People

Susana Rocha

senior researcher

Position
Junior Researcher (Research Unit contract) (since 2023)
CV
View here
Email
srocha@ff.up.pt
Phone number
+351 220 428 500 (ext: 8559)
ORCID
0000-0003-4196-2217
Ciência Vitae
C312-96A1-2A63

Recent publications

  • Melo, D; Coimbra, S; Rocha, S; Santos-Silva, A. 2023. Inhibition of erythrocyte?s catalase, glutathione peroxidase or peroxiredoxin 2-Impact on cytosol and membrane. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 739, DOI: 10.1016/j.abb.2023.109569
  • Rocha, S; Felix, R; Valente, MJ; Bento-Silva, A; Rebelo, R; Amorim, CG; Araujo, AD; Moreira, R; Santos-Silva, A; Montenegro, MCBSM. 2023. Polysulfone Membranes Doped with Human Neutrophil Elastase Inhibitors: Assessment of Bioactivity and Biocompatibility. MEMBRANES, 13, DOI: 10.3390/membranes13010089
  • Sousa, NR; Rocha, S; Santos-Silva, A; Coimbra, S; Valente, MJ. 2022. Cellular and Molecular Pathways Underlying the Nephrotoxicity of Gadolinium. TOXICOLOGICAL SCIENCES, DOI: 10.1093/toxsci/kfab148
  • Rocha, S; Valente, MJ; Coimbra, S; Catarino, C; Rocha-Pereira, P; Oliveira, JG; Madureira, J; Fernandes, JC; Do Sameiro-Faria, M; Miranda, V; Belo, L; Santos-Silva, A; Bronze-da-Rocha, E. 2021. Interleukin 6 (rs1800795) and pentraxin 3 (rs2305619) polymorphisms-association with inflammation and all-cause mortality in end-stage-renal disease patients on dialysis. Scientific Reports, 11, DOI: 10.1038/s41598-021-94075-x
  • Coimbra, S; Rocha, S; Nascimento, H; Valente, MJ; Catarino, C; Rocha-Pereira, P; Sameiro-Faria, M; Oliveira, JG; Madureira, J; Fernandes, JC; Miranda, V; Belo, L; Bronze-da-Rocha, E; Santos-Silva, A. 2021. Cell-free DNA as a marker for the outcome of end-stage renal disease patients on haemodialysis. CLINICAL KIDNEY JOURNAL, 14, DOI: 10.1093/ckj/sfaa115
  • Rocha, S; Rocha-Pereira, P; Cleto, E; Ferreira, F; Belo, L; Santos-Silva, A. 2020. Linkage of typically cytosolic peroxidases to erythrocyte membrane – A possible mechanism of protection in Hereditary Spherocytosis. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1862(3), DOI: 10.1016/j.bbamem.2019.183172
  • Rocha, S; Melo, D; Cleto, E; Ferreira, F; Belo, L; Bronze-da-Rocha, E; Santos-Silva, A. 2019. Linkage of cytosolic antioxidant enzymes to the erythrocyte membrane as protection mechanism in hereditary spherocytosis. FREE RADICAL BIOLOGY AND MEDICINE, 139, DOI:
  • Melo, D; Coimbra, S; Santos-Silva, A; Rocha, S. 2019. Catalase inhibition leads to translocation of glutathione peroxidase to the erythrocyte membrane. FREE RADICAL BIOLOGY AND MEDICINE, 139, DOI:
  • Daniela Melo; Susana Rocha; Susana Coimbra; Alice Santos Silva. 2019. Interplay between Erythrocyte Peroxidases and Membrane. Erythrocyte [Working Title], DOI: 10.5772/intechopen.83590

Main research interests

  • Peroxiredoxin 2 and other erythrocyte antioxidant enzymes (glutathione peroxidase and catalase) interplay with the red blood cell membrane and their importance in healthy and patological conditions as oxidative stress biomarkers.
  • Study of the erythrocyte antioxidant system in several etiologically distinct anemias associated to oxidative stress (human models), such as, Hereditary Spherocytosis, Sickle Cell Anemia, Thalassemias, Glucose-6-phosphate Dehydrogenase Deficiency.
  • Search for accurate and early-on biomarkers of cardiovascular events (CE) on patients with chronic kidney disease (CKD) (Stages 1-5) and evaluation of mortality associated to CE in CKD patients on hemodialysis.
  • development and characterization biomaterials with antioxidant/anti-inflammatory proprieties, namely, modified biomaterials to be used as hemodialysis membranes