Maria João Romão

Research Group Coordinator

Full Professor (since 2012)
Personal Website
Phone number
(+351) 212948310 (ext: 10963/2)
Researcher ID

Main publications

  • Romao, MJ; Coelho, C; Santos-Silva, T; Foti, A; Terao, M; Garattini, E; Leimkuhler, S. 2017. Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics. CURRENT OPINION IN CHEMICAL BIOLOGY, 37, DOI: 10.1016/j.cbpa.2017.01.005
  • Polino, M; Carvalho, AL; Juknaite, L; Portugal, CAM; Coelhoso, IM; Romao, MJ; Crespo, JG. 2017. Ion-Exchange Membranes for Stable Derivatization of Protein Crystals. CRYSTAL GROWTH & DESIGN, 17, DOI: 10.1021/acs.cgd.7b00315
  • Bras, JLA; Pinheiro, BA; Cameron, K; Cuskin, F; Viegas, A; Najmudin, S; Bule, P; Pires, VMR; Romao, MJ; Bayer, EA; Spencer, HL; Smith, S; Gilbert, HJ; Alves, VD; Carvalho, AL; Fontes, CMGA. 2016. Diverse specificity of cellulosome attachment to the bacterial cell surface. Scientific Reports, 6, DOI: 10.1038/srep38292
  • Correia, MAS; Otrelo-Cardoso, AR; Schwuchow, V; Clauss, KGVS; Haumann, M; Romao, MJ; Leimkuhler, S; Santos-Silva, T. 2016. The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes. ACS Chemical Biology, 11, DOI: 10.1021/acschembio.6b00572
  • Terao, M; Romao, MJ; Leimkuhler, S; Bolis, M; Fratelli, M; Coelho, C; Santos-Silva, T; Garattini, E. 2016. Structure and function of mammalian aldehyde oxidases. ARCHIVES OF TOXICOLOGY, 90, DOI: 10.1007/s00204-016-1683-1
  • Coelho, C; Foti, A; Hartmann, T; Santos-Silva, T; Leimkuhler, S; Romao, MJ. 2015. Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase. Nature Chemical Biology, 11, DOI: 10.1038/NCHEMBIO.1895
  • Seixas, JD; Santos, MFA; Mukhopadhyay, A; Coelho, AC; Reis, PM; Veiros, LF; Marques, AR; Penacho, N; Goncalves, AML; Romao, MJ; Bernardes, GJL; Santos-Silva, T; Romao, CC. 2015. A contribution to the rational design of Ru(CO)(3)Cl2L complexes for in vivo delivery of CO. DALTON TRANSACTIONS, 44, DOI: 10.1039/c4dt02966f
  • Coelho, C; Romao, MJ. 2015. Structural and mechanistic insights on nitrate reductases. PROTEIN SCIENCE, 24, DOI: 10.1002/pro.2801

Main research interests

  • Novel methods for protein crystallization
  • Metalloenzymes and Enzymatic Mechanisms
  • Molybdoenzymes
  • Aldehyde Oxidase and Drug Metabolism
  • Cellulosomal enzymes


  • "Agregação" in Biochemistry, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa (2001)
  • PhD in Chemistry, Instituto Superior Técnico, ULisboa (1989)