Helena Vieira, UCIBIO-FCT NOVA
Carbon monoxide against cerebral stroke: challenges and achievements
Chair: Maria João Romão, UCIBIO at FCT NOVA
The seminar will give a brief introduction about our lab “Molecular Mechanisms of Disease” and the work we have been developing in the last 10 years. The main studied pathology is ischemic stroke, which results from the lack of blood supply (ischemia), limiting oxygen and nutrients availability. These events lead to brain damage and neuronal cell loss. Our broaden scientific question tackles the mechanisms underlying ischemia-reperfusion events in brain cells, by targeting several cellular processes: apoptosis, inflammation, autophagy, metabolic shifts, redox signaling and neuronal differentiation. The final objective is to integrate this knowledge and develop new approaches for protecting brain tissue based on: (i) the cytoprotective function of carbon monoxide /heme-oxygenase and (ii) the activation of endogenous mechanisms of defense and conditioning-induced tolerance.