People

Susana Rocha

Independent Researcher

Position
Independent Researcher (since 2016)
Email
srocha@ff.up.pt
Phone number
+351 220 428 500 (ext: 8559)
Researcher ID

Main publications

  • Melo, D; Ribeiro, S; Santos-Silva, A; Rocha, S. 2018. Role of peroxiredoxin 2 in erythrocyte antioxidant defense: peroxidase and chaperone. FREE RADICAL BIOLOGY AND MEDICINE, 120, DOI: 10.1016/j.freeradbiomed.2018.04.274
  • Melo, D; Ribeiro, S; Santos-Silva, A; Rocha, S. 2017. IMPACT OF PEROXIREDOXIN 2, GLUTATHIONE PEROXIDASE AND CATALASE INHIBITION ON OXIDATIVE STRESS MODIFICATIONS OF RED BLOOD CELL MEMBRANE AND CYTOSOL. Haematologica-The Hematology Journal, 102, DOI:
  • Ribeiro, S; Garrido, P; Fernandes, J; Rocha, S; Rocha-Pereira, P; Costa, E; Belo, L; Reis, F; Santos-Silva, A. 2016. Recombinant human erythropoietin-induced erythropoiesis regulates hepcidin expression over iron status in the rat. BLOOD CELLS MOLECULES AND DISEASES, 59, DOI: 10.1016/j.bcmd.2016.04.008
  • Rocha, S; Cleto, E; Barbot, J; Ferreira, F; Quintanilha, A; Belo, L; Lima, M; Bronze-da-Rocha, E; Santos-Silva, A. 2016. IGG MEDIATED OPSONIZATION MECHANISM ACCORDING TO THE UNDERLYING PROTEIN DEFICIENCY IN HEREDITARY SPHEROCYTOSIS: TESTING A HYPOTHESIS. Haematologica-The Hematology Journal, 101, DOI:
  • Rocha, S; Gomes, D; Lima, M; Bronze-da-Rocha, E; Santos-Silva, A. 2015. Peroxiredoxin 2, glutathione peroxidase, and catalase in the cytosol and membrane of erythrocytes under H2O2-induced oxidative stress. FREE RADICAL RESEARCH, 49, DOI: 10.3109/10715762.2015.1028402
  • Paiva-Martins, Fatima; Barbosa, Susana; Silva, Marco; Monteiro, Divanildo; Pinheiro, Victor; Mourao, Jose Luis; Fernandes, Joao; Rocha, Susana; Belo, Luis; Santos-Silva, Alice. 2014. The effect of olive leaf supplementation on the constituents of blood and oxidative stability of red blood cells. Journal of Functional Foods, 9, DOI: 10.1016/j.jff.2014.04.027
  • Rocha, Susana; Costa, Elisio; Rocha-Pereira, Petronila; Ferreira, Fatima; Cleto, Esmeralda; Barbot, Jose; Quintanilha, Alexandre; Belo, Luis; Santos-Silva, Alice. 2011. Erythropoiesis versus inflammation in Hereditary Spherocytosis clinical outcome. CLINICAL BIOCHEMISTRY, 44(13), DOI: 10.1016/j.clinbiochem.2011.06.006
  • Pereira, Rui; Rocha, Susana; Borges, Ana; Nascimento, Henrique; Reis, Flavio; Miranda, Vasco; Faria, Maria do Sameiro; Quintanilha, Alexandre; Belo, Luis; Costa, Elisio; Santos-Silva, Alice. 2011. Elastase release during the hemodialysis procedure seems to induce changes in red blood cell membrane proteins. Hemodialysis International, 15(3), DOI: 10.1111/j.1542-4758.2011.00554.x
  • Rocha, S; Costa, E; Rocha-Pereira, P; Ferreira, F; Cleto, E; Barbot, J; Quintanilha, A; Belo, L; Santos-Silva, A. 2011. Complementary markers for the clinical severity classification of hereditary spherocytosis in unsplenectomized patients. BLOOD CELLS MOLECULES AND DISEASES, 46(2), DOI: 10.1016/j.bcmd.2010.11.001
  • Rocha, Susana; Costa, Elisio; Belo, Luis; Santos-Silva, Alice; Rocha-Pereira, Petronila; Quintanilha, Alexandre; Ferreira, Fatima; Cleto, Esmeralda; Barbot, Jose. 2010. Hereditary spherocytosis and the (TA)(n)TAA polymorphism of UGT1A1 gene promoter region-A comparison of the bilirubin plasmatic levels in the different clinical forms. BLOOD CELLS MOLECULES AND DISEASES, 44(2), DOI: 10.1016/j.bcmd.2009.10.012
  • Rocha, Susana; Costa, Elisio; Rocha-Pereira, Petronila; Ferreira, Fatima; Cleto, Esmeralda; Barbot, Jose; Quintanilha, Alexandre; Belo, Luis; Santos-Silva, Alice. 2010. Erythrocyte membrane protein destabilization versus clinical outcome in 160 Portuguese Hereditary Spherocytosis patients. BRITISH JOURNAL OF HAEMATOLOGY, 149(5), DOI: 10.1111/j.1365-2141.2010.08166.x
  • Rocha, Susana; Costa, Elisio; Coimbra, Susana; Nascimento, Henrique; Catarino, Cristina; Rocha-Pereira, Petronila; Quintanilha, Alexandre; Belo, Luis; Santos-Silva, Alice. 2009. Linkage of cytosolic peroxiredoxin 2 to erythrocyte membrane imposed by hydrogen peroxide-induced oxidative stress. BLOOD CELLS MOLECULES AND DISEASES, 43(1), DOI: 10.1016/j.bcmd.2009.03.002
  • Rocha, S; Vitorino, RMP; Lemos-Amado, FM; Castro, EB; Rocha-Pereira, P; Barbot, J; Cleto, E; Ferreira, F; Quintanilha, A; Belo, L; Santos-Silva, A. 2008. Presence of cytosolic peroxiredoxin 2 in the erythrocyte membrane of patients with hereditary spherocytosis. BLOOD CELLS MOLECULES AND DISEASES, 41(1), DOI: 10.1016/j.bcmd.2008.02.008

Main research interests

  • Peroxiredoxin 2 and other erythrocyte antioxidant enzymes (glutathione peroxidase and catalase) interplay with the red blood cell membrane and their importance in healthy and patological conditions as oxidative stress biomarkers.
  • Study of the erythrocyte antioxidant system in several etiologically distinct anemias associated to oxidative stress (human models), such as, Hereditary Spherocytosis, Sickle Cell Anemia, Thalassemias, Glucose-6-phosphate Dehydrogenase Deficiency.
  • Search for accurate and early-on biomarkers of cardiovascular events (CE) on patients with chronic kidney disease (CKD) (Stages 1-5) and evaluation of mortality associated to CE in CKD patients on hemodialysis.

Degrees

  • Graduation in Biochemistry (Bioquímica), Faculdade de Ciências da Universidade do Porto (2001)
  • PhD in Pharmaceutical Sciences - Biochemistry Specialization, Faculdade de Farmácia da Universidade do Porto (2010)