Human Genetics and Cancer Therapeutics
Cancer diagnostics, biomarkers identification and validation using proteomic approaches. Drug screen and validation using in vitro and in vivo animal models; development of novel combinatorial cancer therapies.
Validation and target delivery of novel antitumor compounds
Alexandra R. Fernandes*, João Jesus, Pedro Martins, Sara Figueiredo, Daniela Rosa, Luísa M.R.D.R.S. Martins, Maria Luísa Corvo, Manuela C. Carvalheiro, Pedro M. Costa, Pedro V. Baptista*. Multifunctional gold-nanoparticles: a nanovectorization tool for the targeted delivery of novel chemotherapeutic agents. Journal of Control Release 2017. dx.doi.org/10.1016/j.jconrel.2016.11.021;
Luisa Corvo, Ana Soraia Mendo, Sara Figueiredo, Miguel Larguinho, Rogério Gaspar, Pedro V. Baptista* and Alexandra R. Fernandes*. Liposomes as delivery system of a Sn(IV) compound for cancer therapy. Pharm Res. 2016 Jun;33(6):1351-8. doi: 10.1007/s11095-016-1876-6.
Validation and Target delivery of novel antitumor compounds.
Startup in the nanodiagnostic field - Nano4 Global Lda.
Co-founder with Pedro Viana Baptista (FCT/UNL) and Filipe Assoreira. Since December 2015.
- “Cytotoxicity and photo-cytotoxicity of nitrosyl ruthenium anticancer drug in aqueous solution or incorporated in a drug delivery system. An innovative purpose for metal based drug”, FAPESP, Alexandra Fernandes (PI-FCT NOVA).
- “Gold multifunctional nanoparticles for targeting cancer – Cetuximab”, Merck-Serono, Total and Unit funding: €72,000, Alexandra Fernandes (PI).
- “Validation of the antitumor/antiin ammatory potential of novel plant extracts”, VITROBIO SA, Total and Unit funding: €5,400, Alexandra Fernandes (PI).
- “RA Detect: One Platform- multiple biomarker detection of rheumatoid arthritis”, EC-H2020, Total Funding: €137,000. Unit Funding: €22,000, Alexandra Fernandes (Collaborator).
- “Unveiling host speci city and host-pathogen interactions of Streptococcus”, FCT-MCTES, Total funding: €199,000, Unit funding: €99,700. Alexandra Fernandes (Collaborator).
Das, K; Datta, A; Frontera, A; Wen, YS; Roma-Rodrigues, C; Raposo, LR; Fernandes, AR; Hung, CH. 2020. Zn(II) and Co(II) derivatives anchored with scorpionate precursor: Antiproliferative evaluation in human cancer cell lines. JOURNAL OF INORGANIC BIOCHEMISTRY, 202, DOI: 10.1016/j.jinorgbio.2019.110881
Amendoeira, A; Garc?a, LR; Fernandes, AR; Baptista, PV. 2020. Light Irradiation of Gold Nanoparticles Toward Advanced Cancer Therapeutics. ADVANCED THERAPEUTICS, 3, DOI: 10.1002/adtp.201900153
Fialho, L; Araujo, D; Alves, VD; Roma-Rodrigues, C; Baptista, PV; Fernandes, AR; Freitas, F; Reis, MAM. 2020. Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, DOI: 10.1080/00914037.2019.1695205