Georgina Correia da Silva

Independent Researcher

Assistant Professor (since 2001)
Phone number
Researcher ID

Main publications

  • Augusto, TV; Correia-da-Silva, G; Rodrigues, CMP; Teixeira, N; Amaral, C. 2018. Acquired resistance to aromatase inhibitors: where we stand!. ENDOCRINE-RELATED CANCER, 25, DOI: 10.1530/ERC-17-0425
  • Almada, M; Costa, L; Fonseca, BM; Amaral, C; Teixeira, N; Correia-Da-Silva, G. 2017. The synthetic cannabinoid WIN-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor. TOXICOLOGY, 385, DOI: 10.1016/j.tox.2017.04.013
  • Almada, M; Fonseca, BM; Amaral, C; Diniz-da-Costa, M; Correia-da-Silva, G; Teixeira, N. 2017. Anandamide oxidative metabolism-induced endoplasmic reticulum stress and apoptosis. APOPTOSIS, 22, DOI: 10.1007/s10495-017-1356-4
  • Fonseca, BM; Teixeira, NA; Correia-da-Silva, G. 2017. Cannabinoids as Modulators of Cell Death: Clinical Applications and Future Directions. Reviews of Physiology Biochemistry and Pharmacology, 173, DOI: 10.1007/112_2017_3
  • Amaral, C; Varela, CL; Mauricio, J; Sobral, AF; Costa, SC; Roleira, FMF; Tavares-da-Silva, EJ; Correia-da-Silva, G; Teixeira, N. 2017. Anti-tumor efficacy of new 7 alpha-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 171, DOI: 10.1016/j.jsbmb.2017.04.002
  • Almada, M; Cunha, S; Fonseca, BM; Amaral, C; Piscitelli, F; Di Marzo, V; Correia-da-Silva, G; Teixeira, N. 2016. Anandamide interferes with human endometrial stromal-derived cell differentiation: An effect dependent on inhibition of cyclooxygenase-2 expression and prostaglandin E-2 release. BIOFACTORS, 42, DOI: 10.1002/biof.1270
  • Almada, M; Amaral, C; Diniz-Da-Costa, M; Correia-Da-Silva, G; Teixeira, NA; Fonseca, BM. 2016. The endocannabinoid anandamide impairs in vitro decidualization of human cells. REPRODUCTION, 152, DOI: 10.1530/REP-16-0364
  • Costa, MA; Fonseca, BM; Mendes, A; Braga, J; Teixeira, NA; Correia-da-Silva, G. 2016. The endocannabinoid 2-arachidonoylglycerol dysregulates the synthesis of proteins by the human syncytiotrophoblast. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1861, DOI: 10.1016/j.bbalip.2015.12.008
  • Costa, MA; Fonseca, BM; Teixeira, NA; Correia-Da-Silva, G. 2015. The endocannabinoid anandamide induces apoptosis in cytotrophoblast cells: Involvement of both mitochondrial and death receptor pathways. PLACENTA, 36(1), DOI: 10.1016/j.placenta.2014.10.011
  • Amaral, C; Lopes, A; Varela, CL; da Silva, ET; Roleira, FMF; Correia-da-Silva, G; Teixeira, N. 2015. Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 69, DOI: 10.1016/j.biocel.2015.10.024
  • Almada, M; Piscitelli, F; Fonseca, BM; Di Marzo, V; Correia-da-Silva, G; Teixeira, N. 2015. Anandamide and decidual remodelling: COX-2 oxidative metabolism as a key regulator. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1851, DOI: 10.1016/j.bbalip.2015.08.011
  • Fonseca, SM; Correia-da-Silva, G; Teixeira, NA. 2015. Anandamide restricts uterine stromal differentiation and is critical for complete decidualization. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 411, DOI: 10.1016/j.mce.2015.04.024
  • Costa, MA; Fonseca, BM; Marques, F; Teixeira, NA; Correia-da-Silva, G. 2015. The psychoactive compound of Cannabis sativa, Delta(9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. TOXICOLOGY, 334, DOI: 10.1016/j.tox.2015.06.005
  • Almada, M; Domingues, MR; Doria, ML; Fonseca, BM; Teixeira, NA; Correia-da-Silva, G. 2015. Lipidomic Approach Towards Deciphering Anandamide Effects in Rat Decidual Cell. JOURNAL OF CELLULAR PHYSIOLOGY, 230, DOI: 10.1002/jcp.24901
  • Costa, MA; Fonseca, BM; Keating, E; Teixeira, NA; Correia-Da-Silva, G. 2014. 2-Arachidonoylglycerol effects in cytotrophoblasts: Metabolic enzymes expression and apoptosis in BeWo cells. REPRODUCTION, 147(3), DOI: 10.1530/REP-13-0563
  • Costa, MA; Fonseca, BM; Keating, E; Teixeira, NA; Correia-Da-Silva, G. 2014. Transient receptor potential vanilloid 1 is expressed in human cytotrophoblasts: Induction of cell apoptosis and impairment of syncytialization. International Journal of Biochemistry and Cell Biology, 57, DOI: 10.1016/j.biocel.2014.10.008
  • Varela, Carla L; Amaral, Cristina; da Silva, Elisiario Tavares; Lopes, Andreia; Correia-da-Silva, Georgina; Carvalho, Rui A; Costa, Saul CP; Roleira, Fernanda MF; Teixeira, Natercia. 2014. Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 87, DOI: 10.1016/j.ejmech.2014.09.074
  • Amaral, Cristina; Varela, Carla; Azevedo, Margarida; da Silva, Elisiario Tavares; Roleira, Fernanda MF; Chen, Shiuan; Correia-da-Silva, Georgina; Teixeira, Natercia. 2013. Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: Aromatase inhibition and autophagy. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, DOI: 10.1016/j.jsbmb.2012.12.017
  • Amaral, C; Varela, C; Borges, M; Tavares Da Silva, E; Roleira, FMF; Correia-Da-Silva, G; Teixeira, N. 2013. Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis. APOPTOSIS, 18(11), DOI: 10.1007/s10495-013-0879-6
  • Amaral, C; Cunha, SC; Fernandes, JO; da Silva, ET; Roleira, FMF; Teixeira, N; Correia-da-Silva, G. 2013. Development of a new gas chromatography-mass spectrometry (GC-MS) methodology for the evaluation of 5 alpha-reductase activity. TALANTA, 107, DOI: 10.1016/j.talanta.2012.12.045
  • Fonseca, BM; Costa, MA; Almada, M; Correia-Da-Silva, G; Teixeira, NA. 2013. Endogenous cannabinoids revisited: A biochemistry perspective. Prostaglandins and Other Lipid Mediators, 102-103, DOI: 10.1016/j.prostaglandins.2013.02.002
  • Fonseca, BM; Correia-Da-Silva, G; Teixeira, NA. 2013. The endocannabinoid anandamide induces apoptosis of rat decidual cells through a mechanism involving ceramide synthesis and p38 MAPK activation. APOPTOSIS, 18(12), DOI: 10.1007/s10495-013-0892-9
  • Amaral, Cristina; Borges, Margarida; Melo, Soraia; da Silva, Elisiario Tavares; Correia-da-Silva, Georgina; Teixeira, Natercia. 2012. Apoptosis and Autophagy in Breast Cancer Cells following Exemestane Treatment. PLoS One, 7(8), DOI: 10.1371/journal.pone.0042398
  • Varela, Carla; Tavares da Silva, Elisiario J; Amaral, Cristina; da Silva, Georgina Correia; Baptista, Teresa; Alcaro, Stefano; Costa, Giosue; Carvalho, Rui A; Teixeira, Natercia AA; Roleira, Fernanda MF. 2012. New Structure-Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation. JOURNAL OF MEDICINAL CHEMISTRY, 55(8), DOI: 10.1021/jm300262w
  • Fonseca, BM; Correia-da-Silva, G; Taylor, AH; Lam, PMW; Marczylo, TH; Konje, JC; Bell, SC; Teixeira, NA. 2010. N-acylethanolamine levels and expression of their metabolizing enzymes during pregnancy. ENDOCRINOLOGY, 151(8), DOI: 10.1210/en.2009-1424

Main research interests

  • Tissue remodeling; apoptosis;autophagy; biology of reproduction; biological activities of new molecules as enzyme inhibitors in breast and prostate cancers; endocrine resistance;endocannabinoids; cannabinoids


  • PhD in Biochemistry, Faculty of Pharmacy Porto University (1998)