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The NanoPlatforms group conveys expertise on physical-chemistry, medicinal chemistry, pharmaceutical and analytical sciences to support research towards the development of innovative nanoplatforms to address current environmental, food industry and biomedical challenges. The group’s  research is focused on the design, synthesis and optimization of inorganic, organic and hybridnanoparticles for multipurpose applications, such as development of plasmonic, electrochemical and fluorescent (bio)sensors and their incorporation in miniaturized detection devices to enhance analytical automation. Other relevant application value-added by the group is the development of more efficient,targeted, spatially and temporally controlled delivery systems to carry multiple molecules for the improvement of their (bio)activity. The use of nanoplatforms as bio-mimetic models to study the complex interactions of drugs, bioactive compounds and/or nanoparticles with lipid cell membranes is another topic of interest. Liposomes, cyclodextrins, micelleplexes, lipid, polymeric, magnetic and gold nanoparticles are tools to produce innovative nanoplatforms with potential application in Nanomedicine, Biomedical Engineering, Biosensing, Functional Foods and Industrial Production.

Research Interests

  • Smart materials as sustainable delivery carriers
  • Nanostructured platforms as biomimetic models
  • Multifunctional (bio)sensors for molecular imaging, targeting and diagnosis
  • Multipurpose nanoplatforms as enhanced analytical automation tools
  • Functionalized nanoplatforms as delivery systems for food applications

Highlights

  • Targeting for treatment approaches using multifunctional platforms
    Multifunctional nanospheres for co-delivery of methotrexate and mild hyperthermia to colon cancer cells
    Multifunctional nanospheres for co-delivery of methotrexate and
    mild hyperthermia to colon cancer cells
    Materials Science and Engineering: C Mater Biol Appl. 2017, 75, 1420.

    Multifunctional platforms have been successfully developed as proof-of-concept for treatment approaches reaching pre-clinical trials and some are ready for clinical trials. This has been achieved by a rational design approach, driven by the optimization of the processes in a way to be financially competitive, easily scaled-up and optimized according to the pathophysiological characteristics of the targeted disease and administration route. In this field we have accomplished:

    - pH sensitive nanoparticles to improve the treatment of tuberculosis. In vivo  results demonstrates that a promising approach was developed and the in vitro  data demonstrated an efficient strategy to increase infected macrophages internalization.

    - Hybrid nanoparticles to target cancer. Multifunctional nanospheres able to provide a combinatorial therapeutic response through hyperthermia and targeted uptake from colorectal cancer were successfully developed and show in vitro  evidences of improved efficacy compared with conventional therapies.

    - Multifunctional nanoparticles as theranostic approaches for chronic inflammatory conditions. Promising formulations are in ex-vivo trials using human samples, either with synovial tissue or with skin biopsies to treat rheumatoid arthritis and psoriasis, respectively.

     

     

  • Multiple lipid nanoparticles: the new generation of lipid nanoparticles
    Multiple Lipid Nanoparticles (MLN), a New Generation of Lipid Nanoparticles for Drug Delivery Systems: Lamivudine-MLN Experimental Design.
    Multiple Lipid Nanoparticles (MLN), a New
    Generation of Lipid Nanoparticles for Drug Delivery
    Systems: Lamivudine-MLN Experimental Design.
    Pharmaceutical Research, 2017, 34, 1204-16.

    A new type of lipid nanoparticles, the multiple lipid nanoparticles (MLN), was developed. An optimized methodology, based on a quality by design approach, was used. MLN have characteristics between nanostructuredlipid carriers (NLC) and multiple emulsions (W/O/W), but without the outer aqueous phase. MLN present large and multiple aqueous vacuoles, which are achieved without the use of any organic solvents, enabling the incorporation of high amounts of both hydrophilic and lipophilic molecules. As MLN are obtained as a semisolid product, they do not require additional water evaporation or separation steps that are often necessary in most formulations, which simplifies the scale-up of this kind of formulation. The designed MLN are suitable for the delivery of drugs and bioactive compounds, due to their low toxicity and high biocompatibility. Additionally, the administration route can be either topical (as a semisolid), or oral (after resuspension).

     

     

  • Ready-to-use nanoplatforms to drug discovery and development
    Influence of doxorubicin on model cell membrane properties: insights from in vitro and in silico studies
    Influence of doxorubicin on model cell membrane properties:
    insights from in vitro and in silico studies
    Scientific Reports, 2017, 7, 6343.

    Ready-to-use nanoplatforms that enable the study of drug-membrane interactions and cellular uptake mechanisms have been successfully designed and exploited. The outcomes have been revealing an undiscussable relation between the interactions of the drug molecules with membrane lipids and both therapeutic and toxic effects. The validation of these nanoplatforms for drug discovery and development was achieved with the most clinically relevant drugs used in cancer diseases. Particularly, the results regarding the combination of anthracyclines-membrane interplay leads to the idea that, when designing and developing new drugs, the different membrane characteristics should be taken into account. In fact, the different properties of cell membranes can modulate anthracyclines behavior, even conditioning their use depending on the type of cancer. Thereby, these nanoplatforms can and should be incorporated in the preclinical phase of anticancer drugs’  development. They allow to predict the pharmacokinetic properties of novel compounds, to clarify their mechanisms of action and toxicity and allow the selection of the best candidates for in vivo evaluation.

     

     

  • Novel and miniaturized (bio)assays for (eco)toxicity screening
    Toxicity assessment of ionic liquids with Vibrio fischeri
    Toxicity assessment of ionic liquids with Vibrio
    fischeri: An alternative fully automated
    methodology
    Journal of Hazardous Materials, 2015, 284, 136-142.

    A generic tool for rapid screening of the (eco)toxicity of chemicals and materials was developed based on a battery of miniaturized (bio)assays, as a part of their sustainable synthesis in the early stage of their development. Molecular and cellular tests are useful to clarify the impact of particular structural elements and to guide their modification to reduce their hazardous potential. The evaluation of toxicity by means of enzymes with important biological functions or whole cell presents additional advantages such as simplicity of laboratory implementation and data interpretation as well as reduction of costs and duration of the assays. With downscaling of conventional procedures in micro conduits, rigorous control of the reaction conditions in terms of time and volumes are attained with advantages regarding assay´s robustness. Thus valuable tools are proposed for the multidimensional assessment of the risk associated to their use.

     

     

  • Antibiotic-porin interactions an in vitro biophysical study
    The binding of free and copper-complexed fluoroquinolones to OmpF porins
    The binding of free and copper-complexed
    fluoroquinolones to OmpF porins: an experimental and
    molecular docking study
    RSC Advances 2017, 7, 10009-100019.

    Biological studies of the uptake of fluoroquinolones and fluoroquinolone-derivatives were performed in several bacterial strains that have a series of porin mutants which lack one or several major outer membrane proteins (OmpF, OmpC, lamB, OmpR). Based on the biological experiments, the in vitro biophysical study of antibiotic-porin interactions using purified porins incorporated into liposomes has been performed. Characterization of the liposome/proteoliposome systems and bacteria, in the presence and absence of compounds, was carried out by fluorescence techniques, light scattering and AFM. Biophysical properties such as fluidity of bacterial membranes has been characterized in a multitude of bacterial strains, from Gram-negatives to Gram-positives, and both susceptible/reference strains and multidrug-resistant clinical isolates, also in the presence and absence of antibiotics. To make the most of the bacterial collection that has been constructed mostly during the last year, antimicrobial susceptibility testing has been performed to assess the potential antimicrobial activity of diverse extracts and compounds, such as antimicrobial peptides and cationic polymers.

     

     

     

     

  • Low-cost ultrasensitive sensors platforms for portable devices
    -
    Office paper decorated with silver nanostars - an
    alternative cost effective platform for trace analyte
    detection by SERS
    Scientific Reports, 2017, 7, 2480.

    To provide reliable and efficient analytical tools for a variety of health, food and environmental challenges, several electrochemical, surface-enhanced Raman spectroscopic and fluorescent (bio)sensors were successfully developed. The excellent performing characteristics (selectivity, sensitivity, linear working range, precision, accuracy, etc.) and the small size of these sensors will enable their inclusion in portable and/or disposable devices, resulting in cost effective sensing strategies for point-of-care or in situ  applications. We have accomplished a low-cost SERS (Surface-enhanced Raman spectroscopy) substrates for point-ofcare portable sensors, using silver nanostars drop-casted on hydrophilic wells patterned on paper, were also implemented. A low limit of detection for rhodamine-6G has been achieved, with good signal uniformity and stability. The optimization of the aqueous synthesis of new fluorescent nanoprobes to prepare gram-amounts of nanomaterials with improved selectivity and surface reactivity, capable of inclusion into portable sensing devices was also achieved. The developed fluorescent nanoprobes were assayed in the determination of various metal ions in distinct samples demonstrating a high efficiency for monitoring Hg(II) levels.

     

Representative Publications

Basso, J; Miranda, A; Sousa, J; Pais, A; Vitorino, C. 2018. Repurposing drugs for glioblastoma: From bench to bedside. CANCER LETTERS, 428, 173-183. DOI: 10.1016/j.canlet.2018.04.039
Silva, J; Mendes, M; Cova, T; Sousa, J; Pais, A; Vitorino, C. 2018. Unstructured Formulation Data Analysis for the Optimization of Lipid Nanoparticle Drug Delivery Vehicles. AAPS PHARMSCITECH, 19, 2383-2394. DOI: 10.1208/s12249-018-1078-0
Santos, AC; Ferreira, C; Veiga, F; Ribeiro, AJ; Panchal, A; Lvov, Y; Agarwal, A. 2018. Halloysite clay nanotubes for life sciences applications: From drug encapsulation to bioscaffold. ADVANCES IN COLLOID AND INTERFACE SCIENCE, 257, 58-70. DOI: 10.1016/j.cis.2018.05.007
Soares, S; Sousa, J; Pais, A; Vitorino, C. 2018. Nanomedicine: Principles, Properties, and Regulatory Issues. Frontiers in Chemistry, 6. DOI: 10.3389/fchem.2018.00360
Simoes, A; Veiga, F; Figueiras, A; Vitorino, C. 2018. A practical framework for implementing Quality by Design to the development of topical drug products: Nanosystem-based dosage forms. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 548, 385-399. DOI: 10.1016/j.ijpharm.2018.06.052
Miranda, M; Sousa, JJ; Veiga, F; Cardoso, C; Vitorino, C. 2018. Bioequivalence of topical generic products. Part 2. Paving the way to a tailored regulatory system. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 122, 264-272. DOI: 10.1016/j.ejps.2018.07.011
Miranda, M; Sousa, JJ; Veiga, F; Cardoso, C; Vitorino, C. 2018. Bioequivalence of topical generic products. Part 1: Where are we now?. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 123, 260-267. DOI: 10.1016/j.ejps.2018.07.050
Magalhaes, M; Almeida, M; Tavares-da-Silva, E; Roleira, FMF; Varela, C; Jorge, J; Goncalves, AC; Carvalho, RA; Veiga, F; Santos, AC; Figueiras, A. 2018. miR-145-loaded micelleplexes as a novel therapeutic strategy to inhibit proliferation and migration of osteosarcoma cells. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 123, 28-42. DOI: 10.1016/j.ejps.2018.07.021
Alexandre CCVieira; Luíse LChaves; Marina Pinheiro; Sofia ACosta Lima; Domingos Ferreira; Bruno Sarmento; Salette Reis. 2018. Mannosylated solid lipid nanoparticles for the selective delivery of rifampicin to macrophages. Artificial Cells Nanomedicine and Biotechnology. DOI: 10.1080/21691401.2018.1434186
De Gracia, J; Saravia, MLMFS; Araújo, AN; Lima, JLFC; Del Valle, M; Poch, M. 1997. Evaluation of natural computation techniques in the modelling and optimization of a sequential injection flow system for colorimetric iron(III) determination. ANALYTICA CHIMICA ACTA, 348(1-3), 143-150. DOI: 10.1016/S0003-2670(97)00204-3
Araújo, AN; Gracia, J; Lima, JLFC; Poch, M; Lúcia, M; Saraiva, MFS. 1997. Colorimetric determination of iron in infant fortified formulas by Sequential Injection Analysis. Fresenius' Journal of Analytical Chemistry, 357(8), 1153-1156. DOI:
Araújo, AN; Lima, JLFC; Saraiva, MLMFS; Zagatto, EAG. 1997. A new approach to dialysis in sequential injection systems: Spectrophotometric determination of L(+)-lactate in wines. AMERICAN JOURNAL OF ENOLOGY AND VITICULTURE, 48(4), 428-432. DOI:
Vicente, S; Zagatto, EAG; Pinto, PCAG; Saraiva, MLMES; Lima, JLFC; Borges, EP. 2006. Exploiting gas diffusion for non-invasive sampling in flow analysis: Determination of ethanol in alcoholic beverages. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 78(1), 23-29. DOI:
Silva, ES; Pinto, PCAG; Lima, JLFC; Saraiva, MLMFS. 2009. Sequential injection spectrophotometric determination of V(V) in environmental polluted waters. WATER SA, 35(3), 283-288. DOI:
Rufino, JL; Pezza, HR; Pezza, L; Pinto, PCAG; Saraiva, MLMFS; Lima, JLFC. 2011. Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations. QUIMICA NOVA, 34(2), 256-261. DOI: 10.1590/S0100-40422011000200016
Pinto, PCAG; Saraiva, MLMFS. 2014. Ionic liquids: A pharmaceutical perspective. Ionic Liquids: Synthesis, Characterization and Applications, 1-42. DOI:
10. Marques, A, Dias, A, Azevedo, A., Pinto, P, Araújo, ARTS, Saraiva, MLMFS. 2016. Determinação da constante de dissociação e coeficiente de partição de líquidos iónicos farmacêuticos com atividade anti-inflamatória. Egitania Sciencia, 18 , 173-188. DOI:
Coelho, JA; Grosso, C; Pereira, AP; Burillo, J; Urieta, JS; Figueiredo, AC; Barroso, JG; Mendes, RL; Palavra, AMF. 2007. Supercritical carbon dioxide extraction of volatiles from Satureja fruticosa Béguinot. FLAVOUR AND FRAGRANCE JOURNAL, 22(5), 438-442. DOI: 10.1002/ffj.1819
Clara Grosso, A; Costa, MM; Ganço, L; Pereira, AL; Teixeira, G; Lavado, JMG; Figueiredo, AC; Barroso, JG; Pedro, LG. 2007. Essential oil composition of Pterospartum tridentatum grown in Portugal. FOOD CHEMISTRY, 102(4), 1083-1088. DOI: 10.1016/j.foodchem.2006.06.049
Grosso, C; Ferraro, V; Figueiredo, AC; Barroso, JG; Coelho, JA; Palavra, AM. 2008. Supercritical carbon dioxide extraction of volatile oil from Italian coriander seeds. FOOD CHEMISTRY, 111(1), 197-203. DOI: 10.1016/j.foodchem.2008.03.031
Grosso, AC; Rodrigues, L; Gomes, I; Martins, ES; Teixeira, G. 2008. Preliminary data on microcharacters and chromosome number in Tornabenea species (Apiaceae) from Cape Verde Islands. PLANT BIOSYSTEMS, 142(1), 87-93. DOI: 10.1080/11263500701872523
Grosso, C; Figueiredo, AC; Burillo, J; Mainar, AM; Urieta, JS; Barroso, JG; Coelho, JA; Palavra, AMF. 2009. Supercritical fluid extraction of the volatile oil from Santolina chamaecyparissus (Journal of Separation Science (2009) 32, 18, (3215-3222) DOI: 10.1002/jssc.200900350). JOURNAL OF SEPARATION SCIENCE, 32(19), 3365-3366. DOI: 10.1002/jssc.200990074
Lucinda JBessa. 2014. Spread of Multidrug-Resistant Enterococcus faecalis Within the Household Setting. Microbial Drug Resistance. DOI:
Bessa, LJ; Dias, VF; Mendes, Â; Martins-Costa, P; Ramos, H; Martins da Costa, P. 2014. How growth ability of multidrug-resistant Escherichia coli is affected by abiotic stress factors. Open Journal of Preventive Medicine. DOI: 10.4236/ojpm.2014.45031
Mendes, Â; Martins da Costa, P; Bessa, LJ. 2014. Qualidade da água fornecida às espécies pecuárias. Veterinary Medicine - Edição Portuguesa. DOI:
Bessa LJ; Barbosa-Vasconcelos A; Mendes A; Vaz-Pires P; Martins da Costa P. 2014. High prevalence of multidrug-resistant Escherichia coli and Enterococcus spp. in river water, upstream and downstream of a wastewater treatment plant.. JOURNAL OF WATER AND HEALTH. DOI: 10.2166/wh.2014.160
Prompanya C; Dethoup T; Bessa LJ; Pinto MM; Gales L; Costa PM; Silva AM; Kijjoa A. 2014. New isocoumarin derivatives and meroterpenoids from the marine sponge-associated fungus Aspergillus similanensis sp. nov. KUFA 0013.. Marine Drugs. DOI: 10.3390/md12105160
Cellini L; Di Campli E; Di Bartolomeo S; Bessa LJ; Baffoni M; Di Giulio M. 2014. New transport medium for cultural recovery of Helicobacter pylori.. JOURNAL OF CLINICAL MICROBIOLOGY. DOI: 10.1128/JCM.02850-14
Bessa LJ; Mendes Â; Gomes R; Curvelo S; Cravo S; Sousa E; Vasconcelos V; Martins da Costa P. 2015. Microbial interaction between a CTXM-15 -producing Escherichia coli and a susceptible Pseudomonas aeruginosa isolated from bronchoalveolar lavage: influence of cefotaxime in the dual-species biofilm formation.. Environmental Microbiology Reports. DOI: 10.1111/1758-2229.12266
Pereira, AL; Bessa, LJ; Leão, PN; Vasconcelos, V; Martins da Costa, P. 2015. Bioactivity of Azolla aqueous and organic extracts against bacteria and fungi. SYMBIOSIS. DOI: 10.1007/s13199-015-0316-4
Bessa, LJ; Buttachon, S; Dethoup, T; Martins, R; Vasconcelos, V; Kijjoa, A; Martins da Costa, P. 2016. Neofiscalin A and fiscalin C are potential novel indole alkaloid alternatives for the treatment of multidrug-resistant Gram-positive bacterial infections.. FEMS MICROBIOLOGY LETTERS. DOI: 10.1093/femsle/fnw150
Oliveira, M; Serrano, I; Van Harten, S; Bessa, LJ; Bernardo, F; da Costa, PM. 2016. Fecal contamination of wastewater treatment plants in Portugal.. Environ Sci Pollut Res Int. DOI: 10.1007/s11356-016-6962-0
Kieffer, N; Poirel, L; Bessa, LJ; Barbosa-Vasconcelos, A; da Costa, PM; Nordmann, P. 2016. VIM-1, VIM-34, and IMP-8 Carbapenemase-Producing Escherichia coli Strains Recovered from a Portuguese River.. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. DOI: 10.1128/AAC.02632-15
Beça, N; Bessa, LJ; Mendes, Â; Santos, J; Leite-Martins, L; Matos, AJ; da Costa, PM. 2015. Coagulase-Positive Staphylococcus: Prevalence and Antimicrobial Resistance.. JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION. DOI: 10.5326/JAAHA-MS-6255
Meireles, D; Leite-Martins, L; Bessa, LJ; Cunha, S; Fernandes, R; de Matos, A; Manaia ,CM; Martins da Costa, P. 2015. Molecular characterization of quinolone resistance mechanisms and extended-spectrum β-lactamase production in Escherichia coli isolated from dogs.. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES. DOI: 10.1016/j.cimid.2015.04.004
Leite-Martins, L; Mahú, MI; Costa, AL; Bessa, LJ; Vaz-Pires, P; Loureiro, L; Niza-Ribeiro, J; de Matos, AJ; Martins da Costa, P. 2015. Prevalence of antimicrobial resistance in faecal enterococci from vet-visiting pets and assessment of risk factors.. VETERINARY RECORD. DOI: 10.1136/vr.102888
Bessa LJ; Palmeira A; Gomes AS; Vasconcelos V; Sousa E; Pinto M; Martins da Costa P. 2015. Synergistic Effects Between Thioxanthones and Oxacillin Against Methicillin-Resistant Staphylococcus aureus.. Bessa, LJ; Palmeira, A; Gomes, AS; Vasconcelos, V; Sousa, E; Pinto, M; Martins da Costa, P. DOI: 10.1089/mdr.2014.0162
Iannitelli, A; Grande, R; di Stefano, A; di Giulio, M; Sozio, P; Bessa, LJ; Laserra, S; Paolini, C; Protasi, F; Cellini, L. 2011. Potential antibacterial activity of carvacrol-loaded poly(DL-lactide-co-glycolide) (PLGA) nanoparticles against microbial biofilm. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 12(8), 5039-5051. DOI: 10.3390/ijms12085039
Grande, R; Di Giulio, M; Bessa, LJ; Di Campli, E; Baffoni, M; Guarnieri, S; Cellini, L. 2011. Extracellular DNA in Helicobacter pylori biofilm: A backstairs rumour. JOURNAL OF APPLIED MICROBIOLOGY, 110(2), 490-498. DOI: 10.1111/j.1365-2672.2010.04911.x
Bessa, LJ; Correia, DM; Cellini, L; Azevedo, NF; Rocha, I. 2012. Optimization of culture conditions to improve helicobacter pylori growth in ham's F-12 medium by response surface methodology. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 25(4), 901-909. DOI:
Baffoni, M; Bessa, LJ; Grande, R; Di Giulio, M; Mongelli, M; Ciarelli, A; Cellini, L. 2012. Laser irradiation effect on Staphylococcus aureus and Pseudomonas aeruginosa biofilms isolated from venous leg ulcer. International Wound Journal, 9(5), 517-524. DOI: 10.1111/j.1742-481X.2011.00910.x
Grande, R; Di Campli, E; Di Bartolomeo, S; Verginelli, F; Di Giulio, M; Baffoni, M; Bessa, LJ; Cellini, L. 2012. Helicobacter pylori biofilm: A protective environment for bacterial recombination. JOURNAL OF APPLIED MICROBIOLOGY, 113(3), 669-676. DOI: 10.1111/j.1365-2672.2012.05351.x
Bessa, LJ; Grande, R; Iorio, DD; Giulio, MD; Campli, ED; Cellini, L. 2013. Helicobacter pylori free-living and biofilm modes of growth: Behavior in response to different culture media. APMIS, 121(6), 549-560. DOI: 10.1111/apm.12020
Bessa, LJ; Fazii, P; Di Giulio, M; Cellini, L. 2013. Bacterial isolates from infected wounds and their antibiotic susceptibility pattern: some remarks about wound infection. International Wound Journal. DOI: 10.1111/iwj.12049
Flores, CE; Loureiro, L; Bessa, LJ; Martins da Costa, P. 2013. Presence of Multidrug-Resistant E. coli, Enterococcus spp. and Salmonella spp. in Lakes and Fountains of Porto, Portugal. Journal of Water Resource and Protection. DOI: 10.4236/jwarp.2013.511117
Duangsrisai S; Choowongkomon K; Bessa LJ; Costa PM; Amat N; Kijjoa A. 2014. Antibacterial and EGFR-tyrosine kinase inhibitory activities of polyhydroxylated xanthones from Garcinia succifolia.. Duangsrisai, S; Choowongkomon, K; Bessa, LJ; Costa, PM; Amat, N; Kijjoa, A. DOI: 10.3390/molecules191219923
Grosso, C; Figueiredo, AC; Burillo, J; Mainar, AM; Urieta, JS; Barroso, JG; Coelho, JA; Palavra, AMF. 2009. Supercritical fluid extraction of the volatile oil from Santolina chamaecyparissus. JOURNAL OF SEPARATION SCIENCE, 32(18), 3215-3222. DOI: 10.1002/jssc.200900350
Silva, FVM; Martins, A; Salta, J; Neng, NR; Nogueira, JMF; Mira, D; Gaspar, N; Justino, J; Grosso, C; Urieta, JS; Palavra, AMS; Rauter, AP. 2009. Phytochemical profile and anticholinesterase and antimicrobial activities of supercritical versus conventional extracts of Satureja montana. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57(24), 11557-11563. DOI: 10.1021/jf901786p
Grosso, C; Figueiredo, AC; Burillo, J; Mainar, AM; Urieta, JS; Barroso, JG; Coelho, JA; Palavra, AMF. 2009. Enrichment of the thymoquinone content in volatile oil from Satureja montana using supercritical fluid extraction. JOURNAL OF SEPARATION SCIENCE, 32(2), 328-334. DOI: 10.1002/jssc.200800490
Grosso, C; Teixeira, G; Gomes, I; Martins, ES; Barroso, JG; Pedro, LG; Figueiredo, AC. 2009. Assessment of the essential oil composition of Tornabenea annua, Tornabenea insularis and Tornabenea tenuissima fruits from Cape Verde Islands. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 37(4), 474-478. DOI: 10.1016/j.bse.2009.07.002
Grosso, C; Oliveira, AC; Mainar, AM; Urieta, JS; Barroso, JG; Palavra, AMF. 2009. Antioxidant activities of the supercritical and conventional satureja montana extracts. JOURNAL OF FOOD SCIENCE, 74(9), C713-C717. DOI: 10.1111/j.1750-3841.2009.01376.x
Grosso, C; Coelho, JP; Pessoa, FLP; Fareleira, JMNA; Barroso, JG; Urieta, JS; Palavra, AF; Sovová, H. 2010. Mathematical modelling of supercritical CO<inf>2</inf>extraction of volatile oils from aromatic plants. CHEMICAL ENGINEERING SCIENCE, 65(11), 3579-3590. DOI: 10.1016/j.ces.2010.02.046
Grosso, C; Coelho, JA; Urieta, JS; Palavra, AMF; Barroso, JG. 2010. Herbicidal activity of volatiles from coriander, winter savory, cotton lavender, and thyme isolated by hydrodistillation and supercritical fluid extraction. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58(20), 11007-11013. DOI: 10.1021/jf102378d
Grosso, C; Figueiredo, AC; Burillo, J; Mainar, AM; Urieta, JS; Barroso, JG; Coelho, JA; Palavra, AMF. 2010. Composition and antioxidant activity of Thymus vulgaris volatiles: Comparison between supercritical fluid extraction and hydrodistillation. JOURNAL OF SEPARATION SCIENCE, 33(14), 2211-2218. DOI: 10.1002/jssc.201000192
Grosso, C.; Vinholes, J.; Valentão, P.; Andrade, P.B.. 2011. Halogenated compounds from seaweed, a biological overview. Seaweed: Ecology, Nutrient Composition and Medicinal Uses, 163-184. DOI:
Duarte, A.M.M.; Grosso, A.C.; Valentão, P.C.R.; Andrade, P.B.. 2014. Quince. Iberian-American Fruits Rich in Bioactive Phytochemicals for Nutrition and Health, 143-150. DOI: 10.13140/2.1.4719.5209
Grosso, C. (Editor). 2016. Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery. Springer International Publishing, Switzerland. Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery. Springer International Publishing, Switzerland, 1-585. DOI: 10.1007/978-3-319-14021-6
Grosso, C.. 2016. Chapter 12 - Future Strategies for the Treatment of Depression. Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery, 557-571. DOI: 10.1007/978-3-319-14021-6_12
Grosso, C., Valentão, P., Andrade, P.B.. 2016. Chapter 1 - Depressive Disorders: Prevalence, Costs, and Theories. Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery, 1-41. DOI: 10.1007/978-3-319-14021-6_1
José Lopes-de-Araújo; Salette Reis; Cláudia Nunes. 2018. Topotecan effect on the structure of normal and cancer plasma membrane lipid models: A multi-model approach. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 123, 515-. DOI: 10.1016/j.ejps.2018.08.006
Catarina Pereira-Leite; Cláudia Nunes; José CBozelli, Jr; Shirley Schreier; Christina SKamma-Lorger; Iolanda MCuccovia; Salette Reis. 2018. Can NO-indomethacin counteract the topical gastric toxicity induced by indomethacin interactions with phospholipid bilayers?. COLLOIDS AND SURFACES B-BIOINTERFACES, 169, 375-. DOI: 10.1016/j.colsurfb.2018.05.019
SMTCavalcanti; CNunes; SACosta Lima; JLSoares-Sobrinho; SReis. 2018. Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 122, 22-. DOI: 10.1016/j.ejps.2018.06.017
Daniela Lopes-de-Campos; Cláudia Nunes; Bruno Sarmento; Sven Jakobtorweihen; Salette Reis. 2018. Metronidazole within phosphatidylcholine lipid membranes: New insights to improve the design of imidazole derivatives. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 129, 204-. DOI: 10.1016/j.ejpb.2018.05.036
Catarina Leal Seabra; Cláudia Nunes; Manuela Brás; Maria Gomez-Lazaro; Celso AReis; Inês CGonçalves; Salette Reis; MCristina LMartins. 2018. Lipid nanoparticles to counteract gastric infection without affecting gut microbiota. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. DOI: 10.1016/j.ejpb.2018.02.030
Catarina Pereira-Leite; Cláudia Nunes; Débora Grahl; José CBozelli; Shirley Schreier; Christina SKamma-Lorger; Iolanda MCuccovia; Salette Reis. 2018. Acemetacin–phosphatidylcholine interactions are determined by the drug ionization state. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. DOI: 10.1039/C8CP01698D
Ulanova, LS; Pinheiro, M; Vibe, C; Nunes, C; Misaghian, D; Wilson, S; Zhu, K; Fenaroli, F; Winther-Larsen, HC; Reis, S; Griffiths, G. 2017. Treatment of Francisella infections via PLGA-and lipid-based nanoparticle delivery of antibiotics in a zebrafish model. DISEASES OF AQUATIC ORGANISMS, 125(1), 19-29. DOI: 10.3354/dao03129
Gomes NM, Bessa LJ, Buttachon S, Costa PM, Buaruang J, Dethoup T, Silva AM, Kijjoa A. 2014. Antibacterial and antibiofilm activities of tryptoquivalines and meroditerpenes isolated from the marine-derived fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the soil fungi N. fischeri and N. siamensis.. Marine Drugs, 12(2), 822-839. DOI: 10.3390/md12020822
Costa, AR; Passos, MLC; Pinto, PCAG; Pereira, SAP; Saraiva, MLMFS. 2018. The role of ionic liquids in the biocatalytic evaluation of bisphenol levels as contaminant: An automatic approach. ANALYST, 143(10), 2426-2434. DOI: 10.1039/c8an00154e
Antti Rahikkala, Sarah A. P. Pereira, Patrícia Figueiredo, Marieta L.C. Passos, André R. T. S. Araújo, M. Lúcia M. F. S. Saraiva, Hélder A. Santos. 2018. Mesoporous Silica Nanoparticles for Targeted and Stimuli-responsive Delivery of Chemotherapeutics: a Review. Advanced Biosystems. DOI: 10.1002/adbi.201800020
Sarah APPereira; Susana PFCosta; Edite Cunha; Marieta LCPassos; André RSTAraújo; MLúcia MFSSaraiva. 2018. Biodegradability of several antipsychotic drugs: manual and automatic assessment. NEW JOURNAL OF CHEMISTRY, 42(15), 13081-. DOI: 10.1039/C8NJ01636D
Susana PFCosta; Edite Cunha; Ana MOAzevedo; Sarah APPereira; Ana FDCNeves; André GVilaranda; André RTSAraujo; Marieta LCPassos; Paula CAGPinto; MLúcia MFSSaraiva. 2018. Microfluidic Chemiluminescence System with Yeast Saccharomyces cerevisiae for Rapid Biochemical Oxygen Demand Measurement. ACS Sustainable Chemistry & Engineering. DOI: 10.1021/acssuschemeng.7b04736
Mancini, S; Nardo, L; Gregori, M; Ribeiro, I; Mantegazza, F; Delerue-Matos, C; Masserini, M; Grosso, C. 2018. Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds. PHYTOMEDICINE, 42, 233-244. DOI: 10.1016/j.phymed.2018.03.053
Bessa, LJ; Ferreira, M; Gameiro, P. 2018. Evaluation of membrane fluidity of multidrug-resistant isolates of Escherichia coli and Staphylococcus aureus in presence and absence of antibiotics. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 181, 150-156. DOI: 10.1016/j.jphotobiol.2018.03.002
Pires, CK; Martelli, PB; Reis, BF; Lima, JLFC; Saraiva, MLMFS. 2003. An automatic flow procedure for the determination of 3-hydroxybutyrate in animal serum and plasma. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 51, 2457-2460. DOI: 10.1021/jf021024n
Pires, CK; Martelli, PB; Reis, BF; Lima, JLFC; Saraiva, MLMFS. 2003. Multicommuted flow system for the determination of glucose in animal blood serum exploiting enzymatic reaction and chemiluminescence detection. JOURNAL OF AUTOMATED METHODS & MANAGEMENT IN CHEMISTRY, 25, 109-114. DOI: 10.1080/14639240310001643463
Pinto, PCAG; Lima, JLFC; Saraiva, MLMFD. 2003. Sequential injection analysis of nitrites and nitrates in human serum using nitrate reductase. CLINICA CHIMICA ACTA, 337, 69-76. DOI: 10.1016/j.cccn.2003.07.012
Pinto, PCAG; Lima, JLFC; Saraiva, MLCMFS. 2005. An enzymatic flow analysis methodology for the determination of nitrates and nitrites in waters. INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY, 85, 29-40. DOI: 10.1080/0306731042000303161
Pinto, PCAG; Saraiva, MLMFS; Reis, S; Lima, JLFC. 2005. Automatic sequential determination of the hydrogen peroxide scavenging activity and evaluation of the antioxidant potential by the 2,2 '-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation assay in wines by sequential injection analysis. ANALYTICA CHIMICA ACTA, 531, 25-32. DOI: 10.1016/j.aca.2004.10.005
Santos, JLM; Clausse, A; Lima, JLRC; Saraiva, MLMFS; Rangel, AS. 2005. Determination of ambroxol in an automated multi-pumping pulsed flow system. ANALYTICAL SCIENCES, 21, 461-464. DOI: 10.2116/analsci.21.461
Perez-Olmos, R; Soto, JC; Zarate, N; Araujo, AN; Lima, JLFC; Saraiva, MLMFS. 2005. Application of sequential injection analysis (SIA) to food analysis. FOOD CHEMISTRY, 90, 471-490. DOI: 10.1016/j.foodchem.2004.04.046
Pinto, PCAG; Saraiva, MLMFS; Santos, JLM; Lima, JLFC. 2005. A pulsed sequential injection analysis flow system for the fluorimetric determination of indomethacin in pharmaceutical preparations. ANALYTICA CHIMICA ACTA, 539, 173-179. DOI: 10.1016/j.aca.2005.03.037
Passos, MLC; Saraiva, MLMFS; Lima, JLFC. 2005. Application of sequential injection analysis to the determination of cationic surfactants, based on the sensitized molybdenum-bromopyrogallol red reaction. ANALYTICAL SCIENCES, 21, 1509-1514. DOI: 10.2116/analsci.21.1509
Zisiou, EP; Pinto, PCAG; Saraiva, MLMFS; Siquet, C; Lima, JLFC. 2005. Sensitive sequential injection determination of naproxen based on interaction with beta-cyclodextrin. TALANTA, 68, 226-230. DOI: 10.1016/j.talanta.2005.07.005
Pinto, PCAG; Lucia, M; Saraiva, MF; Lima, JLFC. 2006. A flow sampling strategy for the analysis of oil samples without pre-treatment in a sequential injection analysis system. ANALYTICA CHIMICA ACTA, 555, 377-383. DOI: 10.1016/j.aca.2005.09.009
Pinto, PCAG; Saraiva, MLMFS; Santos, JLM; Lima, JLFC. 2006. Fluorimetric determination of aminocaproic acid in pharmaceutical formulations using a sequential injection analysis system. TALANTA, 68, 857-862. DOI: 10.1016/j.talanta.2005.06.008
Garcia, JB; Saraiva, MLMFS; Lima, JLFC. 2006. Determination and antioxidant activity evaluation of etodolac, an anti-inflammatory drug, by sequential injection analysis. ANALYTICA CHIMICA ACTA, 573, 371-375. DOI: 10.1016/j.aca.2006.02.044
Silva, ID; Saraiva, MLMFS; Santos, JLM; Lima, JLFC. 2007. Sequential injection spectrophotometric determination of metoclopramide in pharmaceutical preparations. SPECTROSCOPY LETTERS, 40, 51-61. DOI: 10.1080/00387010601093778
Vasiliki, V; Pinto, PCAG; Saraiva, MLMFS; Lima, JLFC. 2007. Sequential injection determination of meloxicam in pharmaceutical formulations with spectrophotometric detection. CANADIAN JOURNAL OF ANALYTICAL SCIENCES AND SPECTROSCOPY, 52, 351-358. DOI:
Lopes, CMPV; Almeida, AA; Saraiva, MLMFS; Lima, JLFC. 2007. Determination of Rh, Pd and Pt in urine samples using a pre-concentration sequential injection analysis system coupled to a quadrupole-inductively coupled plasma-mass spectrometer. ANALYTICA CHIMICA ACTA, 600, 226-232. DOI: 10.1016/j.aca.2007.02.068
Saraiva, MLMFS; Pinto, PCAG; Lima, JLFC. 2007. Evaluation of the relative antioxidant capacity of wine samples and pharmaceutical formulations by sequential injection analysis. FREE RADICAL RESEARCH, 41, S53-S54. DOI:
Passos, MLC; Saraiva, MLMFS; Lima, JLFC; Korn, MGA. 2008. Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 19, 563-568. DOI: 10.1590/S0103-50532008000300027
Araujo, ARTS; Saraiva, MLMFS; Lima, JLFC. 2008. Determination of total and oxidized glutathione in human whole blood with a sequential injection analysis system. TALANTA, 74, 1511-1519. DOI: 10.1016/j.talanta.2007.09.028
Araujo, ARTS; Saraiva, MLMFS; Lima, JLFC; Korn, MGA. 2008. Flow methodology for methanol determination in biodiesel exploiting membrane-based extraction. ANALYTICA CHIMICA ACTA, 613, 177-183. DOI: 10.1016/j.aca.2008.03.005
Pinto, PCAG; Saraiva, MLMFS; Lima, JLFC. 2008. Oxidoreductase Behavior in Ionic Liquids: a Review. ANALYTICAL SCIENCES, 24, 1231-1238. DOI: 10.2116/analsci.24.1231
Passos, MLC; Saraiva, MLMFS; Lima, JLFC. 2008. Enzymatic oxidation in aqueous and micellar media based on horseradish peroxidase-hydrogen peroxide system using a SIA manifold. TALANTA, 77, 484-489. DOI: 10.1016/j.talanta.2008.03.022
Pinto, PCAG; Saraiva, MLMFS; Lima, JLFC. 2008. Sequential injection analysis as a tool for implementation of enzymatic assays in ionic liquids. TALANTA, 77, 479-483. DOI: 10.1016/j.talanta.2008.03.017
Silvestre, CIC; Segundo, MA; Saraiva, MLMFS; Lima, JLFC. 2009. Indirect Sequential Injection Enzymatic Determination of Allopurinol in Pharmaceuticals Based on Xanthine Oxidase Inhibition. SPECTROSCOPY LETTERS, 42, 341-350. DOI: 10.1080/00387010903185538
Araujo, AN; Lima, JLFC; Pinto, PCAG; Saraiva, MLMFS. 2009. Enzymatic Determination of Glucose in Milk Samples by Sequential Injection Analysis. ANALYTICAL SCIENCES, 25, 687-692. DOI: 10.2116/analsci.25.687
Araujo, ARTS; Gaspar, D; Lucio, M; Reis, S; Saraiva, MLMFS; Lima, JLFC. 2009. Sequential injection system for phospholipase A(2) activity evaluation: Studies on liposomes using an environment-sensitive fluorescent probe. TALANTA, 79, 1125-1129. DOI: 10.1016/j.talanta.2009.03.029
Morte, ESB; Korn, MGA; Saraiva, MLMFS; Lima, JLFC; Pinto, PCAG. 2009. Sequential injection fluorimetric determination of Sn in juices of canned fruits. TALANTA, 79, 1100-1103. DOI: 10.1016/j.talanta.2009.02.019
Korn, MGA; Santos, DCMB; Guida, MAB; Barbosa, IS; Passos, MLC; Saraiva, MLMFS; Lima, JLFC. 2010. Evaluation of Digestion Procedures for Simultaneous Determination of Ca, P, Mg, K and Na in Biodiesel by Inductively Coupled Plasma Optical Emission Spectrometry. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 21, 2278-2284. DOI: 10.1590/S0103-50532010001200015
Passos, MLC; Saraiva, MLMFS; Lima, JLFC. 2010. A thionine-based reversible redox sensor in a sequential injection system. ANALYTICA CHIMICA ACTA, 668, 41-46. DOI: 10.1016/j.aca.2010.01.060
Araujo, ARTS; Saraiva, MLMFS; Lima, JLFC. 2010. Flow Injection Analysis with Immobilized Enzymes in Nonaqueous Media. Current Analytical Chemistry, 6, 193-202. DOI:
Grosso, C; Vinholes, J; Goncalves, R; Jager, A; Valentao, P; Andrade, P. 2010. Phytochemical profile and in vitro activities of Capsella bursa-pastoris L. extracts. PLANTA MEDICA, 76, 1239-1240. DOI:
Pinto, PCAG; Lucia, M; Saraiva, MFS; Lima, JLFC. 2011. Sequential Injection Analysis Hyphenated with Other Flow Techniques: A Review. ANALYTICAL LETTERS, 44, 374-397. DOI: 10.1080/00032719.2010.500780
dos Santos, DCMB; Korn, MGA; Korn, M; Pinto, PCAG; Saraiva, MLMFS; Lima, JLFC. 2011. Sequential Injection Chemiluminescence Methodology for Ozone Evaluation. ANALYTICAL LETTERS, 44, 117-126. DOI: 10.1080/00032719.2010.500769
Pinto, PCAG; Costa, ADF; Lima, JLFC; Saraiva, MLMFS. 2011. Automated evaluation of the effect of ionic liquids on catalase activity. CHEMOSPHERE, 82, 1620-1628. DOI: 10.1016/j.chemosphere.2010.11.046
Silvestre, CIC; Pinto, PCAG; Segundo, MA; Saraiva, MLMFS; Lima, JLFC. 2011. Enzyme based assays in a sequential injection format: A review. ANALYTICA CHIMICA ACTA, 689, 160-177. DOI: 10.1016/j.aca.2011.01.048
Araujo, ARTS; Saraiva, MLMFS; Lima, JLFC. 2011. Automatic flow methodology for kinetic and inhibition studies of reactions with poorly water-soluble substrates in ionic liquid systems. ANALYTICA CHIMICA ACTA, 690, 101-107. DOI: 10.1016/j.aca.2011.01.053
Ferreres, F; Gil-Izquierdo, A; Vinholes, J; Grosso, C; Valentao, P; Andrade, PB. 2011. Approach to the study of C-glycosyl flavones acylated with aliphatic and aromatic acids from Spergularia rubra by high-performance liquid chromatography-photodiode array detection/electrospray ionization multi-stage mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 25, 700-712. DOI: 10.1002/rcm.4910
Passos, MLC; Saraiva, MLMFS; Santos, JLM; Reis, S; Lucio, M; Lima, JLFC. 2011. A reagent-free method based on a photo-induced fluorimetry in a sequential injection system. TALANTA, 84, 1309-1313. DOI: 10.1016/j.talanta.2011.02.037
Grosso, C; Vinholes, J; Silva, LR; de Pinho, PG; Goncalves, RF; Valentao, P; Jager, AK; Andrade, PB. 2011. Chemical composition and biological screening of Capsella bursa-pastoris. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, 21, 635-644. DOI: 10.1590/S0102-695X2011005000107
Grosso, C; Andrade, PB; Valentao, P; Mouga, T; Jager, AK. 2011. Seaweeds: new source of MAO-A inhibiting compounds. PLANTA MEDICA, 77, 1416-1417. DOI:
Araujo, ARTS; Maya, F; Saraiva, MLMFS; Lima, JLFC; Estela, JM; Cerda, V. 2011. Flow system for the automatic screening of the effect of phenolic compounds on the luminol-hydrogen peroxide-peroxidase chemiluminescence system. LUMINESCENCE, 26, 571-578. DOI: 10.1002/bio.1272
Vinholes, J; Grosso, C; Andrade, PB; Gil-Izquierdo, A; Valentao, P; de Pinho, PG; Ferreres, F. 2011. In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra. FOOD CHEMISTRY, 129, 454-462. DOI: 10.1016/j.foodchem.2011.04.098
Grosso, C; Bernardo, J; Correia, P; Andrade, C; Valentao, P; Andrade, PB. 2016. In vitro neuroprotection by medicinal plant extracts. PLANTA MEDICA, 82. DOI: 10.1055/s-0036-1596360
Amaral, C; Magalhaes, M; Cabral, C; Veiga, F; Figueiras, A. 2017. Preparation and Characterization of Mixed Polymeric Micelles as a Versatile Strategy for Meloxicam Oral Administration. Letters in Drug Design & Discovery, 14, 1401-1408. DOI: 10.2174/1570180814666170505120728
Almeida, M; Magalhes, M; Veiga, F; Figueiras, A. 2017. Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer. JOURNAL OF POLYMER RESEARCH, 25. DOI: 10.1007/s10965-017-1426-x
Moskvin, M; Babic, M; Reis, S; Cruz, MM; Ferreira, LP; Carvalho, MD; Lima, SAC; Horak, D. 2018. Biological evaluation of surface-modified magnetic nanoparticles as a platform for colon cancer cell theranostics. COLLOIDS AND SURFACES B-BIOINTERFACES, 161, 35-41. DOI: 10.1016/j.colsurfb.2017.10.034
Sanchez-Lopez, E; Egea, MA; Davis, BM; Guo, L; Espina, M; Silva, AM; Calpena, AC; Souto, EMB; Ravindran, N; Ettcheto, M; Camins, A; Garcia, ML; Cordeiro, MF. 2018. Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma. Small, 14. DOI: 10.1002/smll.201701808
Chaves, LL; Lima, SAC; Vieira, ACC; Barreiros, L; Segundo, MA; Ferreira, D; Sarmento, B; Reis, S. 2018. Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 112, 28-37. DOI: 10.1016/j.ejps.2017.11.004
Goncalves, S; Medronho, J; Moreira, E; Grosso, C; Andrade, PB; Valentao, P; Romano, A. 2018. Bioactive properties of Chamaerops humilis L.: antioxidant and enzyme inhibiting activities of extracts from leaves, seeds, pulp and peel. 3 Biotech, 8. DOI: 10.1007/s13205-018-1110-9
Vieira, ACC; Chaves, LL; Pinheiro, S; Pinto, S; Pinheiro, M; Lima, SC; Ferreira, D; Sarmento, B; Reis, S. 2018. Mucoadhesive chitosan-coated solid lipid nanoparticles for better management of tuberculosis. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 536, 478-485. DOI: 10.1016/j.ijpharm.2017.11.071
Barbosa, EA; Oliveira, A; Placido, A; Socodato, R; Portugal, CC; Mafud, AC; Ombredane, AS; Moreira, DC; Vale, N; Bessa, LJ; Joanitti, GA; Alves, C; Gomes, P; Delerue-Matos, C; Mascarenhas, YP; Marani, MM; Relvas, JB; Pintado, M; Leite, JRSA. 2018. Structure and function of a novel antioxidant peptide from the skin of tropical frogs. FREE RADICAL BIOLOGY AND MEDICINE, 115, 68-79. DOI: 10.1016/j.freeradbiomed.2017.11.001
Chaves, LL; Lima, S; Vieira, ACC; Ferreira, D; Sarmento, B; Reis, S. 2018. Overcoming clofazimine intrinsic toxicity: statistical modelling and characterization of solid lipid nanoparticles. Journal of the Royal Society Interface, 15. DOI: 10.1098/rsif.2017.0932
Bessa, LJ; Eaton, P; Dematei, A; Placido, A; Vale, N; Gomes, P; Delerue-Matos, C; Leite, JRSA; Gameiro, P. 2018. Synergistic and antibiofilm properties of ocellatin peptides against multidrug-resistant Pseudomonas aeruginosa. Future Microbiology, 13, 151-163. DOI: 10.2217/fmb-2017-0175
Pereira, SAP; Costa, SPF; Cunha, E; Passos, MLC; Araujo, ARST; Saraiva, MLMFS. 2018. Manual or automated measuring of antipsychotics' chemical oxygen demand. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 152, 55-60. DOI: 10.1016/j.ecoenv.2018.01.023
Silva, A. C; Santos, D.; Ferreira, D.; Souto, E.B.. 2011. Advances in Nanoparticulate Carriers for Oral Peptides and Proteins: Polymeric vs. Lipid Nanoparticles. Encyclopedia of Nanoscience and Nanotechnology. DOI:
Silva, A.C.; Lopes, C.M.; Fonseca, J.; Soares, M.E.; Santos, D.; Souto, E.B.. 2012. Risperidone Release from Solid Lipid Nanoparticles (SLN): Validated HPLC Method and Modelling Kinetic Profile. Current Pharmaceutical Analysis. DOI: 10.2174/157341212803341663
Passos, MLC; Santos, AM; Pereira, AI; Rodrigo Santos, J; Santos, AJC; Saraiva, MLMFS; Lima, JLFC. 2009. Estimation of postmortem interval by hypoxanthine and potassium evaluation in vitreous humor with a sequential injection system. TALANTA, 79(4), 1094-1099. DOI: 10.1016/j.talanta.2009.02.054
Andrade, PB; Grosso, C; Valentao, P; Bernardo, J. 2016. Flavonoids in neurodegeneration: Limitations and strategies to cross CNS barriers. CURRENT MEDICINAL CHEMISTRY, 23(36), 4151-4174. DOI: 10.2174/0929867323666160809094934
Vieira, ACC; Chaves, LL; Pinheiro, M; Ferreira, D; Sarmento, B; Reis, S. 2016. Design and statistical modeling of mannose-decorated dapsone-containing nanoparticles as a strategy of targeting intestinal M-cells. International Journal of Nanomedicine, 11, 2601-2617. DOI: 10.2147/IJN.S104908
Harasimowicz, J; Marques, KL; Silva, AFT; Costa, RCB; Prior, JAV; Rodrigues, SSM; Santos, JLM. 2012. Chemiluminometric evaluation of melatonin and selected melatonin precursors' interaction with reactive oxygen and nitrogen species. ANALYTICAL BIOCHEMISTRY, 420, 1-6. DOI: 10.1016/j.ab.2011.09.008
Sarraguca, JMG; Lopes, JA; Santos, JLM; Lima, JLFC. 2012. MATHEMATICAL SIMULATION OF SIGNAL PROFILES IN FLOW ANALYSIS. ANALYTICAL LETTERS, 45, 85-98. DOI: 10.1080/00032719.2011.582551
Morais, T; Soares, ME; Duarte, JA; Soares, L; Maia, S; Gomes, P; Pereira, E; Fraga, S; Carmo, H; Bastos, MDL. 2012. Effect of surface coating on the biodistribution profile of gold nanoparticles in the rat. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 80, 185-193. DOI: 10.1016/j.ejpb.2011.09.005
Lopes, S; Simeonova, M; Gameiro, P; Rangel, M; Ivanova, G. 2012. Interaction of 5-Fluorouracil Loaded Nanoparticles with 1,2-Dimyristoyl-sn-glycero-3-phosphocholine Liposomes Used as a Cellular Membrane Model. JOURNAL OF PHYSICAL CHEMISTRY B, 116, 667-675. DOI: 10.1021/jp210088n
Costa, P; Goncalves, S; Grosso, C; Andrade, PB; Valentao, P; Bernardo-Gil, MG; Romano, A. 2012. Chemical profiling and biological screening of Thymus lotocephalus extracts obtained by supercritical fluid extraction and hydrodistillation. INDUSTRIAL CROPS AND PRODUCTS, 36, 246-256. DOI: 10.1016/j.indcrop.2011.09.014
Cardoso, AMS; Trabulo, S; Cardoso, AL; Lorents, A; Morais, CM; Gomes, P; Nunes, C; Lucio, M; Reis, S; Padari, K; Pooga, M; de Lima, MCP; Jurado, AS. 2012. S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1818, 877-888. DOI: 10.1016/j.bbamem.2011.12.022
Queiros, C; Silva, AMG; Lopes, SC; Ivanova, G; Gameiro, P; Rangel, M. 2012. A novel fluorescein-based dye containing a catechol chelating unit to sense iron(III). DYES AND PIGMENTS, 93, 1447-1455. DOI: 10.1016/j.dyepig.2011.10.010
Neves, AR; Lucio, M; Lima, JLC; Reis, S. 2012. Resveratrol in Medicinal Chemistry: A Critical Review of its Pharmacokinetics, Drug-Delivery, and Membrane Interactions. CURRENT MEDICINAL CHEMISTRY, 19, 1663-1681. DOI:
Oliveira, SM; Oliveira, HM; Segundo, MA; Rangel, AOSS; Lima, JLFC; Cerda, V. 2012. Automated solid-phase spectrophotometric system for optosensing of bromate in drinking waters. Analytical Methods, 4, 1229-1236. DOI: 10.1039/c2ay05860j
Sousa, I; Claro, V; Pereira, JL; Amaral, AL; Cunha-Silva, L; de Castro, B; Feio, MJ; Pereira, E; Gameiro, P. 2012. Synthesis, characterization and antibacterial studies of a copper(II) levofloxacin ternary complex. JOURNAL OF INORGANIC BIOCHEMISTRY, 110, 64-71. DOI: 10.1016/j.jinorgbio.2012.02.003
Sousa, CT; Nunes, C; Proenca, MP; Leitao, DC; Lima, JLFC; Reis, S; Araujo, JP; Lucio, M. 2012. pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery. COLLOIDS AND SURFACES B-BIOINTERFACES, 94, 288-295. DOI: 10.1016/j.colsurfb.2012.02.003
Magalhaes, LM; Almeida, MIGS; Barreiros, L; Reis, S; Segundo, MA. 2012. Automatic Aluminum Chloride Method for Routine Estimation of Total Flavonoids in Red Wines and Teas. Food Analytical Methods, 5, 530-539. DOI: 10.1007/s12161-011-9278-1
Pinto, PCAG; Costa, SPF; Lima, JLFC; Saraiva, MLMFS. 2012. Automated high-throughput Vibrio fischeri assay for (eco)toxicity screening: Application to ionic liquids. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 80, 97-102. DOI: 10.1016/j.ecoenv.2012.02.013
Vaz, AM; Araujo, ARTS; Santos, JLM; Lima, JLFC; Saraiva, MLMFS. 2012. Automatic miniaturized flow methodology with in-line solid-phase extraction for quinine determination in biological samples. Analytical Methods, 4, 1681-1686. DOI: 10.1039/c2ay05818a
Pinto, PCAG; Costa, SPF; Costa, ADF; Passos, ML; Lima, JLFC; Saraiva, MLMFS. 2012. Trypsin activity in imidazolium based ionic liquids: evaluation of free and immobilized enzyme. JOURNAL OF MOLECULAR LIQUIDS, 171, 16-22. DOI: 10.1016/j.molliq.2012.04.004
Rodrigues, SSM; Santos, JLM. 2012. Chemiluminometric determination of captopril in a multi-pumping flow system. TALANTA, 96, 210-215. DOI: 10.1016/j.talanta.2012.02.016
Frigerio, C; Abreu, VLRG; Santos, JLM. 2012. Evaluation of acetylcysteine promoting effect on CdTe nanocrystals photoluminescence by using a multipumping flow system. TALANTA, 96, 55-61. DOI: 10.1016/j.talanta.2012.02.002
Pinto, PCAG; Costa, SPF; Lima, JLFC; Saraiva, MLMFS. 2012. beta-Galactosidase activity in mixed micelles of imidazolium ionic liquids and sodium dodecylsulfate: A sequential injection kinetic study. TALANTA, 96, 26-33. DOI: 10.1016/j.talanta.2012.02.020
Ribeiro, DSM; Frigerio, C; Santos, JLM; Prior, JAV. 2012. Photoactivation by visible light of CdTe quantum dots for inline generation of reactive oxygen species in an automated multipumping flow system. ANALYTICA CHIMICA ACTA, 735, 69-75. DOI: 10.1016/j.aca.2012.05.034
Frigerio, C; Ribeiro, DSM; Rodrigues, SSM; Abreu, VLRG; Barbosa, JAC; Prior, JAV; Marques, KL; Santos, JLM. 2012. Application of quantum dots as analytical tools in automated chemical analysis: A review. ANALYTICA CHIMICA ACTA, 735, 9-22. DOI: 10.1016/j.aca.2012.04.042
Abreu, VLRG; Santos, JLM; Lima, JLFC. 2012. An Automated Single Interface Flow System for the Spectrophotometric Determination of Ethanol in Beverages Based on Schlieren Effect. Food Analytical Methods, 5, 867-873. DOI: 10.1007/s12161-011-9322-1
Magalhaes, LM; Barreiros, L; Maia, MA; Reis, S; Segundo, MA. 2012. Rapid assessment of endpoint antioxidant capacity of red wines through microchemical methods using a kinetic matching approach. TALANTA, 97, 473-483. DOI: 10.1016/j.talanta.2012.05.002
Castro, CM; Pinheiro, M; Casares, JJ; Lucio, M; Segundo, M; Reis, S; Lima, JLFC. 2012. Study of antioxidants effect at the air-water interface: a biophysical approach to membrane peroxidation. FEBS Journal, 279, 219-219. DOI:
Pereira, D; Correia-da-Silva, G; Valentao, P; Teixeira, N; Andrade, PB. 2012. Biological properties of a lipophilic extract of sea-star Marthasterias glacialis L. upon several cancer cell lines. FEBS Journal, 279, 61-61. DOI:
Pinheiro, M; Lucio, M; Reis, S; Lima, JLFC; Caio, JM; Moiteiro, C; Martin-Romero, MT; Camacho, L; Giner-Casares, JJ. 2012. Molecular Interaction of Rifabutin on Model Lung Surfactant Monolayers. JOURNAL OF PHYSICAL CHEMISTRY B, 116, 11635-11645. DOI: 10.1021/jp303725j
Cardoso, ICS; Amorim, AL; Queiros, C; Lopes, SC; Gameiro, P; de Castro, B; Rangel, M; Silva, AMG. 2012. Microwave-Assisted Synthesis and Spectroscopic Properties of 4 '-Substituted Rosamine Fluorophores and Naphthyl Analogues. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 5810-5817. DOI: 10.1002/ejoc.201200783
Costa, P; Grosso, C; Goncalves, S; Andrade, PB; Valentao, P; Bernardo-Gil, MG; Romano, A. 2012. Supercritical fluid extraction and hydrodistillation for the recovery of bioactive compounds from Lavandula viridis L'Her. FOOD CHEMISTRY, 135, 112-121. DOI: 10.1016/j.foodchem.2012.04.108
Pereira-Leite, C; Nunes, C; Lima, JLFC; Reis, S; Lucio, M. 2012. Interaction of Celecoxib with Membranes: The Role of Membrane Biophysics on its Therapeutic and Toxic Effects. JOURNAL OF PHYSICAL CHEMISTRY B, 116, 13608-13617. DOI: 10.1021/jp304037v
Rocha, S; Domingues, VF; Pinho, C; Fernandes, VC; Delerue-Matos, C; Gameiro, P; Mansilha, C. 2013. Occurrence of Bisphenol A, Estrone, 17 beta-Estradiol and 17 alpha-Ethinylestradiol in Portuguese Rivers. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 90, 73-78. DOI: 10.1007/s00128-012-0887-1
Frigerio, C; Santos, JLM; Barbosa, JAC; Eaton, P; Saraiva, MLMFS; Passos, MLC. 2013. A soft strategy for covalent immobilization of glutathione and cysteine capped quantum dots onto amino functionalized surfaces. CHEMICAL COMMUNICATIONS, 49, 2518-2520. DOI: 10.1039/c3cc00145h
Leite, A; Silva, AMG; Cunha-Silva, L; de Castro, B; Gameiro, P; Rangel, M. 2013. Discrimination of fluorescence light-up effects induced by pH and metal ion chelation on a spirocyclic derivative of rhodamine B. DALTON TRANSACTIONS, 42, 6110-6118. DOI: 10.1039/c2dt32198j
Grosso, C; Jager, AK; Staerk, D. 2013. Coupling of a High-resolution Monoamine Oxidase-A Inhibitor Assay and HPLC-SPE-NMR for Advanced Bioactivity Profiling of Plant Extracts. PHYTOCHEMICAL ANALYSIS, 24, 141-147. DOI: 10.1002/pca.2393
Neves, AR; Lucio, M; Martins, S; Lima, JLC; Reis, S. 2013. Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability. International Journal of Nanomedicine, 8, 177-187. DOI: 10.2147/IJN.S37840
Nunes, C; Sousa, CT; Proenca, MP; Apolinario, A; Lima, JLFC; Reis, S; Araujo, JP; Lucio, M. 2013. Synchrotron small angle X-ray scattering for the evaluation of the interaction of silica nanotubes with lipid membranes. RSC Advances, 3, 10323-10328. DOI: 10.1039/c3ra22974b
Pinto, PCAG; Ribeiro, DMGP; Azevedo, AMO; Dela Justina, V; Cunha, E; Bica, K; Vasiloiu, M; Reis, S; Saraiva, MLMFS. 2013. Active pharmaceutical ingredients based on salicylate ionic liquids: insights into the evaluation of pharmaceutical profiles. NEW JOURNAL OF CHEMISTRY, 37, 4095-4102. DOI: 10.1039/c3nj00731f
Cunha, E; Pinto, PCAG; Carvalho, JPS; Saraiva, MLMFS. 2013. Automated carboxylesterase assay for the evaluation of ionic liquids' human toxicity. JOURNAL OF HAZARDOUS MATERIALS, 244, 563-569. DOI: 10.1016/j.jhazmat.2012.10.045
Pinheiro, M; Arede, M; Nunes, C; Caio, JM; Moiteiro, C; Lucio, M; Reis, S. 2013. Differential Interactions of Rifabutin with Human and Bacterial Membranes: Implication for Its Therapeutic and Toxic Effects. JOURNAL OF MEDICINAL CHEMISTRY, 56, 417-426. DOI: 10.1021/jm301116j
Ferreira, M; Lopes, S; Gameiro, P. 2013. How Different Lipidic Mimetic Systems of E. COLI Membranes Affect Membrane Protein Reconstitution: A Steady-State Fluorescence Anisotropy Study. BIOPHYSICAL JOURNAL, 104, 596A-596A. DOI:
Rangel, M; Moniz, T; Leite, A; Gameiro, P. 2013. Tagging 3-Hydroxy-4-Pyridinone Iron Chelators with Rhodamine B Derivatives is Essential to Target Mycobacterium Avium Infection. BIOPHYSICAL JOURNAL, 104, 251A-251A. DOI:
Gameiro, P; Ferreira, M. 2013. Biophysical and Biological Behaviour of Ciprofloxacin and Ciprofloxacin Derivatives: A Route to Counteract Bacteria Resistance?. BIOPHYSICAL JOURNAL, 104, 250A-250A. DOI:
Lopes, SC; Gameiro, P. 2013. Cardiolipin's Impact on Model Membranes Thermodynamic: Drug-Lipid Interactions and Protein Conformation Implication. BIOPHYSICAL JOURNAL, 104, 242A-242A. DOI:
Pinheiro, M; Giner-Casares, JJ; Lucio, M; Caio, JM; Moiteiro, C; Lima, JLFC; Reis, S; Camacho, L. 2013. Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: A biophysical approach to disease. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1828, 896-905. DOI: 10.1016/j.bbamem.2012.09.015
Passos, MLC; Lima, JLFC; Saraiva, MLMFS. 2013. Laccase-biosilica nanostructures - A miniaturized automatic approach. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 91, 113-119. DOI: 10.1139/cjc-2012-0193
Azevedo, AMO; Ribeiro, DMG; Pinto, PCAG; Lucio, M; Reis, S; Saraiva, MLMFS. 2013. Imidazolium ionic liquids as solvents of pharmaceuticals: Influence on HSA binding and partition coefficient of nimesulide. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 443, 273-278. DOI: 10.1016/j.ijpharm.2012.12.030
Pereira-Leite, C; Carneiro, C; Soares, JX; Afonso, C; Nunes, C; Lucio, M; Reis, S. 2013. Biophysical characterization of the drug-membrane interactions: The case of propranolol and acebutolol. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 84, 183-191. DOI: 10.1016/j.ejpb.2012.12.005
Pinheiro, M; Nunes, C; Caio, JM; Moiteiro, C; Lucio, M; Brezesinski, G; Reis, S. 2013. The Influence of Rifabutin on Human and Bacterial Membrane Models: Implications for Its Mechanism of Action. JOURNAL OF PHYSICAL CHEMISTRY B, 117, 6187-6193. DOI: 10.1021/jp403073v
Ramos, RM; Fernandes, LF; Moreira, IS. 2013. Extending the applicability of the O-ring theory to protein-DNA complexes. COMPUTATIONAL BIOLOGY AND CHEMISTRY, 44, 31-39. DOI: 10.1016/j.compbiolchem.2013.02.005
Molina-Garcia, L; Llorent-Martinez, EJ; Fernandez-de Cordova, ML; Santos, JLM; Rodrigues, SSM; Ruiz-Medina, A. 2013. Study of the quenching effect of quinolones over CdTe-quantum dots using sequential injection analysis and multicommutation. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 80, 147-154. DOI: 10.1016/j.jpba.2013.03.003
Azevedo, CMG; Afonso, CMM; Sousa, D; Lima, RT; Vasconcelos, MH; Pedro, M; Barbosa, J; Correa, AG; Reis, S; Pinto, MMM. 2013. Multidimensional optimization of promising antitumor xanthone derivatives. BIOORGANIC & MEDICINAL CHEMISTRY, 21, 2941-2959. DOI: 10.1016/j.bmc.2013.03.079
Pinheiro, M; Arede, M; Giner-Casares, JJ; Nunes, C; Caio, JM; Moiteiro, C; Lucio, M; Camacho, L; Reis, S. 2013. Effects of a novel antimycobacterial compound on the biophysical properties of a pulmonary surfactant model membrane. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 450, 268-277. DOI: 10.1016/j.ijpharm.2013.03.062
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Valentao, P; Andrade, PB. 2013. Phenolic compounds from Jacaranda caroba (Vell.) A. DC.: Approaches to neurodegenerative disorders. FOOD AND CHEMICAL TOXICOLOGY, 57, 91-98. DOI: 10.1016/j.fct.2013.03.012
Lopes, SC; Gameiro, P. 2013. Does cardiolipin addition produces superior bacterial membrane model systems?. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 42, S125-S125. DOI:
Gameiro, P; Ferreira, M; Lopes, SC. 2013. Fluoroquinolone complexes as metalloantibiotics: a fluorescence spectroscopy study. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 42, S176-S176. DOI:
Ferreira, M; Lopes, SC; Gameiro, P. 2013. New insights in the translocation mechanism of ciprofloxacin revealed by fluorescence quenching. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 42, S176-S176. DOI:
Ribeiro, MFT; Couto, CMCM; Conceicao, PMM; Santos, JLM. 2013. An Automated Multi-Pumping Pulsed Flow System with Spectrophotometric Detection for the Determination of Phosphate in Natural Waters. ANALYTICAL LETTERS, 46, 1769-1778. DOI: 10.1080/00032719.2012.703273
Ruiz-Medina, A; Molina-Garcia, L; Llorent-Martinez, EJ; Santos, JLM; Fernandez-de Cordova, ML. 2013. Rapid Fluorimetric Quantitation of Ibandronate by Coupling Quantum Dots and Multicommutated Flow Injection Analysis. Current Pharmaceutical Analysis, 9, 237-243. DOI:
Nunes, C; Lopes, D; Pinheiro, M; Pereira-Leite, C; Reis, S. 2013. In Vitro Assessment of NSAIDs-Membrane Interactions: Significance for Pharmacological Actions. PHARMACEUTICAL RESEARCH, 30, 2097-2107. DOI: 10.1007/s11095-013-1066-8
Monteiro, JP; Martins, AF; Nunes, C; Morais, CM; Lucio, M; Reis, S; Pinheiro, TJT; Geraldes, CFGC; Oliveira, PJ; Jurado, AS. 2013. A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1828, 1899-1908. DOI: 10.1016/j.bbamem.2013.04.006
Rodrigues, F; Palmeira-de-Oliveira, A; das Neves, J; Sarmento, B; Amaral, MH; Oliveira, MB. 2013. Medicago spp. extracts as promising ingredients for skin care products. INDUSTRIAL CROPS AND PRODUCTS, 49, 634-644. DOI: 10.1016/j.indcrop.2013.06.015
Pinheiro, M; Pereira-Leite, C; Arede, M; Nunes, C; Caio, JM; Moiteiro, C; Giner-Casares, JJ; Lucio, M; Brezesinski, G; Camacho, L; Reis, S. 2013. Evaluation of the Structure-Activity Relationship of Rifabutin and Analogs: A Drug-Membrane Study. CHEMPHYSCHEM, 14, 2808-2816. DOI: 10.1002/cphc.201300262
Mansilha, C; Silva, P; Rocha, S; Gameiro, P; Domingues, V; Pinho, C; Ferreira, IMPLVO. 2013. Bisphenol A migration from plastic materials: direct insight of ecotoxicity in Daphnia magna. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 20, 6007-6018. DOI: 10.1007/s11356-013-1614-0
Llorent-Martinez, EJ; Molina-Garcia, L; Fernandez-de Cordova, ML; Santos, JLM; Rodrigues, SSM; Ruiz-Medina, A. 2013. A novel multi-commutated method for the determination of hydroxytyrosol in enriched foods using mercaptopropionic acid-capped CdTe quantum dots. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment, 30, 1485-1492. DOI: 10.1080/19440049.2013.812248
Pinheiro, M; Nunes, C; Caio, JM; Moiteiro, C; Brezesinski, G; Reis, S. 2013. Interactions of N '-acetyl-rifabutin and N '-butanoyl-rifabutin with lipid bilayers: A synchrotron X-ray study. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 453, 560-568. DOI: 10.1016/j.ijpharm.2013.06.018
Fraga, S; Faria, H; Soares, ME; Duarte, JA; Soares, L; Pereira, E; Costa-Pereira, C; Teixeira, JP; Bastos, MD; Carmo, H. 2013. Influence of the surface coating on the cytotoxicity, genotoxicity and uptake of gold nanoparticles in human HepG2 cells. JOURNAL OF APPLIED TOXICOLOGY, 33, 1111-1119. DOI: 10.1002/jat.2865
Pereira-Leite, C; Nunes, C; Reis, S. 2013. Interaction of nonsteroidal anti-inflammatory drugs with membranes: In vitro assessment and relevance for their biological actions. PROGRESS IN LIPID RESEARCH, 52, 571-584. DOI: 10.1016/j.plipres.2013.08.003
Oliveira, HM; Segundo, MA; Fonseca, AJM; Cabrita, ARJ. 2013. Combining Ultrasound-Assisted Extraction and a Microliter Colorimetric Assay for the Streamlined Determination of Urea in Animal Feedstuff. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61, 9602-9608. DOI: 10.1021/jf403037y
Rosende, M; Magalhaes, LM; Segundo, MA; Miro, M. 2013. Automated Microdialysis-Based System for in Situ Microsampling and Investigation of Lead Bioavailability in Terrestrial Environments under Physiologically Based Extraction Conditions. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 47, 11668-11675. DOI: 10.1021/es401872j
Castro, CM; Pinheiro, M; Lucio, M; Giner-Casares, JJ; Camacho, L; Lima, JLFC; Reis, S; Segundo, MA. 2013. Insights about alpha-tocopherol and Trolox interaction with phosphatidylcholine monolayers under peroxidation conditions through Brewster angle microscopy. COLLOIDS AND SURFACES B-BIOINTERFACES, 111, 626-635. DOI: 10.1016/j.colsurfb.2013.06.043
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Valentao, P; Andrade, PB. 2013. Ellagic Acid and Derivatives from Cochlospermum angolensis Welw. Extracts: HPLC-DAD-ESI/MSn Profiling, Quantification and In Vitro Anti-depressant, Anti-cholinesterase and Anti-oxidant Activities. PHYTOCHEMICAL ANALYSIS, 24, 534-540. DOI: 10.1002/pca.2429
Ribeiro, DSM; Marques, KL; Santos, JLM; Prior, JAV. 2013. Automatic multiple photodegradation unit on a multipumping flow system: Monitoring of ketoprofen. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 271, 77-84. DOI: 10.1016/j.jphotochem.2013.08.008
Pinheiro, M; Arede, M; Caio, JM; Moiteiro, C; Lucio, M; Reis, S. 2013. Drug-membrane interaction studies applied to N '-acetyl-rifabutin. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 85, 597-603. DOI: 10.1016/j.ejpb.2013.02.015
Martins, SM; Sarmento, B; Nunes, C; Lucio, M; Reis, S; Ferreira, DC. 2013. Brain targeting effect of camptothecin-loaded solid lipid nanoparticles in rat after intravenous administration. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 85, 488-502. DOI: 10.1016/j.ejpb.2013.08.011
Azevedo, CMG; Afonso, CMM; Soares, JX; Reis, S; Sousa, D; Lima, RT; Vasconcelos, MH; Pedro, M; Barbosa, J; Gales, L; Pinto, MMM. 2013. Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 69, 798-816. DOI: 10.1016/j.ejmech.2013.09.012
Soares, S; Fonte, P; Costa, A; Andrade, J; Seabra, V; Ferreira, D; Reis, S; Sarmento, B. 2013. Effect of freeze-drying, cryoprotectants and storage conditions on the stability of secondary structure of insulin-loaded solid lipid nanoparticles. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 456, 370-381. DOI: 10.1016/j.ijpharm.2013.08.076
Grosso, C; Valentao, P; Ferreres, F; Andrade, PB. 2013. The Use of Flavonoids in Central Nervous System Disorders. CURRENT MEDICINAL CHEMISTRY, 20, 4694-4719. DOI:
Melo, T; Santos, N; Lopes, D; Alves, E; Maciel, E; Faustino, MAF; Tome, JPC; Neves, MGPMS; Almeida, A; Domingues, P; Segundo, MA; Domingues, MRM. 2013. Photosensitized oxidation of phosphatidylethanolamines monitored by electrospray tandem mass spectrometry. JOURNAL OF MASS SPECTROMETRY, 48, 1357-1365. DOI: 10.1002/jms.3301
Molina-Garcia, L; Santos, JLM; Ruiz-Medina, A; Llorent-Martinez, EJ. 2013. Determination of ketoprofen based on its quenching effect in the fluorescence of quantum dots. JOURNAL OF FOOD AND DRUG ANALYSIS, 21, 426-431. DOI: 10.1016/j.jfda.2013.09.007
Rodrigues, SSM; Lima, AS; Teixeira, LSG; Korn, MDA; Santos, JLM. 2014. Determination of iron in biodiesel based on fluorescence quenching of CdTe quantum dots. FUEL, 117, 520-527. DOI: 10.1016/j.fuel.2013.09.045
Rangel, M; Leite, A; Silva, AMN; Moniz, T; Nunes, A; Amorim, MJ; Queiros, C; Cunha-Silva, L; Gameiro, P; Burgess, J. 2014. Distinctive EPR signals provide an understanding of the affinity of bis-(3-hydroxy-4-pyridinonato) copper(II) complexes for hydrophobic environments. DALTON TRANSACTIONS, 43, 9722-9731. DOI: 10.1039/c4dt00642a
Barbosa, JAC; Abreu, VLRG; Rodrigues, SSM; Frigerio, C; Santos, JLM. 2014. A CdTe-MPA quantum dot fluorescence enhancement flow method for chlorhexidine determination. Analytical Methods, 6, 4240-4246. DOI: 10.1039/c4ay00540f
Carvalho, MM; Ribeiro, DSM; Santos, JLM; Prior, JAV. 2014. pH-sensitive spectrophotometric control of nilutamide in an automatic micro-flow system. NEW JOURNAL OF CHEMISTRY, 38, 2856-2864. DOI: 10.1039/c4nj00158c
Rodrigues, SSM; Oleksiak, Z; Ribeiro, DSM; Pobozy, E; Trojanowicz, M; Prior, JAV; Santos, JLM. 2014. Selective determination of sulphide based on photoluminescence quenching of MPA-capped CdTe nanocrystals by exploiting a gas-diffusion multi-pumping flow method. Analytical Methods, 6, 7956-7966. DOI: 10.1039/c4ay01823k
Moura, CC; Segundo, MA; das Neves, J; Reis, S; Sarmento, B. 2014. Co-association of methotrexate and SPIONs into anti-CD64 antibody-conjugated PLGA nanoparticles for theranostic application. International Journal of Nanomedicine, 9, 4911-4922. DOI: 10.2147/IJN.S68440
Passos, MLC; Pereira, M; Saraiva, MLMFS; Rangel, M; Moniz, T; Santos, JLM; Frigerio, C. 2014. Silica nanostructures synthesis and CdTe quantum dots immobilization for photocatalytical applications. RSC Advances, 4, 59697-59705. DOI: 10.1039/c4ra09748c
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Valentao, P; Andrade, PB. 2014. Assessing Jasminum grandzflorum L. authenticity by HPLC-DAD-ESI/MSn and effects on physiological enzymes and oxidative species. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 88, 157-161. DOI: 10.1016/j.jpba.2013.08.040
Costa, SPF; Justina, VD; Bica, K; Vasiloiu, M; Pinto, PCAG; Saraiva, MLMFS. 2014. Automated evaluation of pharmaceutically active ionic liquids' (eco)toxicity through the inhibition of human carboxylesterase and Vibrio fischeri. JOURNAL OF HAZARDOUS MATERIALS, 265, 133-141. DOI: 10.1016/j.jhazmat.2013.11.052
Fernandes, P; Sousa, I; Cunha-Silva, L; Ferreira, M; de Castro, B; Pereira, EF; Feio, MJ; Gameiro, P. 2014. Synthesis, characterization and antibacterial studies of a copper(II) lomefloxacin ternary complex. JOURNAL OF INORGANIC BIOCHEMISTRY, 131, 21-29. DOI: 10.1016/j.jinorgbio.2013.10.013
Magalhaes, LM; Ramos, II; Reis, S; Segundo, MA. 2014. Antioxidant profile of commercial oenological tannins determined by multiple chemical assays. AUSTRALIAN JOURNAL OF GRAPE AND WINE RESEARCH, 20, 72-79. DOI: 10.1111/ajgw.12058
Magalhaes, LM; Barreiros, L; Reis, S; Segundo, MA. 2014. Kinetic matching approach applied to ABTS assay for high-throughput determination of total antioxidant capacity of food products. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 33, 187-194. DOI: 10.1016/j.jfca.2014.01.003
Chaves, LL; Vieira, ACC; Reis, S; Sarmento, B; Ferreira, DC. 2014. Quality by Design: Discussing and Assessing the Solid Dispersions Risk. Current Drug Delivery, 11, 253-269. DOI:
Rodrigues, SSM; Ribeiro, DSM; Molina-Garcia, L; Medina, AR; Prior, JAV; Santos, JLM. 2014. Fluorescence enhancement of CdTe MPA-capped quantum dots by glutathione for hydrogen peroxide determination. TALANTA, 122, 157-165. DOI: 10.1016/j.talanta.2014.01.031
Grosso, C; Valentao, P; Ferreres, F; Andrade, PB. 2014. Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases. Marine Drugs, 12, 2539-2589. DOI: 10.3390/md12052539
Pinheiro, M; Pisco, S; Silva, AS; Nunes, C; Reis, S. 2014. Evaluation of the effect of rifampicin on the biophysical properties of membranes: Significance for therapeutic and side effects. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 466, 190-197. DOI: 10.1016/j.ijpharm.2014.03.005
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Valentao, P; Azevedo, C; Andrade, PB. 2014. HPLC-DAD-ESI/MSn analysis of phenolic compounds for quality control of Grindelia robusta Nutt. and bioactivities. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 94, 163-172. DOI: 10.1016/j.jpba.2014.01.046
Rodrigues, F; Almeida, I; Sarmento, B; Amaral, MH; Oliveira, MBPP. 2014. Study of the isoflavone content of different extracts of Medicago spp. as potential active ingredient. INDUSTRIAL CROPS AND PRODUCTS, 57, 110-115. DOI: 10.1016/j.indcrop.2014.03.014
Cunha, E; Passos, MLC; Pinto, PCAG; Saraiva, MLMFS. 2014. Improved activity of alpha-chymotrypsin in mixed micelles of cetyltrimethylammonium bromide (CTAB) and ionic liquids: A kinetic study resorting to sequential injection analysis. COLLOIDS AND SURFACES B-BIOINTERFACES, 118, 172-178. DOI: 10.1016/j.colsurfb.2014.03.023
Saraiva, RG; Lopes, JA; Machado, J; Gameiro, P; Feio, MJ. 2014. Discrimination of single-porin Escherichia (E.) coli mutants by ATR and transmission mode FTIR spectroscopy. Journal of Biophotonics, 7, 392-400. DOI: 10.1002/jbio.201200131
Ramos, II; Maia, MA; Reis, S; Magalhaes, LM; Segundo, MA. 2014. Lab-on-valve combined with a kinetic-matching approach for fast evaluation of total antioxidant capacity in wines. Analytical Methods, 6, 3622-3628. DOI: 10.1039/c3ay42185f
Marques, SS; Magalhaes, LM; Toth, IV; Segundo, MA. 2014. Insights on Antioxidant Assays for Biological Samples Based on the Reduction of Copper Complexes-The Importance of Analytical Conditions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 15, 11387-11402. DOI: 10.3390/ijms150711387
Feio, MJ; Sousa, I; Ferreira, M; Cunha-Silva, L; Saraiva, RG; Queiros, C; Alexandre, JG; Claro, V; Mendes, A; Ortiz, R; Lopes, S; Amaral, AL; Lino, J; Fernandes, P; Silva, AJ; Moutinho, L; de Castro, B; Pereira, E; Perello, L; Gameiro, P. 2014. Fluoroquinolone-metal complexes: A route to counteract bacterial resistance?. JOURNAL OF INORGANIC BIOCHEMISTRY, 138, 129-143. DOI: 10.1016/j.jinorgbio.2014.05.007
Rosende, M; Magalhaes, LM; Segundo, MA; Miro, M. 2014. Assessing oral bioaccessibility of trace elements in soils under worst-case scenarios by automated in-line dynamic extraction as a front end to inductively coupled plasma atomic emission spectrometry. ANALYTICA CHIMICA ACTA, 842, 1-10. DOI: 10.1016/j.aca.2014.06.033
Fernandes, M; Pereira, C; Gajo, K; Pereira, E; Carmo, H; Bastos, MD; Fraga, S. 2014. Cytotoxicity of gold and silver nanoparticles in the Caco-2 human intestinal epithelial cell line. TOXICOLOGY LETTERS, 229, S188-S189. DOI: 10.1016/j.toxlet.2014.06.640
Lopes, D; Nunes, C; Martins, MCL; Sarmento, B; Reis, S. 2014. Eradication of Helicobacter pylori: Past, present and future. JOURNAL OF CONTROLLED RELEASE, 189, 169-186. DOI: 10.1016/j.jconrel.2014.06.020
Fonte, P; Soares, S; Sousa, F; Costa, A; Seabra, V; Reis, S; Sarmento, B. 2014. Stability Study Perspective of the Effect of Freeze-Drying Using Cryoprotectants on the Structure of Insulin Loaded into PLGA Nanoparticles. BIOMACROMOLECULES, 15, 3753-3765. DOI: 10.1021/bm5010383
Pinheiro, M; Silva, AS; Pisco, S; Reis, S. 2014. Interactions of isoniazid with membrane models: Implications for drug mechanism of action. CHEMISTRY AND PHYSICS OF LIPIDS, 183, 184-190. DOI: 10.1016/j.chemphyslip.2014.07.002
Queiros, C; Leite, A; Couto, MGM; Moniz, T; Cunha-Silva, L; Gameiro, P; Silva, AMG; Rangel, M. 2014. Tuning the limits of pH interference of a rhodamine ion sensor by introducing catechol and 3-hydroxy-4-pyridinone chelating units. DYES AND PIGMENTS, 110, 193-202. DOI: 10.1016/j.dyepig.2014.04.007
Lima, AS; Rodrigues, SSM; Korn, MGA; Ribeiro, DSM; Santos, JLM; Teixeira, LSG. 2014. Determination of copper in biodiesel samples using CdTe-GSH quantum dots as photoluminescence probes. MICROCHEMICAL JOURNAL, 117, 144-148. DOI: 10.1016/j.microc.2014.06.021
Fraga, S; Brandao, A; Soares, ME; Morais, T; Duarte, JA; Pereira, L; Soares, L; Neves, C; Pereira, E; Bastos, MD; Carmo, H. 2014. Short- and long-term distribution and toxicity of gold nanoparticles in the rat after a single-dose intravenous administration. Nanomedicine-Nanotechnology Biology and Medicine, 10, 1757-1766. DOI: 10.1016/j.nano.2014.06.005
Sasaki, MK; Ribeiro, DSM; Frigerio, C; Prior, JAV; Santos, JLM; Zagatto, EAG. 2014. Chemiluminometric determination of ascorbic acid in pharmaceutical formulations exploiting photo-activation of GSH-capped CdTe quantum dots. LUMINESCENCE, 29, 901-907. DOI: 10.1002/bio.2639
Grosso, C; Ferreres, F; Gil-Izquierdo, A; Valentao, P; Sampaio, M; Lima, J; Andrade, PB. 2014. Box-Behnken factorial design to obtain a phenolic-rich extract from the aerial parts of Chelidonium majus L.. TALANTA, 130, 128-136. DOI: 10.1016/j.talanta.2014.06.043
Pinto, MF; Moura, CC; Nunes, C; Segundo, MA; Lima, SAC; Reis, S. 2014. A new topical formulation for psoriasis: Development of methotrexate-loaded nanostructured lipid carriers. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 477, 519-526. DOI: 10.1016/j.ijpharm.2014.10.067
Rodrigues, F; Pereira, C; Pimentel, FB; Alves, RC; Ferreira, M; Sarmento, B; Amaral, MH; Oliveira, MBPP. 2015. Are coffee silverskin extracts safe for topical use? An in vitro and in vivo approach. INDUSTRIAL CROPS AND PRODUCTS, 63, 167-174. DOI: 10.1016/j.indcrop.2014.10.014
Almeida, IMC; Rodrigues, F; Sarmento, B; Alves, RC; Oliveira, MBPP. 2015. Isoflavones in food supplements: chemical profile, label accordance and permeability study in Caco-2 cells. Food & Function, 6, 938-946. DOI: 10.1039/c4fo01144a
Rodrigues, F; Santos, J; Pimentel, FB; Braga, N; Palmeira-de-Oliveira, A; Oliveira, MBPP. 2015. Promising new applications of Castanea sativa shell: nutritional composition, antioxidant activity, amino acids and vitamin E profile. Food & Function, 6, 2854-2860. DOI: 10.1039/c5fo00571j
Rodrigues, F; Maia, MJ; das Neves, J; Sarmento, B; Amaral, MH; Oliveira, MBPP. 2015. Vaginal suppositories containing Lactobacillus acidophilus: development and characterization. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 41, 1518-1525. DOI: 10.3109/03639045.2014.963864
Cunha, E; Passos, MLC; Pinto, PCAG; Saraiva, MLMFS. 2015. Automated evaluation of the inhibition of glutathione reductase activity: application to the prediction of ionic liquids' toxicity. RSC Advances, 5, 78971-78978. DOI: 10.1039/c5ra04029a
Braga, N; Rodrigues, F; Oliveira, MBPP. 2015. Castanea sativa by-products: a review on added value and sustainable application. NATURAL PRODUCT RESEARCH, 29, 1-18. DOI: 10.1080/14786419.2014.955488
Passos, MLC; Costa, D; Lima, JLFC; Saraiva, MLMFS. 2015. Sequential injection technique as a tool for the automatic synthesis of silver nanoparticles in a greener way. TALANTA, 133, 45-51. DOI: 10.1016/j.talanta.2014.04.089
Ferreira, M; Gameiro, P. 2015. Ciprofloxacin Metalloantibiotic: An Effective Antibiotic with an Influx Route Strongly Dependent on Lipid Interaction?. JOURNAL OF MEMBRANE BIOLOGY, 248, 125-136. DOI: 10.1007/s00232-014-9749-6
Pinheiro, M; Silva, AS; Reis, S. 2015. Molecular interactions of rifabutin with membrane under acidic conditions. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 479, 63-69. DOI: 10.1016/j.ijpharm.2014.12.042
Queiros, C; Leite, A; Silva, AMG; Gameiro, P; de Castro, B; Rangel, M. 2015. Synthesis and spectroscopic characterization of a new tripodal hexadentate iron chelator incorporating catechol units. POLYHEDRON, 87, 1-7. DOI: 10.1016/j.poly.2014.10.003
Rodrigues, F; Palmeira-de-Oliveira, A; das Neves, J; Sarmento, B; Amaral, MH; Oliveira, MBPP. 2015. Coffee silverskin: A possible valuable cosmetic ingredient. PHARMACEUTICAL BIOLOGY, 53, 386-394. DOI: 10.3109/13880209.2014.922589
Grosso, C; Valentao, P; Andrade, C; Andrade, PB. 2015. HPLC-DAD analysis and in vitro enzyme inhibition: An integrated approach to predict herbal binary mixture behaviour employing median effect equation. MICROCHEMICAL JOURNAL, 119, 176-182. DOI: 10.1016/j.microc.2014.12.006
Rodrigues, SSM; Prieto, DR; Ribeiro, DSM; Barrado, E; Prior, JAV; Santos, JLM. 2015. Competitive metal-ligand binding between CdTe quantum dots and EDTA for free Ca2+ determination. TALANTA, 134, 173-182. DOI: 10.1016/j.talanta.2014.11.008
Costa, SPF; Pinto, PCAG; Lapa, RAS; Saraiva, MLMFS. 2015. Toxicity assessment of ionic liquids with Vibrio fischeri: An alternative fully automated methodology. JOURNAL OF HAZARDOUS MATERIALS, 284, 136-142. DOI: 10.1016/j.jhazmat.2014.10.049
Santana, RMM; Oliveira, TD; Rodrigues, SSM; Frigerio, C; Santos, JLM; Korn, M. 2015. Enhancing reactive species generation upon photo-activation of CdTe quantum dots for the chemiluminometric determination of unreacted reagent in UV/S2O82- drug degradation process. TALANTA, 135, 27-33. DOI: 10.1016/j.talanta.2014.12.021
Neves, AR; Reis, S; Segundo, MA. 2015. Development and Validation of a HPLC Method Using a Monolithic Column for Quantification of trans-Resveratrol in Lipid Nanoparticles for Intestinal Permeability Studies. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63, 3114-3120. DOI: 10.1021/acs.jafc.5b00390
Monteiro, C; Fernandes, M; Pinheiro, M; Maia, S; Seabra, CL; Ferreira-da-Silva, F; Costa, F; Reis, S; Gomes, P; Martins, MCL. 2015. Antimicrobial properties of membrane-active dodecapeptides derived from MSI-78. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1848, 1139-1146. DOI: 10.1016/j.bbamem.2015.02.001
Albuquerque, J; Moura, CC; Sarmento, B; Reis, S. 2015. Solid Lipid Nanoparticles: A Potential Multifunctional Approach towards Rheumatoid Arthritis Theranostics. MOLECULES, 20, 11103-11118. DOI: 10.3390/molecules200611103
Lopes, SC; Ferreira, M; Sousa, CF; Gameiro, P. 2015. A fast way to track functional OmpF reconstitution in liposomes: Escherichia coli total lipid extract. ANALYTICAL BIOCHEMISTRY, 479, 54-59. DOI: 10.1016/j.ab.2015.03.026
Pereira-Leite, C; Nunes, C; Schreier, S; Junior, JCB; Cuccovia, IM; Reis, S. 2015. In vitro study of NSAIDs-membrane interactions: the case of indomethacin and derivative. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 44, S196-S196. DOI:
Gameiro, P; Ferreira, M. 2015. Fluoroquinolone derivatives in membrane models: a time-resolved and steady-state fluorescence study. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 44, S69-S69. DOI:
Alves, AC; Nunes, C; Reis, S; Lima, JC. 2015. A biophysical approach to unveil anticancer drug-membrane interactions' effects. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 44, S189-S189. DOI:
Rodrigues, F; Pimentel, FB; Oliveira, MBPP. 2015. Olive by-products: Challenge application in cosmetic industry. INDUSTRIAL CROPS AND PRODUCTS, 70, 116-124. DOI: 10.1016/j.indcrop.2015.03.027
Monteiro, C; Pinheiro, M; Fernandes, M; Maia, S; Seabra, CL; Ferreira-Da-Silva, F; Reis, S; Gomes, P; Martins, MCL. 2015. A 17-mer Membrane-Active MSI-78 Derivative with Improved Selectivity toward Bacterial Cells. MOLECULAR PHARMACEUTICS, 12, 2904-2911. DOI: 10.1021/acs.molpharmaceut.5b00113
Cunha, E; Pinto, PCAG; Lucia, M; Saraiva, MFS. 2015. Evaluation of ionic liquids as alternative solvents for aldolase activity: Use of a new automated SIA methodology. TALANTA, 141, 293-299. DOI: 10.1016/j.talanta.2015.04.028
Ferreira, M; Chaves, LL; Lima, SAC; Reis, S. 2015. Optimization of nanostructured lipid carriers loaded with methotrexate: A tool for inflammatory and cancer therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 492, 65-72. DOI: 10.1016/j.ijpharm.2015.07.013
Ribeiro, S; Vala, H; Garrido, P; Fernandes, J; Costa, E; Belo, L; Reis, F; Silva, AS. 2015. Recombinant human erythropoietin treatment in a rat model of nephrectomy. VIRCHOWS ARCHIV, 467, S32-S32. DOI:
Lima, SAC; Reis, S. 2015. Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: A multi-drug system for theranostic in rheumatoid arthritis. COLLOIDS AND SURFACES B-BIOINTERFACES, 133, 378-387. DOI: 10.1016/j.colsurfb.2015.04.048
Neves, AR; Nunes, C; Reis, S. 2015. New Insights on the Biophysical Interaction of Resveratrol with Biomembrane Models: Relevance for Its Biological Effects. JOURNAL OF PHYSICAL CHEMISTRY B, 119, 11664-11672. DOI: 10.1021/acs.jpcb.5b05419
Gouveia, VM; Lima, SAC; Nunes, C; Reis, S. 2015. Non-Biologic Nanodelivery Therapies for Rheumatoid Arthritis. Journal of Biomedical Nanotechnology, 11, 1701-1721. DOI: 10.1166/jbn.2015.2159
Marques, SS; Magalhaes, LM; Mota, AIP; Soares, TRP; Korsak, B; Reis, S; Segundo, MA. 2015. Myoglobin microplate assay to evaluate prevention of protein peroxidation. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 114, 305-311. DOI: 10.1016/j.jpba.2015.06.006
Rodrigues, F; Sarmento, B; Amaral, MH; Oliveira, MB. 2015. Cytotoxicity evaluation of a new ingredient with cosmetic proposals incorporated into a hand cream. TOXICOLOGY LETTERS, 238, S354-S354. DOI: 10.1016/j.toxlet.2015.08.1010
Chaves, LL; Vieira, ACC; Ferreira, D; Sarmento, B; Reis, S. 2015. Rational and precise development of amorphous polymeric systems with dapsone by response surface methodology. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 81, 662-671. DOI: 10.1016/j.ijbiomac.2015.08.009
Neves, AR; Queiroz, JF; Weksler, B; Romero, IA; Couraud, PO; Reis, S. 2015. Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E. NANOTECHNOLOGY, 26. DOI: 10.1088/0957-4484/26/49/495103
Fonte, P; Araujo, F; Seabra, V; Reis, S; van de Weert, M; Sarmento, B. 2015. Co-encapsulation of lyoprotectants improves the stability of protein-loaded PLGA nanoparticles upon lyophilization. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 496, 850-862. DOI: 10.1016/j.ijpharm.2015.10.032
Alves, AC; Ramos, II; Nunes, C; Magalhaes, LM; Sklenarova, H; Segundo, MA; Lima, JLFC; Reis, S. 2016. On-line automated evaluation of lipid nanoparticles transdermal permeation using Franz diffusion cell and low-pressure chromatography. TALANTA, 146, 369-374. DOI: 10.1016/j.talanta.2015.08.070
Neves, AR; Nunes, C; Reis, S. 2016. Resveratrol induces ordered domains formation in biomembranes: Implication for its pleiotropic action. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1858, 12-18. DOI: 10.1016/j.bbamem.2015.10.005
Marques, SS; Toth, IV; Magalhaes, LM; Reis, S; Segundo, MA. 2016. High-sensitivity programmable flow method for assessment of total antioxidant capacity in biological samples. MICROCHEMICAL JOURNAL, 124, 261-266. DOI: 10.1016/j.microc.2015.09.001
Zelena, L; Marques, SS; Segundo, MA; Miro, M; Pavek, P; Sklenarova, H; Solich, P. 2016. Fully automatic flow-based device for monitoring of drug permeation across a cell monolayer. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 408, 971-981. DOI: 10.1007/s00216-015-9194-0
Soto-Zarazua, MG; Rodrigues, F; Pimentel, FB; Bah, MM; Oliveira, MBPP. 2016. The isoflavone content of two new alfalfa-derived products for instant beverage preparation. Food & Function, 7, 364-371. DOI: 10.1039/c5fo01115a
Neves, AR; Nunes, C; Amenitsch, H; Reis, S. 2016. Effects of resveratrol on the structure and fluidity of lipid bilayers: a membrane biophysical study. Soft Matter, 12, 2118-2126. DOI: 10.1039/c5sm02905h
Peixoto, PS; Toth, IV; Segundo, MA; Lima, JLFC. 2016. Fluoroquinolones and sulfonamides: features of their determination in water. A review. INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY, 96, 185-202. DOI: 10.1080/03067319.2015.1128539
Barbosa, JP; Neves, AR; Silva, AM; Barbosa, MA; Reis, MS; Santos, SG. 2016. Nanostructured lipid carriers loaded with resveratrol modulate human dendritic cells. International Journal of Nanomedicine, 11, 3501-3516. DOI: 10.2147/IJN.S108694
Pinheiro, M; Ribeiro, R; Vieira, A; Andrade, F; Reis, S. 2016. Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis. Drug Design Development and Therapy, 10, 2467-2475. DOI: 10.2147/DDDT.S104395
Rodrigues, F; Gaspar, C; Palmeira-de-Oliveira, A; Sarmento, B; Amaral, MH; Oliveira, MBPP. 2016. Application of Coffee Silverskin in cosmetic formulations: physical/antioxidant stability studies and cytotoxicity effects. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 42, 99-106. DOI: 10.3109/03639045.2015.1035279
Ramdzan, AN; Barreiros, L; Almeida, MIGS; Kolev, SD; Segundo, MA. 2016. Determination of salivary cotinine through solid phase extraction using a bead-injection lab-on-valve approach hyphenated to hydrophilic interaction liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, 1429, 284-291. DOI: 10.1016/j.chroma.2015.12.051
Neves, AR; Queiroz, JF; Lima, SAC; Figueiredo, F; Fernandes, R; Reis, S. 2016. Cellular uptake and transcytosis of lipid-based nanoparticles across the intestinal barrier: Relevance for oral drug delivery. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 463, 258-265. DOI: 10.1016/j.jcis.2015.10.057
Lopes-De-Araujo, J; Neves, AR; Gouveia, VM; Moura, CC; Nunes, C; Reis, S. 2016. Oxaprozin-Loaded Lipid Nanoparticles towards Overcoming NSAIDs Side-Effects. PHARMACEUTICAL RESEARCH, 33, 301-314. DOI: 10.1007/s11095-015-1788-x
Segundo, MA; Abreu, VLRG; Osorio, MV; Nogueira, S; Lin, PKT; Cordeiro-da-Silva, A; Lima, SAC. 2016. Development and validation of HPLC method with fluorometric detection for quantification of bisnaphthalimidopropyldiaminooctane in animal tissues following administration in polymeric nanoparticles. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 120, 290-296. DOI: 10.1016/j.jpba.2015.12.033
Costa, C; Brandao, F; Bessa, MJ; Costa, S; Valdiglesias, V; Kilic, G; Fernandez-Bertolez, N; Quaresma, P; Pereira, E; Pasaro, E; Laffon, B; Teixeira, JP. 2016. In vitro cytotoxicity of superparamagnetic iron oxide nanoparticles on neuronal and glial cells. Evaluation of nanoparticle interference with viability tests. JOURNAL OF APPLIED TOXICOLOGY, 36, 361-372. DOI: 10.1002/jat.3213
Melo, T; Domingues, P; Ferreira, R; Milic, I; Fedorova, M; Santos, SM; Segundo, MA; Domingues, MRM. 2016. Recent Advances on Mass Spectrometry Analysis of Nitrated Phospholipids. ANALYTICAL CHEMISTRY, 88, 2622-2629. DOI: 10.1021/acs.analchem.5b03407
Neves, AR; Martins, S; Segundo, MA; Reis, S. 2016. Nanoscale Delivery of Resveratrol towards Enhancement of Supplements and Nutraceuticals. Nutrients, 8. DOI: 10.3390/nu8030131
Fonte, P; Reis, S; Sarmento, B. 2016. Facts and evidences on the lyophilization of polymeric nanoparticles for drug delivery. JOURNAL OF CONTROLLED RELEASE, 225, 75-86. DOI: 10.1016/j.jconrel.2016.01.034
Ribeiro, R; Pinto, PCAG; Azevedo, AMO; Bica, K; Ressmann, AK; Reis, S; Saraiva, MLMFS. 2016. Automated evaluation of protein binding affinity of anti-inflammatory choline based ionic liquids. TALANTA, 150, 20-26. DOI: 10.1016/j.talanta.2015.12.009
Rodrigues, C; Machado, E; Fernandes, S; Peixe, L; Novais, A. 2016. An update on faecal carriage of ESBL-producing Enterobacteriaceae by Portuguese healthy humans: detection of the H30 subclone of B2-ST131 Escherichia coli producing CTX-M-27. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 71, 1120-1122. DOI: 10.1093/jac/dkv443
Neves, AR; Queiroz, JF; Reis, S. 2016. Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E. JOURNAL OF NANOBIOTECHNOLOGY, 14. DOI: 10.1186/s12951-016-0177-x
Fonte, P; Lino, PR; Seabra, V; Almeida, AJ; Reis, S; Sarmento, B. 2016. Annealing as a tool for the optimization of lyophilization and ensuring of the stability of protein-loaded PLGA nanoparticles. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 503, 163-173. DOI: 10.1016/j.ijpharm.2016.03.011
Barreiros, L; Queiroz, JF; Magalhaes, LM; Silva, AMT; Segundo, MA. 2016. Analysis of 17-beta-estradiol and 17-alpha-ethinylestradiol in biological and environmental matrices - A review. MICROCHEMICAL JOURNAL, 126, 243-262. DOI: 10.1016/j.microc.2015.12.003
Moreira, NFF; Sousa, JM; Macedo, G; Ribeiro, AR; Barreiros, L; Pedrosa, M; Faria, JL; Pereira, MFR; Castro-Silva, S; Segundo, MA; Manaia, CM; Nunes, OC; Silva, AMT. 2016. Photocatalytic ozonation of urban wastewater and surface water using immobilized TiO2 with LEDs: Micropollutants, antibiotic resistance genes and estrogenic activity. WATER RESEARCH, 94, 10-22. DOI: 10.1016/j.watres.2016.02.003
Granja, A; Pinheiro, M; Reis, S. 2016. Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy. Nutrients, 8. DOI: 10.3390/nu8050307
Rodrigues, F; Sarmento, B; Amaral, MH; Oliveira, MBPP. 2016. Exploring the antioxidant potentiality of two food by-products into a topical cream: stability, in vitro and in vivo evaluation. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 42, 880-889. DOI: 10.3109/03639045.2015.1088865
Jimenez-Lopez, J; Molina-Garcia, L; Rodrigues, SSM; Santos, JLM; Ortega-Barrales, P; Ruiz-Medina, A. 2016. Automated determination of Rifamycins making use of MPA-CdTe quantum dots. JOURNAL OF LUMINESCENCE, 175, 158-164. DOI: 10.1016/j.jlumin.2016.02.036
Costa, A; Pinheiro, M; Magalhaes, J; Ribeiro, R; Seabra, V; Reis, S; Sarmento, B. 2016. The formulation of nanomedicines for treating tuberculosis. ADVANCED DRUG DELIVERY REVIEWS, 102, 102-115. DOI: 10.1016/j.addr.2016.04.012
Rodrigues, F; Matias, R; Ferreira, M; Amaral, MH; Oliveira, MBPP. 2016. In vitro and in vivo comparative study of cosmetic ingredients Coffee silverskin and hyaluronic acid. EXPERIMENTAL DERMATOLOGY, 25, 572-574. DOI: 10.1111/exd.13010
Rodrigues, D; Jeronimo, C; Henrique, R; Belo, L; Bastos, MD; de Pinho, PG; Carvalho, M. 2016. Biomarkers in bladder cancer: A metabolomic approach using in vitro and ex vivo model systems. INTERNATIONAL JOURNAL OF CANCER, 139, 256-268. DOI: 10.1002/ijc.30016
das Neves, J; Nunes, R; Rodrigues, F; Sarmento, B. 2016. Nanomedicine in the development of anti-HIV microbicides. ADVANCED DRUG DELIVERY REVIEWS, 103, 57-75. DOI: 10.1016/j.addr.2016.01.017
Gonzalez-Delgado, JA; Castro, PM; Machado, A; Araujo, F; Rodrigues, F; Korsak, B; Ferreira, M; Tome, JPC; Sarmento, B. 2016. Hydrogels containing porphyrin-loaded nanoparticles for topical photodynamic applications. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 510, 221-231. DOI: 10.1016/j.ijpharm.2016.06.037
Alves, AC; Ribeiro, D; Nunes, C; Reis, S. 2016. Biophysics in cancer: The relevance of drug-membrane interaction studies. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1858, 2231-2244. DOI: 10.1016/j.bbamem.2016.06.025
Seabra, CL; Nunes, C; Reis, CA; Gongalves, IC; Reis, S; Martins, MCL. 2016. Anti-Helicobacter pylori activity of lipid nanoparticles loaded with an omega-3 polyunsaturated fatty acid. HELICOBACTER, 21, 142-143. DOI:
Morais, C; Cunha, P; Cardoso, A; Aguiar, L; Vale, N; Lage, E; Pinheiro, M; Nunes, C; Reis, S; Gomes, P; Lima, M; Jurado, A. 2016. MEMBRANE PERTURBATIONS INDUCED BY ACYLATED S4(13) -PV ANALOGS: RELEVANCE TO NUCLEIC ACID DELIVERY. JOURNAL OF PEPTIDE SCIENCE, 22, S104-S106. DOI:
Catelani, TA; Castoldi, K; Toth, IV; Santos, JLM; Lima, JLFD; Pezza, L; Pezza, HR. 2016. An eco-friendly method for analysis of sulfonamides in water samples using a multi-pumping system. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 94, 812-817. DOI: 10.1139/cjc-2016-0092
Soto-Zarazua, MG; Bah, M; Garcia-Alcocer, MG; Berumen, LC; Costa, CS; Bessa, MJ; Rodrigues, F; Teixeira, JP; Oliveira, MBPP. 2016. Assessment of Beneficial and Possible Toxic Effects of Two New Alfalfa-Derived Shelf Products. JOURNAL OF MEDICINAL FOOD, 19, 970-977. DOI: 10.1089/jmf.2016.0024
Silva, EMP; Melo, T; Sousa, BC; Resende, DISP; Magalhaes, LM; Segundo, MA; Silva, AMS; Domingues, MRM. 2016. Do cinnamylideneacetophenones have antioxidant properties and a protective effect toward the oxidation of phosphatidylcholines?. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 121, 331-337. DOI: 10.1016/j.ejmech.2016.05.040
Ferreira, M; Silva, E; Barreiros, L; Segundo, MA; Lima, SAC; Reis, S. 2016. Methotrexate loaded lipid nanoparticles for topical management of skin-related diseases: Design, characterization and skin permeation potential. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 512, 14-21. DOI: 10.1016/j.ijpharm.2016.08.008
Fonte, P; Andrade, F; Azevedo, C; Pinto, J; Seabra, V; van de Weert, M; Reis, S; Sarmento, B. 2016. Effect of the Freezing Step in the Stability and Bioactivity of Protein-Loaded PLGA Nanoparticles Upon Lyophilization. PHARMACEUTICAL RESEARCH, 33, 2777-2793. DOI: 10.1007/s11095-016-2004-3
Neves, AR; Nunes, C; Amenitsch, H; Reis, S. 2016. Resveratrol Interaction with Lipid Bilayers: A Synchrotron X-ray Scattering Study. LANGMUIR, 32, 12914-12922. DOI: 10.1021/acs.langmuir.6b03591
Cunha-Reis, C; Machado, A; Barreiros, L; Araujo, F; Nunes, R; Seabra, V; Ferreira, D; Segundo, MA; Sarmento, B; das Neves, J. 2016. Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs. JOURNAL OF CONTROLLED RELEASE, 243, 43-53. DOI: 10.1016/j.jconrel.2016.09.020
Lopes, D; Jakobtorweihen, S; Nunes, C; Sarmento, B; Reis, S. 2017. Shedding light on the puzzle of drug-membrane interactions: Experimental techniques and molecular dynamics simulations. PROGRESS IN LIPID RESEARCH, 65, 24-44. DOI: 10.1016/j.plipres.2016.12.001
Granja, A; Frias, I; Neves, AR; Pinheiro, M; Reis, S. 2017. Therapeutic Potential of Epigallocatechin Gallate Nanodelivery Systems. Biomed Research International. DOI: 10.1155/2017/5813793
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Gaspar, AS; Wagner, FE; Amaral, VS; Lima, SAC; Khomchenko, VA; Santos, JG; Costa, BFO; Duraes, L. 2017. Development of a biocompatible magnetic nanofluid by incorporating SPIONs in Amazonian oils. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 172, 135-146. DOI: 10.1016/j.saa.2016.04.022
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de Souza, GCS; Ribeiro, DSM; Rodrigues, SSM; Paim, APS; Lavorante, AF; da Silva, VL; Santos, JLM; Araujo, AN; Montenegro, MCBSM. 2016. Clean photoinduced generation of free reactive oxygen species by silica films embedded with CdTe-MTA quantum dots. RSC Advances, 6, 8563-8571. DOI: 10.1039/c5ra23133g
Pinho, BR; Reis, SD; Guedes-Dias, P; Leitao-Rocha, A; Quintas, C; Valentao, P; Andrade, PB; Santos, MM; Oliveira, JMA. 2016. Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease. PHARMACOLOGICAL RESEARCH, 103, 328-339. DOI: 10.1016/j.phrs.2015.11.024
Boonme, P; Kaewbanjong, J; Amnuaikit, T; Andreani, T; Silva, AM; Souto, EB. 2016. Microemulsion and Microemulsion-Based Gels for Topical Antifungal Therapy with Phytochemicals. CURRENT PHARMACEUTICAL DESIGN, 22, 4257-4263. DOI: 10.2174/1381612822666160603015436
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Dias, R; Perez-Gregorio, MR; Mateus, N; De Freitas, V. 2016. Interaction study between wheat-derived peptides and procyanidin B3 by mass spectrometry. FOOD CHEMISTRY, 194, 1304-1312. DOI: 10.1016/j.foodchem.2015.08.108
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Sanchez-Lopez, E; Egea, MA; Cano, A; Espina, M; Calpena, AC; Ettcheto, M; Camins, A; Souto, EB; Silva, AM; Garcia, ML. 2016. PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen-in vitro, ex vivo and in vivo characterization. COLLOIDS AND SURFACES B-BIOINTERFACES, 145, 241-250. DOI: 10.1016/j.colsurfb.2016.04.054
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Mahfoudhi, A; Grosso, C; Goncalves, RF; Khelifi, E; Hammami, S; Achour, S; Trabelsi-Ayadi, M; Valentao, P; Andrade, PB; Mighri, Z. 2016. Evaluation of Antioxidant, Anticholinesterase, and Antidiabetic Potential of Dry Leaves and Stems in Tamarix aphylla Growing Wild in Tunisia. CHEMISTRY & BIODIVERSITY, 13, 1747-1755. DOI: 10.1002/cbdv.201600157
Rodrigues, SSM; Ribeiro, DSM; Soares, JX; Passos, MLC; Saraiva, MLMFS; Santos, JLM. 2017. Application of nanocrystalline CdTe quantum dots in chemical analysis: Implementation of chemo-sensing schemes based on analyte-triggered photoluminescence modulation. COORDINATION CHEMISTRY REVIEWS, 330, 127-143. DOI: 10.1016/j.ccr.2016.10.001
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Sanchez-Lopez, E; Espina, M; Doktorovova, S; Souto, EB; Garcia, ML. 2017. Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye - Part II - Ocular drug-loaded lipid nanoparticles. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 110, 58-69. DOI: 10.1016/j.ejpb.2016.10.013
Osorio, MV; Reis, S; Lima, JLFC; Segundo, MA. 2017. Analytical Features of Diclofenac Evaluation in Water as a Potential Marker of Anthropogenic Pollution. Current Pharmaceutical Analysis, 13, 39-47. DOI: 10.2174/1573412912666160422123841
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Hadidi, L; Babou, L; Zaidi, F; Valentao, P; Andrade, PB; Grosso, C. 2017. Quercus ilex L.: How season, Plant Organ and Extraction Procedure Can Influence Chemistry and Bioactivities. CHEMISTRY & BIODIVERSITY, 14. DOI: 10.1002/cbdv.201600187
de Oliveira, GGG; Feitosa, A; Loureiro, K; Fernandes, AR; Souto, EB; Severino, P. 2017. Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures. SAUDI PHARMACEUTICAL JOURNAL, 25, 99-103. DOI: 10.1016/j.jsps.2016.05.001
Pinto, D; Rodrigues, F; Braga, N; Santos, J; Pimentel, FB; Palmeira-de-Oliveira, A; Oliveira, MBPP. 2017. The Castanea sativa bur as a new potential ingredient for nutraceutical and cosmetic outcomes: preliminary studies. Food & Function, 8, 201-208. DOI: 10.1039/c6fo01469k
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Quelemes, PV; de Araujo, AR; Placido, A; Delerue-Matos, C; Maciel, JS; Bessa, LJ; Ombredane, AS; Joanitti, GA; Soares, MJD; Eaton, P; da Silva, DA; Leite, JRSA. 2017. Quaternized cashew gum: An anti-staphylococcal and biocompatible cationic polymer for biotechnological applications. CARBOHYDRATE POLYMERS, 157, 567-575. DOI: 10.1016/j.carbpol.2016.10.026
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