYSIS TODAY, 91-92, 211-214. DOI: 10.1016/j.cattod.2004.03.035
Santos, ICMS; Simões, MMQ; Pereira, MMMS; Martins, RRL; Neves, MGPMS; Cavaleiro, JAS; Cavaleiro, AMV. 2003. Oxidation of monoterpenes with hydrogen peroxide catalysed by keggin-type tungstoborates. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 195(1-2), 253-262. DOI: 10.1016/S1381-1169(02)00582-4
Santos, ICMS; Balula, MSS; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS; Cavaleiro, AMV. 2003. Tungstoborates as highly active catalysts for cycloalkane oxygenation using hydrogen peroxide. SYNLETT, 1643-1646. DOI:
Cavaleiro, JAS; Silvestre, AJD; Neves, Mgpms; Silva, AMS; Martins, RRL; Monteiro, Smcs; Simoes, MMQ. 2002. Synthesis of natural products. Chemical transformations of natural compounds. Natural Products in the New Millennium: Prospects and Industrial Application, 47, 389-399. DOI:
Martins, RRL; Neves, MGPMS; Silvestre, AJD; Simões, MMQ; Silva, AMS; Tomé, AC; Cavaleiro, JAS; Tagliatesta, P; Crestini, C. 2001. Oxidation of unsaturated monoterpenes with hydrogen peroxide catalysed by manganese(III) porphyrin complexes. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 172(1-2), 33-42. DOI: 10.1016/S1381-1169(01)00120-0
Estrada, AC; Simões, MMQ; Santos, ICMS; Neves, MGPMS; Cavaleiro, JAS; Cavaleiro, AMV. 2010. Catalytic activity of iron-substituted polyoxotungstates in the oxidation of aromatic compounds with hydrogen peroxide. MONATSHEFTE FUR CHEMIE, 141(11), 1223-1235. DOI: 10.1007/s00706-010-0370-9
Rocha, GMSRO; Domingues, RMA; Simões, MMQ; Silva, AMS. 2009. Catalytic activity of tetravalent metal phosphates and phosphonates on the oxidation of (+)-3-carene. APPLIED CATALYSIS A-GENERAL, 353(2), 236-242. DOI: 10.1016/j.apcata.2008.10.041
Estrada, AC; Simões, MMQ; Santos, ICMS; Neves, MGPMS; Silva, AMS; Cavaleiro, JAS; Cavaleiro, AMV. 2009. Iron-substituted polyoxotungstates as catalysts in the oxidation of indane and tetralin with hydrogen peroxide. APPLIED CATALYSIS A-GENERAL, 366(2), 275-281. DOI: 10.1016/j.apcata.2009.07.022
Simões, MMQ; De Paula, R; Neves, MGPMS; Cavaleiro, JAS. 2009. Metalloporphyrins in the biomimetic oxidative valorization of natural and other organic substrates. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 13(4-5), 589-596. DOI:
Estrada, AC; Simões, MMQ; Santos, ICMS; Neves, MGPMS; Silva, AMS; Cavaleiro, JAS; Cavaleiro, AMV. 2009. Transition metal substituted polyoxotungstates in the catalytic oxidation of 1H-indene and 1,2-dihydronaphthalene with hydrogen peroxide. CATALYSIS LETTERS, 128(3-4), 281-289. DOI: 10.1007/s10562-008-9718-8
Santos, ICMS; Simões, MMQ; Balula, MSS; Neves, MGPMS; Cavaleiro, JAS; Cavaleiro, AMV. 2008. A new insight into the oxidation of cyclododecane with hydrogen peroxide in the presence of iron-substituted polyoxotungstates. SYNLETT, 1623-1626. DOI: 10.1055/s-2008-1077876
Santos, ICMS; Paz, FAA; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS; Klinowski, J; Cavaleiro, AMV. 2008. Catalytic homogeneous oxyfunctionalization with hydrogen peroxide in the presence of a peroxotungstate. APPLIED CATALYSIS A-GENERAL, 351(2), 166-173. DOI: 10.1016/j.apcata.2008.09.013
Paula, RD; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS. 2008. Homogeneous olefin epoxidation catalysed by an imidazolium-based manganese porphyrin. CATALYSIS COMMUNICATIONS, 10(1), 57-60. DOI: 10.1016/j.catcom.2008.07.033
Neves, CMB; Fernandes, JA; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS; Almeida Paz, FA. 2011. 2-Amino-6-[(2,6-dichlorophenyl)imino]-3-oxocyclohexa-1,4-dienecarbaldehyde. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 67(11). DOI: 10.1107/S1600536811042619
Villaverde, JJ; Santos, SAO; Simões, MMQ; Neto, CP; Domingues, MRM; Silvestre, AJD. 2011. Analysis of linoleic acid hydroperoxides generated by biomimetic and enzymatic systems through an integrated methodology. INDUSTRIAL CROPS AND PRODUCTS, 34(3), 1474-1481. DOI: 10.1016/j.indcrop.2011.05.001
Sousa, JLC; Santos, ICMS; Simões, MMQ; Cavaleiro, JAS; Nogueira, HIS; Cavaleiro, AMV. 2011. Iron(III)-substituted polyoxotungstates immobilized on silica nanoparticles: Novel oxidative heterogeneous catalysts. CATALYSIS COMMUNICATIONS, 12(6), 459-463. DOI: 10.1016/j.catcom.2010.11.005
Estrada, AC; Simões, MMQ; Santos, ICMS; Neves, MGPMS; Cavaleiro, JAS; Cavaleiro, AMV. 2011. Oxidation of Polycyclic Aromatic Hydrocarbons with Hydrogen Peroxide in the Presence of Transition Metal Mono-Substituted Keggin-Type Polyoxometalates. ChemCatChem, 3(4), 771-779. DOI: 10.1002/cctc.201000264
De Paula, R; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS. 2011. Oxidation of styrene and of some derivatives with H2O 2 catalyzed by novel imidazolium-containing manganese porphyrins: A mechanistic and thermodynamic interpretation. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 345(1-2), 1-11. DOI: 10.1016/j.molcata.2011.05.013
Estrada, AC; Santos, ICMS; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS; Cavaleiro, AMV. 2011. Silica supported transition metal substituted polyoxotungstates: Novel heterogeneous catalysts in oxidative transformations with hydrogen peroxide. APPLIED CATALYSIS A-GENERAL, 392(1-2), 28-35. DOI: 10.1016/j.apcata.2010.10.026
Neves, CMB; Simões, MMQ; Domíngues, MRM; Santos, ICMS; Neves, MGPMS; Paz, FAA; Silva, AMS; Cavaleiro, JAS. 2012. Oxidation of diclofenac catalyzed by manganese porphyrins: Synthesis of novel diclofenac derivatives. RSC Advances, 2(19), 7427-7438. DOI: 10.1039/c2ra20801f
Villaverde, JJ; Santos, SAO; MacIel, E; Simães, MMQ; Neto, CP; Domingues, MRM; Silvestre, AJD. 2012. Formation of oligomeric alkenylperoxides during the oxidation of unsaturated fatty acids: An electrospray ionization tandem mass spectrometry study. JOURNAL OF MASS SPECTROMETRY, 47(2), 163-172. DOI: 10.1002/jms.2047
Neves, CMB; Simões, MMQ; Domingues, FMJ; Neves, MGPMS; Cavaleiro, JAS. 2012. Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin. QUIMICA NOVA, 35(7), 1477-1481. DOI: 10.1590/S0100-40422012000700033
Villaverde, JJ; van der Vlist, V; Santos, SAO; Haarmann, T; Langfelder, K; Pirttimaa, M; Nyyssölä, A; Jylhä, S; Tamminen, T; Kruus, K; de Graaff, L; Neto, CP; Simões, MMQ; Domingues, MRM; Silvestre, AJD; Eidner, J; Buchert, J. 2013. Hydroperoxide production from linoleic acid by heterologous Gaeumannomyces graminis tritici lipoxygenase: Optimization and scale-up. CHEMICAL ENGINEERING JOURNAL, 217, 82-90. DOI: 10.1016/j.cej.2012.11.090
Villaverde, JJ; Santos, SAO; Haarmann, T; Neto, CP; Simões, MMQ; Domingues, MRM; Silvestre, AJD. 2013. Cloned Pseudomonas aeruginosa lipoxygenase as efficient approach for the clean conversion of linoleic acid into valuable hydroperoxides. CHEMICAL ENGINEERING JOURNAL, 231, 519-525. DOI: 10.1016/j.cej.2013.07.064
Ramos, CIV; Pereira, PMR; Santana-Marques, MG; De Paula, R; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS. 2014. Imidazole and imidazolium porphyrins: Gas-phase chemistry of multicharged ions. JOURNAL OF MASS SPECTROMETRY, 49(5), 371-379. DOI: 10.1002/jms.3350
Oliveira, V; Gomes, NCM; Almeida, A; Silva, AMS; Simões, MMQ; Smalla, K; Cunha, A. 2014. Hydrocarbon contamination and plant species determine the phylogenetic and functional diversity of endophytic degrading bacteria. MOLECULAR ECOLOGY, 23(6), 1392-1404. DOI: 10.1111/mec.12559
Duarte, TAG; Santos, ICMS; Simões, MMQ; Neves, MGPMS; Cavaleiro, AMV; Cavaleiro, JAS. 2014. Homogeneous catalytic oxidation of olefins with hydrogen peroxide in the presence of a manganese-substituted polyoxomolybdate. CATALYSIS LETTERS, 144(1), 104-111. DOI: 10.1007/s10562-013-1101-8
Oliveira, V; Gomes, NCM; Cleary, DFR; Almeida, A; Silva, AMS; Simões, MMQ; Silva, H; Cunha, A. 2014. Halophyte plant colonization as a driver of the composition of bacterial communities in salt marshes chronically exposed to oil hydrocarbons. FEMS MICROBIOLOGY ECOLOGY, 90(3), 647-662. DOI: 10.1111/1574-6941.12425
Castro, KADF; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS; Wypych, F; Nakagaki, S. 2014. Glycol metalloporphyrin derivatives in solution or immobilized on LDH and silica: Synthesis, characterization and catalytic features in oxidation reactions. Catalysis Science and Technology, 4(1), 129-141. DOI: 10.1039/c3cy00472d
Coelho, FJRC; Cleary, DFR; Rocha, RJM; Calado, R; Castanheira, JM; Rocha, SM; Silva, AMS; Simões, MMQ; Oliveira, V; Lillebø, AI; Almeida, A; Cunha, A; Lopes, I; Ribeiro, R; Moreira-Santos, M; Marques, CR; Costa, R; Pereira, R; Gomes, NCM. 2015. Unraveling the interactive effects of climate change and oil contamination on laboratory-simulated estuarine benthic communities. GLOBAL CHANGE BIOLOGY, 21(5), 1871-1886. DOI: 10.1111/gcb.12801
Louvado, A; Gomes, NCM; Simões, MMQ; Almeida, A; Cleary, DFR; Cunha, A. 2015. Polycyclic aromatic hydrocarbons in deep sea sediments: Microbe-pollutant interactions in a remote environment. SCIENCE OF THE TOTAL ENVIRONMENT, 526, 312-328. DOI: 10.1016/j.scitotenv.2015.04.048
Duarte, TAG; Estrada, AC; Simões, MMQ; Santos, ICMS; Cavaleiro, AMV; Neves, MGPMS; Cavaleiro, JAS. 2015. Homogeneous catalytic oxidation of styrene and styrene derivatives with hydrogen peroxide in the presence of transition metal-substituted polyoxotungstates. Catalysis Science and Technology, 5(1), 351-363. DOI: 10.1039/c4cy00702f
Castro, KADF; Silva, S; Pereira, PMR; Simões, MMQ; Neves, MDGPMS; Cavaleiro, JAS; Wypych, F; Tomé, JPC; Nakagaki, S. 2015. Galactodendritic porphyrinic conjugates as new biomimetic catalysts for oxidation reactions. INORGANIC CHEMISTRY, 54(9), 4382-4393. DOI: 10.1021/acs.inorgchem.5b00196
Abdelhameed, RM; Simões, MMQ; Silva, AMS; Rocha, J. 2015. Enhanced Photocatalytic Activity of MIL-125 by Post-Synthetic Modification with Cr<sup>III</sup> and Ag Nanoparticles. Chemistry – A European Journal. DOI: 10.1002/chem.201500808
De Paula, R; Santos, ICMS; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS. 2015. An immobilized imidazolyl manganese porphyrin for the oxidation of olefins. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 404-405, 156-166. DOI: 10.1016/j.molcata.2015.04.021
Pereira, CF; Simoes, MQ; Tomé, JPC; Paz, FAA. 2016. Porphyrin-based metal-organic frameworks as heterogeneous catalysts in oxidation reactions. MOLECULES, 21(10). DOI: 10.3390/molecules21101348
Castro, KADF; Rodrigues, JMM; Mendes, RF; Neves, MDGPMS; Simões, MMQ; Cavaleiro, JAS; Almeida Paz, FA; Tomé, JPC; Nakagaki, S. 2016. New copper porphyrins as functional models of catechol oxidase. JOURNAL OF CATALYSIS, 344, 303-312. DOI: 10.1016/j.jcat.2016.09.010
Coelho, FJRC; Cleary, DFR; Costa, R; Ferreira, M; Polónia, ARM; Silva, AMS; Simões, MMQ; Oliveira, V; Gomes, NCM. 2016. Multitaxon activity profiling reveals differential microbial response to reduced seawater pH and oil pollution. MOLECULAR ECOLOGY, 25(18), 4645-4659. DOI: 10.1111/mec.13779
Zucca, P; Neves, CMB; Simões, MMQ; Neves, MDGPMS; Cocco, G; Sanjust, E. 2016. Immobilized lignin peroxidase-like metalloporphyrins as reusable catalysts in oxidative bleaching of industrial dyes. MOLECULES, 21(7). DOI: 10.3390/molecules21070964
Castro, KADF; de Lima, FHC; Simões, MMQ; Neves, MGPMS; Paz, FAA; Mendes, RF; Nakagaki, S; Cavaleiro, JAS. 2017. Synthesis, characterization and catalytic activity under homogeneous conditions of ethylene glycol substituted porphyrin manganese(III) complexes. INORGANICA CHIMICA ACTA, 455, 575-583. DOI: 10.1016/j.ica.2016.05.038
Veríssimo, MIS; Gamelas, JAF; Simões, MMQ; Evtuguin, DV; Gomes, MTSR. 2017. Quantifying acetaldehyde in cider using a Mn(III)-substituted polyoxotungstate coated acoustic wave sensor. SENSORS AND ACTUATORS B-CHEMICAL. DOI: 10.1016/j.snb.2017.09.068
Filipe, OMS; Mota, N; Santos, SAO; Domingues, MRM; Silvestre, AJD; Neves, MGPMS; Simões, MMQ; Santos, EBH. 2017. Identification and characterization of photodegradation products of metoprolol in the presence of natural fulvic acid by HPLC-UV-MS<sup>n</sup>. JOURNAL OF HAZARDOUS MATERIALS, 323, 250-263. DOI: 10.1016/j.jhazmat.2016.05.072
Cardoso, MFDC; Gomes, ATPC; Moreira, CDS; Simões, MMQ; Neves, MGPMS; Da Rocha, DR; Da Silva, FDC; Moreirinha, C; Almeida, A; Ferreira, VF; Cavaleiro, JAS; Tomé, JPC. 2017. Efficient catalytic oxidation of 3-arylthio- and 3-cyclohexylthio-lapachone derivatives to new sulfonyl derivatives and evaluation of their antibacterial activities. MOLECULES, 22(2). DOI: 10.3390/molecules22020302
Oliveira, V; Gomes, NCM; Santos, M; Almeida, A; Lillebø, AI; Ezequiel, J; Serôdio, J; Silva, AMS; Simões, MMQ; Rocha, SM; Cunha, Â. 2017. Effects of the Inoculant Strain Pseudomonas sp. SPN31 nah <sup>+</sup> and of 2-Methylnaphthalene Contamination on the Rhizosphere and Endosphere Bacterial Communities of Halimione portulacoides. CURRENT MICROBIOLOGY, 74(5), 575-583. DOI: 10.1007/s00284-017-1197-y
Santos, ICMS; Gamelas, JAF; Duarte, TAG; Simões, MMQ; Neves, MGPMS; Cavaleiro, JAS; Cavaleiro, AMV. 2017. Catalytic homogeneous oxidation of monoterpenes and cyclooctene with hydrogen peroxide in the presence of sandwich-type tungstophosphates [M<inf>4</inf>(H<inf>2</inf>O)<inf>2</inf>(PW<inf>9</inf>O<inf>34</inf>)<inf>2</inf>]<sup>n−</sup>, M = Co<sup. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 426, 593-599. DOI: 10.1016/j.molcata.2016.10.021
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Silva, AMN; Kong, XL; Hider, RC. 2009. Determination of the pKa value of the hydroxyl group in the alpha-hydroxycarboxylates citrate, malate and lactate by 13C NMR: implications for metal coordination in biological systems. BIOMETALS, 22(5), 771-778. DOI: 10.1007/s10534-009-9224-5
Hider, RC; Silva, AMN; Podinovskaia, M; Ma, Y. 2010. Monitoring the efficiency of iron chelation therapy: The potential of nontransferrin-bound iron. Annals of the New York Academy of Sciences, 1202, 94-99. DOI: 10.1111/j.1749-6632.2010.05573.x
Silva, AMN; Borralho, AC; Pinho, SA; Domingues, MRM; Domingues, P. 2011. Cross-oxidation of angiotensin II by glycerophosphatidylcholine oxidation products. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 25(10), 1413-1421. DOI: 10.1002/rcm.5006
Silva, Andre MN; Vitorino, Rui; Domingues, MRosario M; Spickett, Corinne M; Domingues, Pedro. 2013. Post-translational Modifications and Mass Spectrometry Detection. FREE RADICAL BIOLOGY AND MEDICINE, 65, 925-941. DOI: 10.1016/j.freeradbiomed.2013.08.184
Silva, Andre MN; Marcal, Susana L; Vitorino, Rui; Domingues, Maria RM; Domingues, Pedro. 2013. Characterization of in vitro protein oxidation using mass spectrometry: A time course study of oxidized alpha-amylase. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 530(1), 23-31. DOI: 10.1016/j.abb.2012.12.010
Silva, AMN; Coimbra, JTS; Castro, MM; Oliveira, A; Bras, NF; Fernandes, PA; Ramos MJ; Rangel, M. 2018. Determining the glycation site specificity of human holo-transferrin. JOURNAL OF INORGANIC BIOCHEMISTRY, 186, 95-. DOI: 10.1016/j.jinorgbio.2018.05.016
Silva, AMN; Kong, X; Parkin, MC; Cammack, R; Hider, RC. 2009. Iron(III) citrate speciation in aqueous solution. DALTON TRANSACTIONS, 8616-8625. DOI: 10.1039/b910970f
Carrascal, MA; Silva, M; Ferreira, JA; Azevedo, R; Ferreira, D; Silva, AMN; Ligeiro, D; Santos, LL; Sackstein, R; Videira, PA. 2018. A functional glycoproteomics approach identifies CD13 as a novel E-selectin ligand in breast. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1862(9), 2069-2080. DOI: 10.1016/j.bbagen.2018.05.013
Nuno M. M. Moura; Marco Esteves; Cátia Vieira; Graça M. S. R. O. Rocha; M. Amparo F. Faustino; Adelaide Almeida; José A. S. Cavaleiro; Carlos Lodeiro; M. Graça P. M. S. Neves. 2019. Novel β-functionalized mono-charged porphyrinic derivatives: Synthesis and photoinactivation of Escherichia coli. DYES AND PIGMENTS, 160, 361-371. DOI: 10.1016/j.dyepig.2018.06.048
Vera LMSilva. 2012. Avanços na síntese química: síntese assistida por microondas. QUIMICA NOVA. DOI:
Raquel S. G. R. Seixas, Vera L. M. Silva, Artur M. S. Silva. 2015. Metal-Catalysed Cross-Coupling reactions in the synthesis and transformations of quinolones and acridones" In Synthesis and Modification of Heterocycles by Metal-Catalysed Cross-Coupling Reactions, Topics in Heterocyclic Chemistry, Springer, 2015, In. Topics in heterocyclic chemistry, 45, 159-230. DOI:
Pinto, J; Silva, VLM; Silva, AMG; Silva, AMS; Costa, JCS; Santos, LMNBF; Enes, R; Cavaleiro, JAS; Vicente, AAMOS; Teixeira, JAC. 2013. Erratum: Ohmic heating as a new efficient process for organic synthesis in water (Green Chemistry (2013) 15 (970-975) DOI: 10.1039/c3gc36881e). GREEN CHEMISTRY, 15(12). DOI: 10.1039/c3gc90046k
Lévai, A; Silva, AMS; Cavaleiro, JAS; Patonay, A; Silva, VLM. 2001. Dimethyldioxirane oxidation of (E,E)-cinnamylideneacetophenones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 3213-3219. DOI:
Silva, AMS; Alkorta, I; Elguero, J; Silva, VLM. 2001. A 13C NMR study of the structure of four cinnamic acids and their methyl esters. JOURNAL OF MOLECULAR STRUCTURE, 595(1-3), 1-6. DOI: 10.1016/S0022-2860(01)00486-0
Silva, VLM; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS; Patonay, T. 2004. Condensation of chromone-3-carboxaldehyde with phenylacetic acids: An efficient synthesis of (E)-3-styrylchromones. SYNLETT, 2717-2720. DOI: 10.1055/s-2004-835660
Silva, VLM; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS; Elguero, J. 2004. 3(5)-(2-Hydroxyphenyl)-5(3)-styrylpyrazoles: Synthesis and diels - Alder transformations. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 4348-4356. DOI: 10.1002/ejoc.200400407
Silva, VLM; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS. 2006. Efficient microwave-assisted synthesis of tetrahydroindazoles and their oxidation to indazoles. SYNLETT, 1369-1373. DOI: 10.1055/s-2006-939715
Silva, VLM; Silva, AMS; Pinto, DCGA; Jagerovic, N; Callado, LF; Cavaleiro, JAS; Elguero, J. 2007. Synthesis and pharmacological evaluation of chlorinated N-alkyl-3- and -5-(2-hydroxyphenyl)pyrazoles as CB 1 cannabinoid ligands. MONATSHEFTE FUR CHEMIE, 138(8), 797-811. DOI: 10.1007/s00706-007-0676-4
Silva, VLM; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS; Elguero, J. 2007. Novel (E)- and (Z)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles from (E)- and (Z)-3-styrylchromones: the unexpected case of (E)-3(5)-(2-hydroxyphenyl)-4-(4-nitrostyryl)pyrazoles. TETRAHEDRON LETTERS, 48(22), 3859-3862. DOI: 10.1016/j.tetlet.2007.03.147
Almeida, AIS; Silva, VLM; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS. 2008. Syntheses of novel (E)-N-methyl-2-styryl-4-quinolones. SYNLETT, 2593-2596. DOI: 10.1055/s-0028-1083530
Silva, VLM; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS; Vasas, A; Patonay, T. 2008. Syntheses of (E)- and (Z)-3-styrylchromones. MONATSHEFTE FUR CHEMIE, 139(11), 1307-1315. DOI: 10.1007/s00706-008-0926-0
Silva, VLM; Silva, AMS; Pinto, DCGA; Elguero, J; Cavaleiro, JAS. 2009. Synthesis of new 1H-indazoles through Diels-Alder transformations of 4-styrylpyrazoles under microwave irradiation conditions. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 4468-4479. DOI: 10.1002/ejoc.200900513
Silva, VLM; Silva, AMS; Pinto, DCGA; Rodríguez, P; Gómez, M; Jagerovic, N; Callado, LF; Cavaleiro, JAS; Elguero, J; Fernández-Ruizb, J. 2010. Synthesis and pharmacological evaluation of new (E)- and (Z)-3-aryl-4-styryl-1H-pyrazoles as potential cannabinoid ligands. ARKIVOC, 2010(10), 226-247. DOI:
Almeida, AIS; Silva, VLM; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS. 2012. Diels-alder reactions of (E)-2-styrylquinolin-4(1H)-ones with N-methylmaleimide: New syntheses of acridin-9(10H)-ones. SYNLETT, 23(6), 889-892. DOI: 10.1055/s-0031-1290600
Silva, AMS; Silva, VLM; Claramunt, RM; María, DS; Ferraro, MB; Reviriego, F; Alkorta, I; Elguero, J. 2013. The structures of two aldazines: [1,1′-(1E,1′E)-hydrazine-1,2- diylidenebis(methan-1-yl-1-ylidene)dinaphthalen-2-ol] (Lumogen) and 2,2′-(1E,1′E)-hydrazine-1,2-diylidenebis(methan-1-yl-1-ylidene) diphenol (salicylaldazine) in the solid state a. MAGNETIC RESONANCE IN CHEMISTRY, 51(9), 530-540. DOI: 10.1002/mrc.3983
Pinto, J; Silva, VLM; Silva, AMS; Claramunt, RM; Sanz, D; Torralba, MC; Torres, MR; Reviriego, F; Alkorta, I; Elguero, J. 2013. The structure of azines derived from C-formyl-1H-imidazoles in solution and in the solid state: Tautomerism, configurational and conformational studies. MAGNETIC RESONANCE IN CHEMISTRY, 51(4), 203-221. DOI: 10.1002/mrc.3926
Ferreira, JPA; Silva, VLM; Elguero, J; Silva, AMS. 2013. Synthesis of new pyrazole-1,2,3-triazole dyads. TETRAHEDRON LETTERS, 54(39), 5391-5394. DOI: 10.1016/j.tetlet.2013.07.120
Ferreira, JPA; Silva, VLM; Elguero, J; Silva, AMS. 2013. (E)-3-Halo-2-styryl-4H-chromen-4-ones: Synthesis and transformation to novel pyrazoles. TETRAHEDRON, 69(46), 9701-9709. DOI: 10.1016/j.tet.2013.09.028
Silva, VLM; Silva, AMS. 2014. New synthetic methods for 2,3-diarylacridin-9(10H)-one and (E)-2-aryl-4-styrylfuro[3,2-c]quinoline derivatives. TETRAHEDRON, 70(34), 5310-5320. DOI: 10.1016/j.tet.2014.05.040
Pires, Sonia MG; De Paula, Rodrigo; Simoes, Mario MQ; Neves, MGraca PMS; Santos, Isabel CMS; Tome, Augusto C; Cavaleiro, Jose AS. 2009. A new silica-supported manganese chlorin as a biomimetic oxidation catalyst. CATALYSIS COMMUNICATIONS, 11(1), 24-28. DOI: 10.1016/j.catcom.2009.08.004
Simoes, Mario MQ; Neves, Claudia MB; Pires, Sonia MG; Neves, MGraca PMS; Cavaleiro, Jose AS. 2013. Mimicking P-450 processes and the use of metalloporphyrins. PURE AND APPLIED CHEMISTRY, 85(8), 1671-1681. DOI: 10.1351/PAC-CON-12-11-15
Pires, Sonia MG; De Paula, Rodrigo; Simoes, Mario MQ; Silva, Artur MS; Domingues, MRosario M; Santos, Isabel CMS; Vargas, Maria D; Ferreira, Vitor F; Neves, MGraca PMS; Cavaleiro, Jose AS. 2011. Novel biomimetic oxidation of lapachol with H2O2 catalysed by a manganese(III) porphyrin complex. RSC Advances, 1(7), 1195-1199. DOI: 10.1039/c1ra00578b
Ferreira, Jose AB; Serra, Vanda V; Sanchez-Coronilla, Antonio; Pires, Sonia MG; Faustino, Maria AF; Silva, Artur MS; Neves, Maria GPMS; Cavaleiro, Jose AS; Costa, Silvia MB. 2013. The Near-Mid-IR HOMO-LUMO gap in amide linked porphyrin-rhodamine dyads. CHEMICAL COMMUNICATIONS, 49(78), 8809-8811. DOI: 10.1039/c3cc44925d
Goncalves, Gil AB; Pires, Sonia MG; Simoes, Mario MQ; Neves, MGraca PMS; Marques, Paula AAP. 2014. Three-dimensional graphene oxide: a promising green and sustainable catalyst for oxidation reactions at room temperature. CHEMICAL COMMUNICATIONS, 50(57), 7673-7676. DOI: 10.1039/c4cc02092h
Mesquita, Mariana Q; Menezes, Jose CJMDS; Pires, Sonia MG; Neves, Maria GPMS; Simoes, Mario MQ; Tome, Augusto C; Cavaleiro, Jose AS; Cunha, Angela; Daniel-da-Silva, Ana L; Almeida, Adelaide; Faustino, MAmparo F. 2014. Pyrrolidine-fused chlorin photosensitizer immobilized on solid supports for the photoinactivation of Gram negative bacteria. DYES AND PIGMENTS, 110, 123-133. DOI: 10.1016/j.dyepig.2014.04.025
T A. G. Duarte, Sónia M. G. Pires, Isabel C. M. S. Santos, Mário M. Q. Simões, M. Graça P. M. S. Neves, Ana M. V. Cavaleiro, José A. S. Cavaleiro. 2016. A Mn(III) Polyoxotungstate in the Oxidation of Organosulfur Compounds by H2O2 at Room Temperature: An Environmentally Safe Catalytic Approach. Catalysis Science & Technology, 6(9), 3271-. DOI: 10.1039/C5CY01564B
Silva, VLM; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS; Elguero, J. 2009. Synthesis of (E)- and (Z)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles. MONATSHEFTE FUR CHEMIE, 140(1), 87-95. DOI: 10.1007/s00706-008-0002-9
J. Marques, V. L. M. Silva, A. M. S. Silva, M. P. M. Marques, S. S. Braga. 2014. Ru(II) trithiacyclononane 5-(2-hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole], a complex with facile synthesis and high cytotoxicity against PC-3 and MDA-MB-231 cells. Complex Metals, 1(1), 7-12. DOI:
Clementina M. M. Santos, Vera L. M. Silva, Artur M. S. Silva. 2017. Synthesis of Chromone-Related Pyrazole Compounds. MOLECULES, 22(10), 1665-. DOI: 10.3390/molecules22101665
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Goreti Silva, S; Fernandes, RF; Marques, EF; Do Vale, MLC. 2012. Serine-based bis-quat gemini surfactants: Synthesis and micellization properties. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 345-352. DOI: 10.1002/ejoc.201101118
Sousa, CAD; Rizzo-Aguiar, F; Vale, MLC; García-Mera, X; Caamaño, O; Rodríguez-Borges, JE. 2012. A route to selective functionalization of polyhydroxypyrrolidines. TETRAHEDRON LETTERS, 53(9), 1029-1032. DOI: 10.1016/j.tetlet.2011.12.037
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Lima, LMC; Giannotti, MI; Redondo-Morata, L; Vale, MLC; Marques, EF; Sanz, F. 2013. Morphological and nanomechanical behavior of supported lipid bilayers on addition of cationic surfactants. LANGMUIR, 29(30), 9352-9361. DOI: 10.1021/la400067n
García-Mera, X; Alves, MJ; Goth, A; Do Vale, ML; Rodríguez-Borges, JE. 2013. Highly stereoselective cycloadditions of Danishefsky's diene to (-)-8-phenylmenthyl and (+)-8-phenylneomenthyl glyoxylate N-phenylethylimines. TETRAHEDRON, 69(14), 2909-2919. DOI: 10.1016/j.tet.2013.02.027
Silva, SG; Oliveira, IS; Do Vale, MLC; Marques, EF. 2014. Serine-based gemini surfactants with different spacer linkages: From self-assembly to DNA compaction. Soft Matter, 10(46), 9352-9361. DOI: 10.1039/c4sm01771d
Silva, SG; Vale, MLCD; Marques, EF. 2015. Size, charge, and stability of fully serine-based catanionic vesicles: Towards versatile biocompatible nanocarriers. CHEMISTRY-A EUROPEAN JOURNAL. DOI: 10.1002/chem.201406111
Cardoso, AM; Morais, CM; Cruz, AR; Cardoso, AL; Silva, SG; Do Vale, ML; Marques, EF; Pedroso De Lima, MC; Jurado, AS. 2015. Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression. MOLECULAR PHARMACEUTICS, 12(3), 716-730. DOI: 10.1021/mp5005349
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Pinho, D; Gomes, P; Freire, C; De Castro, B. 2001. Ground state modulation in nickel(III) chemistry by controlling axial ligation in complexes with N3O2 pentadentate ligands. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 1483-1493. DOI:
Gomes, P; Giralt, E; Andreu, D; Ochoa, W; Verdaguer, N. 2002. Probing degeneracy in antigen-antibody recognition at the immunodominant site of foot-and-mouth disease virus. International Journal of Peptide Research and Therapeutics, 59(5), 221-231. DOI: 10.1034/j.1399-3011.2002.01959.x
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Gomes, P; Giralt, E; Andreu, D. 2000. Direct single-step surface plasmon resonance analysis of interactions between small peptides and immobilized monoclonal antibodies. JOURNAL OF IMMUNOLOGICAL METHODS, 235(1-2), 101-111. DOI: 10.1016/S0022-1759(99)00218-5
Ochoa, WF; Kalko, SG; Mateu, MG; Gomes, P; Andreu, D; Domingo, E; Fita, I; Verdaguer, N. 2000. A multiply substituted G-H loop from foot-and-mouth disease virus in complex with a neutralizing antibody: A role for water molecules. JOURNAL OF GENERAL VIROLOGY, 81(6), 1495-1505. DOI:
Blanco, E; Garcia-Briones, M; Sanz-Parra, A; Gomes, P; De Oliveira, E; Luz Valero, M; Andreu, D; Ley, V; Sobrino, F. 2001. Identification of T-cell epitopes in nonstructural proteins of foot-and-mouth disease virus. JOURNAL OF VIROLOGY, 75(7), 3164-3174. DOI: 10.1128/JVI.75.7.3164-3174.2001
Gomes, P; Giralt, E; Andreu, D. 2001. Antigenicity modulation upon peptide cyclization: Application to the GH loop of foot-and-mouth disease virus strain C1-Barcelona. VACCINE, 19(25-26), 3459-3466. DOI: 10.1016/S0264-410X(01)00047-0
Gomes, P; Andreu, D. 2002. Direct kinetic assay of interactions between small peptides and immobilized antibodies using a surface plasmon resonance biosensor. JOURNAL OF IMMUNOLOGICAL METHODS, 259(1-2), 217-230. DOI: 10.1016/S0022-1759(01)00503-8
Gomes, P; Santos, MI; Trigo, MJ; Castanheiro, R; Moreira, R. 2003. Improved synthesis of amino acid and dipeptide chloromethyl esters using bromochloromethane. SYNTHETIC COMMUNICATIONS, 33(10), 1683-1693. DOI: 10.1081/SCC-120018930
Gomes, P; Gomes, JRB; Rodrigues, M; Moreira, R. 2003. Amino acids as selective sulfonamide acylating agents. TETRAHEDRON, 59(38), 7473-7480. DOI: 10.1016/S0040-4020(03)01206-7
Gomes, P; Araújo, MJ; Rodrigues, M; Vale, N; Azevedo, Z; Iley, J; Chambel, P; Morais, J; Moreira, R. 2004. Synthesis of imidazolidin-4-one and 1H-imidazo[2,1-a]isoindole-2,5(3H,9bH)- dione derivatives of primaquine: Scope and limitations. TETRAHEDRON, 60(26), 5551-5562. DOI: 10.1016/j.tet.2004.04.077
Escribano-Romero, E; Jimenez-Clavero, MA; Gomes, P; García, JA; Ley, V. 2004. Heparan sulphate mediates swine vesicular disease virus attachment to the host cell. JOURNAL OF GENERAL VIROLOGY, 85(3), 653-663. DOI: 10.1099/vir.0.19603-0
Abrunhosa, F; Faria, S; Gomes, P; Tomaz, I; Pessoa, JC; Andreu, D; Bastos, M. 2005. Interaction and lipid-induced conformation of two cecropin-melittin hybrid peptides depend on peptide and membrane composition. JOURNAL OF PHYSICAL CHEMISTRY B, 109(36), 17311-17319. DOI: 10.1021/jp051572e
Araújo, MJ; Bom, J; Capela, R; Casimiro, C; Chambel, P; Gomes, P; Iley, J; Lopes, F; Morais, J; Moreira, R; De Oliveira, E; Do Rosário, V; Vale, N. 2005. Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials. JOURNAL OF MEDICINAL CHEMISTRY, 48(3), 888-892. DOI: 10.1021/jm0494624
Gomes, JRB; Gomes, P. 2005. Gas-phase acidity of sulfonamides: Implications for reactivity and prodrug design. TETRAHEDRON, 61(10), 2705-2712. DOI: 10.1016/j.tet.2005.01.034
Gomes, JRB; Sousa, EA; Gonçalves, JM; Monte, MJS; Gomes, P; Pandey, S; Acree Jr, WE; Da Silva, MDMCR. 2005. Energetics of the N-O bonds in 2-hydroxyphenazine-di-N-oxide. JOURNAL OF PHYSICAL CHEMISTRY B, 109(33), 16188-16195. DOI: 10.1021/jp051350g
Santos, C; Mateus, ML; Dos Santos, AP; Moreira, R; De Oliveira, E; Gomes, P. 2005. Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol. Bioorganic and Medicinal Chemistry Letters, 15(6), 1595-1598. DOI: 10.1016/j.bmcl.2005.01.065
Brito, RO; Marques, EF; Gomes, P; Falcão, S; Söderman, O. 2006. Self-assembly in a catanionic mixture with an aminoacid-derived surfactant: From mixed micelles to spontaneous vesicles. JOURNAL OF PHYSICAL CHEMISTRY B, 110(37), 18158-18165. DOI: 10.1021/jp061946j
Chambel, P; Capela, R; Lopes, F; Iley, J; Morais, J; Gouveia, L; Gomes, JRB; Gomes, P; Moreira, R. 2006. Reactivity of imidazolidin-4-one derivatives of primaquine: implications for prodrug design. TETRAHEDRON, 62(42), 9883-9891. DOI: 10.1016/j.tet.2006.08.026
Batista, MKS; Pinto, LF; Gomes, CAR; Gomes, P. 2006. Novel highly-soluble peptide-chitosan polymers: Chemical synthesis and spectral characterization. CARBOHYDRATE POLYMERS, 64(2), 299-305. DOI: 10.1016/j.carbpol.2005.11.040
Middendorf, HD; Alves, N; Zanotti, J-M; Gomes, P; Bastos, M. 2006. Dynamics of an antibiotic oligopeptide. PHYSICA B-CONDENSED MATTER, 385-386, 874-876. DOI: 10.1016/j.physb.2006.05.131
Ribeiro Da Silva, MAV; Cabral, JITA; Gomes, P; Gomes, JRB. 2006. Combined experimental and computational study of the thermochemistry of methylpiperidines. JOURNAL OF ORGANIC CHEMISTRY, 71(10), 3677-3685. DOI: 10.1021/jo052468w
Gomes, JRB; Sousa, EA; Gomes, P; Vale, N; Gonçalves, JM; Pandey, S; Acree Jr, WE; Ribeiro Da Silva, MDMC. 2007. Thermochemical studies on 3-methyl-quinoxaline-2-carboxamide-1,4-dioxide derivatives: Enthalpies of formation and of N-O bond dissociation. JOURNAL OF PHYSICAL CHEMISTRY B, 111(8), 2075-2080. DOI: 10.1021/jp067818c
Gomes, JRB; Sousa, EA; Gonçalves, JM; Gales, L; Damas, AM; Gomes, P; Pandey, S; Acree Jr, WE; Da Silva, MDMCR. 2007. Energetic and structural characterization of 2-R-3-methylquinoxaline-1,4- dioxides (R = benzoyl or tert-butoxycarbonyl): Experimental and computational studies. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 20(7), 491-498. DOI: 10.1002/poc.1184
Gomes, P; Vale, N; Moreira, R. 2007. Cyclization-activated prodrugs. MOLECULES, 12(11), 2484-2506. DOI: 10.3390/12112484
Gomes, P; Gomes, CAR; Batista, MKS; Pinto, LF; Silva, PAP. 2008. Synthesis, structural characterization and properties of water-soluble N-(γ-propanoyl-amino acid)-chitosans. CARBOHYDRATE POLYMERS, 71(1), 54-65. DOI: 10.1016/j.carbpol.2007.05.015
Brito, RO; Marques, EF; Gomes, P; Araújo, MJ; Pons, R. 2008. Structure/property relationships for the thermotropic behavior of lysine-based amphiphiles: From hexagonal to smectic phases. JOURNAL OF PHYSICAL CHEMISTRY B, 112(47), 14877-14887. DOI: 10.1021/jp8042494
Gomes, P; Araújo, MJ; Marques, EF; Falcão, S; Brito, RO. 2008. Straightforward method for the preparation of lysine-based double-chained anionic surfactants. SYNTHETIC COMMUNICATIONS, 38(12), 2025-2036. DOI: 10.1080/00397910801997827
Marques, EF; Brito, RO; Silva, SG; Enrique Rodríguez-Borges, J; Vale, MLD; Gomes, P; Araújo, MJ; Söderman, O. 2008. Spontaneous vesicle formation in catanionic mixtures of amino acid-based surfactants: Chain length symmetry effects. LANGMUIR, 24(19), 11009-11017. DOI: 10.1021/la801518h
Trabulo, S; Mano, M; Faneca, H; Cardoso, AL; Duarte, S; Henriques, A; Paiva, A; Gomes, P; Simões, S; Pedroso de Lima, MC. 2008. S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA. JOURNAL OF GENE MEDICINE, 10(11), 1210-1222. DOI: 10.1002/jgm.1247
Adäo, R; Seixas, R; Gomes, P; Pessoa, JC; Bastos, M. 2008. Membrane structure and interactions of a short Lycotoxin I analogue. JOURNAL OF PEPTIDE SCIENCE, 14(4), 528-534. DOI: 10.1002/psc.993
Raposinho, PD; Xavier, C; Correia, JDG; Falcão, S; Gomes, P; Santos, I. 2008. Melanoma targeting with α-melanocyte stimulating hormone analogs labeled with fac-[99mTc(CO)3]+: Effect of cyclization on tumor-seeking properties. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 13(3), 449-459. DOI: 10.1007/s00775-007-0338-3
Vale, N; Matos, J; Gut, J; Nogueira, F; do Rosário, V; Rosenthal, PJ; Moreira, R; Gomes, P. 2008. Imidazolidin-4-one peptidomimetic derivatives of primaquine: Synthesis and antimalarial activity. Bioorganic and Medicinal Chemistry Letters, 18(14), 4150-4153. DOI: 10.1016/j.bmcl.2008.05.076
Bastos, M; Bai, G; Gomes, P; Andreu, D; Goormaghtigh, E; Prieto, M. 2008. Energetics and partition of two cecropin-melittin hybrid peptides to model membranes of different composition. BIOPHYSICAL JOURNAL, 94(6), 2128-2141. DOI: 10.1529/biophysj.107.119032
Vale, N; Matos, J; Moreira, R; Gomes, P. 2008. Electrospray Ionization-Ion Trap Mass Spectrometry Study of PQAAPro and PQProAA Mimetic Derivatives of the Antimalarial Primaquine. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 19(10), 1476-1490. DOI: 10.1016/j.jasms.2008.06.019
Santos, C; Morais, J; Gouveia, L; De Clercq, E; Pannecouque, C; Nielsen, CU; Steffansen, B; Moreira, R; Gomes, P. 2008. Dipeptide derivatives of AZT: Synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity. ChemMedChem, 3(6), 970-978. DOI: 10.1002/cmdc.200800012
Valldosera, M; Monsò, M; Xavier, C; Raposinho, P; Correia, JDG; Santos, I; Gomes, P. 2008. Comparative study of chemical approaches to the solid-phase synthesis of a tumor-seeking α-MSH analogue. International Journal of Peptide Research and Therapeutics, 14(3), 273-281. DOI: 10.1007/s10989-008-9143-2
Vale, N; Moreira, R; Gomes, P. 2008. Characterization of primaquine imidazolidin-4-ones with antimalarial activity by electrospray ionization-ion trap mass spectrometry. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 270(1-2), 81-93. DOI: 10.1016/j.ijms.2007.12.006
Vale, N; Matos, J; Moreira, R; Gomes, P. 2008. Amino acids as selective acylating agents: regioselective N1-acylation of imidazolidin-4-one derivatives of the antimalarial drug primaquine. TETRAHEDRON, 64(49), 11144-11149. DOI: 10.1016/j.tet.2008.09.058
Fernandes, I; Vale, N; de Freitas, V; Moreira, R; Mateus, N; Gomes, P. 2009. Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine. Bioorganic and Medicinal Chemistry Letters, 19(24), 6914-6917. DOI: 10.1016/j.bmcl.2009.10.081
Gomes, JRB; Monteiro, AR; Campos, BB; Gomes, P; Ribeiro Da Silva, MDMC. 2009. The enthalpies of dissociation of the N-O bonds in two quinoxaline derivatives. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 22(1), 17-23. DOI: 10.1002/poc.1419
Santos, CR; Capela, R; Pereira, CSGP; Valente, E; Gouveia, L; Pannecouque, C; De Clercq, E; Moreira, R; Gomes, P. 2009. Structure-activity relationships for dipeptide prodrugs of acyclovir: Implications for prodrug design. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 44(6), 2339-2346. DOI: 10.1016/j.ejmech.2008.08.009
Marques, F; Gano, L; Batista, MKS; Gomes, CAR; Gomes, P; Santos, I. 2009. Radiochemical and biological evaluation of novel 153Sm/ 166Ho-amino acid-chitosan complexes. Journal of Labelled Compounds and Radiopharmaceuticals, 52(3), 79-83. DOI: 10.1002/jlcr.1571
Vale, N; Moreira, R; Gomes, P. 2009. Primaquine revisited six decades after its discovery. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 44(3), 937-953. DOI: 10.1016/j.ejmech.2008.08.011
Vale, N; Nogueira, F; do Rosário, VE; Gomes, P; Moreira, R. 2009. Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 44(6), 2506-2516. DOI: 10.1016/j.ejmech.2009.01.018
Brito, RO; Marques, EF; Silva, SG; do Vale, ML; Gomes, P; Araújo, MJ; Rodriguez-Borges, JE; Infante, MR; Garcia, MT; Ribosa, I; Vinardell, MP; Mitjans, M. 2009. Physicochemical and toxicological properties of novel amino acid-based amphiphiles and their spontaneously formed catanionic vesicles. COLLOIDS AND SURFACES B-BIOINTERFACES, 72(1), 80-87. DOI: 10.1016/j.colsurfb.2009.03.017
Vale, N; Prudêncio, M; Marques, CA; Collins, MS; Gut, J; Nogueira, F; Matos, J; Rosenthal, PJ; Cushion, MT; Do Rosário, VE; Mota, MM; Moreira, R; Gomes, P. 2009. Imidazoquines as antimalarial and antipneumocystis agents. JOURNAL OF MEDICINAL CHEMISTRY, 52(23), 7800-7807. DOI: 10.1021/jm900738c
Batista, MKS; Gallemí, M; Adeva, A; Gomes, CAR; Gomes, P. 2009. Facile regioselective synthesis of a novel chitosan-pexiganan conjugate with potential interest for the treatment of infected skin lesions. SYNTHETIC COMMUNICATIONS, 39(7), 1228-1240. DOI: 10.1080/00397910802517855
Vale, N; Matos, J; Moreira, R; Gomes, P. 2009. Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 15(5), 627-640. DOI: 10.1255/ejms.1011
Botelho, MC; Soares, R; Vale, N; Ribeiro, R; Camilo, V; Almeida, R; Medeiros, R; Gomes, P; Machado, JC; Correia da Costa, JM. 2010. Schistosoma haematobium: Identification of new estrogenic molecules with estradiol antagonistic activity and ability to inactivate estrogen receptor in mammalian cells. EXPERIMENTAL PARASITOLOGY, 126(4), 526-535. DOI: 10.1016/j.exppara.2010.06.012
Matos, J; Vale, N; Collins, MS; Gut, J; Rosenthal, PJ; Cushion, MT; Moreira, R; Gomes, P. 2010. PRIMACENES: Novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity. MedChemComm, 1(3), 199-201. DOI: 10.1039/c0md00082e
Teixeira, C; Gomes, JRB; Couesnon, T; Gomes, P. 2011. Molecular docking and 3D-quantitative structure activity relationship analyses of peptidyl vinyl sulfones: Plasmodium Falciparum cysteine proteases inhibitors. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 25(8), 763-775. DOI: 10.1007/s10822-011-9459-4
Teixeira, C; Gomes, JRB; Gomes, P. 2011. Falcipains, plasmodium falciparum cysteine proteases as key drug targets against malaria. CURRENT MEDICINAL CHEMISTRY, 18(10), 1555-1572. DOI: 10.2174/092986711795328328
Costa, F; Maia, S; Gomes, P; Martins, MCL. 2011. Covalent immobilization of human lactoferrin-derived peptide (hLF1-11) for the development of an antimicrobial surface. 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials. DOI:
Teixeira, C; Gomes, JRB; Gomes, P; Maurel, F. 2011. Erratum: Viral surface glycoproteins, Gp120 and Gp41, as potential drug targets against HIV-1: Brief overview one quarter of a century past the approval of zidovudine, the first anti-retroviral drug (European Journal of Medicinal Chemistry (2011) 46 . EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 46(8). DOI: 10.1016/j.ejmech.2011.03.042
Costa, F; Carvalho, IF; Montelaro, RC; Gomes, P; Martins, MCL. 2011. Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces. Acta Biomaterialia, 7(4), 1431-1440. DOI: 10.1016/j.actbio.2010.11.005
Oliveira, JR; Martins, MCL; Mafra, L; Gomes, P. 2012. Synthesis of an O-alkynyl-chitosan and its chemoselective conjugation with a PEG-like amino-azide through click chemistry. CARBOHYDRATE POLYMERS, 87(1), 240-249. DOI: 10.1016/j.carbpol.2011.07.043
Viveiros, MLF; Freitas, VLS; Vale, N; Gomes, JRB; Gomes, P; Da Silva, MDMCR. 2012. Synthesis and thermochemical study of quinoxaline-N-oxides: Enthalpies of dissociation of the N-O bond. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 25(5), 420-426. DOI: 10.1002/poc.1932
Vale-Costa, S; Vale, N; Matos, J; Tomás, A; Moreira, R; Gomes, P; Gomes, MS. 2012. Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(11), 5774-5781. DOI: 10.1128/AAC.00873-12
Pérez, B; Teixeira, C; Albuquerque, IS; Gut, J; Rosenthal, PJ; Prudêncio, M; Gomes, P. 2012. PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity. MedChemComm, 3(9), 1170-1172. DOI: 10.1039/c2md20113e
Matos, J; Da Cruz, FP; Cabrita, É; Gut, J; Nogueira, F; Do Rosário, VE; Moreira, R; Rosenthal, PJ; Prudêncio, M; Gomes, P. 2012. Novel potent metallocenes against liver stage malaria. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(3), 1564-1570. DOI: 10.1128/AAC.05345-11
Pérez, BC; Teixeira, C; Figueiras, M; Gut, J; Rosenthal, PJ; Gomes, JRB; Gomes, P. 2012. Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 54, 887-899. DOI: 10.1016/j.ejmech.2012.05.022
Vale, N; Mäkilä, E; Salonen, J; Gomes, P; Hirvonen, J; Santos, HA. 2012. New times, new trends for ethionamide: In vitro evaluation of drug-loaded thermally carbonized porous silicon microparticles. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 81(2), 314-323. DOI: 10.1016/j.ejpb.2012.02.017
Vale, N; Fernandes, I; Moreira, R; Mateus, N; Gomes, P. 2012. Comparative analysis of in vitro rat liver metabolism of the antimalarial primaquine and a derived imidazoquine. Drug Metabolism Letters, 6(1), 15-25. DOI:
Pérez, B; Teixeira, C; Gut, J; Rosenthal, PJ; Gomes, JRB; Gomes, P. 2012. Cinnamic Acid/Chloroquinoline Conjugates as Potent Agents against Chloroquine-Resistant Plasmodium falciparum. ChemMedChem, 7(9), 1537-1540. DOI: 10.1002/cmdc.201200257
Vale, N; Gouveia, MJ; Botelho, M; Sripa, B; Suttiprapa, S; Rinaldi, G; Gomes, P; Brindley, PJ; Correia da Costa, JM. 2013. Carcinogenic liver fluke Opisthorchis viverrini oxysterols detected by LC-MS/MS survey of soluble fraction parasite extract. PARASITOLOGY INTERNATIONAL, 62(6), 535-542. DOI: 10.1016/j.parint.2013.08.001
Botelho, MC; Vale, N; Gouveia, MJ; Rinaldi, G; Santos, J; Santos, LL; Gomes, P; Brindley, PJ; Correia da Costa, JM. 2013. Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haematobium: An oestrogen-DNA adducts mediated pathway?. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 43(1), 17-26. DOI: 10.1016/j.ijpara.2012.10.023
Pérez, B; Antunes, S; Gonçalves, LM; Domingos, A; Gomes, JRB; Gomes, P; Teixeira, C. 2013. Toward the discovery of inhibitors of babesipain-1, a Babesia bigemina cysteine protease: In vitro evaluation, homology modeling and molecular docking studies. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 27(9), 823-835. DOI: 10.1007/s10822-013-9682-2
Pérez, BC; Fernandes, I; Mateus, N; Teixeira, C; Gomes, P. 2013. Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues. Bioorganic and Medicinal Chemistry Letters, 23(24), 6769-6772. DOI: 10.1016/j.bmcl.2013.10.025
Vale-Costa, S; Costa-Gouveia, J; Pérez, B; Silva, T; Teixeira, C; Gomes, P; Gomes, MS. 2013. N-cinnamoylated aminoquinolines as promising antileishmanial agents. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(10), 5112-5115. DOI: 10.1128/AAC.00557-13
Pérez, BC; Teixeira, C; Albuquerque, IS; Gut, J; Rosenthal, PJ; Gomes, JRB; Prudeîncio, M; Gomes, P. 2013. N-Cinnamoylated chloroquine analogues as dual-stage antimalarial leads. JOURNAL OF MEDICINAL CHEMISTRY, 56(2), 556-567. DOI: 10.1021/jm301654b
Vale, N; Gomes, P; Santos, HA. 2013. Metabolism of the antituberculosis drug ethionamide. CURRENT DRUG METABOLISM, 14(1), 151-158. DOI:
Gouveia, MJ; Brindley, PJ; Santos, LL; Correia Da Costa, JM; Gomes, P; Vale, N. 2013. Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review. METABOLISM-CLINICAL AND EXPERIMENTAL, 62(9), 1206-1217. DOI: 10.1016/j.metabol.2013.04.003
Pérez, B; Teixeira, C; Gomes, AS; Albuquerque, IS; Gut, J; Rosenthal, PJ; Prudêncio, M; Gomes, P. 2013. In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites. Bioorganic and Medicinal Chemistry Letters, 23(3), 610-613. DOI: 10.1016/j.bmcl.2012.12.032
Kadhirvel, P; Azenha, M; Shinde, S; Schillinger, E; Gomes, P; Sellergren, B; Silva, AF. 2013. Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen: Comparison of acrylic and sol-gel approaches. JOURNAL OF CHROMATOGRAPHY A, 1314, 115-123. DOI: 10.1016/j.chroma.2013.09.015
Bastos, M; Alves, N; Maia, S; Gomes, P; Inaba, A; Miyazaki, Y; Zanotti, J-M. 2013. Hydration water and peptide dynamics-two sides of a coin. A neutron scattering and adiabatic calorimetry study at low hydration and cryogenic temperatures. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 15(39), 16693-16703. DOI: 10.1039/c3cp51937f
Silva, ALR; Cimas, Á; Vale, N; Gomes, P; Monte, MJS; Ribeiro Da Silva, MDMC. 2013. Experimental and computational study of the energetics of hydantoin and 2-thiohydantoin. JOURNAL OF CHEMICAL THERMODYNAMICS, 58, 158-165. DOI: 10.1016/j.jct.2012.10.010
Perez, B; Teixeira, C; Gomes, JRB; Gomes, P. 2013. Development of plasmodium falciparum protease inhibitors in the past decade (2002-2012). CURRENT MEDICINAL CHEMISTRY, 20(25), 3049-3068. DOI: 10.2174/0929867311320250003
Gomes, JRB; Fajín, JLC; Cordeiro, MNDS; Teixeira, C; Gomes, P; Pillai, RS; Novell-Leruth, G; Toda, J; Jorge, M. 2013. Density functional treatment of interactions and chemical reactions at interfaces. Density Functional Theory: Principles, Applications and Analysis, 1-58. DOI:
Cardoso, AM; Trabulo, S; Cardoso, AL; Maia, S; Gomes, P; Jurado, AS; Pedroso De Lima, MC. 2013. Comparison of the efficiency of complexes based on S413-PV cell-penetrating peptides in plasmid DNA and siRNA delivery. MOLECULAR PHARMACEUTICS, 10(7), 2653-2666. DOI: 10.1021/mp400078h
Santos, J; Gouveia, MJ; Vale, N; De Lurdes Delgado, M; Gonçalves, A; Da Silva, JMT; Oliveira, C; Xavier, P; Gomes, P; Santos, LL; Lopes, C; Barros, A; Rinaldi, G; Brindley, PJ; Da Costa, JMC; Sousa, M; Botelho, MC. 2014. Urinary estrogen metabolites and self-reported infertility in women infected with Schistosoma haematobium. PLoS One, 9(5). DOI: 10.1371/journal.pone.0096774
Freitas, SC; Maia, S; Figueiredo, AC; Gomes, P; Pereira, PJB; Barbosa, MA; Martins, MCL. 2014. Selective albumin-binding surfaces modified with a thrombin-inhibiting peptide. Acta Biomaterialia, 10(3), 1227-1237. DOI: 10.1016/j.actbio.2013.11.023
Gomes, A; Prez, B; Albuquerque, I; Machado, M; Prudpncio, M; Nogueira, F; Teixeira, C; Gomes, P. 2014. N-cinnamoylation of antimalarial classics: Quinacrine analogues with decreased toxicity and dual-stage activity. ChemMedChem, 9(2), 305-310. DOI: 10.1002/cmdc.201300459
Silva, T; Magalhães, B; Maia, S; Gomes, P; Nazmi, K; Bolscher, JGM; Rodrigues, PN; Bastos, M; Gomes, MS. 2014. Killing of mycobacterium avium by lactoferricin peptides: Improved activity of arginine- and d-Amino-Acid-containing molecules. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(6), 3461-3467. DOI: 10.1128/AAC.02728-13
Gomes, JRB; Jorge, M; Gomes, P. 2014. Interaction of chitosan and chitin with Ni, Cu and Zn ions: A computational study. JOURNAL OF CHEMICAL THERMODYNAMICS, 73, 121-129. DOI: 10.1016/j.jct.2013.11.016
Costa, F; Maia, S; Gomes, J; Gomes, P; Martins, MCL. 2014. Characterization of hLF1-11 immobilization onto chitosan ultrathin films, and its effects on antimicrobial activity. Acta Biomaterialia, 10(8), 3513-3521. DOI: 10.1016/j.actbio.2014.02.028
Vale, N; Aguiar, L; Gomes, P. 2014. Antimicrobial peptides: A new class of antimalarial drugs?. Frontiers in Pharmacology, 5(DEC). DOI: 10.3389/fphar.2014.00275
Teixeira, C; Vale, N; Pérez, B; Gomes, A; Gomes, JRB; Gomes, P. 2014. "Recycling" classical drugs for malaria. CHEMICAL REVIEWS, 114(22), 11164-11220. DOI: 10.1021/cr500123g
Costa, FMTA; Maia, SR; Gomes, PAC; Martins, MCL. 2015. Dhvar5 antimicrobial peptide (AMP) chemoselective covalent immobilization results on higher antiadherence effect than simple physical adsorption. BIOMATERIALS, 52(1), 531-538. DOI: 10.1016/j.biomaterials.2015.02.049
Kadhirvel, P; Azenha, M; Gomes, P; Silva, AF; Sellergren, B. 2015. Aminoglutethimide-imprinted xerogels in bulk and spherical formats, based on a multifunctional organo-alkoxysilane precursor. JOURNAL OF CHROMATOGRAPHY A, 1424, 59-68. DOI: 10.1016/j.chroma.2015.10.097
Arcanjo, DDR; Vasconcelos, AG; Nascimento, LA; Mafud, AC; Plácido, A; Alves, MMM; Delerue-Matos, C; Bemquerer, MP; Vale, N; Gomes, P; Oliveira, EB; Lima, FCA; Mascarenhas, YP; Carvalho, FAA; Simonsen, U; Ramos, RM; Leite, JRSA. 2017. Structure-function studies of BPP-BrachyNH<inf>2</inf>and synthetic analogues thereof with Angiotensin I-Converting Enzyme. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 139, 401-411. DOI: 10.1016/j.ejmech.2017.08.019
Moles, E; Galiano, S; Gomes, A; Quiliano, M; Teixeira, C; Aldana, I; Gomes, P; Fernàndez-Busquets, X. 2017. ImmunoPEGliposomes for the targeted delivery of novel lipophilic drugs to red blood cells in a falciparum malaria murine model. BIOMATERIALS, 145, 178-191. DOI: 10.1016/j.biomaterials.2017.08.020
Amador, P; Prudencio, C; Vieira, M; Ferraz, R; Fonte, R; Silva, N; Coelho, P; Fernandes, R. 2009. beta-Lactamases in the Biochemistry and Molecular Biology Laboratory. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 37(5), 301-306. DOI: 10.1002/bmb.20324
Vale, N; Collins, MS; Gut, J; Ferraz, R; Rosenthal, PJ; Cushionc, MT; Moreira, R; Gomes, P. 2008. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(2), 485-488. DOI: 10.1016/j.bmcl.2007.11.105
Fernandes, R; Vieira, M; Ferraz, R; Prudencio, C. 2008. Bloodstream infections caused by multidrugresistant Enterobacteriaceae: report from two Portuguese hospitals. JOURNAL OF HOSPITAL INFECTION, 70(1), 93-95. DOI: 10.1016/j.jhin.2008.05.007
Ferraz, R; Gomes, JRB; de Oliveira, E; Moreira, R; Gomes, P. 2007. Unanticipated stereoselectivity in the reaction of primaquine alpha-aminoamides with substituted benzaldehydes: A computational and experimental study. JOURNAL OF ORGANIC CHEMISTRY, 72(11), 4189-4197. DOI: 10.1021/jo0703202
Ivanova, G; Serafim, LS; Lemos, PC; Ramos, AM; Reis, MAM; Cabrita, EJ. 2009. Influence of feeding strategies of mixed microbial cultures on the chemical composition and microstructure of copolyesters P(3HB-co-3HV) analyzed by NMR and statistical analysis. MAGNETIC RESONANCE IN CHEMISTRY, 47(6), 497-504. DOI: 10.1002/mrc.2423
Rangel, Maria; Moniz, Tania; Leite, Andreia; Gameiro, Paula; Ivanova, Galya. 2013. FLUORESCENT IRON CHELATORS WITH ANTIMICROBIAL ACTIVITY: INSIGHT ON STRUCTURE-ACTIVITY RELATIONSHIPS FROM LIPOSOME PARTITION STUDIES. AMERICAN JOURNAL OF HEMATOLOGY, 88(5), E130-E131. DOI:
Camacho, R; Ferreira, R; Rosa, N; Guimaraes, V; Fonseca, NA; Costa, VS; de Sousa, M; Magalhaes, A. 2012. Predicting the secondary structure of proteins using Machine Learning algorithms. International Journal of Data Mining and Bioinformatics, 6, 571-584. DOI: 10.1504/IJDMB.2012.050265
Lopes, S; Simeonova, M; Gameiro, P; Rangel, M; Ivanova, G. 2012. Interaction of 5-Fluorouracil Loaded Nanoparticles with 1,2-Dimyristoyl-sn-glycero-3-phosphocholine Liposomes Used as a Cellular Membrane Model. JOURNAL OF PHYSICAL CHEMISTRY B, 116, 667-675. DOI: 10.1021/jp210088n
Queiros, C; Silva, AMG; Lopes, SC; Ivanova, G; Gameiro, P; Rangel, M. 2012. A novel fluorescein-based dye containing a catechol chelating unit to sense iron(III). DYES AND PIGMENTS, 93, 1447-1455. DOI: 10.1016/j.dyepig.2011.10.010
Markova, N; Ivanova, G; Enchev, V; Simeonova, M. 2012. Tacticity of poly(butyl-alpha-cyanoacrylate) chains in nanoparticles: NMR spectroscopy and DFT calculations. STRUCTURAL CHEMISTRY, 23, 815-824. DOI: 10.1007/s11224-011-9928-3
Campos, S; Silva, A; Pinho, P; Bastos, M; Branco, P; Ferreira, L; Antunes, L. 2012. Potential effects of non-conjugated metabolites of propofol in clinical variables. TOXICOLOGY LETTERS, 211, S56-S57. DOI: 10.1016/j.toxlet.2012.03.224
Peres, I; Rocha, S; Loureiro, JA; Pereira, MD; Ivanova, G; Coelho, M. 2012. Carbohydrate particles as protein carriers and scaffolds: physico-chemical characterization and collagen stability. JOURNAL OF NANOPARTICLE RESEARCH, 14. DOI: 10.1007/s11051-012-1144-6
Chochkova, M; Dimitrova, D; Ivanova, G; Galabov, A; Milkova, T. 2012. Synthesis of new hydroxycinnamoyl oseltamivir amides and evaluation of their antioxidant and antiviral activities. JOURNAL OF PEPTIDE SCIENCE, 18, S157-S157. DOI:
Chochkova, M; Ivanova, G; Galabov, A; Milkova, T. 2012. Amides of antiviral drug oseltamivir with antioxidant active aminoacids: synthesis and biological activities. JOURNAL OF PEPTIDE SCIENCE, 18, S177-S177. DOI:
Cardoso, ICS; Amorim, AL; Queiros, C; Lopes, SC; Gameiro, P; de Castro, B; Rangel, M; Silva, AMG. 2012. Microwave-Assisted Synthesis and Spectroscopic Properties of 4 '-Substituted Rosamine Fluorophores and Naphthyl Analogues. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 5810-5817. DOI: 10.1002/ejoc.201200783
Leite, A; Silva, AMG; Cunha-Silva, L; de Castro, B; Gameiro, P; Rangel, M. 2013. Discrimination of fluorescence light-up effects induced by pH and metal ion chelation on a spirocyclic derivative of rhodamine B. DALTON TRANSACTIONS, 42, 6110-6118. DOI: 10.1039/c2dt32198j
Paiva, D; Ivanova, G; Pereira, MD; Rocha, S. 2013. Chitosan conjugates for DNA delivery. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 15, 11893-11899. DOI: 10.1039/c3cp51215k
Simeonova, M; Rangel, M; Ivanova, G. 2013. NMR study of the supramolecular structure of dual drug-loaded poly(butylcyanoacrylate) nanoparticles. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 15, 16657-16664. DOI: 10.1039/c3cp51471d
Guo, HZ; Liu, X; Xie, QS; Wang, LS; Peng, DL; Branco, PS; Gawande, MB. 2013. Disproportionation route to monodispersed copper nanoparticles for the catalytic synthesis of propargylamines. RSC Advances, 3, 19812-19815. DOI: 10.1039/c3ra43341b
Rangel, M; Moniz, T; Leite, A; Gameiro, P. 2013. Tagging 3-Hydroxy-4-Pyridinone Iron Chelators with Rhodamine B Derivatives is Essential to Target Mycobacterium Avium Infection. BIOPHYSICAL JOURNAL, 104, 251A-251A. DOI:
Moniz, T; Nunes, A; Silva, AMG; Queiros, C; Ivanova, G; Gomes, MS; Rangel, M. 2013. Rhodamine labeling of 3-hydroxy-4-pyridinone iron chelators is an important contribution to target Mycobacterium avium infection. JOURNAL OF INORGANIC BIOCHEMISTRY, 121, 156-166. DOI: 10.1016/j.jinorgbio.2013.01.002
Mesquita, RBR; Suarez, R; Cerda, V; Rangel, M; Rangel, AOSS. 2013. Exploiting the use of 3,4-HPO ligands as nontoxic reagents for the determination of iron in natural waters with a sequential injection approach. TALANTA, 108, 38-45. DOI: 10.1016/j.talanta.2013.02.058
Georgiev, L; Chochkova, M; Totseva, I; Seizova, K; Marinova, E; Ivanova, G; Ninova, M; Najdenski, H; Milkova, T. 2013. Anti-tyrosinase, antioxidant and antimicrobial activities of hydroxycinnamoylamides. MEDICINAL CHEMISTRY RESEARCH, 22, 4173-4182. DOI: 10.1007/s00044-012-0419-x
Arezes, J; Costa, M; Vieira, I; Dias, V; Kong, XL; Fernandes, R; Vos, M; Carlsson, A; Rikers, Y; Porto, G; Rangel, M; Hider, RC; Pinto, JP. 2013. Non-Transferrin-Bound Iron (NTBI) Uptake by T Lymphocytes: Evidence for the Selective Acquisition of Oligomeric Ferric Citrate Species. PLoS One, 8. DOI: 10.1371/journal.pone.0079870
Melo, T; Santos, N; Lopes, D; Alves, E; Maciel, E; Faustino, MAF; Tome, JPC; Neves, MGPMS; Almeida, A; Domingues, P; Segundo, MA; Domingues, MRM. 2013. Photosensitized oxidation of phosphatidylethanolamines monitored by electrospray tandem mass spectrometry. JOURNAL OF MASS SPECTROMETRY, 48, 1357-1365. DOI: 10.1002/jms.3301
Rangel, M; Leite, A; Silva, AMN; Moniz, T; Nunes, A; Amorim, MJ; Queiros, C; Cunha-Silva, L; Gameiro, P; Burgess, J. 2014. Distinctive EPR signals provide an understanding of the affinity of bis-(3-hydroxy-4-pyridinonato) copper(II) complexes for hydrophobic environments. DALTON TRANSACTIONS, 43, 9722-9731. DOI: 10.1039/c4dt00642a
Gouveia, DD; Silva, AMN; Vitorino, R; Domingues, MRM; Domingues, P. 2014. Efficiency of trypsin digestion for mass-spectrometry-based identification and quantification of oxidized proteins: evaluation of the digestion of oxidized bovine serum albumin. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 20, 271-278. DOI: 10.1255/ejms.1279
Passos, MLC; Pereira, M; Saraiva, MLMFS; Rangel, M; Moniz, T; Santos, JLM; Frigerio, C. 2014. Silica nanostructures synthesis and CdTe quantum dots immobilization for photocatalytical applications. RSC Advances, 4, 59697-59705. DOI: 10.1039/c4ra09748c
Sousa, CAD; Maestro, MA; Garcia-Merac, X; Rodriguez-Borges, JE. 2014. Endo-benzonorbornen-2-ol as an efficient non-natural chiral auxiliary in the asymmetric aza-Diels-Alder reactions between cyclopentadiene and (1-phenylethyl)iminoacetates. RSC Advances, 4, 57768-57772. DOI: 10.1039/c4ra11143e
Coimbra, JTS; Sousa, SF; Fernandes, PA; Rangel, M; Ramos, MJ. 2014. Biomembrane simulations of 12 lipid types using the general amber force field in a tensionless ensemble. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 32, 88-103. DOI: 10.1080/07391102.2012.750250
Fernandes, A; Ivanova, G; Bras, NF; Mateus, N; Ramos, MJ; Rangel, M; de Freitas, V. 2014. Structural characterization of inclusion complexes between cyanidin-3-0-glucoside and beta-cyclodextrin. CARBOHYDRATE POLYMERS, 102, 269-277. DOI: 10.1016/j.carbpol.2013.11.037
Pinto, JP; Arezes, J; Dias, V; Oliveira, S; Viera, I; Costa, M; Vos, M; Carlsson, A; Rikers, Y; Rangel, M; Porto, G. 2014. Physiological implications of NTBI uptake by T lymphocytes. Frontiers in Pharmacology, 5. DOI: 10.3389/fphar.2014.00024
Aguiar, A; Ribeiro, S; Silva, AMN; Cunha-Silva, L; de Castro, B; Silva, AMG; Balula, SS. 2014. An efficient eco-sustainable oxidative desulfurization process using mu-oxo-bridged Fe(III) complex of meso-tetrakis(pentafluorophenyl)porphyrin. APPLIED CATALYSIS A-GENERAL, 478, 267-274. DOI: 10.1016/j.apcata.2014.04.002
Rebelo, SLH; Linhares, M; Simoes, MMQ; Silva, AMS; Neves, MGPMS; Cavaleiro, JAS; Freire, C. 2014. Indigo dye production by enzymatic mimicking based on an iron(III)porphyrin. JOURNAL OF CATALYSIS, 315, 33-40. DOI: 10.1016/j.jcat.2014.04.012
Rangel, M; Leite, A; Silva, A; de Castro, B; Schlindwein, W; Murphy, L. 2014. EPR and XANES studies of anaerobic photolysis of iso-propilpyridinecobaloxime: Elucidation of the reactivity of the Co(II) primary product. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 760, 11-18. DOI: 10.1016/j.jorganchem.2014.01.033
Silva, AMN; Sousa, PRH; Coimbra, JTS; Bras, NF; Vitorino, R; Fernandes, PA; Ramos, MJ; Rangel, M; Domingues, P. 2014. The glycation site specificity of human serum transferrin is a determinant for transferrin's functional impairment under elevated glycaemic conditions. BIOCHEMICAL JOURNAL, 461, 33-42. DOI: 10.1042/BJ20140133
Silva, AMN; Aguiar, A; Balula, SS; Silva, AMG; Rangel, M. 2014. Characterization of a mu-oxo-bridged diiron porphyrin by ESI-LTQ-Orbitrap-MS. JOURNAL OF MASS SPECTROMETRY, 49, 763-765. DOI: 10.1002/jms.3405
Sousa, CAD; Rodriguez-Borges, JE; Garcia-Mera, X. 2014. Synthesis and N-functionalization of isoxazolidines: a new approach to nucleoside analogues. TETRAHEDRON LETTERS, 55, 4628-4631. DOI: 10.1016/j.tetlet.2014.06.076
Stoykova, B; Chochkova, M; Petrova, P; Ivanova, G; Milkova, T. 2014. INVESTIGATION OF alpha-GLUCOSIDASE INHIBITORY ACTIVITY OFN-HYDROXYCINNAMOYL AMINO ACID AMIDES. JOURNAL OF PEPTIDE SCIENCE, 20, S117-S117. DOI:
Stoykova, B; Chochkova, M; Apostolova, R; Petrova, P; Ivanova, G; Nikolova, N; Nikolaeva-Glomb, L; Milkova, T. 2014. NOVEL OSELTAMIVIR AND AMINOADAMANTANE ANALOGUES CONTAINING NON-PROTEINOGENIC AMINO ACID. JOURNAL OF PEPTIDE SCIENCE, 20, S119-S120. DOI:
Stoykova, B; Chochkova, M; Petrova, P; Ivanova, G; Milkova, T. 2014. N-LIPOYL AMINO ACID AMIDES OF ANTI-INFLUENZA DRUGS: SYNTHESIS AND BIOLOGICAL ACTIVITY. JOURNAL OF PEPTIDE SCIENCE, 20, S138-S138. DOI:
Pereira, T; Ivanova, G; Caseiro, AR; Barbosa, PP; Bartolo, PJ; Santos, JD; Luis, AL; Mauricio, AC. 2014. METABOLOMIC STUDIES OF MESENCHYMAL STEM CELLS CONDITIONED MEDIA AND UMBILICAL CORD BLOOD PLASMA. JOURNAL OF PEPTIDE SCIENCE, 20, S290-S290. DOI:
Ponte, F; Fraga, S; Moniz, T; da Silva, DD; Carvalho, F; Carmo, H; Remiao, F; Rangel, M; Bastos, ML. 2014. Development of insulino-mimetic zinc(II) complexes of the class 3-hydroxy-4-pyridinone ligands: In vitro cytotoxicity studies for safety assessment. TOXICOLOGY LETTERS, 229, S55-S55. DOI: 10.1016/j.toxlet.2014.06.226
Feio-Azevedo, R; Costa, VM; Ferreira, LP; Branco, PS; Pereira, FC; Bastos, MD; Carvalho, F; Capela, JP. 2014. Amphetamine and its metabolite 4-hydroxyamphetamine neurotoxicity in differentiated SH-SY5Y neurons. TOXICOLOGY LETTERS, 229, S241-S241. DOI: 10.1016/j.toxlet.2014.06.805
Queiros, C; Leite, A; Couto, MGM; Moniz, T; Cunha-Silva, L; Gameiro, P; Silva, AMG; Rangel, M. 2014. Tuning the limits of pH interference of a rhodamine ion sensor by introducing catechol and 3-hydroxy-4-pyridinone chelating units. DYES AND PIGMENTS, 110, 193-202. DOI: 10.1016/j.dyepig.2014.04.007
da Silva, G; Pires, SMG; Silva, VLM; Simoes, MMQ; Neves, MGPMS; Rebelo, SLH; Silva, AMS; Cavaleiro, JAS. 2014. A green and sustainable method for the oxidation of 1,3-dihydrobenzo[c] thiophenes to sulfones using metalloporphyrin complexes. CATALYSIS COMMUNICATIONS, 56, 68-71. DOI: 10.1016/j.catcom.2014.06.032
Coimbra, JTS; Moniz, T; Bras, NF; Iyanova, G; Fernandes, PA; Ramos, MJ; Rangel, M. 2014. Relevant Interactions of Antimicrobial Iron Chelators and Membrane Models Revealed by Nuclear Magnetic Resonance and Molecular Dynamics Simulations. JOURNAL OF PHYSICAL CHEMISTRY B, 118, 14590-14601. DOI: 10.1021/jp509491p
Nunes, CD; Vaz, PD; Felix, V; Veiros, LF; Moniz, T; Rangel, M; Realista, S; Mourato, AC; Calhorda, MJ. 2015. Vanadyl cationic complexes as catalysts in olefin oxidation. DALTON TRANSACTIONS, 44, 5125-5138. DOI: 10.1039/c4dt03174a
Paiva-Martins, F; Goncalves, P; Borges, JE; Przybylska, D; Ibba, F; Fernandes, J; Santos-Silva, A. 2015. Effects of the olive oil phenol metabolite 3,4-DHPEA-EDAH(2) on human erythrocyte oxidative damage. Food & Function, 6, 2350-2356. DOI: 10.1039/c5fo00203f
Coelho, SC; Rangel, M; Pereira, MC; Coelho, MAN; Ivanova, G. 2015. Structural characterization of functionalized gold nanoparticles for drug delivery in cancer therapy: a NMR based approach. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 17, 18971-18979. DOI: 10.1039/c5cp02717a
Moniz, T; Silva, D; Silva, T; Gomes, MS; Rangel, M. 2015. Antimycobacterial activity of rhodamine 3,4-HPO iron chelators against Mycobacterium avium: analysis of the contribution of functional groups and of chelator's combination with ethambutol. MedChemComm, 6, 2194-2203. DOI: 10.1039/c5md00456j
Staneva, V; Ivanova, G; Simeonova, M. 2015. Surface modified poly (butyl cyanoacrylate) nanoparticles loaded with indomethacin: preparation and physicochemical characterization. Bulgarian Chemical Communications, 47, 93-99. DOI:
Suarez, R; Mesquita, RBR; Rangel, M; Cerda, V; Rangel, AOSS. 2015. Iron speciation by microsequential injection solid phase spectrometry using 3-hydroxy-1(H)-2-methyl-4-pyridinone as chromogenic reagent. TALANTA, 133, 15-20. DOI: 10.1016/j.talanta.2014.03.059
Queiros, C; Leite, A; Silva, AMG; Gameiro, P; de Castro, B; Rangel, M. 2015. Synthesis and spectroscopic characterization of a new tripodal hexadentate iron chelator incorporating catechol units. POLYHEDRON, 87, 1-7. DOI: 10.1016/j.poly.2014.10.003
Dias, MI; Barros, L; Morales, P; Sanchez-Mata, MC; Oliveira, MBPP; Ferreira, ICFR. 2015. Nutritional parameters of infusions and decoctions obtained from Fragaria vesca L. roots and vegetative parts. LWT-FOOD SCIENCE AND TECHNOLOGY, 62, 32-38. DOI: 10.1016/j.lwt.2015.01.034
Teixeira, RS; Cova, TFGG; Silva, SMC; Oliveira, R; do Vale, MLC; Marques, EF; Pais, AACC; Veiga, FJB. 2015. Novel serine-based gemini surfactants as chemical permeation enhancers of local anesthetics: A comprehensive study on structure-activity relationships, molecular dynamics and dermal delivery. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 93, 205-213. DOI: 10.1016/j.ejpb.2015.02.024
Sousa, CAD; Lima, CFRAC; Sampaio-Dias, IE; Garcia-Mera, X; Rodriguez-Borges, JE. 2015. Reactivity and Mechanistic Studies of the Reactions of Chlorodiphenylphosphine and Its Oxide with Methyl Glyoxylate, Glyoxylate Oximes, and Methyl Cyanoformate. HETEROATOM CHEMISTRY, 26, 249-256. DOI: 10.1002/hc.21255
Gomes, A; Machado, M; Lobo, L; Nogueira, F; Prudencio, M; Teixeira, C; Gomes, P. 2015. N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials. ChemMedChem, 10, 1344-1349. DOI: 10.1002/cmdc.201500164
Martins, TS; Pereira, C; Teixeira, V; Leite, A; Rangel, M; Moradas-Ferreira, P; Costa, V. 2015. Role of the sphingomyelinase Isc1p in the regulation of iron homeostasis. YEAST, 32, S127-S128. DOI:
Costa, C; Francisco, V; Silva, SG; do Vale, MLC; Garcia-Rio, L; Marques, EF. 2015. Supramolecular self-assembly between an amino acid-based surfactant and a sulfonatocalixarene driven by electrostatic interactions. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 480, 71-78. DOI: 10.1016/j.colsurfa.2015.03.054
Moreira, ASP; Coimbra, MA; Nunes, FM; Passos, CP; Santos, SAO; Silvestre, AJD; Silva, AMN; Rangel, M; Domingues, MRM. 2015. Chlorogenic acid-arabinose hybrid domains in coffee melanoidins: Evidences from a model system. FOOD CHEMISTRY, 185, 135-144. DOI: 10.1016/j.foodchem.2015.03.086
Fonseca, DA; Guerra, AF; Carvalho, F; Fernandes, E; Ferreira, L; Antunes, P; Antunes, M; Cotrim, MD. 2015. The influence of hyperthermia on the vascular effects of MDMA and its metabolites. TOXICOLOGY LETTERS, 238, S377-S377. DOI: 10.1016/j.toxlet.2015.08.1076
Azevedo, RF; Costa, VM; Pereira, L; Branco, P; Pereira, F; Bastos, ML; Carvalho, F; Capela, J. 2015. Neurotoxicity of amphetamine and its metabolite 4-hydroxynorephedrine on differentiated SH-SY5Y dopaminergic cells. TOXICOLOGY LETTERS, 238, S358-S358. DOI: 10.1016/j.toxlet.2015.08.1022
Dores-Sousa, J; Duarte, J; Seabra, V; Bastos, ML; Carvalho, F; Costa, VM. 2015. A mild cumulative dose of mitoxantrone leads to age-dependent cardiac injury in mice. TOXICOLOGY LETTERS, 238, S155-S156. DOI: 10.1016/j.toxlet.2015.08.484
Gomes, VPM; Torres, C; Rodriguez-Borges, JE; Paiva-Martins, F. 2015. A Convenient Synthesis of Hydroxytyrosol Monosulfate Metabolites. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63, 9565-9571. DOI: 10.1021/acs.jafc.5b04307
Mesquita, RBR; Moniz, T; Miranda, JLA; Gomes, V; Silva, AMN; Rodriguez-Borges, JE; Rangel, AOSS; Rangel, M. 2015. Synthesis and characterization of a 3-hydroxy-4-pyridinone chelator functionalized with a polyethylene glycol (PEG) chain aimed at sequential injection determination of iron in natural waters. POLYHEDRON, 101, 171-178. DOI: 10.1016/j.poly.2015.09.015
Vale, N; Veloso, RC; Gomes, P. 2015. Exploring the Solid-Phase Synthesis of Sulfotyrosine Peptides. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 7413-7425. DOI: 10.1002/ejoc.201500715
Caseiro, AR; Pereira, T; Ivanova, G; Luis, AL; Mauricio, AC. 2016. Neuromuscular Regeneration: Perspective on the Application of Mesenchymal Stem Cells and Their Secretion Products. Stem Cells International. DOI: 10.1155/2016/9756973
Ferraz, R; Noronha, J; Murtinheira, F; Nogueira, F; Machado, M; Prudencio, M; Parapini, S; D'Alessandro, S; Teixeira, C; Gomes, A; Prudencio, C; Gomes, P. 2016. Primaquine-based ionic liquids as a novel class of antimalarial hits. RSC Advances, 6, 56134-56138. DOI: 10.1039/c6ra10759a
Teixeira, C; Barbault, F; Couesnon, T; Gomes, JRB; Gomes, P; Maurel, F. 2016. Striking HIV-1 Entry by Targeting HIV-1 gp41. But, Where Should We Target?. PLoS One, 11. DOI: 10.1371/journal.pone.0146743
Miranda, JLA; Mesquita, RBR; Nunes, A; Rangel, M; Rangel, AOSS. 2016. Iron speciation in natural waters by sequential injection analysis with a hexadentate 3-hydroxy-4-pyridinone chelator as chromogenic agent. TALANTA, 148, 633-640. DOI: 10.1016/j.talanta.2015.05.062
Chiste, RC; Ribeiro, D; Freitas, M; Leite, A; Moniz, T; Rangel, M; Fernandes, E. 2016. Uncovering novel 3-hydroxy-4-pyridinone metal ion complexes with potential anti-inflammatory properties. JOURNAL OF INORGANIC BIOCHEMISTRY, 155, 9-16. DOI: 10.1016/j.jinorgbio.2015.11.009
Moniz, T; de Castro, B; Rangel, M; Ivanova, G. 2016. NMR study of the interaction of fluorescent 3-hydroxy-4-pyridinone chelators with DMPC liposomes. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18, 5027-5033. DOI: 10.1039/c5cp05273d
Goncalves, IC; Magalhaes, A; Costa, AMS; Oliveira, JR; Henriques, PC; Gomes, P; Reis, CA; Martins, MCL. 2016. Bacteria-targeted biomaterials: Glycan-coated microspheres to bind Helicobacter pylori. Acta Biomaterialia, 33, 40-50. DOI: 10.1016/j.actbio.2016.01.029
Cruz, RQ; Morais, CM; Cardoso, AM; Silva, SG; Vale, ML; Marques, EF; de Lima, MCP; Jurado, AS. 2016. Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 104, 7-18. DOI: 10.1016/j.ejpb.2016.04.014
Santos, CS; Carvalho, SMP; Leite, A; Moniz, T; Roriz, M; Rangel, AOSS; Rangel, M; Vasconcelos, MW. 2016. Effect of tris(3-hydroxy-4-pyridinonate) iron(III) complexes on iron uptake and storage in soybean (Glycine max L.). PLANT PHYSIOLOGY AND BIOCHEMISTRY, 106, 91-100. DOI: 10.1016/j.plaphy.2016.04.050
Branco, P; Francisco, D; Monteiro, M; Almeida, MG; Caldeira, J; Arneborg, N; Prista, C; Albergaria, H. 2017. Antimicrobial properties and death-inducing mechanisms of saccharomycin, a biocide secreted by Saccharomyces cerevisiae. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 101, 159-171. DOI: 10.1007/s00253-016-7755-6
Chochkova, MG; Petrova, PP; Stoykova, BM; Ivanova, GI; Sticha, M; Dibo, G; Milkova, TS. 2017. Structure-Activity Relationships of N-Cinnamoyl and Hydroxycinnamoyl Amides on alpha-Glucosidase Inhibition. Journal of Chemistry. DOI: 10.1155/2017/6080129
Dias, AR; Costa-Rodrigues, J; Fernandes, MH; Ferraz, R; Prudencio, C. 2017. The Anticancer Potential of Ionic Liquids. ChemMedChem, 12, 11-18. DOI: 10.1002/cmdc.201600480
Branco, P; Kemsawasd, V; Santos, L; Diniz, M; Caldeira, J; Almeida, MG; Arneborg, N; Albergaria, H. 2017. Saccharomyces cerevisiae accumulates GAPDH-derived peptides on its cell surface that induce death of non-Saccharomyces yeasts by cell-to-cell contact. FEMS MICROBIOLOGY ECOLOGY, 93. DOI: 10.1093/femsec/fix055
Stoykova, B; Chochkova, M; Ivanova, G; Markova, N; Enchev, V; Tsvetkova, I; Najdenski, H; Sticha, M; Milkova, T. 2017. Ultrasound-assisted green bromination of N-cinnamoyl amino acid amides - Structural characterization and antimicrobial evaluation. JOURNAL OF MOLECULAR STRUCTURE, 1135, 144-152. DOI: 10.1016/j.molstruc.2017.01.056
Gonzalez, A; Mesquita, RBR; Avivar, J; Moniz, T; Rangel, M; Cerda, V; Rangel, AOSS. 2017. Microsequential injection lab-on-valve system for the spectrophotometric bi-parametric determination of iron and copper in natural waters. TALANTA, 167, 703-708. DOI: 10.1016/j.talanta.2017.02.055
Silva, T; Moreira, AC; Nazmi, K; Moniz, T; Vale, N; Rangel, M; Gomes, P; Bolscher, JGM; Rodrigues, PN; Bastos, M; Gomes, MS. 2017. Lactoferricin Peptides Increase Macrophages' Capacity To Kill Mycobacterium avium. mSphere, 2. DOI: 10.1128/mSphere.00301-17
Cotton, S; Azevedo, R; Gaiteiro, C; Ferreira, D; Lima, L; Peixoto, A; Fernandes, E; Neves, M; Neves, D; Amaro, T; Cruz, R; Tavares, A; Rangel, M; Silva, AMN; Santos, LL; Ferreira, JA. 2017. Targeted O-glycoproteomics explored increased sialylation and identified MUC16 as a poor prognosis biomarker in advanced-stage bladder tumours. Molecular Oncology, 11, 895-912. DOI: 10.1002/1878-0261.12035
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Silva, AS; Bonifacio, VDB; Raje, VP; Branco, PS; Machado, PFB; Correia, IJ; Aguiar-Ricardo, A. 2015. Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging. RSC Advances, 5, 10733-10738. DOI: 10.1039/c4ra15743e
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Crucho, CIC; Correia-da-Silva, P; Petrova, KT; Barros, MT. 2015. Recent progress in the field of glycoconjugates. CARBOHYDRATE RESEARCH, 402, 124-132. DOI: 10.1016/j.carres.2014.10.005
Marcou, G; de Sousa, JA; Latino, DARS; de Luca, A; Horvath, D; Rietsch, V; Varnek, A. 2015. Expert System for Predicting Reaction Conditions: The Michael Reaction Case. Journal of Chemical Information and Modeling, 55, 239-250. DOI: 10.1021/ci5000698a
Pinto, ISS; Ascenso, OS; Barros, MT; Soares, HMVM. 2015. Pre-treatment of the paper pulp in the bleaching process using biodegradable chelating agents. International Journal of Environmental Science and Technology, 12, 975-982. DOI: 10.1007/s13762-013-0480-0
Pinto, RM; Guerra, M; Copeland, G; Olariu, RI; Rodrigues, P; Banos, MT; Costa, ML; Dias, AA. 2015. The Mechanism of Pyrolysis of Benzyl Azide: Spectroscopic Evidence for Benzenemethanimine Formation. JOURNAL OF PHYSICAL CHEMISTRY A, 119, 4118-4126. DOI: 10.1021/acs.jpca.5b02453
Pires, MJD; Poeira, DL; Marques, MMB. 2015. Metal-Catalyzed Cross-Coupling Reactions of Aminopyridines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 7197-7234. DOI: 10.1002/ejoc.201500952
Costa, JIT; Oliveira, E; Santos, HM; Tome, AC; Neves, MGPMS; Lodeiro, C. 2016. Study of Multiporphyrin Compounds as Colorimetric Sitting-Atop Metal Complexes: Synthesis and Photophysical Studies. ChemPlusChem, 81, 143-153. DOI: 10.1002/cplu.201500386
Moura, NMM; Ramos, CIV; Linhares, I; Santos, SM; Faustino, MAF; Almeida, A; Cavaleiro, JAS; Amado, FML; Lodeiro, C; Neves, MGPMS. 2016. Synthesis, characterization and biological evaluation of cationic porphyrin-terpyridine derivatives. RSC Advances, 6, 110674-110685. DOI: 10.1039/c6ra25373c
Vale, JR; Siopa, F; Branco, PS; Afonso, CAM. 2016. Ring Opening of 6-Azabicyclo[3.1.0]hex-3-en-2-ols in Water under Mild Conditions. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2048-2053. DOI: 10.1002/ejoc.201501468
Pires, SMG; Nunez, C; Serra, VV; Sanchez-Coronilla, A; Faustino, MAF; Simoes, MMQ; Silva, AMS; Neves, MGPMS; Capelo, JL; Lodeiro, C. 2016. Porphyrin-rhodamine conjugates as new materials with sensing ability. DYES AND PIGMENTS, 135, 113-126. DOI: 10.1016/j.dyepig.2016.04.003
Andrade, MM; Barros, MT; Pinto, RC. 2010. APPROACH TO THE VALORIZATION OF CARBOHYDRATES AS RAW MATERIALS BY MICROWAVE-ASSISTED NEAT 1,3-DIPOLAR CYCLOADDITION. SYNTHETIC COMMUNICATIONS, 40, 855-860. DOI: 10.1080/00397910903019959
Branco, PS; Raje, VP; Dourado, J; Gordo, J. 2010. Catalyst-free aziridination and unexpected homologation of aziridines from imines. ORGANIC & BIOMOLECULAR CHEMISTRY, 8, 2968-2974. DOI: 10.1039/c001894e
Pinto, LFV; Justino, GC; Vieira, AJSC; Prabhakar, S; Lobo, AM. 2010. Thermal rearrangement of an N-hydroxyimidazole thiocarbamoyl derivative as a simple entry into the 4-thioimidazole motif. ARKIVOC, 17-23. DOI:
Latino, DARS; Fartaria, RPS; Freitas, FFM; Aires-De-Sousa, J; Fernandes, FMSS. 2010. Approach to Potential Energy Surfaces by Neural Networks. A Review of Recent Work. INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, 110, 432-445. DOI: 10.1002/qua.22198
Vitoriano, BC; Carvalho, LCR; Estevao, MS; Sekera, MH; Marques, MMB. 2010. A Simple Route Toward New Clomiphene Metabolites. SYNLETT, 753-756. DOI: 10.1055/s-0029-1219383
Andrade, MM; Barros, MT. 2010. Fast Synthesis of N-Acylhydrazones Employing a Microwave Assisted Neat Protocol. JOURNAL OF COMBINATORIAL CHEMISTRY, 12, 245-247. DOI: 10.1021/cc9001444
Borges, C; Gomez-Carracedo, MP; Andrade, JM; Duarte, MF; Biscaya, JL; Aires-de-Sousa, J. 2010. Geographical classification of weathered crude oil samples with unsupervised self-organizing maps and a consensus criterion. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 101, 43-55. DOI: 10.1016/j.chemolab.2010.01.001
Carvalho, LR; Corvo, MC; Enugala, R; Marques, MMB; Cabrita, EJ. 2010. Application of HR-MAS NMR in the solid-phase synthesis of a glycopeptide using Sieber amide resin. MAGNETIC RESONANCE IN CHEMISTRY, 48, 323-330. DOI: 10.1002/mrc.2583
Barros, MT; Petrova, KT; Singh, RP. 2010. Synthesis of Hydrophilic and Amphiphilic Acryl Sucrose Monomers and Their Copolymerisation with Styrene, Methylmethacrylate and alpha- and beta-Pinenes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 11, 1792-1807. DOI: 10.3390/ijms11041792
Pontes, H; de Pinho, PG; Fernandes, E; Branco, PS; Ferreira, LM; Carmo, H; Remiao, F; Carvalho, F; Bastos, ML. 2010. Metabolic interactions between ethanol and MDMA in primary cultured rat hepatocytes. TOXICOLOGY, 270, 150-157. DOI: 10.1016/j.tox.2010.02.010
Justino, GC; Vieira, AJSC. 2010. Antioxidant mechanisms of Quercetin and Myricetin in the gas phase and in solution - a comparison and validation of semi-empirical methods. JOURNAL OF MOLECULAR MODELING, 16, 863-876. DOI: 10.1007/s00894-009-0583-1
Barros, MT; Petrova, KT; Singh, RP. 2010. Synthesis and biodegradation studies of new copolymers based on sucrose derivatives and styrene. EUROPEAN POLYMER JOURNAL, 46, 1151-1157. DOI: 10.1016/j.eurpolymj.2010.02.002
Gomez-Carracedo, MP; Andrade, JM; Carrera, GVSM; Aires-de-Sousa, J; Carlosena, A; Prada, D. 2010. Combining Kohonen neural networks and variable selection by classification trees to cluster road soil samples. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 102, 20-34. DOI: 10.1016/j.chemolab.2010.03.002
Santos, PMP; Silva, SAG; Justino, GC; Vieira, AJSC. 2010. Demethylation of theophylline(1,3-dimethylxanthine) to 1-methylxanthine: the first step of an antioxidising cascade. REDOX REPORT, 15, 138-144. DOI: 10.1179/174329210X12650506623726
Santos, PMP; Antunes, AMM; Noronha, J; Fernandes, E; Vieira, AJSC. 2010. Scavenging activity of aminoantipyrines against hydroxyl radical. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 45, 2258-2264. DOI: 10.1016/j.ejmech.2010.01.071
Carmali, S; Alves, VD; Coelhoso, IM; Ferreira, LM; Lourenco, AM. 2010. Recovery of lupanine from Lupinus albus L. leaching waters. SEPARATION AND PURIFICATION TECHNOLOGY, 74, 38-43. DOI: 10.1016/j.seppur.2010.05.005
Marques, MM; Martins, IL; Charneira, C; Vieira, AJSC; Antunes, AMM. 2010. Microwave-based methodology for the preparation of organoselenium compounds. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 240. DOI:
Martins, JG; Gameiro, P; Barros, MT; Soares, HMVM. 2010. Potentiometric and UV-Visible Spectroscopic Studies of Cobalt(II), Copper(II), and Nickel(II) Complexes with N,N '-(S,S)-Bis[1-carboxy-2-(imidazol-4-yl)ethyl]ethylenediamine. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 55, 3410-3417. DOI: 10.1021/je1001494
Gomez-Carracedo, MP; Ballabio, D; Andrade, JM; Aires-de-Sousa, J; Consonni, V. 2010. Comparing roadsoils pollution patterns extracted by MOLMAP and classical three-way decomposition methods. ANALYTICA CHIMICA ACTA, 677, 64-71. DOI: 10.1016/j.aca.2010.07.044
Martins, JG; Pinto, RM; Gameiro, P; Barros, MT; Soares, HMVM. 2010. Aqueous Equilibrium and Solution Structural Studies of the Interaction of N,N'-bis(4-imidazolymethyl)etylenediamine with Ca(II), Cd(II), Co(II), Cu(II), Mg(II), Mn(II), Ni(II), Pb(II) and Zn(II) Metal Ions. JOURNAL OF SOLUTION CHEMISTRY, 39, 1153-1167. DOI: 10.1007/s10953-010-9569-y
Rosa, V; Santos, CIM; Welter, R; Aullon, G; Lodeiro, C; Aviles, T. 2010. Comparison of the Structure and Stability of New alpha-Diimine Complexes of Copper(I) and Silver(I): Density Functional Theory versus Experimental. INORGANIC CHEMISTRY, 49, 8699-8708. DOI: 10.1021/ic100450y
Enugala, R; Carvalho, LCR; Marques, MMB. 2010. Towards Glucosamine Building Blocks: Regioselective One-Pot Protection and Deallylation Procedures. SYNLETT, 2711-2716. DOI: 10.1055/s-0030-1259001
Estevao, MS; Carvalho, LC; Ribeiro, D; Couto, D; Freitas, M; Gomes, A; Ferreira, LM; Fernandes, E; Marques, MMB. 2010. Antioxidant activity of unexplored indole derivatives: Synthesis and screening. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 45, 4869-4878. DOI: 10.1016/j.ejmech.2010.07.059
Carrera, GVSM; Frade, RFM; Aires-de-Sousa, J; Afonso, CAM; Branco, LC. 2010. Synthesis and properties of new functionalized guanidinium based ionic liquids as non-toxic versatile organic materials. TETRAHEDRON, 66, 8785-8794. DOI: 10.1016/j.tet.2010.08.040
Carvalho, LC; Estevao, MS; Ferreira, LM; Fernandes, E; Marques, MMB. 2010. A new insight on the hypochlorous acid scavenging mechanism of tryptamine and tryptophan derivatives. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20, 6475-6478. DOI: 10.1016/j.bmcl.2010.09.067
Barros, MT; Phillips, AMF. 2010. The first enantioselective [3+2] cycloaddition of epoxides to arylisocyanates: asymmetric synthesis of chiral oxazolidinone phosphonates. TETRAHEDRON-ASYMMETRY, 21, 2746-2752. DOI: 10.1016/j.tetasy.2010.10.028
Martins, S; Branco, PS; de la Torre, MC; Sierra, MA; Pereira, A. 2010. New Methodology for the Synthesis of 3-Substituted Coumarins via Palladium-Catalyzed Site-Selective Cross-Coupling Reactions. SYNLETT, 2918-2922. DOI: 10.1055/s-0030-1259014
Lanham, AB; Carvalheira, M; Rodrigues, AM; Cardoso, VV; Benoliel, MJ; Barros, MT; Morgado, MJ; Soares, HMVM; Lemos, PC; Reis, MAM. 2011. Ethylenediamine-N,N '-diglutaric acid (EDDG) as a promising biodegradable chelator: Quantification, complexation and biodegradation. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, 46, 553-559. DOI: 10.1080/10934529.2011.562805
Barros, MT; Petrova, KT; Correia-da-Silva, P; Potewar, TM. 2011. Library of mild and economic protocols for the selective derivatization of sucrose under microwave irradiation. GREEN CHEMISTRY, 13, 1897-1906. DOI: 10.1039/c1gc15228a
Gawande, MB; Branco, PS; Parghi, K; Shrikhande, JJ; Pandey, RK; Ghumman, CAA; Bundaleski, N; Teodoro, OMND; Jayaram, RV. 2011. Synthesis and characterization of versatile MgO-ZrO2 mixed metal oxide nanoparticles and their applications. Catalysis Science & Technology, 1, 1653-1664. DOI: 10.1039/c1cy00259g
Mouquinho, A; Saavedra, M; Maiau, A; Petrova, K; Barros, MT; Figueirinhas, JL; Sotomayor, J. 2011. Films Based on New Methacrylate Monomers: Synthesis, Characterisation and Electro-Optical Properties. MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 542, 132-140. DOI: 10.1080/15421406.2011.570154
Estevao, MS; Carvalho, LC; Ferreira, LM; Fernandes, E; Marques, MMB. 2011. Analysis of the antioxidant activity of an indole library: cyclic voltammetry versus ROS scavenging activity. TETRAHEDRON LETTERS, 52, 101-106. DOI: 10.1016/j.tetlet.2010.10.172
da Silva, MDRG; Pereira, MMA. 2011. New chiral imidazolium ionic liquids from isomannide. CARBOHYDRATE RESEARCH, 346, 197-202. DOI: 10.1016/j.carres.2010.11.011
Ivanova, G; Simeonova, M; Cabrita, EJ; Rangel, M. 2011. NMR Insight into the Supramolecular Structure of Daunorubicin Loaded Polymer Nanoparticles. JOURNAL OF PHYSICAL CHEMISTRY B, 115, 902-909. DOI: 10.1021/jp109738e
Pereira, F; Aires-de-Sousa, J; Bonifacio, VDB; Mata, P; Lobo, AM. 2011. MOLinsight: A Web Portal for the Processing of Molecular Structures by Blind Students. JOURNAL OF CHEMICAL EDUCATION, 88, 361-362. DOI: 10.1021/ed100723v
Martins, JG; Barros, MT; Pinto, RM; Soares, HMVM. 2011. Cadmium(II), Lead(II), and Zinc(II) Ions Coordination of N,N '-(S,S)Bis[1-carboxy-2-(imidazol-4yl)ethyl]ethylenediamine: Equilibrium and Structural Studies. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 56, 398-405. DOI: 10.1021/je1007718
de Fremont, P; Clavier, H; Rosa, V; Aviles, T; Braunstein, P. 2011. Synthesis, Characterization, and Reactivity of Cationic Gold(I) alpha-Diimine Complexes. ORGANOMETALLICS, 30, 2241-2251. DOI: 10.1021/om2000426
Kovalishyn, V; Aires-de-Sousa, J; Ventura, C; Leitao, RE; Martins, F. 2011. QSAR modeling of antitubercular activity of diverse organic compounds. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 107, 69-74. DOI: 10.1016/j.chemolab.2011.01.011
Sushko, I; Novotarskyi, S; Korner, R; Pandey, AK; Rupp, M; Teetz, W; Brandmaier, S; Abdelaziz, A; Prokopenko, VV; Tanchuk, VY; Todeschini, R; Varnek, A; Marcou, G; Ertl, P; Potemkin, V; Grishina, M; Gasteiger, J; Schwab, C; Baskin, II; Palyulin, VA; . 2011. Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 25, 533-554. DOI: 10.1007/s10822-011-9440-2
Ferraz, R; Branco, LC; Prudencio, C; Noronha, JP; Petrovski, Z. 2011. Ionic Liquids as Active Pharmaceutical Ingredients. ChemMedChem, 6, 975-985. DOI: 10.1002/cmdc.201100082
Oliveira, J; Mateus, N; Rodriguez-borges, JE; Cabrita, EJ; Silva, AMS; de Freitas, V. 2011. Synthesis of a new pyranoanthocyanin dimer linked through a methyl-methine bridge. TETRAHEDRON LETTERS, 52, 2957-2960. DOI: 10.1016/j.tetlet.2011.03.125
Assis, AC; Couto, N; Duarte, MF; Rodrigues, P; Barros, MT; Costa, ML; Cabral, BJC; Fernandez, MT. 2011. Azidoacetone as a complexing agent of transition metals Ni2+/Co2+ promoted dissociation of the C-C bond in azidoacetone. JOURNAL OF MASS SPECTROMETRY, 46, 696-704. DOI: 10.1002/jms.1940
Barros, MT; Phillips, MF. 2011. Organocatalyzed Synthesis of Tertiary alpha-Hydroxyphosphonates by a Highly Regioselective Modified Pudovik Reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 4028-4036. DOI: 10.1002/ejoc.201100308
Barros, MT; Mouquinho, AI; Petrova, KT; Saavedra, MD; Sotomayor, JC. 2011. Fast synthesis employing a microwave assisted neat protocol of new monomers potentially useful for the preparation of PDLC films. CENTRAL EUROPEAN JOURNAL OF CHEMISTRY, 9, 557-566. DOI: 10.2478/s11532-011-0046-2
Pinto, RM; Dias, AA; Costa, ML; Rodrigues, P; Barros, MT; Ogden, JS; Dyke, JM. 2011. Thermal Decomposition of Methyl 2-Azidopropionate Studied by UV Photoelectron Spectroscopy and Matrix Isolation IR Spectroscopy: Heterocyclic Intermediate vs Imine Formation. JOURNAL OF PHYSICAL CHEMISTRY A, 115, 8447-8457. DOI: 10.1021/jp2036845
Aviles, T; Jansat, S; Martinez, M; Montilla, F; Rodriguez, C. 2011. Deactivation of the Cobalt Catalyst for the Cyclotrimerization of Acetylenes in Ionic Liquids: Solvent Effects on the Mechanism and Thermal and Pressure Activation Parameters. ORGANOMETALLICS, 30, 3919-3922. DOI: 10.1021/om200376p
Barbosa, DJ; Capela, JP; Oliveira, JMA; Ferreira, L; Branco, P; Fernandes, E; Bastos, ML; Carvalho, F. 2011. "Pro-oxidant effects of ""ecstasy"" and its metabolites in mouse brain synaptosomes". TOXICOLOGY LETTERS, 205, S113-S113. DOI: 10.1016/j.toxlet.2011.05.407
Silva, AMG; Leite, A; Gonzalez, P; Domingues, MRM; Gameiro, P; de Castro, B; Rangel, M. 2011. Use of a porphyrin platform and 3,4-HPO chelating units to synthesize ligands with N-4 and O-4 coordination sites. TETRAHEDRON, 67, 7821-7828. DOI: 10.1016/j.tet.2011.07.063
Pereira, F; Latino, DARS; Aires-de-Sousa, J. 2011. Estimation of Mayr Electrophilicity with a Quantitative Structure-Property Relationship Approach Using Empirical and DFT Descriptors. JOURNAL OF ORGANIC CHEMISTRY, 76, 9312-9319. DOI: 10.1021/jo201562f
Viegas, A; Manso, J; Corvo, MC; Marques, MMB; Cabrita, EJ. 2011. Binding of Ibuprofen, Ketorolac, and Diclofenac to COX-1 and COX-2 Studied by Saturation Transfer Difference NMR. JOURNAL OF MEDICINAL CHEMISTRY, 54, 8555-8562. DOI: 10.1021/jm201090k
Phillips, AMF; Barros, MT. 2012. Synthesis of geminal bisphosphonates via organocatalyzed enantioselective Michael additions of cyclic ketones and 4-piperidones. ORGANIC & BIOMOLECULAR CHEMISTRY, 10, 404-412. DOI: 10.1039/c1ob06473h
Romain, C; Rosa, V; Fliedel, C; Bier, F; Hild, F; Welter, R; Dagorne, S; Aviles, T. 2012. Highly active zinc alkyl cations for the controlled and immortal ring-opening polymerization of epsilon-caprolactone. DALTON TRANSACTIONS, 41, 3377-3379. DOI: 10.1039/c2dt12336c
Li, LD; Lopes, PS; Rosa, V; Figueira, CA; Lemos, MANDA; Duarte, MT; Aviles, T; Gomes, PT. 2012. Synthesis and structural characterisation of (aryl-BIAN)copper(I) complexes and their application as catalysts for the cycloaddition of azides and alkynes. DALTON TRANSACTIONS, 41, 5144-5154. DOI: 10.1039/c2dt11854h
Cabrita, MJ; Aires-De-Sousa, J; Da Silva, MDRG; Rei, F; Freitas, AMC. 2012. Multivariate statistical approaches for wine classification based on low molecular weight phenolic compounds. AUSTRALIAN JOURNAL OF GRAPE AND WINE RESEARCH, 18, 138-146. DOI: 10.1111/j.1755-0238.2012.00182.x
Santos, CIM; Oliveira, E; Barata, JFB; Faustino, MAF; Cavaleiro, JAS; Neves, MGPMS; Lodeiro, C. 2012. Corroles as anion chemosensors: exploiting their fluorescence behaviour from solution to solid-supported devices. JOURNAL OF MATERIALS CHEMISTRY, 22, 13811-13819. DOI: 10.1039/c2jm31281f
Gawande, MB; Velhinho, A; Nogueira, ID; Ghumman, CAA; Teodoro, OMND; Branco, PS. 2012. A facile synthesis of cysteine-ferrite magnetic nanoparticles for application in multicomponent reactions-a sustainable protocol. RSC Advances, 2, 6144-6149. DOI: 10.1039/c2ra20955a
Enugala, R; Marques, MMB. 2012. Synthesis of a 3-hydroxyl-free N-acetyl glucosamine disaccharide. ARKIVOC, 90-100. DOI:
Latino, DARS; Aires-de-Sousa, J. 2012. Automatic Perception of Chemical Similarities Between Metabolic Pathways. Molecular Informatics, 31, 135-144. DOI: 10.1002/minf.201100110
Barbosa, J; Barbosa, DJ; Capela, JP; Oliveira, JMA; Silva, R; Ferreira, LM; Siopa, F; Branco, PS; Fernandes, E; Duarte, JA; Bastos, MDL; Carvalho, F; Carvalho, D. 2012. Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes. BRITISH JOURNAL OF PHARMACOLOGY, 165, 1017-1033. DOI: 10.1111/j.1476-5381.2011.01453.x
Pedras, B; Rosa, V; Welter, R; Lodeiro, C; Aviles, T. 2012. New quinoline alpha-diimine ligands as fluorescent probes for metal ions: Ultrasound-assisted and conventional synthetic methods. INORGANICA CHIMICA ACTA, 381, 143-149. DOI: 10.1016/j.ica.2011.08.063
Estevao, MS; Duarte, FJS; Fernandes, E; Santos, AG; Marques, MMB. 2012. Unexpected reactivity of trifluoromethylated olefins with indole: a mechanistic investigation. TETRAHEDRON LETTERS, 53, 2132-2136. DOI: 10.1016/j.tetlet.2012.02.055
Pereira, MMA. 2012. Immobilized Ionic Liquids in Organic Chemistry. CURRENT ORGANIC CHEMISTRY, 16, 1680-1710. DOI:
Rosa, V; Realista, S; Mourato, A; Abrantes, LM; Henriques, J; Calhorda, MJ; Aviles, T; Drew, MGB; Felix, V. 2012. 1,1 '-Bis(diphenylphosphino)ferrocene bridging two mono(cyclopentadienyl) cobalt moieties: Synthesis, structure, electrochemistry and DFT studies. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 712, 52-56. DOI: 10.1016/j.jorganchem.2012.04.012
Estevao, MS; Carvalho, LCR; Freitas, M; Gomes, A; Viegas, A; Manso, J; Erhardt, S; Fernandes, E; Cabrita, EJ; Marques, MMB. 2012. Indole based cyclooxygenase inhibitors: Synthesis, biological evaluation, docking and NMR screening. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 54, 823-833. DOI: 10.1016/j.ejmech.2012.06.040
Pereira, MMA. 2012. Chiral Ionic Liquids from Carbohydrates: Synthesis and Properties. MINI-REVIEWS IN ORGANIC CHEMISTRY, 9, 243-260. DOI:
Barros, MT; Dey, SS; Maycock, CD; Rodrigues, P. 2012. Preparation of N-arylamines from 2-oxo-7-azobicyclo[4.1.0]heptanes. TETRAHEDRON, 68, 6263-6268. DOI: 10.1016/j.tet.2012.05.054
Lourenco, AM; Ferreira, LM; Branco, PS. 2012. Molecules of Natural Origin, Semi-synthesis and Synthesis with Anti-Inflammatory and Anticancer Utilities. CURRENT PHARMACEUTICAL DESIGN, 18, 3979-4046. DOI:
Maiti, BK; Aviles, T; Matzapetakis, M; Moura, I; Pauleta, SR; Moura, JJG. 2012. Synthesis of [MoS4](2-)-M (M=Cu and Cd) Clusters: Potential NMR Spectroscopic Structural Probes for the Orange Protein. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 4159-4166. DOI: 10.1002/ejic.201200551
Gawande, MB; Rathi, AK; Branco, PS; Nogueira, ID; Velhinho, A; Shrikhande, JJ; Indulkar, UU; Jayaram, RV; Ghumman, CAA; Bundaleski, N; Teodoro, OMND. 2012. Regio- and Chemoselective Reduction of Nitroarenes and Carbonyl Compounds over Recyclable Magnetic Ferrite-Nickel Nanoparticles (Fe3O4-Ni) by Using Glycerol as a Hydrogen Source. CHEMISTRY-A EUROPEAN JOURNAL, 18, 12628-12632. DOI: 10.1002/chem.201202380
Gawande, MB; Rathi, A; Nogueira, ID; Ghumman, CAA; Bundaleski, N; Teodoro, OMND; Branco, PS. 2012. A Recyclable Ferrite-Co Magnetic Nanocatalyst for the Oxidation of Alcohols to Carbonyl Compounds. ChemPlusChem, 77, 865-871. DOI: 10.1002/cplu.201200081
Peca, IN; Petrova, KT; Cardoso, MM; Barros, MT. 2012. Preparation and characterization of polymeric nanoparticles composed of poly(DL-lactide-co-glycolide) and poly(DL-lactide-co-glycolide)-co-poly(ethylene glycol)-10%-Triblock end-capped with a galactose moiety. REACTIVE & FUNCTIONAL POLYMERS, 72, 729-735. DOI: 10.1016/j.reactfunctpolym.2012.06.019
Siopa, F; Pereira, AS; Ferreira, LM; Marques, MM; Branco, PS. 2012. Synthesis of catecholamine conjugates with nitrogen-centered bionucleophiles. BIOORGANIC CHEMISTRY, 44, 19-24. DOI: 10.1016/j.bioorg.2012.05.002
Pinto, RM; Dias, AA; Levita, G; Rodrigues, P; Barros, MT; Dyke, JM; Costa, ML. 2012. Pyrolysis of 3-azidopropionitrile studied by UV photoelectron and matrix-isolation IR spectroscopies: Formation of ketenimine H2C=C=NH. JOURNAL OF MOLECULAR STRUCTURE, 1025, 151-159. DOI: 10.1016/j.molstruc.2012.04.055
Muller, C; Marcou, G; Horvath, D; Aires-de-Sousa, J; Varnek, A. 2012. Models for Identification of Erroneous Atom-to-Atom Mapping of Reactions Performed by Automated Algorithms. Journal of Chemical Information and Modeling, 52, 3116-3122. DOI: 10.1021/ci300418q
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Gawande, MB; Guo, HZ; Rathi, AK; Branco, PS; Chen, YZ; Varma, RS; Peng, DL. 2013. First application of core-shell Ag@Ni magnetic nanocatalyst for transfer hydrogenation reactions of aromatic nitro and carbonyl compounds. RSC Advances, 3, 1050-1054. DOI: 10.1039/c2ra22143h
Gawande, MB; Branco, PS; Nogueira, ID; Ghumman, CAA; Bundaleski, N; Santos, A; Teodoro, OMND; Luque, R. 2013. Catalytic applications of a versatile magnetically separable Fe-Mo (Nanocat-Fe-Mo) nanocatalyst. GREEN CHEMISTRY, 15, 682-689. DOI: 10.1039/c3gc36844k
Gawande, MB; Branco, PS; Varma, RS. 2013. Nano-magnetite (Fe3O4) as a support for recyclable catalysts in the development of sustainable methodologies. CHEMICAL SOCIETY REVIEWS, 42, 3371-3393. DOI: 10.1039/c3cs35480f
Gawande, MB; Bonifacio, VDB; Varma, RS; Nogueira, ID; Bundaleski, N; Ghumman, CAA; Teodoro, OMND; Branco, PS. 2013. Magnetically recyclable magnetite-ceria (Nanocat-Fe-Ce) nanocatalyst - applications in multicomponent reactions under benign conditions. GREEN CHEMISTRY, 15, 1226-1231. DOI: 10.1039/c3gc40375k
Gawande, MB; Bonifacio, VDB; Luque, R; Branco, PS; Varma, RS. 2013. Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis. CHEMICAL SOCIETY REVIEWS, 42, 5522-5551. DOI: 10.1039/c3cs60025d
Rosa, V; Fliedel, C; Ghisolfi, A; Pattacini, R; Aviles, T; Braunstein, P. 2013. Influence of a thioether function in short-bite diphosphine ligands on the nature of their silver complexes: structure of a trinuclear complex and of a coordination polymer. DALTON TRANSACTIONS, 42, 12109-12119. DOI: 10.1039/c3dt50555c
Santos, CIM; Barata, JFB; Faustino, MAF; Lodeiro, C; Neves, MGPMS. 2013. Revisiting Heck-Mizoroki reactions in ionic liquids. RSC Advances, 3, 19219-19238. DOI: 10.1039/c3ra43493a
Carvalho, LCR; Pires, MJD; Fernandes, E; Marques, MMB. 2013. Pd-catalysed amination on a soluble polymer support: arylation of anilines with PEG-supported aryl halides. RSC Advances, 3, 25711-25715. DOI: 10.1039/c3ra45177a
Raje, VP; Morgado, PI; Ribeiro, MP; Correia, IJ; Bonifacio, VDB; Branco, PS; Aguiar-Ricardo, A. 2013. Dual on-off and off-on switchable oligoaziridine biosensor. BIOSENSORS & BIOELECTRONICS, 39, 64-69. DOI: 10.1016/j.bios.2012.06.047
Barros, MT; Dey, SS; Maycock, CD. 2013. Metal-Free Synthesis of Secondary Arylamines: An Aliphatic-to-Aromatic Transformation. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 742-747. DOI: 10.1002/ejoc.201201263
Ferreira, PS; Nogueira, TB; Costa, VM; Branco, PS; Ferreira, LM; Fernandes, E; Bastos, ML; Meisel, A; Carvalho, F; Capela, JP. 2013. "Neurotoxicity of ""ecstasy"" and its metabolites in human dopaminergic differentiated SH-SY5Y cells". TOXICOLOGY LETTERS, 216, 159-170. DOI: 10.1016/j.toxlet.2012.11.015
Fartaria, RPS; Pereira, F; Bonifacio, VDB; Mata, P; Aires-de-Sousa, J; Lobo, AM. 2013. NavMol 2.0 - A Molecular Structure Navigator/Editor for Blind and Visually Impaired Users. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 1415-1419. DOI: 10.1002/ejoc.201201458
Li, LD; Lopes, PS; Figueira, CA; Gomes, CSB; Duarte, MT; Rosa, V; Fliedel, C; Aviles, T; Gomes, PT. 2013. Cationic and Neutral (Ar-BIAN) Copper( I) Complexes Containing Phosphane and Arsane Ancillary Ligands: Synthesis, Molecular Structure and Catalytic Behaviour in Cycloaddition Reactions of Azides and Alkynes. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 1404-1417. DOI: 10.1002/ejic.201201211
Santos, PMP; Vieira, AJSC. 2013. Antioxidising activity of cinnamic acid derivatives against oxidative stress induced by oxidising radicals. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 26, 432-439. DOI: 10.1002/poc.3104
Schnee, G; Fliedel, C; Aviles, T; Dagorne, S. 2013. Neutral and Cationic N-Heterocyclic Carbene Zinc Adducts and the BnOH/Zn(C6F5)(2) Binary Mixture - Characterization and Use in the Ring-Opening Polymerization of beta-Butyrolactone, Lactide, and Trimethylene Carbonate. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2013, 3699-3709. DOI: 10.1002/ejic.201300292
Maiti, BK; Aviles, T; Carepo, MSP; Moura, I; Pauleta, SR; Moura, JJG. 2013. Rearrangement of Mo-Cu-S Cluster Reflects the Structural Instability of Orange Protein Cofactor. ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 639, 1361-1364. DOI: 10.1002/zaac.201300034
Qu, XH; Latino, DARS; Aires-de-Sousa, J. 2013. A big data approach to the ultra-fast prediction of DFT-calculated bond energies. Journal of Cheminformatics, 5. DOI: 10.1186/1758-2946-5-34
Vilas-Boasa, V; Silva, R; Nunes, C; Reis, S; Ferreira, L; Vieira, C; Carvalho, F; Bastos, MD; Remiao, F. 2013. Mechanisms of P-gp inhibition and effects on membrane fluidity of a new rifampicin derivative, 1,8-dibenzoyl-rifampicin. TOXICOLOGY LETTERS, 220, 259-266. DOI: 10.1016/j.toxlet.2013.05.005
Avo, J; Martins, S; Parola, AJ; Lima, JC; Branco, PS; Ramalho, JPP; Pereira, A. 2013. A Family of Styrylcoumarins: Synthesis, Spectroscopic, Photophysical and Photochemical Properties. ChemPlusChem, 78, 789-792. DOI: 10.1002/cplu.201300118
Pereira, F; Ponte-e-Sousa, JC; Fartaria, RPS; Bonifacio, VDB; Mata, P; Aires-de-Sousa, J; Lobo, AM. 2013. Sonified Infrared Spectra and Their Interpretation by Blind and Visually Impaired Students. JOURNAL OF CHEMICAL EDUCATION, 90, 1028-1031. DOI: 10.1021/ed4000124
Santos, CIM; Oliveira, E; Fernandez-Lodeiro, J; Barata, JFB; Santos, SM; Faustino, MAF; Cavaleiro, JAS; Neves, MGPMS; Lodeiro, C. 2013. Corrole and Corrole Functionalized Silica Nanoparticles as New Metal Ion Chemosensors: A Case of Silver Satellite Nanoparticles Formation. INORGANIC CHEMISTRY, 52, 8564-8572. DOI: 10.1021/ic4006295
Vilas-Boas, V; Silva, R; Palmeira, A; Sousa, E; Ferreira, LM; Branco, PS; Carvalho, F; Bastos, MD; Remiao, F. 2013. Development of Novel Rifampicin-Derived P-Glycoprotein Activators/Inducers. Synthesis, In Silico Analysis and Application in the RBE4 Cell Model, Using Paraquat as Substrate. PLoS One, 8. DOI: 10.1371/journal.pone.0074425
Deb, ML; Dey, SS; Bento, I; Barros, MT; Maycock, CD. 2013. Copper-Catalyzed Regioselective Intramolecular Oxidative alpha-Functionalization of Tertiary Amines: An Efficient Synthesis of Dihydro-1,3-Oxazines. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52, 9791-9795. DOI: 10.1002/anie.201304654
Potewar, TM; Petrova, KT; Barros, MT. 2013. Efficient microwave assisted synthesis of novel 1,2,3-triazole-sucrose derivatives by cycloaddition reaction of sucrose azides and terminal alkynes. CARBOHYDRATE RESEARCH, 379, 60-67. DOI: 10.1016/j.carres.2013.06.017
Cunha, BMP; Trindade, IN; Couto, NAS; Costa, PJ; Rodrigues, P; Barros, MT; Costa, ML; Duarte, MF; Fernandez, MT; Madeira, PJA. 2013. Gas-phase interaction between nickel (II) and nitrobenzyl azides: An ESI-MSn study. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 351, 27-36. DOI: 10.1016/j.ijms.2013.05.012
Moura, NMM; Nunez, C; Santos, SM; Faustino, MAF; Cavaleiro, JAS; Neves, MGPMS; Capelo, JL; Lodeiro, C. 2013. Functionalized Porphyrins as Red Fluorescent Probes for Metal Cations: Spectroscopic, MALDI-TOF Spectrometry, and Doped-Polymer Studies. ChemPlusChem, 78, 1230-1243. DOI: 10.1002/cplu.201300216
Gawande, MB; Rathi, AK; Branco, PS; Varma, RS. 2013. Sustainable Utility of Magnetically Recyclable Nano-Catalysts in Water: Applications in Organic Synthesis. Applied Sciences-Basel, 3, 656-674. DOI: 10.3390/app3040656
Costa, N; Matos, S; da Silva, MDRG; Pereira, MMA. 2013. Cyclodextrin-Based Ionic Liquids as Enantioselective Stationary Phases in Gas Chromatography. ChemPlusChem, 78, 1466-1474. DOI: 10.1002/cplu.201300229
Phillips, AMF; Barros, MT. 2014. Enantioselective Organocatalytic Synthesis of alpha-Cyclopropylphosphonates through a Domino Michael Addition/Intramolecular Alkylation Reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 152-163. DOI: 10.1002/ejoc.201301207
Phillips, AMF; Barros, MT; Pacheco, M; Dias, R. 2014. Synthesis and biological evaluation of alpha-hydroxyalkylphosphonates as new antimicrobial agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24, 49-53. DOI: 10.1016/j.bmcl.2013.12.002
Gawande, MB; Bonifacio, VDB; Luque, R; Branco, PS; Varma, RS. 2014. Solvent-Free and Catalysts-Free Chemistry: A Benign Pathway to Sustainability. ChemSusChem, 7, 24-44. DOI: 10.1002/cssc.201300485
Moura, NMM; Nunez, C; Faustino, MAF; Cavaleiro, JAS; Neves, MGPMS; Capelo, JL; Lodeiro, C. 2014. Preparation and ion recognition features of porphyrin-chalcone type compounds as efficient red-fluorescent materials. Journal of Materials Chemistry C, 2, 4772-4783. DOI: 10.1039/c3tc32496f
Crucho, CIC; Barros, MT. 2014. Surfactant-free polymeric nanoparticles composed of PEG, cholic acid and a sucrose moiety. Journal of Materials Chemistry B, 2, 3946-3955. DOI: 10.1039/c3tb21632b
Sa, S; Gawande, MB; Velhinho, A; Veiga, JP; Bundaleski, N; Trigueiro, J; Tolstogouzov, A; Teodoro, OMND; Zboril, R; Varma, RS; Branco, PS. 2014. Magnetically recyclable magnetite-palladium (Nanocat-Fe-Pd) nanocatalyst for the Buchwald-Hartwig reaction. GREEN CHEMISTRY, 16, 3494-3500. DOI: 10.1039/c4gc00558a
Raposo, CD; Petrova, KT; Barros, MT. 2014. MICROWAVE-ASSISTED PROTOCOLS APPLIED TO THE SYNTHESIS OF 1 ',2,3,3 ',4,4 '-HEXA-O-BENZYLSUCROSE. SYNTHETIC COMMUNICATIONS, 44, 3027-3036. DOI: 10.1080/00397911.2014.926555
Petrova, KT; Correia-da-Silva, P; Crucho, CIC; Barros, MT. 2014. Chemoselective Synthesis of Sucrose Building Blocks and Their Polymerization. CURRENT ORGANIC CHEMISTRY, 18, 1788-1802. DOI:
Enugala, R; Pires, MJD; Marques, MMB. 2014. Synthesis of the NAG-NAM disaccharide via a versatile intermediate. CARBOHYDRATE RESEARCH, 384, 112-118. DOI: 10.1016/j.carres.2013.12.007
Barbosa, DJ; Capela, JP; Silva, R; Ferreira, LM; Branco, PS; Fernandes, E; Bastos, ML; Carvalho, F. 2014. Ecstasy-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites. ARCHIVES OF TOXICOLOGY, 88, 515-531. DOI: 10.1007/s00204-013-1147-9
Barbosa, DJ; Capela, JP; Silva, R; Vilas-Boas, V; Ferreira, LM; Branco, PS; Fernandes, E; Bastos, MD; Carvalho, F. 2014. "The mixture of ""ecstasy"" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations". ARCHIVES OF TOXICOLOGY, 88, 455-473. DOI: 10.1007/s00204-013-1120-7
Latino, DARS; Aires-de-Sousa, J. 2014. Automatic NMR-Based Identification of Chemical Reaction Types in Mixtures of Co-Occurring Reactions. PLoS One, 9. DOI: 10.1371/journal.pone.0088499
Martins, JG; Neto, IFF; Pinto, ISS; Soares, EV; Barros, MT; Soares, HMVM. 2014. Alternative chelating agents: Evaluation of the ready biodegradability and complexation properties. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, 49, 344-354. DOI: 10.1080/10934529.2014.846706
Fliedel, C; Vila-Vicosa, D; Calhorda, MJ; Dagorne, S; Aviles, T. 2014. Dinuclear Zinc-N-Heterocyclic Carbene Complexes for Either the Controlled Ring-Opening Polymerization of Lactide or the Controlled Degradation of Polylactide Under Mild Conditions. ChemCatChem, 6, 1357-1367. DOI: 10.1002/cctc.201301015
Zhang, QY; Zheng, FF; Fartaria, R; Latino, DARS; Qu, XH; Campos, T; Zhao, TF; Aires-de-Sousa, J. 2014. A QSPR approach for the fast estimation of DFT/NBO partial atomic charges. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 134, 158-163. DOI: 10.1016/j.chemolab.2014.03.011
Santos, CIM; Oliveira, E; Menezes, JCJMDS; Barata, JFB; Faustino, MAF; Ferreira, VF; Cavaleiro, JAS; Neves, MGPMS; Lodeiro, C. 2014. New coumarin-corrole and -porphyrin conjugate multifunctional probes for anionic or cationic interactions: synthesis, spectroscopy, and solid supported studies. TETRAHEDRON, 70, 3361-3370. DOI: 10.1016/j.tet.2013.07.022
Moura, NMM; Nunez, C; Santos, SM; Faustino, MAF; Cavaleiro, JAS; Paz, FAA; Neves, MGPMS; Capelo, JL; Lodeiro, C. 2014. A New 3,5-Bisporphyrinylpyridine Derivative as a Fluorescent Ratiometric Probe for Zinc Ions. CHEMISTRY-A EUROPEAN JOURNAL, 20, 6684-6692. DOI: 10.1002/chem.201402270
Barbosa, DJ; Serrat, R; Mirra, S; Quevedo, M; de Barreda, EG; Avila, J; Ferreira, LM; Branco, PS; Fernandes, E; Bastos, MD; Capela, JP; Soriano, E; Carvalho, F. 2014. "The Mixture of ""Ecstasy"" and Its Metabolites Impairs Mitochondrial Fusion/Fission Equilibrium and Trafficking in Hippocampal Neurons, at In Vivo Relevant Concentrations". TOXICOLOGICAL SCIENCES, 139. DOI: 10.1093/toxsci/kfu042
Santos, CIM; Oliveira, E; Barata, JFB; Faustino, MAF; Cavaleiro, JAS; Neves, MGPMS; Lodeiro, C. 2014. New gallium(III) corrole complexes as colorimetric probes for toxic cyanide anion. INORGANICA CHIMICA ACTA, 417, 148-154. DOI: 10.1016/j.ica.2013.09.049
Neto, IFF; Pinto, ISS; Barros, MT; Maycock, CD; Soares, HMVM. 2014. Study of the Performance of Nitrilotriacetic Acid and Ethylenediiminopropanedioic Acid as Alternative Biodegradable Chelating Agents for Pulp Bleaching. International Journal of Environmental Research, 8, 613-620. DOI:
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Martins, F; Santos, S; Ventura, C; Elvas-Leitao, R; Santos, L; Vitorino, S; Reis, M; Miranda, V; Correia, HE; Aires-de-Sousa, J; Kovalishyn, V; Latino, DARS; Ramos, J; Viveiros, M. 2014. Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 81, 119-138. DOI: 10.1016/j.ejmech.2014.04.077
Fliedel, C; Mameri, S; Dagorne, S; Aviles, T. 2014. Controlled ring-opening polymerization of trimethylene carbonate and access to PTMC-PLA block copolymers mediated by well-defined N-heterocyclic carbene zinc alkoxides. APPLIED ORGANOMETALLIC CHEMISTRY, 28, 504-511. DOI: 10.1002/aoc.3154
Maiti, BK; Aviles, T; Moura, I; Pauleta, SR; Moura, JJG. 2014. Synthesis and characterization of [S2MoS2Cu(n-SPhF)](2-) (n = o, m, P) clusters: Potential F-19-NMR structural probes for Orange Protein. INORGANIC CHEMISTRY COMMUNICATIONS, 45, 97-100. DOI: 10.1016/j.inoche.2014.04.006
Fliedel, C; Schnee, G; Aviles, T; Dagorne, S. 2014. Group 13 metal (Al, Ga, In, Tl) complexes supported by heteroatom-bonded carbene ligands. COORDINATION CHEMISTRY REVIEWS, 275, 63-86. DOI: 10.1016/j.ccr.2014.04.003
Fliedel, C; Rosa, V; Santos, CIM; Gonzalez, PJ; Almeida, RM; Gomes, CSB; Gomes, PT; Lemos, MANDA; Aullon, G; Welter, R; Aviles, T. 2014. Copper(II) complexes of bis(aryl-imino)acenaphthene ligands: synthesis, structure, DFT studies and evaluation in reverse ATRP of styrene. DALTON TRANSACTIONS, 43, 13041-13054. DOI: 10.1039/c4dt01069h
Petrova, KT; Potewar, TM; Ascenso, OS; Barros, MT. 2014. Amide-linked N-methacryloyl sucrose containing polymers. CARBOHYDRATE POLYMERS, 110, 38-46. DOI: 10.1016/j.carbpol.2014.03.050
Maiti, BK; Maia, LB; Pal, K; Pakhira, B; Aviles, T; Moura, I; Pauleta, SR; Nunez, JL; Rizzi, AC; Brondino, CD; Sarkar, S; Moura, JJG. 2014. One Electron Reduced Square Planar Bis(benzene-1,2-dithiolato) Copper Dianionic Complex and Redox Switch by O-2/HO-. INORGANIC CHEMISTRY, 53, 12799-12808. DOI: 10.1021/ic501742j
Kauf, T; Rosa, V; Fliedel, C; Pattacini, R; Deibel, N; Aviles, T; Sarkar, B; Braunstein, P. 2015. Reactivity of TCNE and TCNQ derivatives of quinonoid zwitterions with Cu(I). DALTON TRANSACTIONS, 44, 5441-5450. DOI: 10.1039/c4dt03956d
Carvalho, LCR; Ribeiro, D; Seixas, RSGR; Silva, AMS; Nave, M; Martins, AC; Erhardt, S; Fernandes, E; Cabrita, EJ; Marques, MMB. 2015. Synthesis and evaluation of new benzimidazole-based COX inhibitors: a naproxen-like interaction detected by STD-NMR. RSC Advances, 5, 49098-49109. DOI: 10.1039/c5ra04984a
Aguiar, A; Leite, A; Silva, AMN; Tome, AC; Cunha-Silva, L; de Castro, B; Rangel, M; Silva, AMG. 2015. Isoxazolidine-fused meso-tetraarylchlorins as key tools for the synthesis of mono- and bis-annulated chlorins. ORGANIC & BIOMOLECULAR CHEMISTRY, 13, 7131-7135. DOI: 10.1039/c5ob00800j
Fliedel, C; Rosa, V; Alves, FM; Martins, AM; Aviles, T; Dagorne, S. 2015. P,O-Phosphinophenolate zinc(II) species: synthesis, structure and use in the ring-opening polymerization (ROP) of lactide, epsilon-caprolactone and trimethylene carbonate. DALTON TRANSACTIONS, 44, 12376-12387. DOI: 10.1039/c5dt00458f
Sousa, CAD; Sampaio-Dias, IE; Rizzo-Aguiar, F; Garcia-Mera, X; Rodriguez-Borges, JE. 2015. Enantiopure synthesis of 7-(1-pyrindanyl)propargyl ethers as rasagiline analogues via chemical or enzymatic resolution of 1-pyrindan-7-ol. RSC Advances, 5, 104509-104515. DOI: 10.1039/c5ra24868j
Phillips, AMF; Nogueira, F; Murtinheira, F; Barros, MT. 2015. Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25, 2112-2116. DOI: 10.1016/j.bmcl.2015.03.077
Martins, IL; Charneira, C; Gandin, V; da Silva, JLF; Justino, GC; Telo, JP; Vieira, AJSC; Marzano, C; Antunes, AMM. 2015. Selenium-Containing Chrysin and Quercetin Derivatives: Attractive Scaffolds for Cancer Therapy. JOURNAL OF MEDICINAL CHEMISTRY, 58, 4250-4265. DOI: 10.1021/acs.jmedchem.5b00230
Crucho, CIC; Barros, MT. 2015. Formulation of functionalized PLGA polymeric nanoparticles for targeted drug delivery. POLYMER, 68, 41-46. DOI: 10.1016/j.polymer.2015.04.083
Petrova, KT; Dey, SS; Barros, MT. 2015. Formation of spherical and core-shell polymeric microparticles from glycopolymers. CARBOHYDRATE POLYMERS, 125, 281-287. DOI: 10.1016/j.carbpol.2015.02.052
Padmanaban, M; Carvalho, LCR; Petkova, D; Lee, JW; Santos, AS; Marques, MMB; Maulide, N. 2015. Investigation of cationic Claisen-type electrophilic rearrangements of amides. TETRAHEDRON, 71, 5994-6005. DOI: 10.1016/j.tet.2015.06.027
Queiros, C; Leite, A; Couto, MGM; Cunha-Silva, L; Barone, G; de Castro, B; Rangel, M; Silva, AMN; Silva, AMG. 2015. The Influence of the Amide Linkage in the Fe-III-Binding Properties of Catechol-Modified Rosamine Derivatives. CHEMISTRY-A EUROPEAN JOURNAL, 21, 15692-15704. DOI: 10.1002/chem.201502093
Raposo, CD; Petrova, KT; Barros, MT. 2015. Synthesis of cross-linked polymeric microparticles containing hexa-O-benzylsucrose. DESIGNED MONOMERS AND POLYMERS, 18, 753-760. DOI: 10.1080/15685551.2015.1070507
Petrova, KT; Potewar, TM; Correia-da-Silva, P; Barros, MT; Calhelha, RC; Ciric, A; Sokovic, M; Ferreira, ICFR. 2015. Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives. CARBOHYDRATE RESEARCH, 417, 66-71. DOI: 10.1016/j.carres.2015.09.003
Sousa, CAD; Pereira, C; Rodriguez-Borges, JE; Freire, C. 2015. L-Serine functionalized clays: Preparation and characterization. POLYHEDRON, 102, 121-129. DOI: 10.1016/j.poly.2015.08.008
Moniz, T; Coimbra, JTS; Bras, NF; Cunha-Silva, L; Ramos, MJ; Fernandes, PA; de Castro, B; Rangel, M. 2016. Synthesis and structural characterization, by spectroscopic and computational methods, of two fluorescent 3-hydroxy-4-pyridinone chelators bearing sulphorhodamine B and naphthalene. RSC Advances, 6, 4200-4211. DOI: 10.1039/c5ra23217a
Sousa, CAD; Sampaio-Dias, IE; Garcia-Mera, X; Lima, CFRAC; Rodriguez-Borges, JE. 2016. On the scope of oxidation of tertiary amines: Meisenheimer rearrangements versus Cope elimination in 2-(cyanoethyl)-2-azanorbornanes. Organic Chemistry Frontiers, 3, 1624-1634. DOI: 10.1039/c6qo00330c
Sousa, ME; Araujo, MJ; do Vale, ML; Andrade, PB; Branco, P; Gomes, P; Moreira, R; Melo, TMVDP; Freitas, V. 2016. 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry. PHARMACEUTICALS, 9. DOI: 10.3390/ph9010015
Rebelo, SLH; Silva, AMN; Medforth, CJ; Freire, C. 2016. Iron(III) Fluorinated Porphyrins: Greener Chemistry from Synthesis to Oxidative Catalysis Reactions. MOLECULES, 21. DOI: 10.3390/molecules21040481
Leite, A; Silva, AMG; Coutinho, C; Cunha-Silva, L; de Castro, B; Rangel, M. 2016. Design of a Water Soluble Fluorescent 3-Hydroxy-4-Pyridinone Ligand Active at Physiological pH Values. JOURNAL OF FLUORESCENCE, 26, 1773-1785. DOI: 10.1007/s10895-016-1869-1
Alves, EA; Soares, JX; Silva, AM; Neves, JF; Cravo, SM; Silva, AM; Rangel, M; Afonso, CM; Netto, AD; Carvalho, F; Oliveira, RJD. 2016. identification of a complex mixture of opioids on krokodil street-like samples. TOXICOLOGY LETTERS, 258, S300-S300. DOI: 10.1016/j.toxlet.2016.06.2039
Peixoto, A; Fernandes, E; Gaiteiro, C; Lima, L; Azevedo, R; Soares, J; Cotton, S; Parreira, B; Neves, M; Amaro, T; Tavares, A; Teixeira, F; Palmeira, C; Rangel, M; Silva, AMN; Reis, CA; Santos, LL; Oliveira, MJ; Ferreira, JA. 2016. Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension. Oncotarget, 7, 63138-63157. DOI: 10.18632/oncotarget.11257
Carvalho, LCR; Queda, F; Santos, CVA; Marques, MMB. 2016. Selective Modification of Chitin and Chitosan: En Route to Tailored Oligosaccharides. Chemistry-An Asian Journal, 11, 3468-3481. DOI: 10.1002/asia.201601041
Sampaio-Dias, IE; Sousa, CAD; Garcia-Mera, X; da Costa, JF; Caamano, O; Rodriguez-Borges, JE. 2016. Novel L-prolyl-L-leucylglycinamide (PLG) tripeptidomimetics based on a 2-azanorbornane scaffold as positive allosteric modulators of the D2R. ORGANIC & BIOMOLECULAR CHEMISTRY, 14, 11065-11069. DOI: 10.1039/c6ob02248k
Pereira, F; Xiao, KX; Latino, DARS; Wu, CC; Zhang, QY; Aires-de-Sousa, J. 2017. Machine Learning Methods to Predict Density Functional Theory B3LYP Energies of HOMO and LUMO Orbitals. Journal of Chemical Information and Modeling, 57, 11-21. DOI: 10.1021/acs.jcim.6b00340
Soares, A; Estevao, MS; Marques, MMB; Kovalishyn, V; Latino, DARS; Aires-de-Sousa, J; Ramos, J; Viveiros, M; Martins, F. 2017. Synthesis and Biological Evaluation of Hybrid 1,5-and 2,5-Disubstituted Indoles as Potentially New Antitubercular Agents. Medicinal Chemistry, 13, 439-447. DOI: 10.2174/1573406413666170209144003
Marques, MP; Alves, VD; Coelhoso, IM. 2017. Concentration of Tea Extracts by Osmotic Evaporation: Optimisation of Process Parameters and Effect on Antioxidant Activity. MEMBRANES, 7. DOI: 10.3390/membranes7010001
Feio-Azevedo, R; Costa, VM; Ferreira, LM; Branco, PS; Pereira, FC; Bastos, ML; Carvalho, E; Capela, JP. 2017. Toxicity of the amphetamine metabolites 4-hydroxyamphetamine and 4-hydroxynorephedrine in human dopaminergic differentiated SH-SY5Y cells. TOXICOLOGY LETTERS, 269, 65-76. DOI: 10.1016/j.toxlet.2017.01.012
Rocha, JA; Andrade, IM; Veras, LMC; Quelemes, PV; Lima, DF; Soares, MJS; Pinto, PLS; Mayo, SJ; Ivanova, G; Rangel, M; Correia, M; Mafud, AC; Mascarenhas, YP; Delerue-Matos, C; de Moraes, J; Eaton, P; Leite, JRSA. 2017. Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves. PHYTOTHERAPY RESEARCH, 31, 624-630. DOI: 10.1002/ptr.5771
Almeida, J; Aguiar, A; Leite, A; Silva, AMN; Cunha-Silva, L; de Castro, B; Rangel, M; Barone, G; Tome, AC; Silva, AMG. 2017. 1,3-Dipolar cycloadditions with meso-tetraarylchlorins - site selectivity and mixed bisadducts. Organic Chemistry Frontiers, 4, 534-544. DOI: 10.1039/c6qo00771f
Specklin, D; Fliedel, C; Gourlaouen, C; Bruyere, JC; Aviles, T; Boudon, C; Ruhlmann, L; Dagorne, S. 2017. N-Heterocyclic Carbene Based Tri-organyl-Zn-Alkyl Cations: Synthesis, Structures, and Use in CO2 Functionalization. CHEMISTRY-A EUROPEAN JOURNAL, 23, 5509-5519. DOI: 10.1002/chem.201605907
Martins, JG; Ferreira, CMH; Dey, SS; Barros, MT; Soares, HMVM. 2017. N,N'-Dihydroxy-N,N'-diisopropylhexanediamide, a siderophore analogue, as a possible iron chelating agent for hydroponic conditions: metal equilibrium studies. Journal of the Iranian Chemical Society, 14, 1079-1088. DOI: 10.1007/s13738-017-1057-5
Dias, SA; Freire, JM; Perez-Peinado, C; Domingues, MM; Gaspar, D; Vale, N; Gomes, P; Andreu, D; Henriques, ST; Castanho, MARB; Veiga, AS. 2017. New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins. Frontiers in Microbiology, 8. DOI: 10.3389/fmicb.2017.00775
Pires, MJD; Purificacao, SI; Santos, AS; Marques, MMB. 2017. The Role of PEG on Pd- and Cu-Catalyzed Cross-Coupling Reactions. SYNTHESIS-STUTTGART, 49, 2337-2350. DOI: 10.1055/s-0036-1589498
Peixoto, D; Figueiredo, M; Gawande, MB; Corvo, MC; Vanhoenacker, G; Afonso, CAM; Ferreira, LM; Branco, PS. 2017. Developments in the Reactivity of 2-Methylimidazolium Salts. JOURNAL OF ORGANIC CHEMISTRY, 82, 6232-6241. DOI: 10.1021/acs.joc.7b00807
Vale, N; Ferreira, A; Fernandes, I; Alves, C; Araujo, MJ; Mateus, N; Gomes, P. 2017. Gemcitabine anti-proliferative activity significantly enhanced upon conjugation with cell-penetrating peptides. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27, 2898-2901. DOI: 10.1016/j.bmcl.2017.04.086
Chagas, R; Lourenco, AM; Monteiro, S; Ferreira, RB; Ferreira, LM. 2017. Is caffeic acid, as the major metabolite present in Moscatel wine protein haze hydrolysate, involved in protein haze formation?. FOOD RESEARCH INTERNATIONAL, 98, 103-109. DOI: 10.1016/j.foodres.2016.09.007
Soares, JX; Alves, EA; Silva, AMN; de Figueiredo, NG; Neves, JF; Cravo, SM; Rangel, M; Netto, ADP; Carvalho, F; Dinis-Oliveira, RJ; Afonso, CM. 2017. Street-Like Synthesis of Krokodil Results in the Formation of an Enlarged Cluster of Known and New Morphinans. CHEMICAL RESEARCH IN TOXICOLOGY, 30, 1609-1621. DOI: 10.1021/acs.chemrestox.7b00126
Ferraz, R; Pinheiro, M; Gomes, A; Teixeira, C; Prudencio, C; Reis, S; Gomes, P. 2017. Effects of novel triple-stage antimalarial ionic liquids on lipid membrane models. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27, 4190-4193. DOI: 10.1016/j.bmcl.2017.07.006
Patil, A; Lande, DN; Nalkar, A; Gejji, SP; Chakrovorty, D; Gonnade, R; Moniz, T; Rangel, M; Pereira, E; Salunke-Gawali, S. 2017. Binding selectivity of vitamin K3 based chemosensors towards nickel(II) and copper(II) metal ions. JOURNAL OF MOLECULAR STRUCTURE, 1143, 495-514. DOI: 10.1016/j.molstruc.2017.04.094
Crucho, CIC; Barros, MT. 2017. Polymeric nanoparticles: A study on the preparation variables and characterization methods. Materials Science & Engineering C-Materials for Biological Applications, 80, 771-784. DOI: 10.1016/j.msec.2017.06.004
Raposo, CD; Petrova, KT; Barros, MT; Calhelha, RC; Sokovic, M; Ferreira, ICFR. 2016. Synthesis, Characterization, Antimicrobial and Antitumor Activities of Sucrose Octa(N-ethyl)carbamate. Medicinal Chemistry, 12, 22-29. DOI:
Zhang, QY; Zheng, FF; Zhao, TF; Qu, XH; Aires-de-Sousa, J. 2016. Machine Learning Estimation of Atom Condensed Fukui Functions. Molecular Informatics, 35, 62-69. DOI: 10.1002/minf.201500113
Cardoso, MM; Peca, IN; Raposo, CD; Petrova, KT; Barros, MT; Gardner, R; Bicho, A. 2016. Doxorubicin-loaded galactose-conjugated poly(d,l-lactide-co-glycolide) nanoparticles as hepatocyte-targeting drug carrier. JOURNAL OF MICROENCAPSULATION, 33, 315-322. DOI: 10.1080/02652048.2016.1185474
Pires, MJD; Poeira, DL; Purificacao, SI; Marques, MMB. 2016. Synthesis of Substituted 4-, 5-, 6-, and 7-Azaindoles from Aminopyridines via a Cascade C-N Cross-Coupling/Heck Reaction. ORGANIC LETTERS, 18, 3250-3253. DOI: 10.1021/acs.orglett.6b01500
Maximo, P; Ferreira, LM; Branco, P; Lima, P; Lourenco, A. 2016. The Role of Spongia sp in the Discovery of Marine Lead Compounds. Marine Drugs, 14. DOI: 10.3390/md14080139
Campos, SP; Pinto, MD; Gomes, G; de Pinho, PG; Monteiro, JA; Felix, LM; Branco, PS; Ferreira, LM; Antunes, LM. 2016. Expression of CYP1A1 and CYP1A2 in the liver and kidney of rabbits after prolonged infusion of propofol. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 68, 521-531. DOI: 10.1016/j.etp.2016.07.006
Chagas, R; Ferreira, LM; Laia, CAT; Monteiro, S; Ferreira, RB. 2016. The challenging SO2-mediated chemical build-up of protein aggregates in wines. FOOD CHEMISTRY, 192, 460-469. DOI: 10.1016/j.foodchem.2015.07.052
Henriques, MX; Rodrigues, T; Carido, M; Ferreira, L; Filipe, SR. 2011. Synthesis of capsular polysaccharide at the division septum of Streptococcus pneumoniae is dependent on a bacterial tyrosine kinase. MOLECULAR MICROBIOLOGY, 82, 515-534. DOI: 10.1111/j.1365-2958.2011.07828.x
Ferraz, R; Branco, LC; Marrucho, IM; Araujo, JMM; Rebelo, LPN; da Ponte, MN; Prudencio, C; Noronha, JP; Petrovski, Z. 2012. Development of novel ionic liquids based on ampicillin. MedChemComm, 3, 494-497. DOI: 10.1039/c2md00269h
Florindo, C; Araujo, JMM; Alves, F; Matos, C; Ferraz, R; Prudencio, C; Noronha, JP; Petrovski, Z; Branco, L; Rebelo, LPN; Marrucho, IM. 2013. Evaluation of solubility and partition properties of ampicillin-based ionic liquids. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 456, 553-559. DOI: 10.1016/j.ijpharm.2013.08.010
Ferraz, R; Costa-Rodrigues, J; Fernandes, MH; Santos, MM; Marrucho, IM; Rebelo, LPN; Prudencio, C; Noronha, JP; Petrovski, Z; Branco, LC. 2015. Antitumor Activity of Ionic Liquids Based on Ampicillin. ChemMedChem, 10, 1480-1483. DOI: 10.1002/cmdc.201500142
Enugala, R; Carvalho, LCR; Pires, MJD; Marques, MMB. 2012. Stereoselective Glycosylation of Glucosamine: The Role of the N-Protecting Group. Chemistry-An Asian Journal, 7, 2482-2501. DOI: 10.1002/asia.201200338
Gawande, MB; Rathi, AK; Nogueira, ID; Varma, RS; Branco, PS. 2013. Magnetite-supported sulfonic acid: a retrievable nanocatalyst for the Ritter reaction and multicomponent reactions. GREEN CHEMISTRY, 15, 1895-1899. DOI: 10.1039/c3gc40457a
Gawande, MB; Rathi, AK; Branco, PS; Potewar, TM; Velhinho, A; Nogueira, ID; Tolstogouzov, A; Ghumman, CAA; Teodoro, OMND. 2013. Nano-MgO-ZrO2 mixed metal oxides: characterization by SIMS and application in the reduction of carbonyl compounds and in multicomponent reactions. RSC Advances, 3, 3611-3617. DOI: 10.1039/c2ra22511e
Gawande, MB; Shelke, SN; Branco, PS; Rathi, A; Pandey, RK. 2012. Mixed metal MgO-ZrO2 nanoparticle-catalyzed O-tert-Boc protection of alcohols and phenols under solvent-free conditions. APPLIED ORGANOMETALLIC CHEMISTRY, 26, 395-400. DOI: 10.1002/aoc.2846
Martins, SMA; Branco, PCS; Pereira, AMDRL. 2012. An Efficient Methodology for the Synthesis of 3-Styryl Coumarins. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 23, 688-693. DOI:
Gawande, MB; Branco, PS. 2011. An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media. GREEN CHEMISTRY, 13, 3355-3359. DOI: 10.1039/c1gc15868f
Gordo, J; Avo, J; Parola, AJ; Lima, JC; Pereira, A; Branco, PS. 2011. Convenient Synthesis of 3-Vinyl and 3-Styryl Coumarins. ORGANIC LETTERS, 13, 5112-5115. DOI: 10.1021/ol201983u
da Silva, DG; de Pinho, PG; Pontes, H; Ferreira, L; Branco, P; Remiao, F; Carvalho, F; Bastos, ML; Carmo, H. 2010. Gas chromatography-ion trap mass spectrometry method for the simultaneous measurement of MDMA (ecstasy) and its metabolites, MDA, HMA, and HMMA in plasma and urine. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 878, 815-822. DOI: 10.1016/j.jchromb.2010.01.042
Barros, MT; Dey, SS; Maycock, CD; Rodrigues, P. 2012. Metal-free direct amination/aromatization of 2-cyclohexenones to iodo-N-arylanilines and N-arylanilines promoted by iodine. CHEMICAL COMMUNICATIONS, 48, 10901-10903. DOI: 10.1039/c2cc35801h
Salema-Oom, M; de Sousa, HR; Assuncao, M; Goncalves, P; Spencer-Martins, I. 2011. Derepression of a baker's yeast strain for maltose utilization is associated with severe deregulation of HXT gene expression. JOURNAL OF APPLIED MICROBIOLOGY, 110, 364-374. DOI: 10.1111/j.1365-2672.2010.04895.x
Costa, Leticia D; Costa, Joana IT; Tome, Augusto C. 2016. Porphyrin Macrocycle Modification: Pyrrole Ring-Contracted or -Expanded Porphyrinoids. MOLECULES, 21(3). DOI: 10.3390/molecules21030320
Carreiro, EP; Moura, NMM; Burke, AJ. 2012. Covalent and Noncovalent Immobilization of Arylid-BOX Ligands and Their Derivatives: Evaluation in the Catalytic Asymmetric Cyclopropanation of Styrenes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 518-528. DOI: 10.1002/ejoc.201100781
Carreiro, Elisabete P; Prates Ramalho, JP; Burke, Anthony J. 2011. Chiral monooxazolines as modular copper(I)-heterocomplex building blocks: investigations on the catalytic asymmetric cyclopropanation of alkenes. TETRAHEDRON, 67(25), 4640-4648. DOI: 10.1016/j.tet.2011.04.066
Marques, Carolina S; Burke, Anthony J. 2011. Advances in the Catalytic Asymmetric Arylation of Imines using Organoboron Reagents: An Approach to Chiral Arylamines. ChemCatChem, 3(4), 635-645. DOI: 10.1002/cctc.201000369
Marques, Carolina S; Burke, Anthony J. 2012. Expeditious and novel synthesis of alpha-hydroxyesters via rhodium-NHC catalyzed arylation of ethyl glyoxalate. TETRAHEDRON, 68(35), 7211-7216. DOI: 10.1016/j.tet.2012.05.129
Marques, Carolina S; Burke, Anthony J. 2012. Chiral Diphosphane- and NHC-Containing Ruthenium Catalysts for the Catalytic Asymmetric Arylation of Aldimines with Organoboron Reagents. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 4232-4239. DOI: 10.1002/ejoc.201200556
Marques, CS; Peixoto, D; Burke, AJ. 2015. Transition-metal-catalyzed intramolecular cyclization of amido(hetero)arylboronic acid aldehydes to isoquinolinones and derivatives. RSC Advances, 5(26), 20108-20114. DOI: 10.1039/c5ra00404g
Marinho, Vanda RD; Prates Ramalho, JP; Rodrigues, Ana Isabel; Burke, Anthony J. 2011. Evaluation of Phosphinoamidoester-Derived Pd Catalysts in the Asymmetric Allylic Alkylation Reaction: Theoretical Studies and Mechanistic Insights. CHIRALITY, 23(5), 383-388. DOI: 10.1002/chir.20936
Marinho, Vanda Raquel; Ramalho, JPPrates; Rodrigues, Ana I; Burke, Anthony J. 2009. A Comparison of (R,R)-Me-DUPHOS and (R,R)-DUPHOS-iPr Ligands in the Pd-0-Catalysed Asymmetric Allylic Alkylation Reaction: Stereochemical and Kinetic Considerations. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 6311-6317. DOI: 10.1002/ejoc.200900649
Marques, Carolina S; Burke, Anthony J. 2010. Catalytic Enantioselective Addition of Phenylboronic Acid and Phenylboroxine to N-Tosylimines: Pd-II and Rh-I Catalysis. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 1639-1643. DOI: 10.1002/ejoc.200901139
Carreiro, Elisabete Palma; Burke, Anthony J; Ramalho, JPPrates; Rodrigues, Ana Isabel. 2009. Arylid-OX and Arylid-BOX derived catalysts: applications in catalytic asymmetric cyclopropanation. TETRAHEDRON-ASYMMETRY, 20(11), 1272-1278. DOI: 10.1016/j.tetasy.2009.04.005
Marques, CS; Ramalho, JPP; Burke, AJ. 2009. The benzilic ester rearrangement: Synthesis of labelled compounds and theoretical studies. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 22(8), 735-739. DOI: 10.1002/poc.1509
Marinho, Vanda R; Burke, Anthony J. 2009. Application of Walphos Ligand in the Pd(0)-Catalyzed Asymmetric Allylic Alkylation Reaction. SYNTHETIC COMMUNICATIONS, 39(24), 4423-4428. DOI: 10.1080/00397910902906578
Burke, AJ; Marinho, VR; Furtado, OMR. 2010. Recent multiple transition metal catalysed single-pot reactions. CURRENT ORGANIC SYNTHESIS, 7(2), 94-119. DOI: 10.2174/157017910790820283
Marinho, Vanda Raquel; Rodrigues, Ana Isabel; Burke, Anthony J. 2008. Novel chiral P,O-ligands for homogeneous Pd(0) catalysed asymmetric allylic alkylation reactions. TETRAHEDRON-ASYMMETRY, 19(4), 454-458. DOI: 10.1016/j.tetasy.2008.01.024
Martins, JG; Barrulas, PC; Marques, CS; Burke, AJ. 2008. New route to N-alkylated trans-pyrrolidine diols from 2,2,3,3- tetramethoxybutane-protected dimethyl tartrate. SYNTHETIC COMMUNICATIONS, 38(9), 1365-1374. DOI: 10.1080/00397910801916520
Burke, AJ; Marques, CS. 2007. Mechanistic and synthetic aspects of the benzilic acid and ester rearrangements. MINI-REVIEWS IN ORGANIC CHEMISTRY, 4(4), 310-316. DOI: 10.2174/157019307782411707
Marques, CS; Burke, AJ. 2008. Rh(I)-catalyzed asymmetric hydrosilylation and hydroboration/oxidation reactions using berens ligand. SYNTHETIC COMMUNICATIONS, 38(23), 4207-4214. DOI: 10.1080/00397910802323106
Burke, Anthony J. 2008. Chiral oxoperoxomolybdenum(VI) complexes for enantioselective olefin epoxidation: Some mechanistic and stereochemical reflections. COORDINATION CHEMISTRY REVIEWS, 252(1-2), 170-175. DOI: 10.1016/j.ccr.2007.05.002
Marques, Carolina S; Burke, Anthony J. 2007. Palladium catalysed enantioselective asymmetric allylic alkylations using the Berens' DIOP analogue. TETRAHEDRON-ASYMMETRY, 18(15), 1804-1808. DOI: 10.1016/j.tetasy.2007.07.004
Carreiro, ED; Burke, AJ. 2006. Catalytic epoxidation of olefins using MoO3 and TBHP: Mechanistic considerations and the effect of amine additives on the reaction. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 249(1-2), 123-128. DOI: 10.1016/j.molcata.2005.12.043
Carreiro, ED; Yong-En, G; Burke, AJ. 2005. Approaches towards catalytic asymmetric epoxidations with methyltrioxorhenium(VII) (MTO): Synthesis and evaluation of chiral non-racemic 2-substituted pyridines. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 235(1-2), 285-292. DOI: 10.1016/j.molcata.2005.03.022
Burke, AJ; Maycock, CD; Ventura, MR. 2006. Stereoselective alkylation of tartrate derivatives. A concise route to (+)-O-methylpiscidic acid and natural analogues. Organic and Biomolecular Chemistry, 4(12), 2361-2363. DOI: 10.1039/b606362b
Carreiro, EDP; Yong-En, G; Burke, AJ. 2006. Synthesis, characterisation and reactivity of oxodiperoxo-[2-(1-pyrazolyl)- 6-menthylpyridine]molybdenum(VI): The first chiral 2-(1-pyrazole) pyridineoxodiperoxomolybdenum(VI) complex. INORGANICA CHIMICA ACTA, 359(5), 1519-1523. DOI: 10.1016/j.ica.2005.11.021
Burke, AJ; Davies, SG; Garner, AC; McCarthy, TD; Roberts, PM; Smith, AD; Rodriguez-Solla, H; Vickers, RJ. 2004. Asymmetric synthesis and applications of beta-amino Weinreb amides: asymmetric synthesis of (S)-coniine. ORGANIC & BIOMOLECULAR CHEMISTRY, 2(9), 1387-1394. DOI: 10.1039/b402531h
Carreiro, ED; Burke, AJ; Curto, MJM; Teixeira, AJ. 2004. An efficient and selective method for the epoxidation of olefins using urea-hydrogen peroxide and methyltrioxorhenium (VII) (MTO) catalyst with heterocyclic aromatic amines. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 217(1-2), 69-72. DOI: 10.1016/j.molcata.2004.03.036
Carreiro, ED; Chercheja, S; Burke, AJ; Ramalho, JPP; Rodrigues, AI. 2005. Isbut-Box: A new chiral C-2 symmetric bis-oxazoline for catalytic enantioselective synthesis. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 236(1-2), 38-45. DOI: 10.1016/j.molcata.2005.04.011
Bunnage, ME; Burke, AJ; Davies, SG; Millican, NL; Nicholson, RL; Roberts, PM; Smith, AD. 2003. Asymmetric synthesis of anti-(2S,3S)- and syn-(2R,3S)-diaminobutanoic acid. ORGANIC & BIOMOLECULAR CHEMISTRY, 1(21), 3708-3715. DOI: 10.1039/b306936m
Barros, MT; Burke, AJ; Lou, JD; Maycock, CD; Wahnon, JR. 2004. Highly stereoselective aldol reaction for the synthesis of gamma-lactones starting from tartaric acid. JOURNAL OF ORGANIC CHEMISTRY, 69(23), 7847-7850. DOI: 10.1021/jo049027h
Barros, MT; Burke, AJ; Maycock, CD. 1999. The alkylation of a novel acetal derived from (2R,3R)-(+)-tartaric acid: An unexpected rearrangement. TETRAHEDRON LETTERS, 40(8), 1583-1586. DOI: 10.1016/S0040-4039(98)02650-1
Bennett, M; Burke, AJ; O'Sullivan, WI. 1998. Erratum: Aspects of the Algar-Flynn-Oyamada (AFO) reaction (Tetrahedron (1996) 52 (7163)). TETRAHEDRON, 54(34). DOI: 10.1016/S0040-4020(98)00629-2
Burke. . Design, Synthesis and Bioassays of 3-Substituted-3-Hydroxyoxindoles: Donepezil Analogues for Cholinesterase Inhibition,. ChemistrySelect, 1, 3580-. DOI:
Burke, AJ; Schmalle, HW; Brady, BA; O'Sullivan, WI. 2000. (E)-6-methoxy-3-(alpha-methoxybenzylidene)benzo[b]furan-2(3H)-one at 173 K. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 56, 484-486. DOI:
Lamosa, P; Burke, A; Peist, R; Huber, R; Liu, M-Y; Silva, G; Rodrigues-Pousada, C; LeGall, J; Maycock, C; Santos, H. 2000. Thermostabilization of proteins by diglycerol phosphate, a new compatible solute from the hyperthermophile Archaeoglobus fulgidus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 66(5), 1974-1979. DOI: 10.1128/AEM.66.5.1974-1979.2000
Burke, AJ; O'Sullivan, WI. 1998. Flavonoid epoxides. Part 22. Establishment of the configuration of the diastereomeric solvolysis products of 2-arylmethylenebenzo[b]furan-3(2H)-one (aurone) epoxides. TETRAHEDRON, 54(10), 2169-2180. DOI: 10.1016/S0040-4020(97)10429-X
Burke, AJ; O'Sullivan, WI. 1997. Flavonoid epoxides. Part 20. Some unusual reactions of dimethyldioxirane (DMD) with flavonoid compounds. TETRAHEDRON, 53(25), 8491-8500. DOI: 10.1016/S0040-4020(97)00506-1
Bennett, M; Burke, AJ; O'Sullivan, WI. 1996. Aspects of the Algar-Flynn-Oyamada (AFO) reaction. TETRAHEDRON, 52(20), 7163-7178. DOI: 10.1016/0040-4020(96)00334-1
Bunnage, M.E. and Burke, A.J. and Davies, S.G. and Goodwin, C.J.. 1995. Asymmetric synthesis of the N-terminal component of microginin: (2S,3R)-3-amino-2-hydroxydecanoic acid, its (2R,3R)-epimer and (3R)-3-aminodecanoic acid. TETRAHEDRON-ASYMMETRY, 6(1), 165-176. DOI:
Burke, AJ; Davies, SG; Hedgecock, CJR. 1996. Asymmetric Synthesis of (2S,3S)- and (2R,3S)-2,3-Diaminobutanoic Acids, Non-Protein Amino-Acid Diastereomers found in a number of Peptide Antibiotics. SYNLETT, 1996(7), 621-622. DOI:
Bannage, ME; Burke, AJ; Davies, SG; Goodwin, CJ. 1994. Asymmetric synthesis of (2S,3R)-3-amino-2-hydroxydecanoic acid: The unknown amino acid component of microginin. TETRAHEDRON-ASYMMETRY, 5(2), 203-206. DOI: 10.1016/S0957-4166(00)86173-X
Burke, AJ; Carreiro, EP. 2013. Asymmetric Epoxidation and Sulfoxidation. Comprehensive Inorganic Chemistry II (Second Edition): From Elements to Applications, 6, 309-382. DOI: 10.1016/B978-0-08-097774-4.00614-8
Marques, Carolina S; Burke, Anthony J. 2013. Enantioselective catalytic synthesis of ethyl mandelate derivatives using Rh(I)-NHC catalysts and organoboron reagents. TETRAHEDRON-ASYMMETRY, 24(11), 628-632. DOI: 10.1016/j.tetasy.2013.04.011
Carreiro, EP; Costa, AR; Cordeiro, MM; Martins, R; Pires, TO; Saraiva, M; Antunes, CM; Burke, AJ. 2015. Novel hydroxyamides and amides containing d-glucopyranose or d-fructose units: Biological assays in MCF-7 and MDST8 cell lines. Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.12.036
Genoni, A; Benaglia, M; Mattiolo, E; Rossi, S; Raimondi, L; Barrulas, PC; Burke, AJ. 2015. Synthesis of an advanced precursor of Rivastigmine: Cinchona-derived quaternary ammonium salts as organocatalysts for stereoselective imine reductions. TETRAHEDRON LETTERS, 56(42), 5752-5756. DOI: 10.1016/j.tetlet.2015.08.086
Totobenazara, J; Burke, AJ. 2015. New click-chemistry methods for 1,2,3-triazoles synthesis: Recent advances and applications. TETRAHEDRON LETTERS, 56(22), 2853-2859. DOI: 10.1016/j.tetlet.2015.03.136
Burke, AJ; Marques, CS. 2015. Catalytic Arylation Methods: From the Academic Lab to Industrial Processes. Catalytic Arylation Methods: From the Academic Lab to Industrial Processes, 1-508. DOI: 10.1002/9783527672707
Marques, CS; Burke, AJ. 2015. Modular Catalytic Synthesis of 3-Amino-3-aryl-2-oxindoles: Rh Catalysis with Isatin-Derived N-Boc-Protected Ketimines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. DOI: 10.1002/ejoc.201501399
Burke. 2015. Palladium catalysed sequential imine arylation/Suzuki–Miyaura coupling: synthesis of α-(biarylyl)benzylamines. TETRAHEDRON, 71, 3314-. DOI: 10.1016/j.tet.2015.03.105
Peixoto, D; Locati, A; Marques, CS; Goth, A; Ramalho, JPP; Burke, AJ. 2015. A catalytic route to dibenzodiazepines involving Buchwald-Hartwig coupling: Reaction scope and mechanistic consideration. RSC Advances, 5(121), 99990-99999. DOI: 10.1039/c5ra19599c
Carolina SMarques; Anthony JBurke. 2016. Enantioselective Rhodium(I)-Catalyzed Additions of Arylboronic Acids to N -1,2,3-Triazole-Isatin Derivatives: Accessing N -(1,2,3-Triazolmethyl)-3-hydroxy-3-aryloxindoles. ChemCatChem, 8(22), 3518-. DOI: 10.1002/cctc.201600901
Davide Brenna; Maurizio Benaglia; Riccardo Porta; Silvia Fernandes; Anthony JBurke. 2017. Stereoselective Metal-Free Reduction of Chiral Imines in Batch and Flow Mode: A Convenient Strategy for the Synthesis of Chiral Active Pharmaceutical Ingredients. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017(1), 39-. DOI: 10.1002/ejoc.201601268
Benaglia; Burke. 2016. Stereoselective Reduction of Imines with Trichlorosilane Using Solid-Supported Chiral Picolinamides. MOLECULES, 21, 1182-. DOI: 10.3390/molecules21091182
Carolina Marques; Anthony Burke; Simon Lawrence. 2018. Pd-Catalyzed One-Pot Borylation/Intramolecular Asymmetric Arylation on α-Ketiminoamides: Innovative Approach to Chiral 3-Amino-2-oxindoles. SYNLETT. DOI: 10.1055/s-0036-1590940
Anthony JBurke. 2016. Recent advances in metal catalyzed intramolecular aryl additions—accessing bioactive molecules. TETRAHEDRON LETTERS, 57(11), 1197-. DOI: 10.1016/j.tetlet.2016.02.023
Brenna, D; Pirola, M; Raimondi, L; Burke, AJ; Benaglia, M. 2016. A stereoselective, catalytic strategy for the in-flow synthesis of advanced precursors of rasagiline and tamsulosin. Bioorganic and Medicinal Chemistry. DOI: 10.1016/j.bmc.2017.01.023
Amor ASan Juan; Patrícia Bacalhau; Albertino Goth; ATeresa Caldeira; Rosário Martins; Anthony JBurke. 2016. Insights into (S)-Rivastigmine inhibition of ButyrylCholinesterase (BuChE): Molecular Docking and Saturation Transfer Difference NMR (STD-NMR). BIOORGANIC CHEMISTRY, 67, 105-. DOI: 10.1016/j.bioorg.2016.06.002
Viana, H; Carreiro, EP; Goth, A; Bacalhau, P; Caldeira, AT; Do Rosário Martins, M; Burke, AJ. 2016. Sequential alcohol oxidation/putative homo Claisen-Tishchenko-type reaction to give esters: A key process in accessing novel biologically active lactone macrocycles. RSC Advances, 6(68), 63214-63223. DOI: 10.1039/c6ra07547a
Bacalhau, P; San Juan, AA; Marques, CS; Peixoto, D; Goth, A; Guarda, C; Silva, M; Arantes, S; Caldeira, AT; Martins, R; Burke, AJ. 2016. New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives. BIOORGANIC CHEMISTRY, 67, 1-8. DOI: 10.1016/j.bioorg.2016.05.004
Armando JLPombeiro; Anthony JBurke. 2018. Virtual Collection of Portuguese Catalysis. ChemCatChem, 10(13), 2712-. DOI: 10.1002/cctc.201801006
Teixeira, C; Barbault, F; Rebehmed, J; Liu, K; Xie, L; Lu, H; Jiang, S; Fan, B; Maurel, F. 2008. Molecular modeling studies of N-substituted pyrrole derivatives-Potential HIV-1 gp41 inhibitors. Bioorganic and Medicinal Chemistry, 16(6), 3039-3048. DOI: 10.1016/j.bmc.2007.12.034
Liu, K; Lu, H; Hou, L; Qi, Z; Teixeira, C; Barbault, F; Fan, B-T; Liu, S; Jiang, S; Xie, L. 2008. Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41. JOURNAL OF MEDICINAL CHEMISTRY, 51(24), 7843-7854. DOI: 10.1021/jm800869t
Teixeira, C; Serradji, N; Maurel, F; Barbault, F. 2009. Docking and 3D-QSAR studies of BMS-806 analogs as HIV-1 gp120 entry inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 44(9), 3524-3532. DOI: 10.1016/j.ejmech.2009.03.028
Fernandes, JA; Lima, S; Braga, SS; Ribeiro-Claro, P; Rodriguez-Borges, JE; Teixeira, C; Pillinger, M; Teixeira-Dias, JJC; Gonçalves, IS. 2005. Inclusion complex formation of diferrocenyldimethylsilane with β-cyclodextrin. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 690(21-22), 4801-4808. DOI: 10.1016/j.jorganchem.2005.07.073
Barbault, F; Ren, B; Rebehmed, J; Teixeira, C; Luo, Y; Smila-Castro, O; Maurel, F; Fan, B; Zhang, L; Zhang, L. 2008. Flexible computational docking studies of new aminoglycosides targeting RNA 16S bacterial ribosome site. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 43(8), 1648-1656. DOI: 10.1016/j.ejmech.2007.10.022
Gago, S; Rodríguez-Borges, JE; Teixeira, C; Santos, AM; Zhao, J; Pillinger, M; Nunes, CD; Petrovski, Z; Santos, TM; Kühn, FE; Romão, CC; Gonçalves, IS. 2005. Synthesis, characterization and catalytic studies of bis(chloro)dioxomolybdenum(VI)-chiral diimine complexes. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 236(1-2), 1-6. DOI: 10.1016/j.molcata.2005.03.032
Ferraz, R; Teixeira, C; Gomes, P; Prudêncio, C. 2018. Bioactivity of Ionic Liquids. RSC Smart Materials, 2018-January(28), 404-422. DOI: 10.1039/9781788011839-00404
Teixeira, C; Serradji, N; Amroune, S; Storck, K; Rogez-Kreuz, C; Clayette, P; Barbault, F; Maurel, F. 2013. Is the conformational flexibility of piperazine derivatives important to inhibit HIV-1 replication?. Journal of Molecular Graphics and Modelling, 44, 91-103. DOI: 10.1016/j.jmgm.2013.05.003
Rebehmed, J; Barbault, F; Teixeira, C; Maurel, F. 2008. 2D and 3D QSAR studies of diarylpyrimidine HIV-1 reverse transcriptase inhibitors. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 22(11), 831-841. DOI: 10.1007/s10822-008-9217-4
Ribeiro, D; Freitas, M; Tome, SM; Silva, AMS; Porto, G; Cabrita, EJ; Marques, MMB; Fernandes, E. 2014. Inhibition of LOX by flavonoids: a structure-activity relationship study. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 72, 137-145. DOI: 10.1016/j.ejmech.2013.11.030
Vaz Serra, V; Camoes, F; Vieira, SI; Faustino, MAF; Tomé, JPC; Pinto, DCGA; Neves, MGPMS; Tomé, AC; Silva, AMS; Da Cruz E Silva, EF; Cavaleiro, JAS. 2009. Synthesis and biological evaluation of novel chalcone-porphyrin conjugates. ACTA CHIMICA SLOVENICA, 56(3), 603-611. DOI:
Carvalho, LCR; Fernandes, E; Marques, MMB. 2011. Developments Towards Regioselective Synthesis of 1,2-Disubstituted Benzimidazoles. CHEMISTRY-A EUROPEAN JOURNAL, 17, 12544-12555. DOI: 10.1002/chem.201101508
Moniz, T; Queiros, C; Ferreira, R; Leite, A; Gameiro, P; Silva, AMG; Rangel, M. 2013. Design of a water soluble 1,8-naphthalimide/3-hydroxy-4-pyridinone conjugate: Investigation of its spectroscopic properties at variable pH and in the presence of Fe3+, Cu2+ and Zn2+. DYES AND PIGMENTS, 98, 201-211. DOI: 10.1016/j.dyepig.2013.02.020
Pereira, T; Ivanova, G; Caseiro, AR; Barbosa, P; Bartolo, PJ; Santos, JD; Luis, AL; Mauricio, AC. 2014. MSCs Conditioned Media and Umbilical Cord Blood Plasma Metabolomics and Composition. PLoS One, 9. DOI: 10.1371/journal.pone.0113769
Ferraz, R; Teixeira, V; Rodrigues, E; Fernandes, R; Prudencio, C; Noronha, JP; Petrovski, Z; Branco, LC. 2014. Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria. RSC Advances, 4, 4301-4307. DOI: 10.1039/c3ra44286a