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The Natural Products –  Chemistry and Bioactivity group conveys expertise in the discovery and elucidation of new chemical entities, either naturally-occurring or obtained by hemi-synthesis, as well as their biological evaluation. Among natural sources, we are particularly interested in plant and animal samples, both from terrestrial and marine origin. Research activities are focused in drug discovery, namely for the treatment of cancer and diabetes, as well as inflammatory and neurodegenerative diseases. The group works to identify pharmacological modulators of human disease-related proteins, for which a targeted screening approach is employed that combines yeast, human cell lines and animal models. We look for new targeted therapies with potentialapplication in personalized therapy.

Research Interests

  • Metabolite Profiling of Natural Matrices

  • Anticancer Drug Discovery

  • Anti-Inflamatory Drug Discovery

  • Antidiabetic Drug Discovery

  • Proteostasis

  • Neurodegenerative Diseases

Highlights

  • Eco-friendly methods to extract bioactive compounds from agroindustrial waste
    Optimization of the recovery of high-value compounds from pitaya fruit by-products
    Optimization of the recovery of high-value compounds from pitaya fruit by-products using microwave-assisted extraction Food Chemistry, 2017, 230, 463-474.

    Sterols and alkaloids found in sea stars and anemones were shown to modulate key enzymes and inflammatory signaling cascades at noncytotoxic concentrations, being potential new antiinflammatory agents to develop multi-target approaches for several human diseases connected with chronic inflammation. In the case of tomato glycoalkaloids, we have shown they are neurotoxic in human cells. Also, the anticancer activity of a lipophilic sea star extract was demonstrated, with identification of the main compounds responsible for the cell cycle arrest and apoptosis with involvement of the endoplasmic reticulum.

     

     

     

     

     

     

     

     

  • Anticancer and anti-inflammatory molecules from tomato plant and spiny sea star
    Palmitic acid and ergosta-7,22-dien-3-ol contribute to the ERstress
    Palmitic acid and ergosta-7,22-dien-3-ol contribute to the ERstress- mediated apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells.

     Sterols and alkaloids found in sea stars and

    anemones were shown to modulate key enzymes

    and inflammatory signaling cascades at noncytotoxic

    concentrations, being potential new antiinflammatory

    agents to develop multi-target

    approaches for several human diseases connected

    with chronic inflammation. In the case of tomato

    glycoalkaloids, we have shown they are neurotoxic

    in human cells. Also, the anticancer activity of a

    lipophilic sea star extract was demonstrated, with

    identification of the main compounds responsible

    for the cell cycle arrest and apoptosis with

    involvement of the endoplasmic reticulum.

     

     

     

     

     

  • Iron oxide nanoparticles trigger inflammation in vivo

     The in vitro  study of coated and non-coated iron oxide nanoparticles (IONs) provided evidence of

    cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways.

    IONs did not cause severe organ damage in CD-1 mice following acute administration. However, they

    accumulate mainly in liver and spleen, being able to trigger an inflammatory process in vivo .

    Quantitative histochemistry for macrophage biodistribution on mice
    Quantitative histochemistry for macrophage biodistribution
    on mice liver and spleen after the administration of a
    pharmacological relevant dose of polyacrylic acid-coated iron
    oxide nanoparticles.
    Nanotoxicology, 2017,11, 256-266.

     

     

     

  • Zebrafish – an adequate model for studying histone deacetylases
    Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish
    Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease. Pharmacological Research, 2016, 103, 328-39.

     Zebrafish as animal model for Parkinson Disease

    (PD) was established considering the main

    behavioral and metabolic features that characterize

    the PD phenotypes. The functional homology of its

    histone deacetylases HDAC1 and HDAC6 isoforms

    was revealed. This study highlighted parameters

    dependent on the integrity of zebrafish neuronal

    circuits as a valuable complement to cell-based

    studies. Also, the demonstration of the feasibility of

    targeting HDAC1 and 6 in zebrafish paves the way

    for future studies investigating KDAC modulators in

    other disease contexts in this high-throughput

    model organism.

     

     

     

  • Yeast models as screening tools for human diseases

     Innovative yeast targeted screening approaches were developed and used to identify the tryptophanolderived

    oxazoloisoindolinones SLMP53-1, as a novel reactivator of wild-type (wt) and mutant p53, as well

    as DIMP53-1 as a novel dual inhibitor of the p53-MDM2/MDMX interactions. Using human tumor cell

    lines and xenograft mouse models, it was shown that both SLMP53-1 and DIMP53-1 have multifunctional

    activity targeting the major hallmarks of cancer through its antiproliferative, proapoptotic, antiangiogenic,

    anti-invasive and antimigratory properties. Additionally, they did not reveal toxic side effects in animal

    models. These preclinical results indicate that SLMP53-1 and DIMP53-1 are promising drug candidates in

    anticancer therapy.

    A yeast model of the Parkinson's disease-associated protein Parkin.
    A yeast model of the Parkinson's disease-associated protein Parkin.
    Experimental Cell Research, 2015, 333, 73-79.

     

Representative Publications

Andrade, PB; Valentao, P. 2018. Insights into Natural Products in Inflammation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19. DOI: 10.3390/ijms19030644
Gomes, AS; Ramos, H; Soares, J; Saraiva, L. 2018. p53 and glucose metabolism: an orchestra to be directed in cancer therapy. PHARMACOLOGICAL RESEARCH, 131, 75-86. DOI: 10.1016/j.phrs.2018.03.015
Soares, T; Freitas, M; Carvalho, F; Fernandes, E. 2018. Silver nanoparticles stimulate neutrophils oxidative burst through the activation of protein kinase C. FREE RADICAL BIOLOGY AND MEDICINE, 120, S110-S111. DOI: 10.1016/j.freeradbiomed.2018.04.364
Bogalho, F; Duarte, S; Cardoso, M; Almeida, A; Cabecas, R; Lino, C; Pena, A. 2018. Exposure assessment of Portuguese infants to Aflatoxin M1 in breast milk and maternal social-demographical and food consumption determinants. FOOD CONTROL, 90, 140-145. DOI: 10.1016/j.foodcont.2018.02.043
Puig, CG; Goncalves, RF; Valentao, P; Andrade, PB; Reigosa, MJ; Pedrol, N. 2018. The Consistency Between Phytotoxic Effects and the Dynamics of Allelochemicals Release from Eucalyptus globulus Leaves Used as Bioherbicide Green Manure. JOURNAL OF CHEMICAL ECOLOGY, 44, 658-670. DOI: 10.1007/s10886-018-0983-8
Brandao, P; Loureiro, JB; Carvalho, S; Hamadou, MH; Cravo, S; Moreira, J; Pereira, D; Palmeira, A; Pinto, M; Saraiva, L; Cidade, H. 2018. Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 156, 711-721. DOI: 10.1016/j.ejmech.2018.07.037
Fernandes, ER; Carvalho, FD; Remiao, FG; Bastos, LM; Pinto, MM; Gottlieb, OR. 1995. Hepatoprotective activity of xanthones and xanthonolignoids against tert-Butylhydroperoxide-Induced toxicity in isolated rat hepatocytes - Comparison with silybin. PHARMACEUTICAL RESEARCH, 12(11), 1756-1760. DOI: 10.1023/A:1016230125496
Fernandes, EGR; Silva, AMS; Cavaleiro, JAS; Silva, FM; Borges, MFM; Pinto, MMM. 1998. <sup>1</sup>H and<sup>13</sup>C NMR spectroscopy of mono-, di-, tri- and tetrasubstituted xanthones. MAGNETIC RESONANCE IN CHEMISTRY, 36(4), 305-309. DOI: 10.1002/(SICI)1097-458X(199804)36:4<305::AID-OMR193>3.0.CO;2-N
Pinto, DCGA; Silva, AMS; Lévai, A; Cavaleiro, JAS; Patonay, T; Elguero, J. 2000. Synthesis of 3-benzoyl-4-styryl-2-pyrazolines and their oxidation to the corresponding pyrazoles. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2593-2599. DOI:
Pinto, DCGA; Silva, AMS; Cavaleiro, JAS. 2000. Synthesis of 3-(2-benzyloxy-6-hydroxyphenyl)-1-methylpyrazoles by the reaction of chromones with methylhydrazine. JOURNAL OF HETEROCYCLIC CHEMISTRY, 37(6), 1629-1634. DOI:
Pinto, DCGA; Silva, AMS; Cavaleiro, JAS. 2000. A convenient synthesis of new (E)-5-hydroxy-2-styrylchromones by modifications of the Baker-Venkataraman method. NEW JOURNAL OF CHEMISTRY, 24(2), 85-92. DOI: 10.1039/a908539d
Lávai, A; Patonay, T; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS. 2002. Synthesis of 3-aryl-5-styryl-2-pyrazolines by the reaction of (E,E)-cinnamylideneacetophenones with hydrazines and their oxidation into pyrazoles. JOURNAL OF HETEROCYCLIC CHEMISTRY, 39(4), 751-758. DOI:
Silva, AMS; Pinto, DCGA; Cavaleiro, JAS; Martínez, A; Castro, A; Elguero, J. 2002. An experimental NMR and semi-empirical theoretical study of the conformation of styrylchromones and styryl alkyl or aryl ketones (benzylidene ketones). Journal of Chemical Research - Part S, 162-164. DOI:
Pinto, DCGA; Silva, AMS; Almeida, LMPM; Cavaleiro, JAS; Elguero, J. 2002. 3-Aroyl-5-hydroxyflavones: Synthesis and transformation into aroylpyrazoles. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 3807-3815. DOI:
Sandulache, A; Silva, AMS; Pinto, DCGA; Almeida, LMPM; Cavaleiro, JAS. 2003. Wittig reactions of chromone-3-carboxaldehydes with benzylidenetriphenyl phosphoranes: A new synthesis of 3-styrylchromones. NEW JOURNAL OF CHEMISTRY, 27(11), 1592-1598. DOI: 10.1039/b303554a
Pinto, DCGA; Silva, AMS; Cavaleiro, JAS; Elguero, J. 2003. New bis(chalcones) and their transformation into bis(pyrazoline) and bis(pyrazole) derivatives. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 747-755. DOI:
Pinto, DCGA; Silva, AMS; Almeida, LMPM; Carrillo, JR; Díaz-Ortiz, A; De La Hoz, A; Cavaleiro, JAS. 2003. First diels - Alder reactions of 3-styrylchromones under microwave irradiation. SYNLETT, 1415-1418. DOI:
Lévai, A; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS; Alkorta, I; Elguero, J; Jekö, J. 2004. Synthesis of pyrazolyl-2-pyrazolines by treatment of 3-(3-aryl-3- oxopropenyl)chromen-4-ones with hydrazine and their oxidation to bis(pyrazoles). EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 4672-4679. DOI: 10.1002/ejoc.200400465
Silva, AMS; Pinto, DCGA; Cavaleiro, JAS; Levai, A; Patonay, T. 2004. Synthesis and reactivity of styrylchromones. ARKIVOC, 2004(7), 106-123. DOI:
Silva, AMS; Pinto, DCGA. 2005. Structure elucidation of xanthone derivatives: Studies of nuclear magnetic resonance spectroscopy. CURRENT MEDICINAL CHEMISTRY, 12(21), 2481-2497. DOI: 10.2174/092986705774370718
Pinto, DCGA; Silva, AMS; Brito, CM; Sandulache, A; Carrillo, JR; Prieto, P; Díaz-Ortiz, A; De La Hoz, A; Cavaleiro, JAS. 2005. Reactivity of 3-styrylchromones as dienes in Diels-Alder reactions under microwave irradiation: A new synthesis of xanthones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2973-2986. DOI: 10.1002/ejoc.200500073
Patoilo, DT; Silva, AMS; Pinto, DCGA; Tomé, AC; Cavaleiro, JAS. 2007. Synthesis of 5-hydroxy-2-(naphth-2-yl)chromone derivatives. JOURNAL OF HETEROCYCLIC CHEMISTRY, 44(6), 1345-1350. DOI:
Pinto, DCGA; Silva, AMS; Cavaleiro, JAS. 2007. Baker-venkataraman rearrangement under microwave irradiation: A new strategy for the synthesis of 3-aroyl-5-hydroxyflavones. SYNLETT, 1897-1900. DOI: 10.1055/s-2007-984525
Seixas, RSGR; Pinto, DCGA; Silva, AMS; Cavaleiro, JAS. 2008. Synthesis of novel 3-alkyl-3′,4′,5,7-tetrahydroxyflavones. AUSTRALIAN JOURNAL OF CHEMISTRY, 61(9), 718-724. DOI: 10.1071/CH08162
Silva, AMS; Filipe, P; Seixas, RSGR; Pinto, DCGA; Patterson, LK; Hug, GL; Cavaleiro, JAS; Mazière, J-C; Santus, R; Morlière, P. 2008. One-electron reduction of superoxide radical-anions by 3- alkylpolyhydroxyflavones in micelles. Effect of antioxidant alkyl chain length on micellar structure and reactivity. JOURNAL OF PHYSICAL CHEMISTRY B, 112(37), 11456-11461. DOI: 10.1021/jp805889g
Patonay, T; Kiss-Szikszai, A; Silva, VML; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS; Jeko, J. 2008. Microwave-induced synthesis and regio- and stereoselective epoxidation of 3-styrylchromones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 1937-1946. DOI: 10.1002/ejoc.200701081
De Paula, R; Faustino, MAF; Pinto, DCGA; Neves, MGPMS; Cavaleiro, JAS. 2008. Kinetic study of meso-tetraphenylporphyrin synthesis under microwave irradiation. JOURNAL OF HETEROCYCLIC CHEMISTRY, 45(2), 453-459. DOI:
Seixas, RSGR; Silva, AMS; Pinto, DCGA; Cavaleiro, JAS. 2008. A new synthesis of benzo[b]acridones. SYNLETT, 3193-3197. DOI: 10.1055/s-0028-1087372
Marinho, J; Pedro, M; Pinto, DCGA; Silva, AMS; Cavaleiro, JAS; Sunkel, CE; Nascimento, MSJ. 2008. 4′-Methoxy-2-styrylchromone a novel microtubule-stabilizing antimitotic agent. BIOCHEMICAL PHARMACOLOGY, 75(4), 826-835. DOI: 10.1016/j.bcp.2007.10.014
Filipe, P; Silva, AMS; Seixas, RSGR; Pinto, DCGA; Santos, A; Patterson, LK; Silva, JN; Cavaleiro, JAS; Freitas, JP; Mazière, J-C; Santus, R; Morlière, P. 2009. The alkyl chain length of 3-alkyl-3′,4′,5,7-tetrahydroxyflavones modulates effective inhibition of oxidative damage in biological systems: Illustration with LDL, red blood cells and human skin keratinocytes. BIOCHEMICAL PHARMACOLOGY, 77(6), 957-964. DOI: 10.1016/j.bcp.2008.11.023
Castanheiro, RAP; Pinto, MMM; Cravo, SMM; Pinto, DCGA; Silva, AMS; Kijjoa, A. 2009. Improved methodologies for synthesis of prenylated xanthones by microwave irradiation and combination of heterogeneous catalysis (K10 clay) with microwave irradiation. TETRAHEDRON, 65(19), 3848-3857. DOI: 10.1016/j.tet.2009.03.019
Rocha-Pereira, J; Cunha, R; Pinto, DCGA; Silva, AMS; Nascimento, MSJ. 2010. (E)-2-Styrylchromones as potential anti-norovirus agents. Bioorganic and Medicinal Chemistry, 18(12), 4195-4201. DOI: 10.1016/j.bmc.2010.05.006
Talhi, O; Fernandes, JA; Pinto, DCGA; Silva, AMS; Almeida Paz, FA. 2011. 1,3-Dicyclohexylimidazolidine-2,4,5-trione. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 67(12). DOI: 10.1107/S1600536811046253
Pinto, DCGA; Silva, AMS; Cavaleiro, JAS; Foces-Foces, C; Llamas-Saiz, AL; Jagerovic, N; Elguero, J. 1999. Synthesis and molecular structure of 3-(2-Benzyloxy-6-hydroxyphenyl)-5- styrylpyrazoles. Reaction of 2-styrylchromones and hydrazine hydrate. TETRAHEDRON, 55(33), 10187-10200. DOI: 10.1016/S0040-4020(99)00546-3
Silva, AMS; Pinto, DCGA; Tavares, HR; Cavaleiro, JAS; Jimeno, ML; Elguero, J. 1998. Novel (E)- and (Z)-2-styrylchromones from (E,E)-2′-hydroxycinnamylideneacetophenones - Xanthones from daylight photooxidative cyclization of (E)-2-styrylchromones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2031-2038. DOI:
Pinto, DCGA; Silva, AMS; Almeida, LMPM; Cavaleiro, JAS; Lévai, A; Patonay, T. 1998. Synthesis of 4-Aryl-3-(2-chromonyl)-2-pyrazolines by the 1,3-Dipolar Cycloaddition of 2-Styrylchromones with Diazomethane. JOURNAL OF HETEROCYCLIC CHEMISTRY, 35(1), 217-224. DOI:
Pinto, DCGA; Silva, AMS; Cavaleiro, JAS. 1997. Novel (E)-3-(2′-benzyloxy-6′-hydroxyphenyl)-5-styrylpyrazoles from (E)-2-styrylchromones. HETEROCYCLIC COMMUNICATIONS, 3(5), 433-436. DOI:
Pinto, DCGA; Silva, AMS; Cavaleiro, JAS. 1996. A convenient synthesis of 3-cinnamoyl-5-hydroxy-2-styrylchromones by a modified Baker-Venkataraman transformation. HETEROCYCLIC COMMUNICATIONS, 2(2), 145-148. DOI:
Pinto, DCGA; Silva, AMS; Cavaleiro, JAS. 1996. Syntheses of 5-Hydroxy-2-(phenyl or styryl)chromones and of Some Halo Derivatives. JOURNAL OF HETEROCYCLIC CHEMISTRY, 33(6), 1887-1893. DOI:
Silva, AMS; Pinto, DCGA; Cavaleiro, JAS. 1994. 5-Hydroxy-2-(phenyl or styryl) chromones: One-pot synthesis and C-6, C-8 13C NMR assignments. TETRAHEDRON LETTERS, 35(32), 5899-5902. DOI:
Pinto, DCGA; Silva, AMS; Cavaleiro, JAS. 1994. Synthesis of 6,8-(dibromo or diiodo)-5-hydroxy-2-(phenyl or styryl)chromones. TETRAHEDRON LETTERS, 35(50), 9459-9460. DOI: 10.1016/S0040-4039(00)78570-4
Talhi, O; Pinto, DCGA; Silva, AMS. 2013. Synthesis of 5-(2-hydroxybenzoyl)-1,3-disubstituted uracils. SYNLETT, 24(9), 1147-1149. DOI: 10.1055/s-0033-1338932
Lopes, SP; Menezes, JCJMDS; Hackbarth, S; Pinto, DCGA; Faustino, MAF; Silva, AMS; Neves, MGPMS; Röder, B; Cavaleiro, JAS. 2013. New flavonoid-porphyrin conjugates via Buchwald-Hartwig amination: Synthesis and photophysical studies. TETRAHEDRON LETTERS, 54(38), 5253-5256. DOI: 10.1016/j.tetlet.2013.07.089
Talhi, O; Makhloufi-Chebli, M; Pinto, DCGA; Hamdi, M; Silva, AMS. 2013. Hydroxylated Polyfunctionalized Benzo[c]coumarins by an Organocatalyzed Tandem 1,4-Conjugate Addition, Decarboxylation and Aromatization Reaction. SYNLETT, 24. DOI: 10.1055/s-0033-1339895
Talhi, O; Fernandes, JA; Pinto, DCGA; Almeida Paz, FA; Silva, ASM. 2013. Diastereoselective synthesis of benzofuran-3(2H)-one-hydantoin dyads. TETRAHEDRON, 69(26), 5413-5420. DOI: 10.1016/j.tet.2013.04.111
Anis Bertella; Kheira Benlahcen; Sidaoui Abouamama; Diana CGAPinto; Karim Maamar; Mebrouk Kihal; Artur MSSilva. 2018. Artemisia herba-alba Asso. essential oil antibacterial activity and acute toxicity. INDUSTRIAL CROPS AND PRODUCTS, 116, 137-. DOI: 10.1016/j.indcrop.2018.02.064
Carlos FMSilva; Vasco FBatista; Diana CGAPinto; Artur MSSilva. 2018. Challenges with chromone as a privileged scaffold in drug discovery. Expert Opinion on Drug Discovery, 1-. DOI: 10.1080/17460441.2018.1494720
Daniela Ferreira; Diana CGAPinto; Helena Silva; Ana Paula Girol; Maria de Lourdes Pereira. 2018. Salicornia ramosissima J. Woods seeds affected the normal regenerative function on carbon tetrachloride-induced liver and kidney injury. BIOMEDICINE & PHARMACOTHERAPY. DOI: 10.1016/j.biopha.2018.07.153
Pereira, D.M. 2014. Naturally-derived molecules as a strategy for countering E. faecalis infection. Advances in Food Analysis Research (Ed: A. Haynes), Nova Science Publishers, Inc., pp. 151-166. DOI:
Pereira, D.M; Correia-da-Silva, G; Valentão, P; Teixeira, N; Andrade, P. 2013. The anti-inflammatory effect of unsaturated fatty acids and ergosta-7,22-dien-3-ol from the echinoderm Marthasterias glacialis involves prevention of CHOP pathway-mediated ER-stress and NF-κB activation.. PLoS One. DOI:
Barbosa, M.; Fernandes, F; Pereira, D.M; Valentão, P; Andrade, P.B. 2016. UHPLC-QqQ-MS/MS method for phytoprostane profiling in macroalgae.. PHARMACEUTICALS. DOI:
Oliveira, A.P; Sá, I; Grosso, C; Pereira, D.M.,Valentão, P; Andrade, P.B. 2016. Natural products: tools for inflammation management. PHARMACEUTICALS. DOI:
Pereira, D.M; Ribeiro, V.; Valentão, P; Andrade, P.B. 2016. ER stress and protein quality control pathways: Exploring the natural products chemical space.. PHARMACEUTICALS. DOI:
David Pereira. 2014. Global, regional and national incidence and death for HIV, tuberculosis and malaria 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. DOI: 10.1016/S0140-6736(14)60844-8
Lim, SS; Allen, K; Bhutta, ZA; Dandona, L; Forouzanfar, MH; Fullman, N; Gething, PW; Goldberg, EM; Hay, SI; Holmberg, M; Kinfu, Y; Kutz, MJ; Larson, HJ; Liang, X; Lopez, AD; Lozano, R; McNellan, CR; Mokdad, AH; Mooney, MD; Naghavi, M; Olsen, HE; Pigo. 2016. Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015. The Lancet, 388(10053), 1813-1850. DOI: 10.1016/S0140-6736(16)31467-2
Kassebaum, NJ; Barber, RM; Bhutta, ZA; Dandona, L; Gething, PW; Hay, SI; Kinfu, Y; Larson, HJ; Liang, X; Lim, SS; Lopez, AD; Lozano, R; Mensah, GA; Mokdad, AH; Naghavi, M; Pinho, C; Salomon, JA; Steiner, C; Vos, T; Wang, H; Abajobir, AA; Abate, KH; A. 2016. Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. LANCET. DOI: 10.1016/s0140-6736(16)31470-2
Wang, HD; Wolock, TM; Carter, A; Nguyen, G; Kyu, HH; Gakidou, E; Hay, SI; Mills, EJ; Trickey, A; Msemburi, W; Coates, MM; Mooney, MD; Fraser, MS; Sligar, A; Salomon, J; Larson, HJ; Friedman, J; Abajobir, AA; Abate, KH; Abbas, KM; Abd El Razek, MM; Ab. 2016. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the Global Burden of Disease Study 2015. Lancet HIV. DOI: 10.1016/s2352-3018(16)30087-x
El Bcheraoui, C; Wang, H; Charara, R; Khalil, I; Moradi-Lakeh, M; Afshin, A; Collison, M; Daoud, F; Chew, A; Krohn, KJ; Carter, A; Foreman, KJ; He, F; Kassebaum, NJ; Kutz, M; Mirarefin, M; Nguyen, G; Silpakit, N; Sligar, A; Abajobir, AA; Abate, KH; A. 2017. Trends in HIV/AIDS morbidity and mortality in Eastern Mediterranean countries, 1990–2015: findings from the Global Burden of Disease 2015 study. International Journal of Public Health, 1-14. DOI: 10.1007/s00038-017-1023-0
Pascoal Neto, C; Cordeiro, N; Seca, A; Domingues, F; Gandini, A; Robert, D. 1996. Isolation and characterization of a lignin-like polymer of the cork of Quercus suber L.. HOLZFORSCHUNG, 50(6), 563-568. DOI:
Pascoal Neto, C; Seca, A; Fradinho, D; Coimbra, MA; Domingues, F; Evtuguin, D; Silvestre, A; Cavaleiro, JAS. 1996. Chemical composition and structural features of the macromolecular components of Hibiscus cannabinus grown in Portugal. INDUSTRIAL CROPS AND PRODUCTS, 5(3), 189-196. DOI: 10.1016/0926-6690(96)89448-9
Neto, CP; Seca, A; Nunes, AM; Coimbra, MA; Domingues, F; Evtuguin, D; Silvestre, A; Cavaleiro, JAS. 1997. Variations in chemical composition and structure of macromolecular components in different morphological regions and maturity stages of Arundo donax. INDUSTRIAL CROPS AND PRODUCTS, 6(1), 51-58. DOI: 10.1016/S0926-6690(96)00205-1
Seca, AML; Cavaleiro, JAS; Domingues, FMJ; Silvestre, AJD; Evtuguin, D; Neto, CP. 1998. Structural Characterization of the Bark and Core Lignins from Kenaf (Hibiscus cannabinus). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 46(8), 3100-3108. DOI:
Seca, AML; Cavaleiro, JAS; Domingues, FMJ; Silvestre, AJD; Evtuguin, D; Neto, CP. 2000. Structural characterization of the lignin from the nodes and internodes of Arundo donax reed. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 48(3), 817-824. DOI: 10.1021/jf9910988
Seca, AML; Silva, AMS; Silvestre, AJD; Cavaleiro, JAS; Domingues, FMJ; Neto, CP. 2000. Chemical composition of the light petroleum extract of Hibiscus cannabinus bark and core. PHYTOCHEMICAL ANALYSIS, 11(6), 345-350. DOI: 10.1002/1099-1565(200011/12)11:6&lt;345::AID-PCA540&gt;3.0.CO;2-T
Seca, AML; Silva, AMS; Silvestre, AJD; Cavaleiro, JoséAS; Domingues, FMJ; Pascoal-Neto, C. 2001. Lignanamides and other phenolic constituents from the bark of kenaf (Hibiscus cannabinus). PHYTOCHEMISTRY, 58(8), 1219-1223. DOI: 10.1016/S0031-9422(01)00311-9
Da Seca, AML; Domingues, FMDJ. 2006. Basic density and pulp yield relationship with some chemical parameters in eucalyptus trees. PESQUISA AGROPECUARIA BRASILEIRA, 41(12), 1687-1691. DOI: 10.1590/S0100-204X2006001200001
Moujir, L; Seca, AML; Silva, AMS; López, MR; Padilla, N; Cavaleiro, JAS; Neto, CP. 2007. Cytotoxic activity of lignans from Hibiscus cannabinus. FITOTERAPIA, 78(5), 385-387. DOI: 10.1016/j.fitote.2007.03.010
Seca, AML; Silva, AMS. 2008. The chemical composition of hexane extract from bark of Juniperus brevifolia. NATURAL PRODUCT RESEARCH, 22(11), 975-983. DOI: 10.1080/14786410701654602
Seca, AML; Pinto, DCGA; Silva, AMS. 2008. Structural elucidation of pimarane and isopimarane diterpenoids: The <sup>13</sup>C NMR contribution. Natural Product Communications, 3(3), 399-412. DOI:
Seca, AML; Silva, AMS; Bazzocchi, IL; Jimenez, IA. 2008. Diterpene constituents of leaves from Juniperus brevifolia. PHYTOCHEMISTRY, 69(2), 498-505. DOI: 10.1016/j.phytochem.2007.07.026
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Sousa, C; Pereira, DM; Pereira, JA; Bento, A; Rodrigues, MA; Dopico-Garcia, S; Valentao, P; Lopes, G; Ferreres, F; Seabra, RM; Andrade, PB. 2008. Multivariate analysis of tronchuda cabbage (Brassica oleracea L. var. costata DC) phenolics: Influence of fertilizers. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56, 2231-2239. DOI: 10.1021/jf073041o
Gupta, S; Rodrigues, LM; Esteves, AP; Oliveira-Campos, AMF; Nascimento, MSJ; Nazareth, N; Cidade, H; Neves, MP; Fernandes, E; Pinto, M; Cerqueira, NMFSA; Bras, N. 2008. Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 43, 771-780. DOI: 10.1016/j.ejmech.2007.06.002
Chaves, S; Gil, M; Canario, S; Jelic, R; Romao, MJ; Trincao, J; Herdtweck, E; Sousa, J; Diniz, C; Fresco, P; Santos, MA. 2008. Biologically relevant O,S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition. DALTON TRANSACTIONS, 1773-1782. DOI: 10.1039/017172b
Pontes, H; Santos-Marques, MJ; Fernandes, E; Duarte, JA; Remiao, F; Carvalho, F; Bastos, ML. 2008. Effect of chronic ethanol exposure on the hepatotoxicity of ecstasy in mice: An ex vivo study. TOXICOLOGY IN VITRO, 22, 910-920. DOI: 10.1016/j.tiv.2008.01.010
Amaral, JS; Valentao, P; Andrade, PB; Martins, RC; Seabra, RM. 2008. Do cultivar, geographical location and crop season influence phenolic profile of walnut leaves?. MOLECULES, 13, 1321-1332. DOI: 10.3390/molecules13061321
Sousa, C; Valentao, P; Ferreres, F; Seabra, RM; Andrade, PB. 2008. Tronchuda cabbage (Brassica oleracea L. var. costata DC): Scavenger of reactive nitrogen spedes. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56, 4205-4211. DOI: 10.1021/jf072740y
Ribeiro, B; Andrade, PB; Baptista, P; Barros, L; Ferreira, ICFR; Seabra, RM; Valentao, P. 2008. Leucopaxillus giganteus mycelium: Effect of nitrogen source on organic acids and alkaloids. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56, 4769-4774. DOI: 10.1021/jf8001526
Gomes, A; Fernandes, E; Lima, JLFC; Mira, L; Corvo, ML. 2008. Molecular mechanisms of anti-inflammatory activity mediated by flavonoids. CURRENT MEDICINAL CHEMISTRY, 15, 1586-1605. DOI: 10.2174/092986708784911579
Sousa, T; Pinho, D; Morato, M; Marques-Lopes, J; Fernandes, E; Afonso, J; Oliveira, S; Carvalho, F; Albino-Teixeira, A. 2008. Role of superoxide and hydrogen peroxide in hypertension induced by an antagonist of adenosine receptors. EUROPEAN JOURNAL OF PHARMACOLOGY, 588, 267-276. DOI: 10.1016/j.ejphar.2008.04.044
Costa, D; Gomes, A; Lima, JLFC; Fernandes, E. 2008. Singlet oxygen scavenging activity of nonsteroidal anti-inflammatory drugs. REDOX REPORT, 13, 153-160. DOI: 10.1179/135100008X308876
Andrade, PB; Pereira, DM; Ferreres, F; Valentao, P. 2008. Recent trends in high throughput analysis and antioxidant potential screening for phenolics. Current Pharmaceutical Analysis, 4, 137-150. DOI: 10.2174/157341208785161263
Ribeiro, B; Lopes, R; Andrade, PB; Seabra, RM; Goncalves, RF; Baptista, P; Quelhas, I; Valentao, P. 2008. Comparative study of phytochemicals and antioxidant potential of wild edible mushroom caps and stipes. FOOD CHEMISTRY, 110, 47-56. DOI: 10.1016/j.foodchem.2008.01.054
Gomes, A; Fernandes, E; Garcia, MBQ; Silva, AMS; Pinto, DCGA; Santos, CMM; Cavaleiro, JAS; Lima, JLFC. 2008. Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity. BIOORGANIC & MEDICINAL CHEMISTRY, 16, 7939-7943. DOI: 10.1016/j.bmc.2008.07.072
Guerra, L; Pereira, C; Andrade, PB; Rodrigues, MA; Ferreres, F; De Pinho, PG; Seabra, RM; Valentao, P. 2008. Targeted metabolite analysis and antioxidant potential of Rumex induratus. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56, 8184-8194. DOI: 10.1021/jf801385z
Leal, S; Carlos, SA; Goncalves, J; Fresco, P; Diniz, C. 2008. Immunohistochemical Characterization of Adenosine Receptors in Rat Aorta and Tail Arteries. MICROSCOPY RESEARCH AND TECHNIQUE, 71, 703-709. DOI: 10.1002/jemt.20609
Pontes, H; Duarte, JA; de Pinho, PG; Soares, ME; Fernandes, E; Dinis-Oliveira, RJ; Sousa, C; Silva, R; Carmo, H; Casal, S; Remiao, F; Carvalho, F; Bastos, ML. 2008. Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice. TOXICOLOGY, 252, 64-71. DOI: 10.1016/j.tox.2008.07.064
Ribeiro, B; Andrade, PB; Silva, BM; Baptista, P; Seabra, RM; Valentao, P. 2008. Comparative Study on Free Amino Acid Composition of Wild Edible Mushroom Species. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56, 10973-10979. DOI: 10.1021/jf802076p
Alves, E; Binienda, Z; Carvalho, F; Alves, CJ; Fernandes, E; Bastos, MDL; Tavares, MA; Summavielle, T. 2009. ACETYL-L-CARNITINE PROVIDES EFFECTIVE IN VIVO NEUROPROTECTION OVER 3,4-METHYLENEDIOXIMETHAMPHETAMINE-INDUCED MITOCHONDRIAL NEUROTOXICITY IN THE ADOLESCENT RAT BRAIN. NEUROSCIENCE, 158, 514-523. DOI: 10.1016/j.neuroscience.2008.10.041
Pereira, DM; Noites, A; Valentao, P; Ferreres, F; Pereira, JA; Vale-Silva, L; Pinto, E; Andrade, PB. 2009. Targeted Metabolite Analysis and Biological Activity of Pieris brassicae Fed with Brassica rapa var. rapa. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57, 483-489. DOI: 10.1021/jf8031638
Taveira, M; Pereira, DM; Sousa, C; Ferreres, F; Andrade, PB; Martins, A; Pereira, JA; Valentao, P. 2009. In Vitro Cultures of Brassica oleracea L. var. costata DC: Potential Plant Bioreactor for Antioxidant Phenolic Compounds. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57, 1247-1252. DOI: 10.1021/jf803496x
Ferreres, F; Sousa, C; Pereira, DM; Valentao, P; Taveira, M; Martins, A; Pereira, JA; Seabra, RM; Andrade, PB. 2009. Screening of Antioxidant Phenolic Compounds Produced by In Vitro Shoots of Brassica oleracea L. var. costata DC. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 12, 230-240. DOI: 10.2174/138620709787581756
Ferreres, F; Krskova, Z; Goncalves, RF; Valentao, P; Pereira, JA; Dusek, J; Martin, J; Andrade, PB. 2009. Free Water-Soluble Phenolics Profiling in Barley (Hordeum vulgare L.). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57, 2405-2409. DOI: 10.1021/jf8037727
Sousa, C; Pereira, DM; Valentao, P; Ferreres, F; Pereira, JA; Seabra, RM; Andrade, PB. 2009. Pieris brassicae Inhibits Xanthine Oxidase. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57, 2288-2294. DOI: 10.1021/jf803831v
Sousa, C; Pereira, DM; Taveira, M; Dopico-Garcia, S; Valentao, P; Pereira, JA; Bento, A; Andrade, PB. 2009. Brassica oleracea var. costata: comparative study on organic acids and biomass production with other cabbage varieties. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 89, 1083-1089. DOI: 10.1002/jsfa.3559
Costa, RM; Magalhaes, AS; Pereira, JA; Andrade, PB; Valentao, P; Carvalho, M; Silva, BM. 2009. Evaluation of free radical-scavenging and antihemolytic activities of quince (Cydonia oblonga) leaf: A comparative study with green tea (Camellia sinensis). FOOD AND CHEMICAL TOXICOLOGY, 47, 860-865. DOI: 10.1016/j.fct.2009.01.019
Alves, E; Summavielle, T; Alves, CJ; Custodio, JBA; Fernandes, E; Bastos, MD; Tavares, MA; Carvalho, F. 2009. Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. ADDICTION BIOLOGY, 14, 185-193. DOI: 10.1111/j.1369-1600.2008.00143.x
De Pinho, PG; Goncalves, RF; Valentao, P; Pereira, DM; Seabra, RM; Andrade, PB; Sottomayor, M. 2009. Volatile composition of Catharanthus roseus (L.) G. Don using solid-phase microextraction and gas chromatography/mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 49, 674-685. DOI: 10.1016/j.jpba.2008.12.032
Pereira, DM; Valentao, P; Pereira, JA; Andrade, PB. 2009. Phenolics: From Chemistry to Biology. MOLECULES, 14, 2202-2211. DOI: 10.3390/molecules14062202
Ferreres, F; Gomes, D; Valentao, P; Goncalves, R; Pio, R; Chagas, EA; Seabra, RM; Andrade, PB. 2009. Improved loquat (Eriobotrya japonica Lindl.) cultivars: Variation of phenolics and antioxidative potential. FOOD CHEMISTRY, 114, 1019-1027. DOI: 10.1016/j.foodchem.2008.10.065
Magalhaes, AS; Silva, BM; Pereira, JA; Andrade, PB; Valentao, P; Carvalho, M. 2009. Protective effect of quince (Cydonia oblonga Miller) fruit against oxidative hemolysis of human erythrocytes. FOOD AND CHEMICAL TOXICOLOGY, 47, 1372-1377. DOI: 10.1016/j.fct.2009.03.017
Pereira, DM; Ferreres, F; Oliveira, J; Valentao, P; Andrade, PB; Sottomayor, M. 2009. Targeted metabolite analysis of Catharanthus roseus and its biological potential. FOOD AND CHEMICAL TOXICOLOGY, 47, 1349-1354. DOI: 10.1016/j.fct.2009.03.012
Freitas, M; Porto, G; Lima, JLFC; Fernandes, E. 2009. Optimization of experimental settings for the analysis of human neutrophils oxidative burst in vitro. TALANTA, 78, 1476-1483. DOI: 10.1016/j.talanta.2009.02.050
Oliveira, I; Valentao, P; Lopes, R; Andrade, PB; Bento, A; Pereira, JA. 2009. Phytochemical characterization and radical scavenging activity of Portulaca oleraceae L. leaves and stems. MICROCHEMICAL JOURNAL, 92, 129-134. DOI: 10.1016/j.microc.2009.02.006
Gomes, A; Fernandes, E; Silva, AMS; Pinto, DCGA; Santos, CMM; Cavaleiro, JAS; Lima, JLFC. 2009. Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways. BIOCHEMICAL PHARMACOLOGY, 78, 171-177. DOI: 10.1016/j.bcp.2009.03.028
de Pinho, PG; Valentao, P; Goncalves, RF; Sousa, C; Seabra, RM; Andrade, PB. 2009. Volatile composition of Brassica oleracea L. var. costata DC leaves using solid-phase microextraction and gas chromatography/ion trap mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 23, 2292-2300. DOI: 10.1002/rcm.4148
Pereira, DM; Faria, J; Gaspar, L; Valentao, P; Andrade, PB. 2009. Boerhaavia diffusa: Metabolite profiling of a medicinal plant from Nyctaginaceae. FOOD AND CHEMICAL TOXICOLOGY, 47, 2142-2149. DOI: 10.1016/j.fct.2009.05.033
Silva, LR; Videira, R; Monteiro, AP; Valentao, P; Andrade, PB. 2009. Honey from Luso region (Portugal): Physicochemical characteristics and mineral contents. MICROCHEMICAL JOURNAL, 93, 73-77. DOI: 10.1016/j.microc.2009.05.005
Taveira, M; de Pinho, PG; Goncalves, RF; Andrade, PB; Valentao, P. 2009. Determination of eighty-one volatile organic compounds in dietary Rumex induratus leaves by GC/IT-MS, using different extractive techniques. MICROCHEMICAL JOURNAL, 93, 67-72. DOI: 10.1016/j.microc.2009.04.008
Ribeiro, B; de Pinho, PG; Andrade, PB; Baptista, P; Valentao, P. 2009. Fatty acid composition of wild edible mushrooms species: A comparative study. MICROCHEMICAL JOURNAL, 93, 29-35. DOI: 10.1016/j.microc.2009.04.005
Freitas, M; Lima, JLFC; Fernandes, E. 2009. Optical probes for detection and quantification of neutrophils' oxidative burst. A review. ANALYTICA CHIMICA ACTA, 649, 8-23. DOI: 10.1016/j.aca.2009.06.063
Santos, MMM; Newton, AS; Coutinho, I; Gloria, PMC; Saraiva, L; Moreira, R. 2009. VINYL SULFONES AS CASPASE INHIBITORS. DRUGS OF THE FUTURE, 34, 176-176. DOI:
Fernandes, F; Pereira, DM; de Pinho, PG; Valentao, P; Pereira, JA; Bento, A; Andrade, PB. 2009. Metabolic fate of dietary volatile compounds in Pieris brassicae (vol 93, pg 99, 2009). MICROCHEMICAL JOURNAL, 93, 247-247. DOI: 10.1016/j.microc.2009.09.001
Coutinho, I; Pereira, G; Leao, M; Goncalves, J; Corte-Real, M; Saraiva, L. 2009. Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system. FEBS LETTERS, 583, 3582-3588. DOI: 10.1016/j.febslet.2009.10.030
Gomes, A; Freitas, M; Fernandes, E; Lima, JLFC. 2010. Biological Activities of 2-Styrylchromones. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 10, 1-7. DOI:
Ferreres, F; Pereira, DM; Valentao, P; Oliveira, JMA; Faria, J; Gaspar, L; Sottomayor, M; Andrade, PB. 2010. Simple and reproducible HPLC-DAD-ESI-MS/MS analysis of alkaloids in Catharanthus roseus roots. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 51, 65-69. DOI: 10.1016/j.jpba.2009.08.005
Freitas, M; Porto, G; Lima, JLFC; Fernandes, E. 2010. Zinc activates neutrophils' oxidative burst. BIOMETALS, 23, 31-41. DOI: 10.1007/s10534-009-9264-x
Ferreres, F; Pereira, DM; Valentao, P; Andrade, PB. 2010. First report of non-coloured flavonoids in Echium plantagineum bee pollen: differentiation of isomers by liquid chromatography/ion trap mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 24, 801-806. DOI: 10.1002/rcm.4454
Patinha, D; Morato, M; Afonso, J; Pinho, D; Correia, C; Albino-Teixeira, A. 2010. Effect of 2-chloroadenosine on sodium and potassium excretion in diabetic Wistar and SHR rats. Purinergic Signalling, 6, 103-103. DOI:
Morato, M; Patinha, D; Afonso, J; Correia, C; Albino-Teixeira, A. 2010. Endogenous and exogenous adenosine and structural alterations in diabetic nephropathy: a possible role of the renin-angiotensin system?. Purinergic Signalling, 6, 100-101. DOI:
Ferreres, F; Taveira, M; Pereira, DM; Valentao, P; Andrade, PB. 2010. Tomato (Lycopersicon esculentum) Seeds: New Flavonols and Cytotoxic Effect. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58, 2854-2861. DOI: 10.1021/jf904015f
Custodio, JBA; Santos, MS; Goncalves, DIR; Moreno, AJM; Fernandes, E; Bastos, ML; Carvalho, F; Vicente, JAF; Fernandes, MAS. 2010. Comparative effects of 3,4-methylenedioxymethamphetamine and 4-methylthioamphetamine on rat liver mitochondrial function. TOXICOLOGY, 270, 99-105. DOI: 10.1016/j.tox.2010.01.022
Valentao, P; Trindade, P; Gomes, D; de Pinho, PG; Mouga, T; Andrade, PB. 2010. Codium tomentosum and Plocamium cartilagineum: Chemistry and antioxidant potential. FOOD CHEMISTRY, 119, 1359-1368. DOI: 10.1016/j.foodchem.2009.09.015
Morato, MSR; Patinha, D; Afonso, J; Sousa, T; Albino-Teixeira, A. 2010. Renal effects of adenosine on diabetic Wistar and SHR rats. Purinergic Signalling, 6, 140-141. DOI:
Leao, M; Coutinho, I; Neves, M; Cidade, H; Paiva, A; Sousa, E; Pinto, M; Goncalves, J; Pereira, C; Saraiva, L. 2010. Searching for small-molecule modulators of p53 activity and inhibitors of p53-MDM2 interaction, using yeast expression systems. FEBS Journal, 277, 173-174. DOI:
Pereira, DM; Ferreres, F; Oliveira, JMA; Gaspar, L; Faria, J; Valentao, P; Sottomayor, M; Andrade, PB. 2010. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. PHYTOMEDICINE, 17, 646-652. DOI: 10.1016/j.phymed.2009.10.008
Pereira, DM; Faria, J; Gaspar, L; Ferreres, F; Valentao, P; Sottomayor, M; Andrade, PB. 2010. Exploiting Catharanthus roseus roots: Source of antioxidants. FOOD CHEMISTRY, 121, 56-61. DOI: 10.1016/j.foodchem.2009.12.002
Ferreres, F; Pereira, DM; Gil-Izquierdo, A; Valentao, P; Botelho, J; Mouga, T; Andrade, PB. 2010. HPLC-PAD-atmospheric pressure chemical ionization-MS metabolite profiling of cytotoxic carotenoids from the echinoderm Marthasterias glacialis (spiny sea-star). JOURNAL OF SEPARATION SCIENCE, 33, 2250-2257. DOI: 10.1002/jssc.201000197
Freitas, M; Lima, JLFC; Porto, G; Fernandes, E. 2010. Metal-induced oxidative burst in isolated human neutrophils. MICROCHEMICAL JOURNAL, 96, 167-171. DOI: 10.1016/j.microc.2010.03.002
Carvalho, M; Jeronimo, C; Valentao, P; Andrade, PB; Silva, BM. 2010. Green tea: A promising anticancer agent for renal cell carcinoma. FOOD CHEMISTRY, 122, 49-54. DOI: 10.1016/j.foodchem.2010.02.014
Taveira, M; Silva, LR; Vale-Silva, LA; Pinto, E; Valentao, P; Ferreres, F; De Pinho, PG; Andrade, PB. 2010. Lycopersicon esculentum Seeds: An Industrial Byproduct as an Antimicrobial Agent. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58, 9529-9536. DOI: 10.1021/jf102215g
Amaral, JS; Valentao, P; Andrade, PB; Martins, RC; Seabra, RM. 2010. Phenolic composition of hazelnut leaves: Influence of cultivar, geographical origin and ripening stage. SCIENTIA HORTICULTURAE, 126, 306-313. DOI: 10.1016/j.scienta.2010.07.026
Valentao, P; Goncalves, RF; Belo, C; de Pinho, PG; Andrade, PB; Ferreres, F. 2010. Improving the knowledge on Piper betle Targeted metabolite analysis and effect on acetylcholinesterase. JOURNAL OF SEPARATION SCIENCE, 33, 3168-3176. DOI: 10.1002/jssc.201000429
Freitas, M; Gomes, A; Porto, G; Fernandes, E. 2010. Nickel induces oxidative burst, NF-kappa B activation and interleukin-8 production in human neutrophils. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 15, 1275-1283. DOI: 10.1007/s00775-010-0685-3
Freitas, M; Fernandes, E. 2011. Zinc, cadmium and nickel increase the activation of NF-kappa B and the release of cytokines from THP-1 monocytic cells. Metallomics, 3, 1238-1243. DOI: 10.1039/c1mt00050k
Ruscher, K; Fernandes, E; Capela, JP; Bastos, MD; Wieloch, T; Dirnagl, U; Meisel, A; Carvalho, F. 2011. Effect of 3,4-methylenedioxyamphetamine on dendritic spine dynamics in rat neocortical neurons - Involvement of heat shock protein 27. BRAIN RESEARCH, 1370, 43-52. DOI: 10.1016/j.brainres.2010.11.022
Santos, RP; Mendes, LS; Silva, BM; de Pinho, PG; Valentao, P; Andrade, PB; Pereira, JA; Carvalho, M. 2011. Phytochemical profiles and inhibitory effect on free radical-induced human erythrocyte damage of Dracaena draco leaf: A potential novel antioxidant agent. FOOD CHEMISTRY, 124, 927-934. DOI: 10.1016/j.foodchem.2010.07.021
Pinho, D; Morato, M; Couto, MR; Marques-Lopes, J; Tavares, I; Albino-Teixeira, A. 2011. Does Chronic Pain Alter the Normal Interaction Between Cardiovascular and Pain Regulatory Systems? Pain Modulation in the Hypertensive-Monoarthritic Rat. JOURNAL OF PAIN, 12, 194-204. DOI: 10.1016/j.jpain.2010.06.009
Talaia, C; Morato, M; Quintas, C; Goncalves, J; Queiroz, G. 2011. Functional crosstalk of prejunctional receptors on the modulation of noradrenaline release in mesenteric vessels: A differential study of artery and vein. EUROPEAN JOURNAL OF PHARMACOLOGY, 652, 33-39. DOI: 10.1016/j.ejphar.2010.10.075
Silva, RD; Manon, S; Goncalves, J; Saraiva, L; Corte-Real, M. 2011. Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein Kinase C alpha. EXPERIMENTAL CELL RESEARCH, 317, 781-790. DOI: 10.1016/j.yexcr.2010.12.001
Coutinho, I; Pereira, C; Pereira, G; Goncalves, J; Corte-Real, M; Saraiva, L. 2011. Distinct regulation of p53-mediated apoptosis by protein kinase C alpha, delta, epsilon and zeta: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. EXPERIMENTAL CELL RESEARCH, 317, 1147-1158. DOI: 10.1016/j.yexcr.2011.02.007
Ferreres, F; Figueiredo, R; Bettencourt, S; Carqueijeiro, I; Oliveira, J; Gil-Izquierdo, A; Pereira, DM; Valentao, P; Andrade, PB; Duarte, P; Barcelo, AR; Sottomayor, M. 2011. Identification of phenolic compounds in isolated vacuoles of the medicinal plant Catharanthus roseus and their interaction with vacuolar class III peroxidase: an H2O2 affair?. JOURNAL OF EXPERIMENTAL BOTANY, 62, 2841-2854. DOI: 10.1093/jxb/erq458
Pereira, DM; Cheel, J; Areche, C; San-Martin, A; Rovirosa, J; Silva, LR; Valentao, P; Andrade, PB. 2011. Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium flabelliforme against Several Cancer Cell Lines. Marine Drugs, 9, 852-862. DOI: 10.3390/md9050852
Gloria, PMC; Coutinho, I; Goncalves, LM; Baptista, C; Soares, J; Newton, AS; Moreira, R; Saraiva, L; Santos, MMM. 2011. Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 46, 2141-2146. DOI: 10.1016/j.ejmech.2011.02.067
Costa, P; Goncalves, S; Andrade, PB; Valentao, P; Romano, A. 2011. Inhibitory effect of Lavandula viridis on Fe2+-induced lipid peroxidation, antioxidant and anti-cholinesterase properties. FOOD CHEMISTRY, 126, 1779-1786. DOI: 10.1016/j.foodchem.2010.12.085
Grosso, C; Vinholes, J; Silva, LR; de Pinho, PG; Goncalves, RF; Valentao, P; Jager, AK; Andrade, PB. 2011. Chemical composition and biological screening of Capsella bursa-pastoris. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, 21, 635-644. DOI: 10.1590/S0102-695X2011005000107
Ferreres, F; Taveira, M; Gil-Izquierdo, A; Oliveira, L; Teixeira, T; Valentao, P; Simoes, N; Andrade, PB. 2011. High-performance liquid chromatography-diode array detection-electrospray ionization multi-stage mass spectrometric screening of an insect/plant system: the case of Spodoptera littoralis/Lycopersicon esculentum phenolics and alkaloids. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 25, 1972-1980. DOI: 10.1002/rcm.5077
Silva, BM; Santos, RP; Mendes, LS; de Pinho, PG; Valentao, P; Andrade, PB; Pereira, JA; Carvalho, M. 2011. Dracaena draco L. fruit: Phytochemical and antioxidant activity assessment. FOOD RESEARCH INTERNATIONAL, 44, 2182-2189. DOI: 10.1016/j.foodres.2010.09.031
Couto, C; Silva, LR; Valentao, P; Velazquez, E; Peix, A; Andrade, PB. 2011. Effects induced by the nodulation with Bradyrhizobium japonicum on Glycine max (soybean) metabolism and antioxidant potential. FOOD CHEMISTRY, 127, 1487-1495. DOI: 10.1016/j.foodchem.2011.01.135
Pinho, BR; Sousa, C; Valentao, P; Andrade, PB. 2011. Is Nitric Oxide Decrease Observed with Naphthoquinones in LPS Stimulated RAW 264.7 Macrophages a Beneficial Property?. PLoS One, 6. DOI: 10.1371/journal.pone.0024098
Vinholes, J; Grosso, C; Andrade, PB; Gil-Izquierdo, A; Valentao, P; de Pinho, PG; Ferreres, F. 2011. In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra. FOOD CHEMISTRY, 129, 454-462. DOI: 10.1016/j.foodchem.2011.04.098
Ferreres, F; Gil-Izquierdo, A; Valentao, P; Andrade, PB. 2011. Structural characterization of phenolics and betacyanins in Gomphrena globosa by high-performance liquid chromatography-diode array detection/electrospray ionization multi-stage mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 25, 3441-3446. DOI: 10.1002/rcm.5248
Martins, J; Castelo-Branco, M; Batista, A; Oliveiros, B; Santiago, AR; Galvao, J; Fernandes, E; Carvalho, F; Cavadas, C; Ambrosio, AF. 2011. Effects of 3,4-Methylenedioxymethamphetamine Administration on Retinal Physiology in the Rat. PLoS One, 6. DOI: 10.1371/journal.pone.0029583
Veloso, AD; do Rego, AMB; Ferraria, AM; Ferreira, LFV; Ferreira, DP; Tavares, PB; Videira, R; Viana, AS; Oliveira, MC. 2017. One-Step Cathodic and Anodic Synthesis of Hydrophilic Carbon Nanomaterials. ChemElectroChem, 4, 2693-2702. DOI: 10.1002/celc.201700386
Monteiro, LS; Oliveira, S; Paiva-Martins, F; Ferreira, PMT; Pereira, DM; Andrade, PB; Valentao, P. 2017. Synthesis and preliminary biological evaluation of new phenolic and catecholic dehydroamino acid derivatives. TETRAHEDRON, 73, 6199-6209. DOI: 10.1016/j.tet.2017.09.012
Proenca, C; Freitas, M; Ribeiro, D; Sousa, JLC; Carvalho, F; Silva, AMS; Fernandes, PA; Fernandes, E. 2018. Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure activity relationship study. FOOD AND CHEMICAL TOXICOLOGY, 111, 474-481. DOI: 10.1016/j.fct.2017.11.039
Sousa, JB; Fresco, P; Diniz, C; Goncalves, J. 2018. Adenosine Receptor Ligands on Cancer Therapy: A Review of Patent Literature. Recent Patents on Anti-Cancer Drug Discovery, 13, 40-69. DOI: 10.2174/1574892812666171108115959
Russo, D; Miglionico, R; Carmosino, M; Bisaccia, F; Andrade, PB; Valentao, P; Milella, L; Armentano, MF. 2018. A Comparative Study on Phytochemical Profiles and Biological Activities of Sclerocarya birrea (A.Rich.) Hochst Leaf and Bark Extracts. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19. DOI: 10.3390/ijms19010186
Bessa, C; Soares, J; Raimundo, L; Loureiro, JB; Gomes, C; Reis, F; Soares, ML; Santos, D; Dureja, C; Chaudhuri, SR; Lopez-Haber, C; Kazanietz, MG; Goncalves, J; Simoes, MF; Rijo, P; Saraiva, L. 2018. Discovery of a small-molecule protein kinase C delta-selective activator with promising application in colon cancer therapy. Cell Death & Disease, 9. DOI: 10.1038/s41419-017-0154-9
Goncalves, S; Medronho, J; Moreira, E; Grosso, C; Andrade, PB; Valentao, P; Romano, A. 2018. Bioactive properties of Chamaerops humilis L.: antioxidant and enzyme inhibiting activities of extracts from leaves, seeds, pulp and peel. 3 Biotech, 8. DOI: 10.1007/s13205-018-1110-9
Mariz-Ponte, N; Mendes, RJ; Sario, S; de Oliveira, JMPF; Melo, P; Santos, C. 2018. Tomato plants use non-enzymatic antioxidant pathways to cope with moderate UV-A/B irradiation: A contribution to the use of UV-A/B in horticulture. JOURNAL OF PLANT PHYSIOLOGY, 221, 32-42. DOI: 10.1016/j.jplph.2017.11.013
Mouho, DG; Oliveira, AP; Kodjo, CG; Valentao, P; Gil-Izquierdo, A; Andrade, PB; Ouattara, ZA; Bekro, YA; Ferreres, F. 2018. Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark. FOOD AND CHEMICAL TOXICOLOGY, 112, 134-144. DOI: 10.1016/j.fct.2017.12.043
Puig, CG; Reigosa, MJ; Valentao, P; Andrade, PB; Pedrol, N. 2018. Unravelling the bioherbicide potential of Eucalyptus globulus Labill: Biochemistry and effects of its aqueous extract. PLoS One, 13. DOI: 10.1371/journal.pone.0192872
Pereira, DM; Valentao, P; Andrade, PB. 2018. Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones. Chemical Science, 9, 1740-1752. DOI: 10.1039/c7sc04712f
Videira, RA; Andrade, PB; Monteiro, LS; Valentao, P; Ferreira, PMT; Pereira, DM. 2018. Toxicity and structure-activity relationship (SAR) of alpha,beta-dehydroamino acids against human cancer cell lines. TOXICOLOGY IN VITRO, 47, 26-37. DOI: 10.1016/j.tiv.2017.10.027
Almeida, IF; Fernandes, E; Lima, JLFC; Valentão, P; Andrade, PB; Seabra, RM; Costa, PC; Bahia, MF. 2009. Oxygen and nitrogen reactive species are effectively scavenged by eucalyptus globulus leaf water extract. JOURNAL OF MEDICINAL FOOD, 12(1), 175-183. DOI: 10.1089/jmf.2008.0046
Almeida, IF; Fernandes, E; Lima, JLFC; Costa, PC; Bahia, MF. 2008. Protective effect of Castanea sativa and Quercus robur leaf extracts against oxygen and nitrogen reactive species. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 91(2-3), 87-95. DOI: 10.1016/j.jphotobiol.2008.02.001
Santos, CMM; Freitas, M; Ribeiro, D; Gomes, A; Silva, AMS; Cavaleiro, JAS; Fernandes, E. 2010. 2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure-activity relationship study. Bioorganic and Medicinal Chemistry, 18(18), 6776-6784. DOI: 10.1016/j.bmc.2010.07.044
Bernardo, J; Ferreres, F; Gil-Izquierdo, Á; Videira, RA; Valentão, P; Veiga, F; Andrade, PB. 2018. In vitro multimodal-effect of Trichilia catigua A. Juss. (Meliaceae) bark aqueous extract in CNS targets. JOURNAL OF ETHNOPHARMACOLOGY, 211, 247-255. DOI: 10.1016/j.jep.2017.09.039
Araújo, AR; Pereira, DM; Aroso, IM; Santos, T; Batista, MT; Cerqueira, MT; Marques, AP; Reis, RL; Pires, RA. 2015. Cork extracts reduce UV-mediated DNA fragmentation and cell death. RSC Advances, 5(116), 96151-96157. DOI: 10.1039/c5ra15712a
Pereira, David M. 2017. Modulation of Proteostasis and Proteolytic Pathways as an Anti-Cancer Strategy. Recent Patents on Anti-Cancer Drug Discovery, 12(1), 2-3. DOI: 10.2174/157489281201170112201259
Sousa, C; Lopes, G; Pereira, DM; Taveira, M; Valentao, P; Seabra, RM; Pereira, JA; Baptista, P; Ferreres, F; Andrade, PB. 2007. Screening of antioxidant compounds during sprouting of Brassica oleracea L. var. costata DC. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING. DOI: 10.2174/138620707781662817
Morliere, P; Patterson, LK; Santos, CMM; Silva, AMS; Maziere, JC; Filipe, P; Gomes, A; Fernandes, E; Garcia, MBQ; Santus, R. 2012. The dependence of alpha-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment. ORGANIC & BIOMOLECULAR CHEMISTRY, 10, 2068-2076. DOI: 10.1039/c2ob06612b
Gomez-Casati, DF; Clemente, M; Inga, A; Saraiva, L; Spampinato, CP. 2012. Contribution of Yeast and Plant Research for Improving Human Health. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. DOI: 10.1155/2012/738436
Pereira, C; Bessa, C; Soares, J; Leao, M; Saraiva, L. 2012. Contribution of Yeast Models to Neurodegeneration Research. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. DOI: 10.1155/2012/941232
Escuredo, O; Silva, LR; Valentao, P; Seijo, MC; Andrade, PB. 2012. Assessing Rubus honey value: Pollen and phenolic compounds content and antibacterial capacity. FOOD CHEMISTRY, 130, 671-678. DOI: 10.1016/j.foodchem.2011.07.107
Lopes, G; Sousa, C; Silva, LR; Pinto, E; Andrade, PB; Bernardo, J; Mouga, T; Valentao, P. 2012. Can Phlorotannins Purified Extracts Constitute a Novel Pharmacological Alternative for Microbial Infections with Associated Inflammatory Conditions?. PLoS One, 7. DOI: 10.1371/journal.pone.0031145
Gaspar, L; Oliveira, AP; Silva, LR; Andrade, PB; de Pinho, PG; Botelho, J; Valentao, P. 2012. Metabolic and biological prospecting of Coreopsis tinctoria. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, 22, 350-358. DOI: 10.1590/S0102-695X2011005000224
Pereira, C; Coutinho, I; Soares, J; Bessa, C; Leao, M; Saraiva, L. 2012. New insights into cancer-related proteins provided by the yeast model. FEBS Journal, 279, 697-712. DOI: 10.1111/j.1742-4658.2012.08477.x
Costa, P; Goncalves, S; Grosso, C; Andrade, PB; Valentao, P; Bernardo-Gil, MG; Romano, A. 2012. Chemical profiling and biological screening of Thymus lotocephalus extracts obtained by supercritical fluid extraction and hydrodistillation. INDUSTRIAL CROPS AND PRODUCTS, 36, 246-256. DOI: 10.1016/j.indcrop.2011.09.014
Pereira, DM; Valentao, P; Correia-da-Silva, G; Teixeira, N; Andrade, PB. 2012. Plant Secondary Metabolites in Cancer Chemotherapy: Where are We?. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 13, 632-650. DOI:
Oliveira, AP; Costa, RM; Magalhaes, AS; Pereira, JA; Carvalho, M; Valentao, P; Andrade, PB; Silva, BM. 2012. Targeted metabolites and biological activities of Cydonia oblonga Miller leaves. FOOD RESEARCH INTERNATIONAL, 46, 496-504. DOI: 10.1016/j.foodres.2010.10.021
Fernandes, F; Sousa, C; Ferreres, F; Valentao, P; Remiao, F; Pereira, JA; Andrade, PB. 2012. Kale Extract Increases Glutathione Levels in V79 Cells, but Does not Protect Them Against Acute Toxicity Induced by Hydrogen Peroxide. MOLECULES, 17, 5269-5288. DOI: 10.3390/molecules17055269
Sousa, C; Fernandes, F; Valentao, P; Rodrigues, AS; Coelho, M; Teixeira, JP; Silva, S; Ferreres, F; de Pinho, PG; Andrade, PB. 2012. Brassica oleracea L. Var. costata DC and Pieris brassicae L. Aqueous Extracts Reduce Methyl Methanesulfonate-Induced DNA Damage in V79 Hamster Lung Fibroblasts. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60, 5380-5387. DOI: 10.1021/jf300941s
Silva, RD; Saraiva, L; Coutinho, I; Goncalves, J; Corte-Real, M. 2012. Yeast as a Powerful Model System for the Study of Apoptosis Regulation by Protein Kinase C Isoforms. CURRENT PHARMACEUTICAL DESIGN, 18, 2492-2500. DOI:
Mariutti, LRB; Pereira, DM; Mercadante, AZ; Valentao, P; Teixeira, N; Andrade, PB. 2012. Further Insights on the Carotenoid Profile of the Echinoderm Marthasterias glacialis L.. Marine Drugs, 10, 1498-1510. DOI: 10.3390/md10071498
Leao, M; Pereira, C; Bisio, A; Ciribilli, Y; Soares, J; Paiva, A; Sousa, E; Pinto, M; Inga, A; Saraiva, L. 2012. Discovery of a New Inhibitor of P53/MDM2 Interaction Using a Yeast Target-based Screening Strategy. EUROPEAN JOURNAL OF CANCER, 48, S229-S229. DOI:
Girones-Vilaplana, A; Valentao, P; Moreno, DA; Ferreres, F; Garcia-Viguera, C; Andrade, PB. 2012. New Beverages of Lemon Juice Enriched with the Exotic Berries Maqui, Acai, and Blackthorn: Bioactive Components and in Vitro Biological Properties. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60, 6571-6580. DOI: 10.1021/jf300873k
Ferreres, F; Goncalves, RF; Gil-Izquierdo, A; Valentao, P; Silva, AMS; Silva, JB; Santos, D; Andrade, PB. 2012. Further Knowledge on the Phenolic Profile of Colocasia esculenta (L.) Shott. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60, 7005-7015. DOI: 10.1021/jf301739q
Saffi, RG; Almeida, IF; Fernandes, E; Lobo, JMS. 2012. Evaluation of the antioxidant activity of a eucalyptus extract in human keratinocytes. INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, 34, 359-359. DOI:
Pereira, C; Leao, M; Soares, J; Bessa, C; Saraiva, L. 2012. New Therapeutic Strategies for Cancer and Neurodegeneration Emerging from Yeast Cell-based Systems. CURRENT PHARMACEUTICAL DESIGN, 18, 4223-4235. DOI:
Soares, AF; Diniz, C; Fresco, P. 2012. A(3)-adenosine receptor effects on malignant melanoma cells. FEBS Journal, 279, 547-547. DOI:
Pereira, D; Correia-da-Silva, G; Valentao, P; Teixeira, N; Andrade, PB. 2012. Biological properties of a lipophilic extract of sea-star Marthasterias glacialis L. upon several cancer cell lines. FEBS Journal, 279, 61-61. DOI:
Reinoso, BD; Couto, D; Moure, A; Fernandes, E; Dominguez, H; Parajo, JC. 2012. Optimization of antioxidants - Extraction from Castanea sativa leaves. CHEMICAL ENGINEERING JOURNAL, 203, 101-109. DOI: 10.1016/j.cej.2012.06.122
Gomes, A; Couto, D; Alves, A; Dias, I; Freitas, M; Porto, G; Duarte, JA; Fernandes, E. 2012. Trihydroxyflavones with antioxidant and anti-inflammatory efficacy. BIOFACTORS, 38, 378-386. DOI: 10.1002/biof.1033
Ferreres, F; Gil-Izquierdo, A; Vinholes, J; Silva, ST; Valentao, P; Andrade, PB. 2012. Bauhinia forficata Link authenticity using flavonoids profile: Relation with their biological properties. FOOD CHEMISTRY, 134, 894-904. DOI: 10.1016/j.foodchem.2012.02.201
Diaz, B; Gomes, A; Freitas, M; Fernandes, E; Nogueira, DR; Gonzalez, J; Moure, A; Levoso, A; Vinardell, MP; Mitjans, M; Dominguez, H; Parajo, JC. 2012. Valuable Polyphenolic Antioxidants from Wine Vinasses. Food and Bioprocess Technology, 5, 2708-2716. DOI: 10.1007/s11947-011-0569-8
Girones-Vilaplana, A; Valentao, P; Andrade, PB; Ferreres, F; Moreno, DA; Garcia-Viguera, C. 2012. Phytochemical profile of a blend of black chokeberry and lemon juice with cholinesterase inhibitory effect and antioxidant potential. FOOD CHEMISTRY, 134, 2090-2096. DOI: 10.1016/j.foodchem.2012.04.010
Pereira, DM; Vinholes, J; de Pinho, PG; Valentao, P; Mouga, T; Teixeira, N; Andrade, PB. 2012. A gas chromatography-mass spectrometry multi-target method for the simultaneous analysis of three classes of metabolites in marine organisms. TALANTA, 100, 391-400. DOI: 10.1016/j.talanta.2012.08.004
Costa, P; Grosso, C; Goncalves, S; Andrade, PB; Valentao, P; Bernardo-Gil, MG; Romano, A. 2012. Supercritical fluid extraction and hydrodistillation for the recovery of bioactive compounds from Lavandula viridis L'Her. FOOD CHEMISTRY, 135, 112-121. DOI: 10.1016/j.foodchem.2012.04.108
Pereira, C; Bessa, C; Saraiva, L. 2012. Endocytosis inhibition during H2O2-induced apoptosis in yeast. FEMS YEAST RESEARCH, 12, 755-760. DOI: 10.1111/j.1567-1364.2012.00825.x
Faleh, E; Oliveira, AP; Valentao, P; Ferchichi, A; Silva, BM; Andrade, PB. 2012. Influence of Tunisian Ficus carica fruit variability in phenolic profiles and in vitro radical scavenging potential. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, 22, 1282-1289. DOI: 10.1590/S0102-695X2012005000132
Silva, LR; Valentao, P; Faria, J; Ferreres, F; Sousa, C; Gil-Izquierdo, A; Pinho, BR; Andrade, PB. 2012. Phytochemical investigations and biological potential screening with cellular and non-cellular models of globe amaranth (Gomphrena globosaL.) inflorescences. FOOD CHEMISTRY, 135, 756-763. DOI: 10.1016/j.foodchem.2012.05.015
Taveira, M; Ferreres, F; Gil-Izquierdo, A; Oliveira, L; Valentao, P; Andrade, PB. 2012. Fast determination of bioactive compounds from Lycopersicon esculentum Mill. leaves. FOOD CHEMISTRY, 135, 748-755. DOI: 10.1016/j.foodchem.2012.05.016
Chiste, RC; Freitas, M; Mercadante, AZ; Fernandes, E. 2012. The potential of extracts of Caryocar villosum pulp to scavenge reactive oxygen and nitrogen species. FOOD CHEMISTRY, 135, 1740-1749. DOI: 10.1016/j.foodchem.2012.06.027
Costa, P; Goncalves, S; Valentao, P; Andrade, PB; Coelho, N; Romano, A. 2012. Thymus lotocephalus wild plants and in vitro cultures produce different profiles of phenolic compounds with antioxidant activity. FOOD CHEMISTRY, 135, 1253-1260. DOI: 10.1016/j.foodchem.2012.05.072
Ferreres, F; Lopes, G; Gil-Izquierdo, A; Andrade, PB; Sousa, C; Mouga, T; Valentao, P. 2012. Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties. Marine Drugs, 10, 2766-2781. DOI: 10.3390/md10122766
Pereira, C; Lopes, E; Mesquita, JR; Nascimento, MSJ; Saraiva, L. 2012. Production and purification of theVP1 capsid protein of a novel canine norovirus using the Saccharomyces cerevisiae expression system. JOURNAL OF MICROBIOLOGICAL METHODS, 91, 358-360. DOI: 10.1016/j.mimet.2012.09.007
Oliveira, AP; Baptista, P; Andrade, PB; Martins, F; Pereira, JA; Silva, BM; Valentao, P. 2012. Characterization of Ficus carica L. cultivars by DNA and secondary metabolite analysis: Is genetic diversity reflected in the chemical composition?. FOOD RESEARCH INTERNATIONAL, 49, 710-719. DOI: 10.1016/j.foodres.2012.09.019
Pereira, C; Saraiva, L. 2013. Interference of aging media on the assessment of yeast chronological life span by propidium iodide staining. FOLIA MICROBIOLOGICA, 58, 81-84. DOI: 10.1007/s12223-012-0186-6
Martins, N; Goncalves, S; Andrade, PB; Valentao, P; Romano, A. 2013. Changes on organic acid secretion and accumulation in Plantago almogravensis Franco and Plantago algarbiensis Samp. under aluminum stress. PLANT SCIENCE, 198, 1-6. DOI: 10.1016/j.plantsci.2012.09.001
Capela, JP; Araujo, SD; Costa, VM; Ruscher, K; Fernandes, E; Bastos, MD; Dirnagl, U; Meisel, A; Carvalho, F. 2013. The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons. NEUROTOXICOLOGY, 34, 254-263. DOI: 10.1016/j.neuro.2012.09.005
Silva, LR; Pereira, MJ; Azevedo, J; Goncalves, RF; Valentao, P; de Pinho, PG; Andrade, PB. 2013. Glycine max (L.) Merr., Vigna radiata L. and Medicago sativa L. sprouts: A natural source of bioactive compounds. FOOD RESEARCH INTERNATIONAL, 50, 167-175. DOI: 10.1016/j.foodres.2012.10.025
Sousa, JB; Fresco, P; Diniz, C. 2013. Endothelial nitric oxide modulatory role on vascular sympathetic reactivity. PROCEEDINGS OF THE 6TH EUROPEAN CONGRESS OF PHARMACOLOGY, 43-47. DOI:
Falcato-Soares, A; Diniz, C; Fresco, P. 2013. Characterization of Adenosine Receptors in Human and Mouse Melanoma Cells. PROCEEDINGS OF THE 6TH EUROPEAN CONGRESS OF PHARMACOLOGY, 29-34. DOI:
Santos, CMM; Garcia, MBQ; Silva, AMS; Santus, R; Morliere, P; Fernandes, E. 2013. Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry. TETRAHEDRON LETTERS, 54, 85-90. DOI: 10.1016/j.tetlet.2012.10.103
Ferreres, F; Vinholes, J; Gil-Izquierdo, A; Valentao, P; Goncalves, RF; Andrade, PB. 2013. In vitro studies of alpha-glucosidase inhibitors and antiradical constituents of Glandora diffusa (Lag.) DC Thomas infusion. FOOD CHEMISTRY, 136, 1390-1398. DOI: 10.1016/j.foodchem.2012.09.089
Freitas, M; Barcellos-de-Souza, P; Barja-Fidalgo, C; Fernandes, E. 2013. Nickel induces apoptosis in human neutrophils. BIOMETALS, 26, 13-21. DOI: 10.1007/s10534-012-9590-2
Fernandez-Agullo, A; Pereira, E; Freire, MS; Valentao, P; Andrade, PB; Gonzalez-Alvarez, J; Pereira, JA. 2013. Influence of solvent on the antioxidant and antimicrobial properties of walnut (Juglans regia L.) green husk extracts. INDUSTRIAL CROPS AND PRODUCTS, 42, 126-132. DOI: 10.1016/j.indcrop.2012.05.021
Patinha, D; Fasching, A; Pinho, D; Albino-Teixeira, A; Morato, M; Palm, F. 2013. Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 304, F614-F622. DOI: 10.1152/ajprenal.00285.2012
Rocha-Pereira, C; Sousa, JB; Vieira-Rocha, MS; Fresco, P; Goncalves, J; Diniz, C. 2013. Differential inhibition of noradrenaline release mediated by inhibitory A(1)-adenosine receptors in the mesenteric vein and artery from normotensive and hypertensive rats. NEUROCHEMISTRY INTERNATIONAL, 62, 399-405. DOI: 10.1016/j.neuint.2013.02.010
Silva, LR; Azevedo, J; Pereira, MJ; Valentao, P; Andrade, PB. 2013. Chemical assessment and antioxidant capacity of pepper (Capsicum annuum L.) seeds. FOOD AND CHEMICAL TOXICOLOGY, 53, 240-248. DOI: 10.1016/j.fct.2012.11.036
Moita, E; Gil-Izquierdo, A; Sousa, C; Ferreres, F; Silva, LR; Valentao, P; Dominguez-Perles, R; Baenas, N; Andrade, PB. 2013. Integrated Analysis of COX-2 and iNOS Derived Inflammatory Mediators in LPS-Stimulated RAW Macrophages Pre-Exposed to Echium plantagineum L. Bee Pollen Extract. PLoS One, 8. DOI: 10.1371/journal.pone.0059131
Leao, M; Gomes, S; Pedraza-Chaverri, J; Machado, N; Sousa, E; Pinto, M; Inga, A; Pereira, C; Saraiva, L. 2013. alpha-Mangostin and Gambogic Acid as Potential Inhibitors of the p53-MDM2 Interaction Revealed by a Yeast Approach. JOURNAL OF NATURAL PRODUCTS, 76, 774-778. DOI: 10.1021/np400049j
Fernandes, F; Ramalhosa, E; Pires, P; Verdial, J; Valentao, P; Andrade, P; Bento, A; Pereira, JA. 2013. Vitis vinifera leaves towards bioactivity. INDUSTRIAL CROPS AND PRODUCTS, 43, 434-440. DOI: 10.1016/j.indcrop.2012.07.031
Leao, M; Pereira, C; Bisio, A; Ciribilli, Y; Paiva, AM; Machado, N; Palmeira, A; Fernandes, MX; Sousa, E; Pinto, M; Inga, A; Saraiva, L. 2013. Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach. BIOCHEMICAL PHARMACOLOGY, 85, 1234-1245. DOI: 10.1016/j.bcp.2013.01.032
Andrade, PB; Barbosa, M; Matos, RP; Lopes, G; Vinholes, J; Mouga, T; Valentao, P. 2013. Valuable compounds in macroalgae extracts. FOOD CHEMISTRY, 138, 1819-1828. DOI: 10.1016/j.foodchem.2012.11.081
Freitas, M; Costa, VM; Ribeiro, D; Couto, D; Porto, G; Carvalho, F; Fernandes, E. 2013. Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils. TOXICOLOGY LETTERS, 219, 170-177. DOI: 10.1016/j.toxlet.2013.03.007
Rocha-Pereira, C; Arribas, SM; Fresco, P; Gonzalez, MC; Goncalves, J; Diniz, C. 2013. Impaired Inhibitory Function of Presynaptic A(1)-Adenosine Receptors in SHR Mesenteric Arteries. JOURNAL OF PHARMACOLOGICAL SCIENCES, 122, 59-70. DOI: 10.1254/jphs.12266FP
Eusebio, N; Pinheiro, T; Amorim, AA; Gamboa, F; Saraiva, L; Gusmao, L; Amorim, A; Araujo, R. 2013. SNaPaer. A Practical Single Nucleotide Polymorphism Multiplex Assay for Genotyping of Pseudomonas aeruginosa. PLoS One, 8. DOI: 10.1371/journal.pone.0066083
Falcao, SI; Vale, N; Gomes, P; Domingues, MRM; Freire, C; Cardoso, SM; Vilas-Boas, M. 2013. Phenolic Profiling of Portuguese Propolis by LC-MS Spectrometry: Uncommon Propolis Rich in Flavonoid Glycosides. PHYTOCHEMICAL ANALYSIS, 24, 309-318. DOI: 10.1002/pca.2412
Pinho, BR; Santos, MM; Fonseca-Silva, A; Valentao, P; Andrade, PB; Oliveira, JMA. 2013. How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs. BRITISH JOURNAL OF PHARMACOLOGY, 169, 1072-1090. DOI: 10.1111/bph.12186
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Valentao, P; Andrade, PB. 2013. Phenolic compounds from Jacaranda caroba (Vell.) A. DC.: Approaches to neurodegenerative disorders. FOOD AND CHEMICAL TOXICOLOGY, 57, 91-98. DOI: 10.1016/j.fct.2013.03.012
Costa, P; Goncalves, S; Valentao, P; Andrade, PB; Romano, A. 2013. Accumulation of phenolic compounds in in vitro cultures and wild plants of Lavandula viridis L'Her and their antioxidant and anti-cholinesterase potential. FOOD AND CHEMICAL TOXICOLOGY, 57, 69-74. DOI: 10.1016/j.fct.2013.03.006
Cabana, R; Silva, LR; Valentao, P; Viturro, CI; Andrade, PB. 2013. Effect of different extraction methodologies on the recovery of bioactive metabolites from Satureja parvifolia (Phil.) Epling (Lamiaceae). INDUSTRIAL CROPS AND PRODUCTS, 48, 49-56. DOI: 10.1016/j.indcrop.2013.04.003
Silva, G; Pereira, RB; Valentao, P; Andrade, PB; Sousa, C. 2013. Distinct fatty acid profile of ten brown macroalgae. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, 23, 608-613. DOI: 10.1590/S0102-695X2013005000048
Pereira, D; Correia-da-Silva, G; Valentao, P; Teixeira, N; Andrade, PB. 2013. Modulation of Cox-2 and iNOS expression in macrophages by a lipophylic extract of the sea-star Marthasterias glacialis: cooperative effect of fatty acids and ergosta-7,22-dien-3-ol. FEBS Journal, 280, 288-288. DOI:
Teixeira, J; Silva, T; Andrade, PB; Borges, F. 2013. Alzheimer's Disease and Antioxidant Therapy: How Long How Far?. CURRENT MEDICINAL CHEMISTRY, 20, 2939-2952. DOI:
Pereira, RB; Sousa, C; Costa, A; Andrade, PB; Valentao, P. 2013. Glutathione and the Antioxidant Potential of Binary Mixtures with Flavonoids: Synergisms and Antagonisms. MOLECULES, 18, 8858-8872. DOI: 10.3390/molecules18088858
Gonzalez, N; Ribeiro, D; Fernandes, E; Nogueira, DR; Conde, E; Moure, A; Vinardell, MP; Mitjans, M; Dominguez, H. 2013. Potential use of Cytisus scoparius extracts in topical applications for skin protection against oxidative damage. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 125, 83-89. DOI: 10.1016/j.jphotobiol.2013.05.003
Lopes, G; Pinto, E; Andrade, PB; Valentao, P. 2013. Antifungal Activity of Phlorotannins against Dermatophytes and Yeasts: Approaches to the Mechanism of Action and Influence on Candida albicans Virulence Factor. PLoS One, 8. DOI: 10.1371/journal.pone.0072203
Barbosa, DJ; Serrat, R; Mirra, S; Quevedo, M; de Barreda, EG; Avila, J; Fernandes, E; Bastos, MD; Capela, JP; Carvalho, F; Soriano, E. 2013. "Ecstasy" impairs mitochondrial trafficking in hippocampal neurons by a Tau phosphorylation-dependent mechanism involving GSK3 beta. TOXICOLOGY LETTERS, 221, S166-S166. DOI: 10.1016/j.toxlet.2013.05.358
Araujo, SD; Costa, VM; Pereira, FC; Fernandes, E; Bastos, MD; Carvalho, FD; Capela, JP. 2013. 'Ecstasy' and amphetamine neurotoxicity to cultured rat cortical neurons in a continuous exposure model. TOXICOLOGY LETTERS, 221, S233-S233. DOI: 10.1016/j.toxlet.2013.05.569
Ribeiro, D; Freitas, M; Tome, SM; Silva, AMS; Porto, G; Fernandes, E. 2013. A structure-activity relationship study of flavonoids as dual inhibitors of LOX and COX. FREE RADICAL BIOLOGY AND MEDICINE, 65, S47-S47. DOI: 10.1016/j.freeradbiomed.2013.08.075
Couto, D; Dias, I; Freitas, M; Porto, G; Lopez-Quintela, MA; Rivas, J; Freitas, P; Carvalho, F; Fernandes, E. 2013. Polyacrylic acid coated and naked iron oxide nanoparticles: Their effects on neutrophils' oxidative burst and inflammatory process. FREE RADICAL BIOLOGY AND MEDICINE, 65, S27-S28. DOI: 10.1016/j.freeradbiomed.2013.08.022
Chiste, RC; Freitas, M; Mercadante, AZ; Fernandes, E. 2013. Carotenoids inhibit peroxyl radical-induced oxidation of hemoglobin and lipids in human erythrocytes. FREE RADICAL BIOLOGY AND MEDICINE, 65, S46-S47. DOI: 10.1016/j.freeradbiomed.2013.08.074
Chiste, RC; Freitas, M; Mercadante, AZ; Fernandes, E. 2013. Carotenoids inhibit lipid peroxidation induced by tert-butyl hydroperoxide, but not the depletion of glutathione induced by peroxyl radicals in human erythrocytes. FREE RADICAL BIOLOGY AND MEDICINE, 65, S30-S30. DOI: 10.1016/j.freeradbiomed.2013.08.028
Soares, J; Pereira, N; Leao, M; Pereira, C; Santos, M; Saraiva, L. 2013. A new p53 activator with potential antitumor activity discovered using yeast-based assays. YEAST, 30, 200-200. DOI:
Oliveira, AP; Matos, RP; Silva, ST; Andrade, PB; Ferreres, F; Gil-Izquierdo, A; Meireles, S; Brandao, TM; Valentao, P. 2013. A New Iced Tea Base Herbal Beverage with Spergularia rubra Extract: Metabolic Profile Stability and In Vitro Enzyme Inhibition. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61, 8650-8656. DOI: 10.1021/jf401884u
Soares, AS; Costa, VM; Diniz, C; Fresco, P. 2013. Potentiation of cytotoxicity of paclitaxel in combination with Cl-IB-MECA in human C32 metastatic melanoma cells: A new possible therapeutic strategy for melanoma. BIOMEDICINE & PHARMACOTHERAPY, 67, 777-789. DOI: 10.1016/j.biopha.2013.08.003
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Valentao, P; Andrade, PB. 2013. Ellagic Acid and Derivatives from Cochlospermum angolensis Welw. Extracts: HPLC-DAD-ESI/MSn Profiling, Quantification and In Vitro Anti-depressant, Anti-cholinesterase and Anti-oxidant Activities. PHYTOCHEMICAL ANALYSIS, 24, 534-540. DOI: 10.1002/pca.2429
Bessa, C; Pereira, C; Leao, M; Maciel, C; Gomes, S; Goncalves, J; Corte-Real, M; Costa, V; Saraiva, L. 2013. Using yeast to uncover the regulation of protein kinase C delta by ceramide. FEMS YEAST RESEARCH, 13, 700-705. DOI: 10.1111/1567-1364.12069
Costa, P; Goncalves, S; Valentao, P; Andrade, PB; Almeida, C; Nogueira, JMF; Romano, A. 2013. Metabolic profile and biological activities of Lavandula pedunculata subsp lusitanica (Chaytor) Franco: Studies on the essential oil and polar extracts. FOOD CHEMISTRY, 141, 2501-2506. DOI: 10.1016/j.foodchem.2013.05.055
Pereira, DM; Valentao, P; Teixeira, N; Andrade, PB. 2013. Amino acids, fatty acids and sterols profile of some marine organisms from Portuguese waters. FOOD CHEMISTRY, 141, 2412-2417. DOI: 10.1016/j.foodchem.2013.04.120
Grosso, C; Valentao, P; Ferreres, F; Andrade, PB. 2013. The Use of Flavonoids in Central Nervous System Disorders. CURRENT MEDICINAL CHEMISTRY, 20, 4694-4719. DOI:
Leao, M; Gomes, S; Soares, J; Bessa, C; Maciel, C; Ciribilli, Y; Pereira, C; Inga, A; Saraiva, L. 2013. Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity. FEBS Journal, 280, 6498-6507. DOI: 10.1111/febs.12552
Pinho, BR; Ferreres, F; Valentao, P; Andrade, PB. 2013. Nature as a source of metabolites with cholinesterase-inhibitory activity: an approach to Alzheimer's disease treatment. JOURNAL OF PHARMACY AND PHARMACOLOGY, 65, 1681-1700. DOI: 10.1111/jphp.12081
Silva, LR; Pereira, MJ; Azevedo, J; Mulas, R; Velazquez, E; Gonzalez-Andres, F; Valentao, P; Andrade, PB. 2013. Inoculation with Bradyrhizobium japonicum enhances the organic and fatty acids content of soybean (Glycine max (L.) Merrill) seeds. FOOD CHEMISTRY, 141, 3636-3648. DOI: 10.1016/j.foodchem.2013.06.045
Goncalves, RF; Silva, AMS; Silva, AM; Valentao, P; Ferreres, F; Gil-Izquierdo, A; Silva, JB; Santos, D; Andrade, PB. 2013. Influence of taro (Colocasia esculenta L. Shott) growth conditions on the phenolic composition and biological properties. FOOD CHEMISTRY, 141, 3480-3485. DOI: 10.1016/j.foodchem.2013.06.009
Benfeito, S; Silva, T; Garrido, J; Andrade, PB; Sottomayor, MJ; Borges, F; Garrido, EM. 2014. Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity. Biomed Research International. DOI: 10.1155/2014/709036
Pereira, DM; Correia-da-Silva, G; Valentao, P; Teixeira, N; Andrade, PB. 2014. Palmitic Acid and Ergosta-7,22-dien-3-ol Contribute to the Apoptotic Effect and Cell Cycle Arrest of an Extract from Marthasterias glacialis L. in Neuroblastoma Cells. Marine Drugs, 12, 54-68. DOI: 10.3390/md12010054
Pereira, DM; Correia-da-Silva, G; Valentao, P; Teixeira, N; Andrade, PB. 2014. GC-MS Lipidomic Profiling of the Echinoderm Marthasterias glacialis and Screening for Activity Against Human Cancer and Non-Cancer Cell Lines. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 17, 450-457. DOI:
Freitas, M; Viswanathan, S; Nouws, HPA; Oliveira, MBPP; Delerue-Matos, C. 2014. Iron oxide/gold core/shell nanomagnetic probes and CdS biolabels for amplified electrochemical immunosensing of Salmonella typhimurium. BIOSENSORS & BIOELECTRONICS, 51, 195-200. DOI: 10.1016/j.bios.2013.07.048
Silva, LR; Azevedo, J; Pereira, MJ; Carro, L; Velazquez, E; Peix, A; Valentao, P; Andradet, PB. 2014. Inoculation of the Nonlegume Capsicum annuum L. with Rhizobium Strains. 2. Changes in Sterols, Triterpenes, Fatty Acids, and Volatile Compounds. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62, 565-573. DOI: 10.1021/jf4046655
Silva, LR; Azevedo, J; Pereira, MJ; Carro, L; Velazquez, E; Peix, A; Valentao, P; Andradet, PB. 2014. Inoculation of the Nonlegume Capsicum annuum (L.) with Rhizobium Strains. 1. Effect on Bioactive Compounds, Antioxidant Activity, and Fruit Ripeness. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62, 557-564. DOI: 10.1021/jf4046649
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Valentao, P; Andrade, PB. 2014. Assessing Jasminum grandzflorum L. authenticity by HPLC-DAD-ESI/MSn and effects on physiological enzymes and oxidative species. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 88, 157-161. DOI: 10.1016/j.jpba.2013.08.040
Couto, D; Freitas, M; Vilas-Boas, V; Dias, I; Porto, G; Lopez-Quintela, MA; Rivas, J; Freitas, P; Carvalho, F; Fernandes, E. 2014. Interaction of polyacrylic acid coated and non-coated iron oxide nanoparticles with human neutrophils. TOXICOLOGY LETTERS, 225, 57-65. DOI: 10.1016/j.toxlet.2013.11.020
Pereira, DM; Correia-da-Silva, G; Valenta, P; Teixeira, N; Andrade, PB. 2014. Anti-Inflammatory Effect of Unsaturated Fatty Acids and Ergosta-7,22-dien-3-ol from Marthasterias glacialis: Prevention of CHOP-Mediated ER-Stress and NF-kappa B Activation. PLoS One, 9. DOI: 10.1371/journal.pone.0088341
Pinho, BR; Sousa, C; Valentao, P; Oliveira, JMA; Andrade, PB. 2014. Modulation of Basophils' Degranulation and Allergy-Related Enzymes by Monomeric and Dimeric Naphthoquinones. PLoS One, 9. DOI: 10.1371/journal.pone.0090122
Taveira, M; Sousa, C; Valentao, P; Ferreres, F; Teixeira, JP; Andrade, PB. 2014. Neuroprotective effect of steroidal alkaloids on glutamate-induced toxicity by preserving mitochondrial membrane potential and reducing oxidative stress. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 140, 106-115. DOI: 10.1016/j.jsbmb.2013.12.013
Patinha, D; Afonso, J; Sousa, T; Morato, M; Albino-Teixeira, A. 2014. Activation of adenosine receptors improves renal antioxidant status in diabetic Wistar but not SHR rats. UPSALA JOURNAL OF MEDICAL SCIENCES, 119, 10-18. DOI: 10.3109/03009734.2013.851748
Lopes, G; Daletos, G; Proksch, P; Andrade, PB; Valentao, P. 2014. Anti-Inflammatory Potential of Monogalactosyl Diacylglycerols and a Monoacylglycerol from the Edible Brown Seaweed Fucus spiralis Linnaeus. Marine Drugs, 12, 1406-1418. DOI: 10.3390/md12031406
Chiste, RC; Freitas, M; Mercadante, AZ; Fernandes, E. 2014. Carotenoids inhibit lipid peroxidation and hemoglobin oxidation, but not the depletion of glutathione induced by ROS in human erythrocytes. LIFE SCIENCES, 99, 52-60. DOI: 10.1016/j.lfs.2014.01.059
Pereira, C; Lopes-Rodrigues, V; Coutinho, I; Neves, MP; Lima, RT; Pinto, M; Cidade, H; Vasconcelos, MH; Saraiva, L. 2014. Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and-7 screening assays. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 54, 8-16. DOI: 10.1016/j.ejps.2013.12.017
Grosso, C; Valentao, P; Ferreres, F; Andrade, PB. 2014. Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases. Marine Drugs, 12, 2539-2589. DOI: 10.3390/md12052539
Soares, AS; Costa, VM; Diniz, C; Fresco, P. 2014. Combination of Cl-IB-MECA with paclitaxel is a highly effective cytotoxic therapy causing mTOR-dependent autophagy and mitotic catastrophe on human melanoma cells. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 140, 921-935. DOI: 10.1007/s00432-014-1645-z
Pereira, C; Martins, LM; Saraiva, L. 2014. LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1840, 2025-2031. DOI: 10.1016/j.bbagen.2014.02.015
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Valentao, P; Azevedo, C; Andrade, PB. 2014. HPLC-DAD-ESI/MSn analysis of phenolic compounds for quality control of Grindelia robusta Nutt. and bioactivities. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 94, 163-172. DOI: 10.1016/j.jpba.2014.01.046
Moita, E; Sousa, C; Andrade, PB; Fernandes, F; Pinho, BR; Silva, LR; Valentao, P. 2014. Effects of Echium plantagineum L. Bee Pollen on Basophil Degranulation: Relationship with Metabolic Profile. MOLECULES, 19, 10635-10649. DOI: 10.3390/molecules190710635
Patinha, D; Afonso, J; Sousa, T; Morato, M; Albino-Teixeira, A. 2014. Diabetes-induced increase of renal medullary hydrogen peroxide and urinary angiotensinogen is similar in normotensive and hypertensive rats. LIFE SCIENCES, 108, 71-79. DOI: 10.1016/j.lfs.2014.05.011
Barbosa, DJ; Serrat, R; Mirra, S; Quevedo, M; de Barreda, EG; Avila, J; Fernandes, E; Bastos, MDL; Capela, JP; Carvalho, F; Soriano, E. 2014. MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner. ARCHIVES OF TOXICOLOGY, 88, 1561-1572. DOI: 10.1007/s00204-014-1209-7
Sousa, JB; Vieira-Rocha, MS; Sa, C; Ferreirinha, F; Correia-de-Sa, P; Fresco, P; Diniz, C. 2014. Lack of Endogenous Adenosine Tonus on Sympathetic Neurotransmission in Spontaneously Hypertensive Rat Mesenteric Artery. PLoS One, 9. DOI: 10.1371/journal.pone.0105540
Bessa, C; Harilal, N; Pereira, C; Maciel, C; Goncalves, J; Rijo, P; Simoes, MF; Saraiva, L. 2014. A selective activator of protein kinase C discovered using yeast. FEBS Journal, 281, 431-432. DOI:
Ferreres, F; Oliveira, AP; Gil-Izquierdo, A; Valentao, P; Andrade, PB. 2014. Piper betle Leaves: Profiling Phenolic Compounds by HPLC/DAD-ESI/MSn and Anti-cholinesterase Activity. PHYTOCHEMICAL ANALYSIS, 25, 453-460. DOI: 10.1002/pca.2515
Barbosa, M; Valentao, P; Andrade, PB. 2014. Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases. Marine Drugs, 12, 4934-4972. DOI: 10.3390/md12094934
Chiste, RC; Freitas, M; Mercadante, AZ; Fernandes, E. 2014. Carotenoids are Effective Inhibitors of in vitro Hemolysis of Human Erythrocytes, as Determined by a Practical and Optimized Cellular Antioxidant Assay. JOURNAL OF FOOD SCIENCE, 79, H1841-H1847. DOI: 10.1111/1750-3841.12580
Quintas, C; Pinho, D; Pereira, C; Saraiva, L; Goncalves, J; Queiroz, G. 2014. Microglia P2Y(6) receptors mediate nitric oxide release and astrocyte apoptosis. Journal of Neuroinflammation, 11. DOI: 10.1186/s12974-014-0141-3
Azevedo, R; Costa, VM; Barbosa, D; Gomes, A; Pita, I; Sequeira, A; Pereira, F; Duarte-Araujo, M; Duarte, JA; Fernandes, E; Bastos, ML; Carvalho, F; Capela, J. 2014. Aged rats are more prone to "ecstasy" neurotoxicity than adolescent rats. TOXICOLOGY LETTERS, 229, S241-S241. DOI: 10.1016/j.toxlet.2014.06.804
Nogueira, TB; Araujo, SD; Carvalho, F; Pereira, FC; Fernandes, E; Bastos, ML; Costa, VM; Capela, JP. 2014. MODELING CHRONIC BRAIN EXPOSURE TO AMPHETAMINES USING PRIMARY RAT NEURONAL CORTICAL CULTURES. NEUROSCIENCE, 277, 417-434. DOI: 10.1016/j.neuroscience.2014.07.009
Soares, AS; Costa, VM; Diniz, C; Fresco, P. 2014. The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 74, 847-860. DOI: 10.1007/s00280-014-2557-y
Mariutti, LRB; Rodrigues, E; Chiste, RC; Fernandes, E; Mercadante, AZ. 2014. The Amazonian fruit Byrsonima crassifolia effectively scavenges reactive oxygen and nitrogen species and protects human erythrocytes against oxidative damage. FOOD RESEARCH INTERNATIONAL, 64, 618-625. DOI: 10.1016/j.foodres.2014.07.032
Piston, M; Machado, I; Branco, CS; Cesio, V; Heinzen, H; Ribeiro, D; Fernandes, E; Chiste, RC; Freitas, M. 2014. Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynara cardunculus L. subsp cardunculus) are effective scavengers of physiologically relevant ROS and RNS. FOOD RESEARCH INTERNATIONAL, 64, 150-156. DOI: 10.1016/j.foodres.2014.05.078
Moreira-Rodrigues, M; Graca, AL; Ferreira, M; Afonso, J; Serrao, P; Morato, M; Ferreirinha, F; Correia-de-Sa, P; Ebert, SN; Moura, D. 2014. Attenuated Aortic Vasodilation and Sympathetic Prejunctional Facilitation in Epinephrine-Deficient Mice: Selective Impairment of beta(2)-Adrenoceptor Responses. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 351, 243-249. DOI: 10.1124/jpet.114.217281
Rebelo, MJ; Sousa, C; Valentao, P; Rego, R; Andrade, PB. 2014. Phenolic profile of Douro wines and evaluation of their (NO)-N-center dot scavenging capacity in LPS-stimulated RAW 264.7 macrophages. FOOD CHEMISTRY, 163, 16-22. DOI: 10.1016/j.foodchem.2014.04.070
Grosso, C; Ferreres, F; Gil-Izquierdo, A; Valentao, P; Sampaio, M; Lima, J; Andrade, PB. 2014. Box-Behnken factorial design to obtain a phenolic-rich extract from the aerial parts of Chelidonium majus L.. TALANTA, 130, 128-136. DOI: 10.1016/j.talanta.2014.06.043
Pereira, DM; Valentao, P; Andrade, PB. 2014. Nano- and Microdelivery Systems for Marine Bioactive Lipids. Marine Drugs, 12, 6014-6027. DOI: 10.3390/md12126014
Ribeiro, AB; Chiste, RC; Freitas, M; da Silva, AF; Visentainer, JV; Fernandes, E. 2014. Psidium cattleianum fruit extracts are efficient in vitro scavengers of physiologically relevant reactive oxygen and nitrogen species. FOOD CHEMISTRY, 165, 140-148. DOI: 10.1016/j.foodchem.2014.05.079
Samardjieva, KA; Goncalves, RF; Valentao, P; Andrade, PB; Pissarra, J; Pereira, S; Tavares, F. 2015. Zinc Accumulation and Tolerance in Solanum nigrum are Plant Growth Dependent. INTERNATIONAL JOURNAL OF PHYTOREMEDIATION, 17, 272-279. DOI: 10.1080/15226514.2014.898018
Soares, AS; Costa, VM; Diniz, C; Fresco, P. 2015. Inosine Strongly Enhances Proliferation of Human C32 Melanoma Cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K Pathways. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 116, 25-36. DOI: 10.1111/bcpt.12280
Leao, M; Gomes, S; Bessa, C; Soares, J; Raimundo, L; Monti, P; Fronza, G; Pereira, C; Saraiva, L. 2015. Studying p53 family proteins in yeast: Induction of autophagic cell death and modulation by interactors and small molecules. EXPERIMENTAL CELL RESEARCH, 330, 164-177. DOI: 10.1016/j.yexcr.2014.09.028
Pereira, RB; Taveira, M; Valentao, P; Sousa, C; Andrade, PB. 2015. Fatty acids from edible sea hares: anti-inflammatory capacity in LPS-stimulated RAW 264.7 cells involves iNOS modulation. RSC Advances, 5, 8981-8987. DOI: 10.1039/c4ra14333g
Sousa, JB; Fresco, P; Diniz, C. 2015. Endothelial dysfunction impairs vascular neurotransmission in tail arteries. NEUROCHEMISTRY INTERNATIONAL, 80, 7-13. DOI: 10.1016/j.neuint.2014.11.001
Couto, D; Freitas, M; Carvalho, F; Fernandes, E. 2015. Iron Oxide Nanoparticles: An Insight into their Biomedical Applications. CURRENT MEDICINAL CHEMISTRY, 22, 1808-1828. DOI:
Gomes, A; Capela, JP; Ribeiro, D; Freitas, M; Silva, AMS; Pinto, DCGA; Santos, CMM; Cavaleiro, JAS; Lima, JLFC; Fernandes, E. 2015. Inhibition of NF-kB Activation and Cytokines Production in THP-1 Monocytes by 2-Styrylchromones. Medicinal Chemistry, 11, 560-566. DOI:
Berto, A; Ribeiro, AB; Sentandreu, E; de Souza, NE; Mercadante, AZ; Chiste, RC; Fernandes, E. 2015. The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts. Food & Function, 6, 3081-3090. DOI: 10.1039/c5fo00722d
Ribeiro, AB; Berto, A; Ribeiro, D; Freitas, M; Chiste, RC; Visentainer, JV; Fernandes, E. 2015. Stem bark and flower extracts of Vismia cauliflora are highly effective antioxidants to human blood cells by preventing oxidative burst in neutrophils and oxidative damage in erythrocytes. PHARMACEUTICAL BIOLOGY, 53, 1691-1698. DOI: 10.3109/13880209.2014.1001407
Ribeiro, AB; Berto, A; Chiste, RC; Freitas, M; Visentainer, JV; Fernandes, E. 2015. Bioactive compounds and scavenging capacity of extracts from different parts of Vismia cauliflora against reactive oxygen and nitrogen species. PHARMACEUTICAL BIOLOGY, 53, 1267-1276. DOI: 10.3109/13880209.2014.974063
Chiste, RC; Freitas, M; Mercadante, AZ; Fernandes, E. 2015. Superoxide Anion Radical: Generation and Detection in Cellular and Non-Cellular Systems. CURRENT MEDICINAL CHEMISTRY, 22, 4234-4256. DOI: 10.2174/0929867322666151029104311
Naghavi, M; Wang, HD; Lozano, R; Davis, A; Liang, XF; Zhou, MG; Vollset, SE; Ozgoren, AA; Abdalla, S; Abd-Allah, F; Aziz, MIA; Abera, SF; Aboyans, V; Abraham, B; Abraham, JP; Abuabara, KE; Abubakar, I; Abu-Raddad, LJ; Abu-Rmeileh, NME; Achoki, T; Ade. 2015. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. LANCET, 385, 117-171. DOI: 10.1016/S0140-6736(14)61682-2
Soares, J; Pereira, NAL; Monteiro, A; Leao, M; Bessa, C; dos Santos, DJVA; Rairnundo, L; Queiroz, G; Bisio, A; Inga, A; Pereira, C; Santos, MMM; Saraiva, L. 2015. Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 66, 138-147. DOI: 10.1016/j.ejps.2014.10.006
Rocha, J; Eduardo-Figueira, M; Barateiro, A; Fernandes, A; Brites, D; Pinto, R; Freitas, M; Fernandes, E; Mota-Filipe, H; Sepodes, B. 2015. Erythropoietin Reduces Acute Lung Injury and Multiple Organ Failure/Dysfunction Associated to a Scald-Burn Inflammatory Injury in the Rat. INFLAMMATION, 38, 312-326. DOI: 10.1007/s10753-014-0035-7
Girones-Vilaplana, A; Valentao, P; Andrade, PB; Ferreres, F; Moreno, DA; Garcia-Viguera, C. 2015. Beverages of lemon juice and exotic noni and papaya with potential for anticholinergic effects. FOOD CHEMISTRY, 170, 16-21. DOI: 10.1016/j.foodchem.2014.08.021
Grosso, C; Valentao, P; Andrade, C; Andrade, PB. 2015. HPLC-DAD analysis and in vitro enzyme inhibition: An integrated approach to predict herbal binary mixture behaviour employing median effect equation. MICROCHEMICAL JOURNAL, 119, 176-182. DOI: 10.1016/j.microc.2014.12.006
Barroso, MF; Freitas, M; Oliveira, MBPP; de-los-Santos-Alvarez, N; Lobo-Castanon, MJ; Delerue-Matos, C. 2015. 3D-nanostructured Au electrodes for the event-specific detection of MON810 transgenic maize. TALANTA, 134, 158-164. DOI: 10.1016/j.talanta.2014.10.017
Silva, S; Sepodes, B; Rocha, J; Direito, R; Fernandes, A; Brites, D; Freitas, M; Fernandes, E; Bronze, MR; Figueira, ME. 2015. Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 26, 360-368. DOI: 10.1016/j.jnutbio.2014.11.011
Pereira, C; Costa, V; Martins, LM; Saraiva, L. 2015. A yeast model of the Parkinson's disease-associated protein Parkin. EXPERIMENTAL CELL RESEARCH, 333, 73-79. DOI: 10.1016/j.yexcr.2015.02.018
Flores-Felix, JD; Silva, LR; Rivera, LP; Marcos-Garcia, M; Garcia-Fraile, P; Martinez-Molina, E; Mateos, PF; Velazquez, E; Andrade, P; Rivas, R. 2015. Plants Probiotics as a Tool to Produce Highly Functional Fruits: The Case of Phyllobacterium and Vitamin C in Strawberries. PLoS One, 10. DOI: 10.1371/journal.pone.0122281
Couto, D; Sousa, R; Andrade, L; Leander, M; Lopez-Quintela, MA; Rivas, J; Freitas, P; Lima, M; Porto, G; Porto, B; Carvalho, F; Fernandes, E. 2015. Polyacrylic acid coated and non-coated iron oxide nanoparticles are not genotoxic to human T lymphocytes. TOXICOLOGY LETTERS, 234, 67-73. DOI: 10.1016/j.toxlet.2015.02.010
Teixeira, J; Oliveira, C; Amorim, R; Silva, T; Cagide, F; Garrido, J; Oliveira, PJ; Andrade, PB; Borges, F. 2015. Targeting dietary phenolic acids to mitochondria: improving hydroxybenzoic acids antioxidant properties. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 45, 31-31. DOI:
Soares, J; Raimundo, L; Pereira, NAL; dos Santos, DJVA; Perez, M; Queiroz, G; Leao, M; Santos, MMM; Saraiva, L. 2015. A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins. PHARMACOLOGICAL RESEARCH, 95-96, 42-52. DOI: 10.1016/j.phrs.2015.03.006
Vos, T; Barber, RM; Bell, B; Bertozzi-Villa, A; Biryukov, S; Bolliger, I; Charlson, F; Davis, A; Degenhardt, L; Dicker, D; Duan, L; Erskine, H; Feigin, VL; Ferrari, AJ; Fitzmaurice, C; Fleming, T; Graetz, N; Guinovart, C; Haagsma, J; Hansen, GM; Hans. 2015. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. LANCET, 386, 743-800. DOI: 10.1016/S0140-6736(15)60692-4
Ribeiro, D; Freitas, M; Lima, JLFC; Fernandes, E. 2015. Proinflammatory Pathways: The Modulation by Flavonoids. MEDICINAL RESEARCH REVIEWS, 35, 877-936. DOI: 10.1002/med.21347
Couto, D; Freitas, M; Porto, G; Lopez-Quintela, MA; Rivas, J; Freitas, P; Carvalho, F; Fernandes, E. 2015. Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways. ARCHIVES OF TOXICOLOGY, 89, 1759-1769. DOI: 10.1007/s00204-014-1325-4
Silva, P; Fernandes, E; Carvalho, F. 2015. Dual effect of red wine on liver redox status: a concise and mechanistic review. ARCHIVES OF TOXICOLOGY, 89, 1681-1693. DOI: 10.1007/s00204-015-1538-1
Teixeira-Gomes, A; Costa, VM; Feio-Azevedo, R; Duarte, J; Duarte-Araujo, M; Fernandes, E; Bastos, ML; Carvalho, F; Capela, J. 2015. "Ecstasy" acute toxicity to the brain and peripheral organs in adolescent rats following a human relevant binge dose. TOXICOLOGY LETTERS, 238, S156-S156. DOI: 10.1016/j.toxlet.2015.08.486
Soares, T; Ribeiro, D; Fernandes, E; Freitas, M. 2015. Size-dependent cytotoxicity of silver nanoparticles in human neutrophils. TOXICOLOGY LETTERS, 238, S216-S216. DOI: 10.1016/j.toxlet.2015.08.640
Ribeiro, D; Kupski, L; Furlong, EB; Freitas, M; Fernandes, E. 2015. Pro-inflammatory and toxic effects of ochratoxin and ochratoxin alpha in human neutrophils. TOXICOLOGY LETTERS, 238, S88-S88. DOI: 10.1016/j.toxlet.2015.08.294
Garcia, J; Costa, VM; Carvalho, A; Silvestre, R; Duarte, A; Dourado, D; Oliveira, R; Baptista, P; Bastos, ML; Carvalho, F. 2015. Discovery of an effective antidote for Amanita phalloides poisoning. TOXICOLOGY LETTERS, 238, S157-S157. DOI: 10.1016/j.toxlet.2015.08.487
Fonseca, DA; Guerra, AF; Carvalho, F; Fernandes, E; Ferreira, L; Antunes, P; Antunes, M; Cotrim, MD. 2015. The influence of hyperthermia on the vascular effects of MDMA and its metabolites. TOXICOLOGY LETTERS, 238, S377-S377. DOI: 10.1016/j.toxlet.2015.08.1076
Oliveira, M; Pereira, C; Bessa, C; Araujo, R; Saraiva, L. 2015. Chronological aging in conidia of pathogenic Aspergillus: Comparison between species. JOURNAL OF MICROBIOLOGICAL METHODS, 118, 57-63. DOI: 10.1016/j.mimet.2015.08.021
Berto, A; Ribeiro, AB; de Souza, NE; Fernandes, E; Chiste, RC. 2015. Bioactive compounds and scavenging capacity of pulp, peel and seed extracts of the Amazonian fruit Quararibea cordata against ROS and RNS. FOOD RESEARCH INTERNATIONAL, 77, 236-243. DOI: 10.1016/j.foodres.2015.06.018
Flores-Felix, JD; Marcos-Garcia, M; Silva, LR; Menendez, E; Martinez-Molina, E; Mateos, PF; Velazquez, E; Garcia-Fraile, P; Andrade, P; Rivas, R. 2015. Rhizobium as plant probiotic for strawberry production under microcosm conditions. SYMBIOSIS, 67, 25-32. DOI: 10.1007/s13199-015-0373-8
Teixeira, R; Dopico-Garcia, S; Andrade, PB; Valentao, P; Lopez-Vilarino, JM; Gonzalez-Rodriguez, V; Cela-Perez, C; Silva, LR. 2015. Volatile phenols depletion in red wine using molecular imprinted polymers. JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 52, 7735-7746. DOI: 10.1007/s13197-015-1892-2
Leao, M; Soares, J; Gomes, S; Raimundo, L; Ramos, H; Bessa, C; Queiroz, G; Domingos, S; Pinto, M; Inga, A; Cidade, H; Saraiva, L. 2015. Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction. LIFE SCIENCES, 142, 60-65. DOI: 10.1016/j.lfs.2015.10.015
Forouzanfar, MH; Alexander, L; Anderson, HR; Bachman, VF; Biryukov, S; Brauer, M; Burnett, R; Casey, D; Coates, MM; Cohen, A; Delwiche, K; Estep, K; Frostad, JJ; Astha, KC; Kyu, HH; Moradi-Lakeh, M; Ng, M; Slepak, EL; Thomas, BA; Wagner, J; Aasvang, . 2015. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. LANCET, 386, 2287-2323. DOI: 10.1016/S0140-6736(15)00128-2
Correia-Costa, L; Sousa, T; Morato, M; Cosme, D; Afonso, J; Moura, C; Mota, C; Areias, JC; Guerra, A; Schaefer, F; Afonso, AC; Barros, H; Albino-Teixeira, A; Azevedo, A. 2016. Association of myeloperoxidase levels with cardiometabolic factors and renal function in prepubertal children. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 46, 50-59. DOI: 10.1111/eci.12564
Soares, T; Ribeiro, D; Proenca, C; Chiste, RC; Fernandes, E; Freitas, M. 2016. Size-dependent cytotoxicity of silver nanoparticles in human neutrophils assessed by multiple analytical approaches. LIFE SCIENCES, 145, 247-254. DOI: 10.1016/j.lfs.2015.12.046
Soares, J; Raimundo, L; Pereira, NAL; Monteiro, A; Gomes, S; Bessa, C; Pereira, C; Queiroz, G; Bisio, A; Fernandes, J; Gomes, C; Reis, F; Goncalves, J; Inga, A; Santos, MMM; Saraiva, L. 2016. Reactivation of wild-type and mutant p53 by tryptophanol-derived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule. Oncotarget, 7, 4326-4343. DOI:
Chiste, RC; Ribeiro, D; Freitas, M; Leite, A; Moniz, T; Rangel, M; Fernandes, E. 2016. Uncovering novel 3-hydroxy-4-pyridinone metal ion complexes with potential anti-inflammatory properties. JOURNAL OF INORGANIC BIOCHEMISTRY, 155, 9-16. DOI: 10.1016/j.jinorgbio.2015.11.009
Oliveira, M; Pereira, C; Bessa, C; Araujo, R; Saraiva, L. 2016. Hydrogen peroxide-induced secondary necrosis in conidia of Aspergillus fumigatus. CANADIAN JOURNAL OF MICROBIOLOGY, 62, 95-101. DOI: 10.1139/cjm-2015-0561
Gomes, S; Leao, M; Raimundo, L; Ramos, H; Soares, J; Saraiva, L. 2016. p53 family interactions and yeast: together in anticancer therapy. DRUG DISCOVERY TODAY, 21, 616-624. DOI: 10.1016/j.drudis.2016.02.007
Proenca, C; Albuquerque, HMT; Ribeiro, D; Freitas, M; Santos, CMM; Silva, AMS; Fernandes, E. 2016. Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 115, 381-392. DOI: 10.1016/j.ejmech.2016.03.043
Teixeira-Gomes, A; Costa, VM; Feio-Azevedo, R; Duarte, JA; Duarte-Araujo, M; Fernandes, E; Bastos, MD; Carvalho, F; Capela, JP. 2016. "Ecstasy" toxicity to adolescent rats following an acute low binge dose. BMC Pharmacology & Toxicology, 17. DOI: 10.1186/s40360-016-0070-0
Casas, MP; Rodriguez-Hermida, V; Perez-Larran, P; Conde, E; Liveri, MT; Ribeiro, D; Fernandes, E; Dominguez, H. 2016. In vitro bioactive properties of phlorotannins recovered from hydrothermal treatment of Sargassum muticum. SEPARATION AND PURIFICATION TECHNOLOGY, 167, 117-126. DOI: 10.1016/j.seppur.2016.05.003
Silva, S; Carvalho, F; Fernandes, E; Antunes, MJ; Cotrim, MD. 2016. Contractile effects of 3,4-methylenedioxymethamphetamine on the human internal mammary artery. TOXICOLOGY IN VITRO, 34, 187-193. DOI: 10.1016/j.tiv.2016.04.002
Barizao, EO; Visentainer, JV; Almeida, VD; Ribeiro, D; Chiste, RC; Fernandes, E. 2016. Citharexylum solanaceum fruit extracts: Profiles of phenolic compounds and carotenoids and their relation with ROS and RNS scavenging capacities. FOOD RESEARCH INTERNATIONAL, 86, 24-33. DOI: 10.1016/j.foodres.2016.05.007
Kupski, L; Freitas, M; Ribeiro, D; Furlong, EB; Fernandes, E. 2016. Ochratoxin A activates neutrophils and kills these cells through necrosis, an effect eliminated through its conversion into ochratoxin alpha. TOXICOLOGY, 368, 91-102. DOI: 10.1016/j.tox.2016.09.001
Tavares-da-Silva, EJ; Varela, CL; Pires, AS; Encarnacao, JC; Abrantes, AM; Botelho, MF; Carvalho, RA; Proenca, C; Freitas, M; Fernandes, E; Roleira, FMF. 2016. Combined dual effect of modulation of human neutrophils' oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives. BIOORGANIC & MEDICINAL CHEMISTRY, 24, 3556-3564. DOI: 10.1016/j.bmc.2016.05.065
Sousa, JLC; Proenca, C; Freitas, M; Fernandes, E; Silva, AMS. 2016. New polyhydroxylated flavon-3-ols and 3-hydroxy-2-styrylchromones: synthesis and ROS/RNS scavenging activities. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 119, 250-259. DOI: 10.1016/j.ejmech.2016.04.057
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Lemos, A; Leao, M; Soares, J; Palmeira, A; Pinto, M; Saraiva, L; Sousa, ME. 2016. Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction. MEDICINAL RESEARCH REVIEWS, 36, 789-844. DOI: 10.1002/med.21393
Figueira, ME; Oliveira, M; Direito, R; Rocha, J; Alves, P; Serra, AT; Duarte, C; Bronze, R; Fernandes, A; Brites, D; Freitas, M; Fernandes, E; Sepodes, B. 2016. Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat. BIOMEDICINE & PHARMACOTHERAPY, 83, 1191-1202. DOI: 10.1016/j.biopha.2016.08.040
Florez, N; Gonzalez-Munoz, MJ; Ribeiro, D; Fernandes, E; Dominguez, H; Freitas, M. 2017. Algae Polysaccharides' Chemical Characterization and their Role in the Inflammatory Process. CURRENT MEDICINAL CHEMISTRY, 24, 149-175. DOI: 10.2174/0929867323666161028160416
Felix, L; Oliveira, MM; Videira, R; Maciel, E; Alves, ND; Nunes, FM; Alves, A; Almeida, JM; Domingues, MRM; Peixoto, FP. 2017. Carvedilol exacerbate gentamicin-induced kidney mitochondrial alterations in adult rat. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 69, 83-92. DOI: 10.1016/j.etp.2016.11.006
Rodrigues, D; Freitas, M; Costa, VM; Lopez-Quintela, MA; Rivas, J; Freitas, P; Carvalho, F; Fernandes, E; Silva, P. 2017. Quantitative histochemistry for macrophage biodistribution on mice liver and spleen after the administration of a pharmacological-relevant dose of polyacrylic acid-coated iron oxide nanoparticles. Nanotoxicology, 11, 256-266. DOI: 10.1080/17435390.2017.1291865
Boeing, JS; Ribeiro, D; Chiste, RC; Visentainer, JV; Costa, VM; Freitas, M; Fernandes, E. 2017. Chemical characterization and protective effect of the Bactris setosa Mart. fruit against oxidative/nitrosative stress. FOOD CHEMISTRY, 220, 427-437. DOI: 10.1016/j.foodchem.2016.09.188
Valente, MJ; Bastos, MDL; Fernandes, E; Carvalho, F; de Pinho, PG; Carvalho, M. 2017. Neurotoxicity of beta-Keto Amphetamines: Deathly Mechanisms Elicited by Methylone and MDPV in Human Dopaminergic SH-SY5Y Cells. ACS Chemical Neuroscience, 8, 850-859. DOI: 10.1021/acschemneuro.6b00421
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Santos, CMM; Ribeiro, D; Silva, AMS; Fernandes, E. 2017. 2,3-Diarylxanthones as Potential Inhibitors of Arachidonic Acid Metabolic Pathways. INFLAMMATION, 40, 956-964. DOI: 10.1007/s10753-017-0540-6
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Sousa, C; Moita, E; Valentao, P; Fernandes, F; Monteiro, P; Andrade, PB. 2015. Effects of Colored and Noncolored Phenolics of Echium plantagineum L. Bee Pollen in Caco-2 Cells under Oxidative Stress Induced by tert-Butyl Hydroperoxide. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63, 2083-2091. DOI: 10.1021/jf505568h
Grosso, C; Valentao, P; Ferreres, F; Andrade, PB. 2015. Alternative and Efficient Extraction Methods for Marine-Derived Compounds. Marine Drugs, 13, 3182-3230. DOI: 10.3390/md13053182
Sousa, JB; Vieira-Rocha, MS; Arribas, SM; Gonzalez, MC; Fresco, P; Diniz, C. 2015. Endothelial and Neuronal Nitric Oxide Activate Distinct Pathways on Sympathetic Neurotransmission in Rat Tail and Mesenteric Arteries. PLoS One, 10. DOI: 10.1371/journal.pone.0129224
Fitzmaurice, C; Dicker, D; Pain, A; Hamavid, H; Moradi-Lakeh, M; Maclntyre, MF; Allen, C; Hansen, G; Woodbrook, R; Wolfe, C; Hamadeh, RR; Moore, A; Werdecker, A; Gessner, BD; Te Ao, B; McMahon, B; Karimkhani, C; Yu, CH; Cooke, GS; Schwebel, DC; Carpe. 2015. The Global Burden of Cancer 2013 Global Burden of Disease Cancer Collaboration. JAMA Oncology, 1, 505-527. DOI: 10.1001/jamaoncol.2015.0735
Sousa, S; Rodriguez-Alcala, LM; Wrobel, M; Carvalho, A; Gomes, AM. 2015. Impact of drying processes on the fatty acid composition of Chlorella vulgaris. FEBS Journal, 282, 236-236. DOI:
Barbosa, M; Collado-Gonzalez, J; Andrade, PB; Ferreres, F; Valentao, P; Galano, JM; Durand, T; Gil-Izquierdo, A. 2015. Nonenzymatic alpha-Linolenic Acid Derivatives from the Sea: Macroalgae as Novel Sources of Phytoprostanes. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63, 6466-6474. DOI: 10.1021/acs.jafc.5b01904
Oliveira, AP; Lobo-da-Cunha, A; Taveira, M; Ferreira, M; Valentao, P; Andrade, PB. 2015. Digestive Gland from Aplysia depilans Gmelin: Leads for Inflammation Treatment. MOLECULES, 20, 15766-15780. DOI: 10.3390/molecules200915766
Pereira, RB; Andrade, PB; Valentao, P. 2015. A Comprehensive View of the Neurotoxicity Mechanisms of Cocaine and Ethanol. NEUROTOXICITY RESEARCH, 28, 253-267. DOI: 10.1007/s12640-015-9536-x
Amaro, HM; Fernandes, F; Valentao, P; Andrade, PB; Sousa-Pinto, I; Malcata, FX; Guedes, AC. 2015. Effect of Solvent System on Extractability of Lipidic Components of Scenedesmus obliquus (M2-1) and Gloeothece sp on Antioxidant Scavenging Capacity Thereof. Marine Drugs, 13, 6453-6471. DOI: 10.3390/md13106453
Murray, CJL; Barber, RM; Foreman, KJ; Ozgoren, AA; Abd-Allah, F; Abera, SF; Aboyans, V; Abraham, JP; Abubakar, I; Abu-Raddad, LJ; Abu-Rmeileh, NM; Achoki, T; Ackerman, IN; Ademi, Z; Adou, AK; Adsuar, JC; Afshin, A; Agardh, EE; Alam, SS; Alasfoor, D; . 2015. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. LANCET, 386, 2145-2191. DOI: 10.1016/S0140-6736(15)61340-X
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Fernandes, A; Valentao, P; Andrade, PB. 2015. Comparing the phenolic profile of Pilocarpus pennatifolius Lem. by HPLC-DAD-ESI/MSn with respect to authentication and enzyme inhibition potential. INDUSTRIAL CROPS AND PRODUCTS, 77, 391-401. DOI: 10.1016/j.indcrop.2015.09.006
Sousa, C; Andrade, PB; Valentao, P. 2016. Relationships of Echium plantagineum L. bee pollen, dietary flavonoids and their colonic metabolites with cytochrome P450 enzymes and oxidative stress. RSC Advances, 6, 6084-6092. DOI: 10.1039/c5ra26736f
Pinho, BR; Reis, SD; Guedes-Dias, P; Leitao-Rocha, A; Quintas, C; Valentao, P; Andrade, PB; Santos, MM; Oliveira, JMA. 2016. Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease. PHARMACOLOGICAL RESEARCH, 103, 328-339. DOI: 10.1016/j.phrs.2015.11.024
Barbosa, M; Valentao, P; Andrade, PB. 2016. Biologically Active Oxylipins from Enzymatic and Nonenzymatic Routes in Macroalgae. Marine Drugs, 14. DOI: 10.3390/md14010023
Ribeiro, AB; Chiste, RC; Lima, JLFC; Fernandes, E. 2016. Solanum diploconos fruits: profile of bioactive compounds and in vitro antioxidant capacity of different parts of the fruit. Food & Function, 7, 2249-2257. DOI: 10.1039/c6fo00326e
Oliveira, AP; Ferreira, JG; Riboira, S; Andrade, PB; Valentao, P. 2016. Bioactive Natural Products from Piper betle L. Leaves and their alpha-Glucosidase Inhibitory Potential. Records of Natural Products, 10, 771-781. DOI:
Figueiredo-Gonzalez, M; Grosso, C; Valentao, P; Andrade, PB. 2016. alpha-Glucosidase and alpha-amylase inhibitors from Myrcia spp.: a stronger alternative to acarbose?. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 118, 322-327. DOI: 10.1016/j.jpba.2015.10.042
Pereira, RB; Andrade, PB; Valentao, P. 2016. Chemical Diversity and Biological Properties of Secondary Metabolites from Sea Hares of Aplysia Genus. Marine Drugs, 14. DOI: 10.3390/md14020039
Pires, J; Borges, S; Carvalho, A; Pereira, C; Pereira, AM; Fernandes, C; Araujo, JP; Freire, C. 2016. Magnetically recyclable mesoporous iron oxide-silica materials for the degradation of acetaminophen in water under mild conditions. POLYHEDRON, 106, 125-131. DOI: 10.1016/j.poly.2016.01.007
Ferreira, V; Fernandes, F; Pinto-Carnide, O; Valentao, P; Falco, V; Martin, JP; Ortiz, JM; Arroyo-Garcia, R; Andrade, PB; Castro, I. 2016. Identification of Vitis vinifera L. grape berry skin color mutants and polyphenolic profile. FOOD CHEMISTRY, 194, 117-127. DOI: 10.1016/j.foodchem.2015.07.142
Sousa, ME; Araujo, MJ; do Vale, ML; Andrade, PB; Branco, P; Gomes, P; Moreira, R; Melo, TMVDP; Freitas, V. 2016. 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry. PHARMACEUTICALS, 9. DOI: 10.3390/ph9010015
Kyu, HH; Pinho, C; Wagner, JA; Brown, JC; Bertozzi-Villa, A; Charlson, FJ; Coffeng, LE; Dandona, L; Erskine, HE; Ferrari, AJ; Fitzmaurice, C; Fleming, TD; Forouzanfar, MH; Graetz, N; Guinovart, C; Haagsma, J; Higashi, H; Kassebaum, NJ; Larson, HJ; Li. 2016. Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013 Findings From the Global Burden of Disease 2013 Study. JAMA Pediatrics, 170, 267-287. DOI: 10.1001/jamapediatrics.2015.4276
Carqueijeiro, I; Guimaraes, AL; Bettencourt, S; Martinez-Cortes, T; Guedes, JG; Gardner, R; Lopes, T; Andrade, C; Bispo, C; Martins, NP; Andrade, P; Valentao, P; Valente, IM; Rodrigues, JA; Duarte, P; Sottomayor, M. 2016. Isolation of Cells Specialized in Anticancer Alkaloid Metabolism by Fluorescence-Activated Cell Sorting. PLANT PHYSIOLOGY, 171, 2371-2378. DOI: 10.1104/pp.16.01028
Babou, L; Hadidi, L; Grosso, C; Zaidi, F; Valentao, P; Andrade, PB. 2016. Study of phenolic composition and antioxidant activity of myrtle leaves and fruits as a function of maturation. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 242, 1447-1457. DOI: 10.1007/s00217-016-2645-9
Couto, D; Freitas, M; Costa, VM; Chiste, RC; Almeida, A; Lopez-Quintela, MA; Rivas, J; Freitas, P; Silva, P; Carvalho, F; Fernandes, E. 2016. Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity. JOURNAL OF APPLIED TOXICOLOGY, 36, 1321-1331. DOI: 10.1002/jat.3323
Forouzanfar, MH; Afshin, A; Alexander, LT; Anderson, HR; Bhutta, ZA; Biryukov, S; Brauer, M; Burnett, R; Cercy, K; Charlson, FJ; Cohen, AJ; Dandona, L; Estep, K; Ferrari, AJ; Frostad, JJ; Fullman, N; Gething, PW; Godwin, WW; Griswold, M; Kinfu, Y; Ky. 2016. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. LANCET, 388, 1659-1724. DOI: 10.1016/S0140-6736(16)31679-8
de Carvalho, ALMB; Medeiros, PSC; Costa, FM; Ribeiro, VP; Sousa, JB; Diniz, C; Marques, MPM. 2016. Anti-Invasive and Anti-Proliferative Synergism between Docetaxel and a Polynuclear Pd-Spermine Agent. PLoS One, 11. DOI: 10.1371/journal.pone.0167218
Freitas, M; Correr, W; Cancino-Bernardi, J; Barroso, MF; Delerue-Matos, C; Zucolotto, V. 2016. Impedimetric immunosensors for the detection of Cry1Ab protein from genetically modified maize seeds. SENSORS AND ACTUATORS B-CHEMICAL, 237, 702-709. DOI: 10.1016/j.snb.2016.06.149
Fernandes, F; Barbosa, M; Oliveira, AP; Azevedo, IC; Sousa-Pinto, I; Valento, P; Andrade, PB. 2016. The pigments of kelps (Ochrophyta) as part of the flexible response to highly variable marine environments. JOURNAL OF APPLIED PHYCOLOGY, 28, 3689-3696. DOI: 10.1007/s10811-016-0883-7
Mahfoudhi, A; Grosso, C; Goncalves, RF; Khelifi, E; Hammami, S; Achour, S; Trabelsi-Ayadi, M; Valentao, P; Andrade, PB; Mighri, Z. 2016. Evaluation of Antioxidant, Anticholinesterase, and Antidiabetic Potential of Dry Leaves and Stems in Tamarix aphylla Growing Wild in Tunisia. CHEMISTRY & BIODIVERSITY, 13, 1747-1755. DOI: 10.1002/cbdv.201600157
Figueiredo-Gonzalez, M; Valentao, P; Andrade, PB. 2016. Tomato plant leaves: From by-products to the management of enzymes in chronic diseases. INDUSTRIAL CROPS AND PRODUCTS, 94, 621-629. DOI: 10.1016/j.indcrop.2016.09.036
Ferreres, F; Magalhaes, SCQ; Gil-Izquierdo, A; Valentao, P; Cabrita, ARJ; Fonseca, AJM; Andrade, PB. 2017. HPLC-DAD-ESI/MSn profiling of phenolic compounds from Lathyrus cicera L. seeds. FOOD CHEMISTRY, 214, 678-685. DOI: 10.1016/j.foodchem.2016.07.129
Magalhaes, SCQ; Fernandes, F; Cabrita, ARJ; Fonseca, AJM; Valentao, P; Andrade, PB. 2017. Alkaloids in the valorization of European Lupinus spp. seeds crop. INDUSTRIAL CROPS AND PRODUCTS, 95, 286-295. DOI: 10.1016/j.indcrop.2016.10.033
Lopes, G; Andrade, PB; Valentao, P. 2017. Phlorotannins: Towards New Pharmacological Interventions for Diabetes Mellitus Type 2. MOLECULES, 22. DOI: 10.3390/molecules22010056
Goncalves, S; Moreira, E; Grosso, C; Andrade, PB; Valentao, P; Romano, A. 2017. Phenolic profile, antioxidant activity and enzyme inhibitory activities of extracts from aromatic plants used in Mediterranean diet. JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 54, 219-227. DOI: 10.1007/s13197-016-2453-z
Hadidi, L; Babou, L; Zaidi, F; Valentao, P; Andrade, PB; Grosso, C. 2017. Quercus ilex L.: How season, Plant Organ and Extraction Procedure Can Influence Chemistry and Bioactivities. CHEMISTRY & BIODIVERSITY, 14. DOI: 10.1002/cbdv.201600187
da Silva, DC; Andrade, PB; Ribeiro, V; Valentao, P; Pereira, DM. 2017. Recent Patents on Proteasome Inhibitors of Natural Origin. Recent Patents on Anti-Cancer Drug Discovery, 12, 4-15. DOI: 10.2174/1574892812666161123142037
Magalhaes, SCQ; Taveira, M; Cabrita, ARJ; Fonseca, AJM; Valentao, P; Andrade, PB. 2017. European marketable grain legume seeds: Further insight into phenolic compounds profiles. FOOD CHEMISTRY, 215, 177-184. DOI: 10.1016/j.foodchem.2016.07.152
Silva, TC; de Andrade, PB; Paiva-Martins, F; Valentao, P; Pereira, DM. 2017. In Vitro Anti-Inflammatory and Cytotoxic Effects of Aqueous Extracts from the Edible Sea Anemones Anemonia sulcata and Actinia equina. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18. DOI: 10.3390/ijms18030653
Sousa, JB; Diniz, C. 2017. The Adenosinergic System as a Therapeutic Target in the Vasculature: New Ligands and Challenges. MOLECULES, 22. DOI: 10.3390/molecules22050752
Dieleman, JL; Campbell, M; Chapin, A; Eldrenkamp, E; Fan, VY; Haakenstad, A; Kates, J; Li, ZY; Matyasz, T; Micah, A; Reynolds, A; Sadat, N; Schneider, MT; Sorensen, R; Abbas, KM; Abera, SF; Kiadaliri, AA; Ahmed, MB; Alam, K; Alizadeh-Navaei, R; Alker. 2017. Future and potential spending on health 2015-40: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries. LANCET, 389, 2005-2030. DOI: 10.1016/S0140-6736(17)30873-5
Dieleman, J; Campbell, M; Chapin, A; Eldrenkamp, E; Fan, VY; Haakenstad, A; Kates, J; Liu, YY; Matyasz, T; Micah, A; Reynolds, A; Sadat, N; Schneider, MT; Sorensen, R; Evans, T; Evans, D; Kurowski, C; Tandon, A; Abbas, KM; Abera, SF; Kiadaliri, AA; A. 2017. Evolution and patterns of global health financing 1995-2014: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries. LANCET, 389, 1981-2004. DOI: 10.1016/S0140-6736(17)30874-7
Diniz, C; Suliburska, J; Ferreira, IMPLVO. 2017. New insights into the antiangiogenic and proangiogenic properties of dietary polyphenols. MOLECULAR NUTRITION & FOOD RESEARCH, 61. DOI: 10.1002/mnfr.201600912
Oliveira, AP; Sa, I; Pereira, DM; Goncalves, RF; Andrade, PB; Valentao, P. 2017. Exploratory Studies on the in Vitro Anti-inflammatory Potential of Two Herbal Teas (Annona muricata L. and Jasminum grandiflorum L.), and Relation with Their Phenolic Composition. CHEMISTRY & BIODIVERSITY, 14. DOI: 10.1002/cbdv.201700002
Fernandes, F; Andrade, PB; Ferreres, F; Gil-Izquierdo, A; Sousa-Pinto, I; Valentao, P. 2017. The chemical composition on fingerprint of Glandora diffusa and its biological properties. Arabian Journal of Chemistry, 10, 583-595. DOI: 10.1016/j.arabjc.2015.01.012
da Silva, DC; Andrade, PB; Valentao, P; Pereira, DM. 2017. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2 alpha branch of the endoplasmic reticulum. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 171, 178-186. DOI: 10.1016/j.jsbmb.2017.03.009
Ferreira, V; Fernandes, F; Carrasco, D; Hernandez, MG; Pinto-Carnide, O; Arroyo-Garcia, R; Andrade, P; Valentao, P; Falco, V; Castro, I. 2017. Spontaneous variation regarding grape berry skin color: A comprehensive study of berry development by means of biochemical and molecular markers. FOOD RESEARCH INTERNATIONAL, 97, 149-161. DOI: 10.1016/j.foodres.2017.03.050
Barber, RM; Fullman, N; Sorensen, RJD; Bollyky, T; McKee, M; Nolte, E; Abajobir, AA; Abate, KH; Abbafati, C; Abbas, KM; Abd-Allah, F; Abdulle, AM; Abdurahman, AA; Abera, SF; Abraham, B; Abreha, GF; Adane, K; Adelekan, AL; Adetifa, IMO; Afshin, A; Aga. 2017. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015. LANCET, 390, 231-266. DOI: 10.1016/S0140-6736(17)30818-8
Teixeira, J; Oliveira, C; Amorim, R; Cagide, F; Garrido, J; Ribeiro, JA; Pereira, CM; Silva, AF; Andrade, PB; Oliveira, PJ; Borges, F. 2017. Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria. Scientific Reports, 7. DOI: 10.1038/s41598-017-07272-y
Bernardo, J; Ferreres, F; Gil-Izquierdo, A; Valentao, P; Andrade, PB. 2017. Medicinal species as MTDLs: Turnera diffusa Willd. Ex Schult inhibits CNS enzymes and delays glutamate excitotoxicity in SH-SY5Y cells via oxidative damage. FOOD AND CHEMICAL TOXICOLOGY, 106, 466-476. DOI: 10.1016/j.fct.2017.06.014
Ferreres, F; Duangsrisai, S; Gomes, NGM; Suksungworn, R; Pereira, DM; Gil-Izquierdo, A; Valentao, P; Choowongkomon, K; Andrade, PB. 2017. Anti-inflammatory properties of the stem bark from the herbal drug Vitex peduncularis Wall. ex Schauer and characterization of its polyphenolic profile. FOOD AND CHEMICAL TOXICOLOGY, 106, 8-16. DOI: 10.1016/j.fct.2017.05.020
Pereira, DM; Silva, TC; Losada-Barreiro, S; Valentao, P; Paiva-Martins, F; Andrade, PB. 2017. Toxicity of phenolipids: Protocatechuic acid alkyl esters trigger disruption of mitochondrial membrane potential and caspase activation in macrophages. CHEMISTRY AND PHYSICS OF LIPIDS, 206, 16-27. DOI: 10.1016/j.chemphyslip.2017.05.013
Teixeira, J; Cagide, F; Benfeito, S; Soares, P; Garrido, J; Baldeiras, I; Ribeiro, JA; Pereira, CM; Silva, AF; Andrade, PB; Oliveira, PJ; Borges, F. 2017. Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models. JOURNAL OF MEDICINAL CHEMISTRY, 60, 7084-7098. DOI: 10.1021/acs.jmedchem.7b00741
Ferreres, F; Grosso, C; Gil-Izquierdo, A; Valentao, P; Mota, AT; Andrade, PB. 2017. Optimization of the recovery of high-value compounds from pitaya fruit by-products using microwave-assisted extraction. FOOD CHEMISTRY, 230, 463-474. DOI: 10.1016/j.foodchem.2017.03.061
Fullman, N; Barber, RM; Abajobir, AA; Abate, KH; Abbafati, C; Abbas, KM; Abd-Allah, F; Abdulle, AM; Abera, SF; Aboyans, V; Abu-Raddad, LJ; Abu-Rmeileh, NME; Adedeji, IA; Adetokunboh, O; Afshin, A; Agrawal, A; Agrawal, S; Kiadaliri, AA; Ahmadieh, H; A. 2017. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. LANCET, 390, 1423-1459. DOI:
Gakidou, E; Afshin, A; Abajobir, AA; Abate, KH; Abbafati, C; Abbas, KM; Abd-Allah, F; Abdulle, AM; Abera, SF; Aboyans, V; Abu-Raddad, LJ; Abu-Rmeileh, NME; Abyu, GY; Adedeji, IA; Adetokunboh, O; Afarideh, M; Agrawal, A; Agrawal, S; Kiadaliri, AA; Ahm. 2017. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. LANCET, 390, 1345-1422. DOI:
Hay, SI; Abajobir, AA; Abate, KH; Abbafati, C; Abbas, KM; Abd-Allah, F; Abdulle, AM; Abebo, TA; Abera, SF; Aboyans, V; Abu-Raddad, LJ; Ackerman, IN; Adedeji, IA; Adetokunboh, O; Afshin, A; Aggarwal, R; Agrawal, S; Agrawal, A; Kiadaliri, AA; Ahmed, MB. 2017. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. LANCET, 390, 1260-1344. DOI:
Vos, T; Abajobir, AA; Abbafati, C; Abbas, KM; Abate, KH; Abd-Allah, F; Abdulle, AM; Abebo, TA; Abera, SF; Aboyans, V; Abu-Raddad, LJ; Ackerman, IN; Adamu, AA; Adetokunboh, O; Afarideh, M; Afshin, A; Agarwal, SK; Aggarwal, R; Agrawal, A; Agrawal, S; K. 2017. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. LANCET, 390, 1211-1259. DOI:
Naghavi, M; Abajobir, AA; Abbafati, C; Abbas, KM; Abd-Allah, F; Abera, SF; Aboyans, V; Adetokunboh, O; Arnlov, J; Afshin, A; Agrawal, A; Kiadaliri, AA; Ahmadi, A; Ahmed, MB; Aichour, AN; Aichour, I; Aichour, MTE; Aiyar, S; Al-Eyadhy, A; Alahdab, F; A. 2017. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. LANCET, 390, 1151-1210. DOI:
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Fernandes, E; Toste, SA; Lima, JLFC; Reis, S. 2003. The metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species. FREE RADICAL BIOLOGY AND MEDICINE, 35, 1008-1017. DOI: 10.1016/S0891-5849(03)00437-4
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Carvalho, M; Remiao, F; Milhazes, N; Borges, F; Fernandes, E; Monteiro, MD; Goncalves, MJ; Seabra, V; Amado, F; Carvalho, F; Bastos, ML. 2004. Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro. CHEMICAL RESEARCH IN TOXICOLOGY, 17, 623-632. DOI: 10.1021/tx049960f
Carmo, H; Hengstler, JG; de Boer, D; Ringel, M; Remiao, F; Carvalho, F; Fernandes, E; dos Reys, LA; Oesch, F; Bastos, MD. 2005. Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human. TOXICOLOGY, 206, 75-89. DOI: 10.1016/j.tox.2004.07.004
das Neves, RNP; Carvalho, F; Carvalho, M; Fernandes, E; Soares, E; Bastos, MD; Pereira, MD. 2004. Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice. TOXICOLOGIC PATHOLOGY, 32, 527-535. DOI: 10.1080/01926230490502566
Sousa, T; Fernandes, E; Nunes, C; Laranjinha, J; Carvalho, F; Pinho, D; Morato, M; Albino-Teixeira, A. 2005. Scavenging of nitric oxide by an antagonist of adenosine receptors. JOURNAL OF PHARMACY AND PHARMACOLOGY, 57, 399-404. DOI: 10.1211/0022357055614
Gomes, A; Fernandes, E; Lima, JLFC. 2006. Use of fluorescence probes for detection of reactive nitrogen species: A review. JOURNAL OF FLUORESCENCE, 16, 119-139. DOI: 10.1007/s10895-005-0030-3
Meneses, SRP; Marques, KL; Pires, CK; Santos, JLM; Fernandes, E; Lima, JLFC; Zagatto, EAG. 2005. Evaluation of the total antioxidant capacity by using a multipumping flow system with chemiluminescent detection. ANALYTICAL BIOCHEMISTRY, 345, 90-95. DOI: 10.1016/j.ab.2005.07.017
Gomes, A; Costa, D; Lima, JLFC; Fernandes, E. 2006. Antioxidant activity of beta-blockers: An effect mediated by scavenging reactive oxygen and nitrogen species?. BIOORGANIC & MEDICINAL CHEMISTRY, 14, 4568-4577. DOI: 10.1016/j.bmc.2006.02.023
Costa, D; Gomes, A; Reis, S; Lima, JLFC; Fernandes, E. 2005. Hydrogen peroxide scavenging activity by non-steroidal anti-inflammatory drugs. LIFE SCIENCES, 76, 2841-2848. DOI: 10.1016/j.lfs.2004.10.052
Costa, D; Vieira, A; Fernandes, E. 2006. Dipyrone and aminopyrine are effective scavengers of reactive nitrogen species. REDOX REPORT, 11, 136-142. DOI: 10.1179/135100006X116637
Abreu, P; Matthew, S; Gonzalez, T; Costa, D; Segundo, MA; Fernandes, E. 2006. Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides. LIFE SCIENCES, 78, 1578-1585. DOI: 10.1016/j.lfs.2005.07.037
Costa, D; Marques, AP; Reis, RL; Lima, JLFC; Fernandes, E. 2006. Inhibition of human neutrophil oxidative burst by pyrazolone derivatives. FREE RADICAL BIOLOGY AND MEDICINE, 40, 632-640. DOI: 10.1016/j.freeradbiomed.2005.09.017
Gomes, A; Fernandes, E; Lima, JLFC. 2005. Fluorescence probes used for detection of reactive oxygen species. JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 65, 45-80. DOI: 10.1016/j.jbbm.2005.10.003
Costa, D; Moutinho, L; Lima, JLFC; Fernandes, E. 2006. Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 29, 1659-1670. DOI: 10.1248/bpb.29.1659
Almeida, IF; Fernandes, E; Lima, JLFC; Costa, PC; Fernanda Bahia, M. 2008. Walnut (Juglans regia) leaf extracts are strong scavengers of pro-oxidant reactive species. FOOD CHEMISTRY, 106(3), 1014-1020. DOI: 10.1016/j.foodchem.2007.07.017
Carvalho, F; Soares, ME; Fernandes, E; Remiao, F; Carvalho, M; Duarte, JA; Pires-das-Neves, R; Pereira, MD; Bastos, MD. 2007. Repeated administration of d-amphetamine results in a time-dependent and dose-independent sustained increase in urinary excretion of p-hydroxyamphetamine in mice. JOURNAL OF HEALTH SCIENCE, 53, 371-377. DOI: 10.1248/jhs.53.371
Capela, JP; Macedo, C; Branco, PS; Ferreira, LM; Lobo, AM; Fernandes, E; Remiao, F; Bastos, ML; Dirnagl, U; Meisel, A; Carvalho, F. 2007. Neurotoxicity mechanisms of thioether ecstasy metabolites. NEUROSCIENCE, 146, 1743-1757. DOI: 10.1016/j.neuroscience.2007.03.028
Ribeiro, MFT; Dias, ACB; Santos, JLM; Fernandes, E; Lima, JLFC; Zagatto, EAG. 2007. A multipumping flow system for in vitro screening of peroxynitrite scavengers. JOURNAL OF BIOMOLECULAR SCREENING, 12, 875-880. DOI: 10.1177/1087057107305402
Macedo, C; Branco, PS; Ferreira, LM; Lobo, AM; Capela, JP; Fernandes, E; Bastos, MD; Carvalho, F. 2007. Synthesis and cyclic voltammetry studies of 3,4-methylenedioxymethamphetamine (MDMA) human metabolites. JOURNAL OF HEALTH SCIENCE, 53, 31-42. DOI: 10.1248/jhs.53.31
Costa, D; Fernandes, E; Santos, JLM; Pinto, DCGA; Silva, AMS; Lima, JLFC. 2007. New noncellular fluorescence microplate screening assay for scavenging activity against singlet oxygen. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 387, 2071-2081. DOI: 10.1007/s00216-006-0998-9
Capela, JP; Fernandes, E; Remiao, F; Bastos, ML; Meisel, A; Carvalho, F. 2007. Ecstasy induces apoptosis via 5-HT2A-receptor stimulation in cortical neurons. NEUROTOXICOLOGY, 28, 868-875. DOI: 10.1016/j.neuro.2007.04.005
Alves, E; Summavielle, T; Alves, CJ; Gomes-Da-Silva, J; Barata, JC; Fernandes, E; Bastos, MDL; Tavares, MA; Carvalho, F. 2007. Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. JOURNAL OF NEUROSCIENCE, 27, 10203-10210. DOI: 10.1523/JNEUROSCI.2645-07.2007
Gomes, A; Fernandes, E; Silva, AMS; Santos, CMM; Pinto, DCGA; Cavaleiro, JAS; Lima, JLFC. 2007. 2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species. BIOORGANIC & MEDICINAL CHEMISTRY, 15, 6027-6036. DOI: 10.1016/j.bmc.2007.06.046
Proenca, C; Ribeiro, D; Soares, T; Tome, SM; Silva, AMS; Lima, JLFC; Fernandes, E; Freitas, M. 2017. Chlorinated Flavonoids Modulate the Inflammatory Process in Human Blood. INFLAMMATION, 40, 1155-1165. DOI: 10.1007/s10753-017-0559-8
Ribeiro, D; Freitas, M; Tome, SM; Silva, AMS; Laufer, S; Lima, JLFC; Fernandes, E. 2015. Flavonoids Inhibit COX-1 and COX-2 Enzymes and Cytokine/Chemokine Production in Human Whole Blood. INFLAMMATION, 38, 858-870. DOI: 10.1007/s10753-014-9995-x
Freitas, M; Ribeiro, D; Tome, SM; Silva, AMS; Fernandes, E. 2014. Synthesis of chlorinated flavonoids with anti-inflammatory and proapoptotic activities in human neutrophils. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 86, 153-164. DOI: 10.1016/j.ejmech.2014.08.035
Ribeiro, D; Freitas, M; Tome, SM; Silva, AMS; Porto, G; Cabrita, EJ; Marques, MMB; Fernandes, E. 2014. Inhibition of LOX by flavonoids: a structure-activity relationship study. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 72, 137-145. DOI: 10.1016/j.ejmech.2013.11.030
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