People

Anjos Macedo

Independent Researcher

Position
Assistant Professor (since 1994)
Email
anjos.macedo@fct.unl.pt
Phone number
(+351) 212948356 (ext: 10939)
Researcher ID

Main publications

  • Viegas, CSB; Santos, L; Macedo, AL; Matos, AA; Silva, AP; Neves, PL; Staes, A; Gevaert, K; Morais, R; Vermeer, C; Schurgers, L; Simes, DC. 2018. Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein). ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38, DOI: 10.1161/ATVBAHA.117.310578
  • Viegas, CSB; Costa, RM; Santos, L; Videira, PA; Silva, Z; Araujo, N; Macedo, AL; Matos, AP; Vermeer, C; Simes, DC. 2017. Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases. PLoS One, 12, DOI: 10.1371/journal.pone.0177829
  • Viegas, CSB; Rafael, MS; Enriquez, JL; Teixeira, A; Vitorino, R; Luis, IM; Costa, RM; Santos, Sofia; Cavaco, S; Neves, J; Macedo, AL; Willems, BAG; Vermeer, C; Simes, DC. 2015. Gla-Rich Protein Acts as a Calcification Inhibitor in the Human Cardiovascular System. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 35, DOI: 10.1161/ATVBAHA.114.304823
  • Zamora-Carreras, H; Torres, M; Bustamante, N; Macedo, AL; Rodriguez, R; Villalba, M; Bruix, M. 2015. The C-terminal domains of two homologous Oleaceae beta-1,3-glucanases recognise carbohydrates differently: Laminarin binding by NMR. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 580, DOI: 10.1016/j.abb.2015.07.004
  • Viegas, A; Sardinha, J; Freire, F; Duarte, DF; Carvalho, AL; Fontes, CMGA; Romao, MJ; Macedo, AL; Cabrita, EJ. 2013. Solution structure, dynamics and binding studies of a family 11 carbohydrate-binding module from Clostridium thermocellum (CtCBM11). BIOCHEMICAL JOURNAL, 451, DOI: 10.1042/BJ20120627
  • Micaelo, NM; Macedo, AL; Goodfellow, BJ; Felix, V. 2010. Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins. JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 29, DOI: 10.1016/j.jmgm.2010.07.008
  • Goodfellow, BJ; Duarte, ICN; Macedo, AL; Volkman, BF; Nunes, SG; Moura, I; Markley, JL; Moura, JJG. 2010. An NMR structural study of nickel-substituted rubredoxin. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 15, DOI: 10.1007/s00775-009-0613-6

Main research interests

  • Understanding biomolecular function in disease
  • - Gla-rich proteins in vascular calcification events (Col. D. Simes, CCMAR - UAlg & AP Matos, CiiEM)
  • - NMR applications in Paramagnetic Systems / Metalloproteins (col. C. Luchinat, CERM, UFlorence & C.Geraldes, UCoimbra - joint PhD project | José Pedro Silva (grant #PD/BD/135180/2017))
  • - NMR Structural studies of proteins and peptides:
  • -- Antimicrobial Peptides; mode of action (col. H.Albergaria, LNEG)
  • -- Heme binding proteins and heme scavenging solutions (collaboration: B. Goodfellow, UAveiro and M. Picciolli, CERM, UFlorence)