Cristina Isabel Borges Dias Amaral


Postdoc (since 2013)
Phone number
Researcher ID

Main publications

  • Amaral C; Augusto TV; Tavares-da-Silva E; Roleira FMF; Correia-da-Silva G; Teixeira N. 2018. Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance.. The Journal of steroid biochemistry and molecular biology, DOI: 10.1016/j.jsbmb.2018.05.006
  • Augusto, TV; Correia-da-Silva, G; Rodrigues, CMP; Teixeira, N; Amaral, C. 2018. Acquired resistance to aromatase inhibitors: where we stand!. ENDOCRINE-RELATED CANCER, 25, DOI: 10.1530/ERC-17-0425
  • Amaral, C; Augusto, T; Roleira, F; Tavares-Da-Silva, E; Correia-Da-Silva, G; Teixeira, N. 2017. Estrogen-dependent breast cancer: The importance of androgen receptor in exemestane treatment. ANNALS OF ONCOLOGY, 28, DOI:
  • Amaral, C; Varela, CL; Mauricio, J; Sobral, AF; Costa, SC; Roleira, FMF; Tavares-da-Silva, EJ; Correia-da-Silva, G; Teixeira, N. 2017. Anti-tumor efficacy of new 7 alpha-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 171, DOI: 10.1016/j.jsbmb.2017.04.002
  • Sobral, AF; Amaral, C; Correia-da-Silva, G; Teixeira, N. 2016. Unravelling exemestane: From biology to clinical prospects. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 163, DOI: 10.1016/j.jsbmb.2016.03.019
  • Varela, CL; Amaral, C; Correia-da-Silva, G; Costa, SC; Carvalho, RA; Costa, G; Alcaro, S; Teixeira, NAA; Tavares-da-Silva, EJ; Roleira, FMF. 2016. Exploring new chemical functionalities to improve aromatase inhibition of steroids. BIOORGANIC & MEDICINAL CHEMISTRY, 24, DOI: 10.1016/j.bmc.2016.04.056
  • Amaral, C; Correia-da-Siva, G; Roleira, FMF; da Silva, ET; Teixeira, N. 2016. Estrogen-Dependent breast cancer: Autophagy as a potential mechanism of exemestane-acquired resistance. MEDICINE, 95, DOI:
  • Amaral, C; Lopes, A; Varela, CL; da Silva, ET; Roleira, FMF; Correia-da-Silva, G; Teixeira, N. 2015. Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 69, DOI: 10.1016/j.biocel.2015.10.024
  • Varela, Carla L; Amaral, Cristina; da Silva, Elisiario Tavares; Lopes, Andreia; Correia-da-Silva, Georgina; Carvalho, Rui A; Costa, Saul CP; Roleira, Fernanda MF; Teixeira, Natercia. 2014. Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 87, DOI: 10.1016/j.ejmech.2014.09.074
  • Amaral, C; Varela, C; Correia-da-Silva, G; da Silva, ET; Carvalho, RA; Costa, SCP; Cunha, SC; Fernandes, JO; Teixeira, N; Roleira, FMF. 2013. New steroidal 17 beta-carboxy derivatives present anti-5 alpha-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line. BIOCHIMIE, 95, DOI: 10.1016/j.biochi.2013.07.023
  • Amaral, C; Cunha, SC; Fernandes, JO; da Silva, ET; Roleira, FMF; Teixeira, N; Correia-da-Silva, G. 2013. Development of a new gas chromatography-mass spectrometry (GC-MS) methodology for the evaluation of 5 alpha-reductase activity. TALANTA, 107, DOI: 10.1016/j.talanta.2012.12.045
  • Varela, Carla L; Amaral, Cristina; Correia-da-Silva, Georgina; Carvalho, Rui A; Teixeira, Natercia A; Costa, Saul C; Roleira, Fernanda MF; Tavares-da-Silva, Elisiario J. 2013. Design, synthesis and biochemical studies of new 7 alpha-allylandrostanes as aromatase inhibitors. STEROIDS, 78(7), DOI: 10.1016/j.steroids.2013.02.016
  • Amaral, Cristina; Varela, Carla; Azevedo, Margarida; da Silva, Elisiario Tavares; Roleira, Fernanda MF; Chen, Shiuan; Correia-da-Silva, Georgina; Teixeira, Natercia. 2013. Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: Aromatase inhibition and autophagy. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, DOI: 10.1016/j.jsbmb.2012.12.017
  • Amaral, C; Varela, C; Borges, M; Tavares Da Silva, E; Roleira, FMF; Correia-Da-Silva, G; Teixeira, N. 2013. Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis. APOPTOSIS, 18(11), DOI: 10.1007/s10495-013-0879-6
  • Amaral, Cristina; Borges, Margarida; Melo, Soraia; da Silva, Elisiario Tavares; Correia-da-Silva, Georgina; Teixeira, Natercia. 2012. Apoptosis and Autophagy in Breast Cancer Cells following Exemestane Treatment. PLoS One, 7(8), DOI: 10.1371/journal.pone.0042398
  • Varela, Carla; Tavares da Silva, Elisiario J; Amaral, Cristina; da Silva, Georgina Correia; Baptista, Teresa; Alcaro, Stefano; Costa, Giosue; Carvalho, Rui A; Teixeira, Natercia AA; Roleira, Fernanda MF. 2012. New Structure-Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation. JOURNAL OF MEDICINAL CHEMISTRY, 55(8), DOI: 10.1021/jm300262w

Main research interests

  • Hormone-dependent breast cancer, aromatase, Aromatase inhibitors, Endocrine/Acquired Resistance
  • Hormone-dependent Prostate Cancer, 5 alpha-reductase, 5 alpha-reductase inhibitors
  • Biological effects and mechanism of action of Steroidal/non-steroidal/natural compounds
  • Apoptosis, Autophagy, Cell cycle, Cell signalling pathways


  • PhD in Pharmaceutical Sciences - Biochemistry, Faculdade de Farmácia da Universidade do Porto (2013)
  • MSc in Biochemistry, Universidade da Beira Interior (2008)
  • Graduation in Biochemistry, Universidade da Beira Interior (2007)