Cristina Isabel Borges Dias Amaral


Phone number
Researcher ID
Ciência Vitae

Main publications

  • Almada, M; Amaral, C; Oliveira, A; Fernandes, PA; Ramos, MJ; Fonseca, BM; Correia-da-Silva, G; Teixeira, N. 2020. Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling. REPRODUCTIVE TOXICOLOGY, 93, DOI: 10.1016/j.reprotox.2020.01.003
  • Almada, M; Oliveira, A; Amaral, C; Fernandes, PA; Ramos, MJ; Fonseca, B; Correia-da-Silva, G; Teixeira, N. 2019. Anandamide targets aromatase: A breakthrough on human decidualization. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1864, DOI: 10.1016/j.bbalip.2019.08.008
  • Augusto, TV; Amaral, C; Varela, CL; Bernardo, F; da Silva, ET; Roleira, FFM; Costa, S; Teixeira, N; Correia-da-Silva, G. 2019. Effects of new C6-substituted steroidal aromatase inhibitors in hormone-sensitive breast cancer cells: Cell death mechanisms and modulation of estrogen and androgen receptors. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 195, DOI: 10.1016/j.jsbmb.2019.105486
  • El-Abid, H; Amaral, C; Cunha, SC; Augusto, TV; Fernandes, JO; Correia-da-Silva, G; Teixeira, N; Moumni, M. 2019. Chemical composition and anti-cancer properties of Juniperus oxycedrus L. essential oils on estrogen receptor-positive breast cancer cells. Journal of Functional Foods, 59, DOI: 10.1016/j.jff.2019.05.042
  • Roleira, FMF; Varela, C; Amaral, C; Costa, SC; Correia-da-Silva, G; Moraca, F; Costa, G; Alcaro, S; Teixeira, NAA; da Silva, EJT. 2019. C-6 alpha- vs C-7 alpha-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships. JOURNAL OF MEDICINAL CHEMISTRY, 62, DOI: 10.1021/acs.jmedchem.9b00157

Main research interests

  • Biological effects and mechanism of action of Steroidal/non-steroidal/natural compounds
  • Apoptosis, Autophagy, Cell cycle, Cell signalling pathways
  • Hormone-dependent breast cancer, aromatase, Aromatase inhibitors, Endocrine/Acquired Resistance
  • Hormone-dependent Prostate Cancer, 5 alpha-reductase, 5 alpha-reductase inhibitors


  • PhD in Pharmaceutical Sciences - Biochemistry, Faculdade de Farmácia da Universidade do Porto (2013)
  • MSc in Biochemistry, Universidade da Beira Interior (2008)
  • Graduation in Biochemistry, Universidade da Beira Interior (2007)