Toxicology

Toxicology

The TOXI Group is developing research in toxicology applied to marine biotechnology, environment and human disease. The group consists of 3 complimentary research laboratories (Toxicology, BioTox, and SeaTox Labs).
 

The Toxicology Lab aims at evaluating the toxicodynamics and toxicokinetics of xenobiotics, namely toxins, drugs of abuse, pesticides, metals, nanomaterials and anti-cancer drugs. These studies have allowed us to develop and patent new antidotes, and ways to modulate pharmacokinetic factors for increasing the xenobiotics safety. The use of metabolomic tools has also allowed us to thrive in the evaluation of specific markers of Toxicology and go deeper into studies of cancer biochemical pathways.
 

The SeaTox Lab aims at firmly establishing itself at the international forefront of novel technologies in Marine Toxicology within its possible range of applications, from the monitoring and testing of emerging environmental toxicants to the discovery of novel bioproducts, with emphasis on animal pigments and proteinaceous toxins.
 

The Biotox Lab aims at developing studies on environmental toxicology (e.g. effects of nanomaterials, heavy metals, quantum dots and endocrine disruptors in organisms). We have also been studying the effects of climate change on the marine biota. A recently implemented research line on food toxicology and food quality is based upon the development of biosensors and analytical methodologies to detect contaminants in seaweeds.
 

In the 2013-2017 period the group has: published 328 papers in international journals with 2701 citations as well as 31 books or book chapters, and 1 patent; supervised 19 PhD theses and 55 MSc theses; participated in 3 international projects and 15 national projects (6 of which as PI), with an approximate total funding of 1.7 M€.

TOXI Research Labs
Recent publications
Serrano, VM; Cardoso, AR; Diniz, M; Sales, MGF. 2020. In-situ production of Histamine-imprinted polymeric materials for electrochemical monitoring of fish. SENSORS AND ACTUATORS B-CHEMICAL, 311, DOI: 10.1016/j.snb.2020.127902
Silva, B; Silva, R; Fernandes, C; de Pinho, PG; Remiao, F. 2020. Enantioselectivity on the absorption of methylone and pentedrone using Caco-2 cell line: Development and validation of an UHPLC method for cathinones quantification. TOXICOLOGY AND APPLIED PHARMACOLOGY, 395, DOI: 10.1016/j.taap.2020.114970
Mesquita, I; Ferreira, C; Moreira, D; Kluck, GEG; Barbosa, AM; Torrado, E; Dinis-Oliveira, RJ; Goncalves, LG; Beauparlant, CJ; Droit, A; Berod, L; Sparwasser, T; Bodhale, N; Saha, B; Rodrigues, F; Cunha, C; Carvalho, A; Castro, AG; Estaquier, J; Silvestre, R. 2020. The Absence of HIF-1 alpha Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. Cell Reports, 30, DOI: 10.1016/j.celrep.2020.02.098
Mauricio, R; Jorge, J; Dias, R; Noronha, JP; Amaral, L; Daam, MA; Mano, AP; Diniz, MS. 2020. The use of peracetic acid for estrogen removal from urban wastewaters: E2 as a case study. ENVIRONMENTAL MONITORING AND ASSESSMENT, 192, DOI: 10.1007/s10661-020-8079-7
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